BMB Seminars

Biochemistry and Molecular Biophysics Seminar Archive


2016


  • 2016-11-29 – Maria Kontoyianni, Ph.D.A Computational Strategy to Probe Cytochrome P450 3A4-Drug Complexes (more…)


Jonathan Schlebach – 1/12/16 – Vanderbilt University School of Medicine – The Safety Dance: Biophysics of Membrane Protein Misfolding and Disease

Tanja Mittag – 1/19/16 – St. Jude Children’s Research Hospital – The Role of Protein Disorder and Multivalency in the Organization of the Cell

Sarah Keane – 1/26/16 – HHMI; University of Maryland, Baltimore – Structure of the HIV-1 5′ Leader

Richard Hite – 2/2/16 – The Rockefeller University – CryoEM Structure of the Slo2.2 Na+-activated K+ Channel

Ariele Follis – 2/9/16 – St. Jude Children’s Research Hospital – Protein Dynamics Mediate Cell Signaling in Apoptotic Regulation by Cytosolic p53

Andrea Soranno – 2/11/16 – University of Zürich, Switzerland – Single Molecule Spectroscopy of Intrinsically Disordered Proteins

Priya Banerjee – 2/16/16 – The Scripps Research Institute – Functional Modulation of Protein Order-Disorder Transitions, One Molecule at a Time

Rui Zhang – 2/18/16 – HHMI, University of California, Berkeley – Mechanistic Origin of Microtubule Dynamic Instability Revealed by High-resolution Cryo-EM

Roland Dolle – 2/23/16 – Brysten Biomedical, LLC – Analgesic Delta Opioid Receptor Agonists: Discovery to Clinical Trials

James Havranek – 3/8/16 – Washington University at Saint Louis – Tools and Applications of Protein Engineering

Matthew Lew – 3/15/16 – Washington University at Saint Louis – Single Molecules and Computational Optics for Nanoscale Biological Imaging

Joseph D. Puglisi – 3/21/16 – Stanford University – Dynamics of Translation

Patrick Loria – 3/22/16 – Yale University – The Role of Microsecond-Millisecond Motions in Enzyme Function

Ken Dill – 3/29/16 – Stony Brook University – Towards a Physical Chemistry of the Cell

Evgeny Nudler – 4/5/16 – New York University – New Principles of Transcription-Coupled DNA Repair

H. Jane Dyson – 4/12/16 – The Scripps Research Institute – Disorder and Partial Order in Protein-Protein Interactions

Tony Koleske – 4/18/16 – Yale University – Adhesive and Cytoskeletal Control of Dendrite and Synapse Stability

Jonathan Howard – 4/19/16 – Yale University – Beat Generation: Ciliary and Flagellar Motion Driven by Cooperative Molecular Motors

Min Lu – 4/26/16 – Rosalind Franklin University of Medicine and Science – Mechanistic Studies of MATE Multidrug Transporters

Roberto Galletto – 4/28/16 – Washington University School of Medicine in St. Louis – Helicases, Polymerases and Protein Blocks: What Does What at Telomeres?

Weikai Li – 5/10/16 – Washington University School of Medicine in St. Louis – Structural Biology of Bloody Membrane Proteins

Jim Janetka, Ph.D – 2016-09-06 – Washington University in Saint Louis –
“A fresh “out of the cell” look at bacteria and tumors: Targeting pathogenic mechanisms in cancer and infection”

Kim Stroka, Ph.D – 2016-09-20 – University of Maryland, College Park – “Evaluation of Blood-Brain Barrier Mechanobiology using Biomimetic Models” (Host: John Cooper)

Lucia Strader, Ph.D – 2016-10-04 – Washington University in Saint Louis – “ARF Transcription Factors: Protein aggregation as a regulator of gene transcription”

Rama Ranganathan, M.D., Ph.D – 2016-10-11 – UT Southwestern Medical Center – “TBA” (Host: Student Invited Speaker)

Jeff Peng, Ph.D. – 2016-10-18 – University of Notre Dame – “TBA” (Host: Kathleen Hall)

Dave Thomas, Ph.D – 2016-11-01 – University of Minnesota – TBA” (Host: Michael Greenberg)

Selba Kutluay, Ph.D – 2016-11-08 – Washington University in Saint Louis – “HIV-1 integrase binds the viral RNA genome and is essential during virion morphogenesis”

Michelle Arkin, PH.D – 2016-11-15 – University of California, San Francisco – “TBA” (Host: Greg Bowman)


2015

Mikhail Grigoriev – 1/20/15 – Laboratoire de Biologie Moléculaire Eucaryote (LBME) – TIP49 (Pontin/Reptin) AAA+ ATPases: Conformational Flexibility and ATP Hydrolysis

Ashok Deniz – 1/27/15 – The Scripps Research Institute – Single-Molecule Biophysics of Protein Disorder

Benjamin Wylie – 2/3/15 – Texas Tech – Transmembrane Allostery in K+ Channels

Vince Hilser – 2/17/15 – Johns Hopkins University – Parallel Tuning of Activation and Repression in Intrinsic Disorder-Mediated Allostery
CANCELLED

Jessica Kate Tyler – 2/23/15 – University of Texas MD Anderson Cancer Center – Chromatin Packaging as a Mediator of Nuclear Processes and Aging
SPECIAL SEMINAR

Gavin King – 2/24/15 – University of Missouri, Columbia – A Precise Three-Dimensional Force Microscope for Biophysics

Jonathan A. Ellman – 3/17/15 – Yale University – A Substrate-based Fragment Approach for Enzyme Inhibitor Discovery

John Gross – 3/24/15 – University of California, San Francisco – Resolving the Host-Pathogen Conflict Between APOBEC3 Innate Immunity and the Lentiviral Protein Vif

Yifan Cheng – 4/7/15 – University of California, San Francisco – Study of Integral Membrane Proteins by Single Particle cryoEM

Jianmin Gao – 4/14/15 – Boston College – Novel Strategies for Targeting Membrane Lipids

Andrew H. Marcus – 4/28/15 – University of Oregon – Studies of Structure and Dynamics of Protein-DNA Complexes by Single Molecule and Two-Dimensional Fluorescence Spectroscopy

Joseph Corbo – 5/12/15 – Washington University in St. Louis – Seeing Red: A Biochemical Switch for Far-Red Vision

Robin Shields-Cutler – 6/9/15 – Washington University in St. Louis – How the Human Urinary Metabolome Supercharges Antimicrobial Defenses
2015 Ceil M. DeGutis Prize Awardee in Chemical Biology/Medicinal Chemistry

Stephen V. Frye – 9/1/15 – The University of North Carolina at Chapel Hill – Targeting Chromatin Regulation: Progress Towards Chemical Probes for Methyl-Lysine Readers

Michael Summers – 9/15/15 – University of Maryland-Baltimore – Insights into the Structural Basis and Mechanism of HIV-1 Genome Packaging

Melanie Ott – 9/22/15 – University of California-San Francisco – Epigenetic Regulation of HIV Transcription

Eva Nogales – 10/13/15 – University of California-Berkeley – Macromolecular Assembly and Function Visualized Using Cryo-EM

Keir Newman – 10/20/15 – NHLBI, NIH – A Chink in the Armor: Spontaneous Periodic Defects in Collagen Control Collagenase Activity

Vince Hilser – 11/17/15 – John Hopkins University – Parallel Tuning of Activation and Repression in Intrinsic Disorder-Mediated Allostery

Jessica Brown – 11/18/15 – Yale University – Structural Insights into the Stabilization of MALAT1 Noncoding RNA by a Bipartite Triple Helix

David Baker – 12/1/15 – University of Washington, Seattle – Post-Evolutionary Biology: Design of Novel Protein Structures, Functions and Assemblies

Steve Sligar – 12/2/15 – University of Illinois, Urbana – Revealing the Structures and Function of Membrane Proteins Through Nanotechnology


2014

Warner C. Greene – 1/14/14 – Gladstone Institutes – University of California, San Francisco – CD4 T Cell Death in HIV/AIDS: A Suicide Not a Murder

Diwakar Shukla – 1/21/14 – Stanford University – The Secrets in the Landscapes: Elucidating Activation Mechanism of GPCRs and Kinases for Selective Drug Design
SPECIAL SEMINAR

Greg Bowman – 1/28/14 – University of California, Berkeley – Controlling Protein Function via Hidden Allosteric Sites
SPECIAL SEMINAR

Justin MacCallum – 2/11/14 – Stony Brook University – Predicting and Understanding Protein Structure Using Physical Modeling
SPECIAL SEMINAR

Karissa Sanbonmatsu – 2/25/14 – Los Alamos National Laboratory – Strategies for Atomistic Simulations of Large Biomolecular Complexes: Movement of tRNA Through the Ribosome
SPECIAL SEMINAR

Lynette Cegelski – 3/4/14 – Stanford University – Structure, Function, and Inhibition of Bacterial Biofilms: Insights from Small Molecules and a Big Magnet

Alex Dickson – 3/11/14 – University of Michigan – Using Networks to Investigate Protein Dynamics
SPECIAL SEMINAR

Rob Phillips – 3/18/14 – California Institute of Technology – The Statistical Mechanical Genome

Jiajie Diao – 3/20/14 – Stanford University – Studies of the Molecular Mechanism of SNARE-mediated Membrane Fusion at the Single-vesicle Level
SPECIAL SEMINAR

Darrel W. Stafford – 3/25/14 – University of North Carolina, Chapel Hill – The Vitamin K Cycle

Guishan Zheng – 4/1/14 – Harvard University – How Does “The Perfect” Enzyme Work?
SPECIAL SEMINAR

Michael J. Greenberg – 4/8/14 – University of Pennsylvania – Cytoskeletal Force Sensing in Health and Disease
SPECIAL SEMINAR

Enrico Di Cera – 4/15/14 – Saint Louis University, Saint Louis – Mechanisms of Ligand Binding: A Critical Appraisal

Arthur Laganowsky – 4/17/14 – University of Oxford, Brasenose College, Oxford, United Kingdom – Selectivity of Membrane Proteins Toward Individual Phospholipids
SPECIAL SEMINAR

David P. Giedroc – 4/22/14 – Indiana University, Bloomington – Transition Metal Chemistry at the Host-Microbial Pathogen Interface

Sarah Walker – 4/24/14 – Eunice Kennedy Shriver National Institute of Child Health and Human Development – NIH – Yeast eIF4B Binds to the Ribosome and Promotes eIF4A Activity During Translation Initiation
SPECIAL SEMINAR

Charles S. Craik – 5/6/14 – University of California, San Francisco – Understanding the Role of Proteolysis in Disease

John F. DiPersio – 5/13/14 – Washington University School of Medicine, St. Louis – Innovations in Stem Cell Transplantation

Zhou-Feng Chen – 5/20/14 – Washington University School of Medicine, St. Louis – Why We Scratch: Exploring Itch Receptor Signaling and Circuits

David Odde – 7/21/14 – University of Minnesota – Nanoscale Dynamics and Modeling of Microtubule Self-Assembly

James Hurley – 9/9/14 – University of California, Berkeley – The Structural Choreography of Cellular Self-Cannibalism

Alexandre Morozov – 9/18/14 – Rutgers University – A Surprising Degree of Nucleosome Crowding and Unwrapping in S. cerevisiae

Yibing Shan – 9/23/14 – D.E. Shaw Research – Structural Biology of Protein Kinases by Way of Large-scale Molecular Dynamics Simulation

Michael Poirier – 9/30/14 – Ohio State University – Functions of Chromatin Dynamics

Evan Sadler – 10/14/14 – Washington University School of Medicine – Structure and Regulation of the Metalloprotease ADAMTS13

Anders Carlsson – 10/21/14 – Washington University in St. Louis – How Actin Polymerization Bends Cell Membranes

Bruce Sullenger – 11/4/14 – Duke University Medical Center – Nucleic Acid Aptamers and Scavengers for Treatment of Thrombosis and Inflammation

Denton Hoyer – 11/6/14 – Yale Center for Molecular Discovery – Kickstarting Academic Research….Lessons learned in new target discovery and validation
SPECIAL SEMINAR

Melanie Ott – 11/11/14 – Gladstone Institute of Virology and Immunology – TBA
CANCELLED

R. Kip Guy – 11/13/14 – St. Jude Children’s Research Hospital – (+)-SJ733, a clinical candidate for malaria targeting PfATP4

Joan Steitz – 11/18/14 – Yale University School of Medicine – Noncoding RNAs:with a viral twist
Carl And Gerty Cori Lecture

Gunda Georg – 11/20/14 – College of Pharmacy, University of Minnesota – Drug Discovery in Academia: Minnelide for Pancreatic Cancer and Gamendazole for Male Contraception
SPECIAL SEMINAR

Matthew Bogyo – 12/2/14 – Stanford University – Small Molecule Probes of Protease Activity: Applications to Cancer, Inflammation and Infectious Diseases

Steve Blacklow – 12/9/14 – Harvard University – Unraveling the Mechanism of Normal and Oncogenic Notch Signaling

David Millar – 12/10/14 – Scripps Institute – Visualizing Protein Function at the Single-Molecule Level

Craig Lindsey – 12/11/14 – Vanderbilt University Medical Center – Academic Drug Discovery Focused on Allosteric Modulation
SPECIAL SEMINAR


2013

Jason Weber – 1/23/13 – Washington University School of Medicine in St. Louis – Tumor Suppression of the Interferon Response

Christian Eggeling – 2/1/13 – University of Oxford, Oxford, United Kingdom – Studying Membrane Heterogeneity with STED Nanoscopy

Fang Li – 2/13/13 – University of Minnesota – Receptor Recognition Mechanisms of Coronaviruses

Gerald L. Hazelbauer – University of Missouri – Columbia – Dissecting the Complex Interactions of Transmembrane Chemotaxis Signaling Complexes Utilizing Nanodiscs

Joshua Wand – 3/13/13 – University of Pennsylvania – The Dark Energy of Proteins Comes to Light: Conformational Entropy in Protein Function

William Dowhan – 3/20/13 – University of Texas – Houston Medical School – Protein Gymnastics in the Lipid Bilayer: Lipids as Determinants of Protein Structure

Scott C. Blanchard – 3/22/13 – Weill Cornell Medical College – Single-Molecule Imaging of Integral Membrane Protein-Facilitated Transport
SPECIAL SEMINAR

Wolf-Dietrich Heyer – 3/27/13 – University of California – Davis – Mechanisms of Recombinational DNA Repair

Julian (J-L) Chen – 4/1/13 – Arizona State University – The Inner Workings of Telomerase: A Remarkable Reverse Transcriptase
SPECIAL SEMINAR

Mark P. Foster – 4/3/13 – Ohio State University – Mapping the Landscape of Biological Regulation with NMR and Biophysics

Edward Yu – 4/5/13 – Iowa State University – Structure and Mechanism of the Tripartite CusCBA Heavy-Metal Efflux Complex
SPECIAL SEMINAR

Ken Blumer – 4/10/13 – Washington University School of Medicine – Signaling by an Unusual G Protein Heterotrimer

Amy Pasquinelli – 4/15/13 – University of California, San Diego – Pinning Down MicroRNA Targets In Vivo
SPECIAL SEMINAR

Erik Sontheimer – 4/17/13 – Northwestern University – CRISPR RNA-Derived Genetic Interference in Bacteria

Sarah Woodson – 5/1/13 – Johns Hopkins University – Visualizing RNA Motions During Ribosome Assembly

James A. Spudich – 5/8/13 – Stanford University – The Underlying Molecular Basis of Human Hypertrophic and Dilated Cardiomyopathies
CORI LECTURE

Robert Batey – 5/15/13 – University of Colorado, Boulder – Structural Insights into Genetic Regulation by Metabolite-Binding mRNAs

Michael Stone – 5/22/13 – University of California, Santa Cruz – Single-Molecule Studies of Telomeres and Telomerase

Ahmet Yildiz – 9/17/13 – University of California, Berkeley – Single Molecule Analysis of Molecular Motors

Tom Baranski – 9/24/13 – Washington University School of Medicine, St. Louis – G Protein Signaling: An Old Receptor Superfamily Learns Some New Tricks

Gerald R. Smith – 10/4/13 – Fred Hutchinson Cancer Research Center – Seattle, Washington – How Bacteria Repair Broken DNA – a Target for New Antibiotics
SPECIAL SEMINAR

Harald Schwalbe – 10/4/13 – Johann Wolfgang Goethe Universität – NMR of RNA
SPECIAL SEMINAR

Michael Ostap – 10/15/13 – University of Pennsylvania – From Force-Sensing to Organelle Transport – Using Single Molecule, Biochemical, and Structural Techniques to Understand Cytoskeletal Motors

Ailong Ke – 10/22/13 – Cornell University – RNA-based Bacterial Immunity and Gene Regulatory Networks: i) CRISPR RNA Interference and ii) tRNA Sensing by T-box Riboswitch

Sheila Stewart – 10/29/13 – Washington University School of Medicine, St. Louis – Why is FEN1 Dancing with the Leading Strand Replication Machinery?

Dan Leahy – 11/5/13 – John Hopkins University – Is There Really Anything More to Learn About EGFR/ErbB Mechanism?

Brad Nolen – 11/12/13 – University of Oregon – Activation of Arp2/3 Complex by non-WASP-like Nucleation Promoting Factors

Christina Stallings – 11/19/13 – Washington University School of Medicine in St. Louis – New Mechanisms of Regulating Transcription During Mycobacterium Tuberculosis Pathogenesis


2012

Brian Volkman – 1/18/12 – Medical College of Wisconsin, Milwaukee, WI – Extreme Protein Dynamism: Functional Unfolding in the Native State

James McNew – 1/25/12 – Rice University, Houston, TX – Molecular Analysis of Membrane Fusion by the GTPase Atlastin

Jacques Baenziger – 2/8/12 – Washington University School of Medicine, St. Louis, MO – The Molecular Language of Carbohydrates: A New Level of Hormone Regulation

James Havranek – 3/7/12 – Washington University School of Medicine, St. Louis, MO – Computational Protein Design: Algorithms and Applications

Michael Tomasson – 3/14/12 – Washington University School of Medicine, St. Louis, MO – Activation of a Novel snRNP by Chromosomal Translocation t(4;14) in Multiple Myeloma

Stephen Bell – 3/21/12 – MIT, Cambridge, MA – From Initiator to Initiation: A Biochemical Exploration of Eukaryotic DNA Replication

Stuart Kornfeld – 3/28/12 – Washington University School of Medicine, St. Louis, MO – New Insights into the Man-6-P Lysosomal Targeting System

John Silva – 4/4/12 – Washington University School of Medicine, St. Louis, MO – Molecular Biophysics of Ion Channels

Jeff Gelles – 4/11/12 – Brandeis University, Waltham, MA – Understanding Transcription Regulation by Studying One Molecule at a Time

Richard Youle – 4/25/12 – Surgical Neurology Branch, NINDS, Bethesda, MD – TBA
(Cancelled)

Herschel Wade – 5/22/12 – Johns Hopkins, Baltimore, MD – When Its All a Blur: Multi-drug Recognition in BmrR

William R. Montfort – 5/16/12 – University of Arizona, Tucson, AZ – Nitric Oxide Signaling: from Moth to Man

Christopher D. Lima – 9/5/12 – Sloan Kettering Institute, New York City, NY – Post-translational Modification and Signaling by SUMO, a Ubiquitin-like Modifier
(Interdisciplinary Seminar Series)

Brendan Lee – 9/12/12 – Baylor College of Medicine, Houston, TX – From the Bedside and Back: Novel Mechanism for Systemic Regulation of Nitric Oxide Metabolism
(Interdisciplinary Seminar Series)

Thomas V. O’Halloran – 9/19/12 – Northwestern University, Evanston, IL – Zinc Fluxes Control Mammalian Fertilization and Development
(Interdisciplinary Seminar Series)

Roger R. Markwald – 9/27/12 – Medical University of South Carolina, Charleston, SC – Veni, Vidi, Vici; from Fibroblast Origin, Through Visualization to Defeating Pathological Valve and Myocardial Remodeling
(Interdisciplinary Seminar Series)

Timothy A. Springer – 10/3/12 – Harvard University, Cambridge, MA – Integrins, from Lymphocyte Homing to Therapy for Multiple Sclerosis
(Interdisciplinary Seminar Series)

Helen Piwnica-Worms – 10/10/12 – Washington University School of Medicine, St. Louis – Translation of Fundamental Cell Cycle Principles to Targeted Cancer Therapies
(Interdisciplinary Seminar Series)

W. James Nelson – 10/17/12 – Stanford University – Evolution of epithelia and mechanisms of cell-cell adhesion
(Interdisciplinary Seminar Series)

Carl S. Thummel – 10/24/12 – University of Utah – Drosophila as a Model System to Study the Regulation of Energy Metabolism
(Interdisciplinary Seminar Series)

Scott Showalter – 11/7/12 – Pennsylvania State University – Carbon Detected NMR Methods Probe Folding-Upon-Binding of Intrinsically Disordered Proteins

Roberto Dominguez – 11/14/12 – University of Pennsylvania – At the Interface Between the Plasma Membrane and the Actin Cytoskeleton


2011

Brian Shoichet – 1/26/11 – UC, San Francisco, CA – The Chemical Basis of Pharmacology

Phoebe Rice – 3/9/11 – University of Chicago, Chicago, IL – Orchestrating Site-specific Recombination and Transposition

Neal Devaraj – 3/10/11 – Harvard University, Cambridge, MA – Biomedical Applications of Tetrazine Cycloadditions: Live Cell Microscopy, Clinical Diagnostics, and In-Vivo Imaging

Joshua Grimley – 3/14/11 – Duke University, Durham, NC – Development and Application of Chemical Biology Tools: Small Molecules to Proteins

Young-Hoon Ahn – 3/21/11 – John Hopkins University, Baltimore, MD – Sulforaphane and Rhodamine Analogs as Probes for Chemoprevention and Probes for Chemoprevention and Bioimaging

Charles Sanders – 3/23/11 – Vanderbilt University, Nashville, TN – Relationship of Binding Cholesterol to the Amyloid Precursor Protein to Alzheimer’s Disease

Chao Zhang – 3/28/11 – UC, San Francisco, CA – Genome-Wide Chemical Genetic Analysis of Protein Kinases

Melissa Jurica – 5/11/11 – UC, Santa Cruz, CA – Views of the Dynamic Human Spliceosome

James A. Wells – 5/13/11 – UC, San Francisco, CA – Engineering Cells to Death
(Cori Lecture)

Philip Cole – 5/18/11 – John Hopkins University, Baltimore, MD – Chemical Approaches to Sorting Out Protein Phosphorylation

Matthew R. Redinbo – 5/25/11 – University of North Carolina, Chapel Hill, NC – Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Jeff Lichtman – 9/7/11 – Harvard University – Imaging the Connectome
(Interdisciplinary Seminar Series)

John D. York – 9/14/11 – Duke University – Inositol Phosphate Communication: Insights in the Cell’s ‘iPhone’
(Interdisciplinary Seminar Series)

Matthew G. Vander Heiden – 9/21/11 – Massachusetts Institute of Technology – Metabolic Alterations that Support Cell Proliferation
(Interdisciplinary Seminar Series)

Matthew Lang – 11/2/11 – Vanderbilt University – Single-molecule Studies of CIpXP Machinery Fully Loaded

Vasanthy Narayanaswami – 11/9/11 – California State University, Long Beach – Oxidative Stress and Apoliprotein E

Stephen Harrison – 11/16/11 – HHMI-Harvard University – Molecular Organization of Kinetochores

John Kuriyan – 11/30/11 – Harvard University – Structural Mechanisms in Tyrosine Kinase Regulation
(Signalling/Cell Cycle Series)

Jon Lorsch – 12/7/11 – Johns Hopkins – A Knotty Problem: Probing the Molecular Mechanics of mRNA Recruitment to the Eukaryotic Ribosome


2010

Thomas Record – 3/10/10 – University of Wisconsin, Madison, WI – Mechanism of Active DNA Opening by E. coli RNA Polymerase in Transcription Initiation

Steve Hahn – 3/17/10 – Fred Hutchinson Cancer Research Center, Seattle, WA – Mechanisms of Initiation and Activation of Transcription by RNA Polymerase II

Steve White – 3/31/10 – UCI, Irvine, CA – Making Sense of Voltage Sensors
(Quad Seminar)

Carlos Bustamante – 4/28/10 – UC, Berkeley, CA – Grabbing the Cat by the Tail: Discrete Steps by a DNA Packaging Motor and the Inter-Subunit Coordination in a Ring- ATPase
(Quad Seminar)

James Keck – 10/6/10 – University of Wisconsin, Madison, WI – SSB: Central Organizer and Achilles’ Heel of Bacterial Genome Maintenance

Ronen Marmorstein – 10/13/10 – Wistar Institute, Philadelphia, PA – Structure, Chemistry and Evolution of Histone Acetyltransferases

Fred Dyda – 10/20/10 – DHHS/NIH/NIDDK, Bethesda, MD – When Dynamin Meets Dynamin: A Catalytically Stimulating Encounter

Thomas Perkins – 10/27/10 – JILA, NIST, CU-Boulder, Boulder, CO – From Molecular Motors to Membrane Proteins: Measuring Single Molecules with Optical Traps and Atomic Force Microscopes

Enrique De La Cruz – 11/3/10 – Yale University, New Haven, CT – How Cofilin Severs an Actin Filament

James Hurley – 11/10/10 – NIDDK, NIH, DHHS, Bethesda, MD – From Protein Kinase C to the ESCRTs:Two Tales of Structural Membrane Biology

Rick Russell – 12/8/10 – UT at Austin, Austin, TX – How Do DEAD-box Helicase Help RNAs Fold?


2009

Michael Ibba – 1/14/09 – Ohio State University, Columbus, OH – Exploring New Roles for Elongation Factor Tu Inside and Outside Translation

Florence Lederer – 4/28/09 – Paris, France – Mobility and Electron Transfer in a Flavohemoprotein, Flavocytochrome b2

Jonathan Widom – 5/6/09 – Evanston, IL – The Genomic Code for Nucleosome Positioning
(Quad Seminar)

Stephen B.H. Kent – 9/9/09 – University of Chicago, Chicago, IL – A Synthetic Protein with a Novel Topology yet to be Discovered in Nature

Stewart Shuman – 9/16/09 – Sloan Kettering Institute, New York, NY – Mechanisms of DNA Break Repair in Mycobacteria

Charles McHenry – 9/30/09 – Univeristy of Colorado, Boulder, CO – Transactions at the Replication Fork: Functional, Mechanistic and Chemical Biology Studies

Daniel Bogenhagen – 10/21/09 – State University New York, Stony Brook, NY – Mitochondrial Biogenesis and Heredity

Ruben L. Gonzalez, Jr. – 12/9/09 – Columbia University, New York, NY – Translation Factor Control of Ribosome Dynamics During Protein Synthesis


2008

Lynette Cegelski – 1/16/08 – Washington University, St. Louis, MO – On the Battleground Against Bacterial Pathogens: Where Solid-State NMR Joins Chemical Biology

Arne Gennerich – 1/23/08 – UC, San Francisco, CA – Molecular Mechanism of Cytoplasmic Dynein

Guobin Luo – 1/31/08 – Harvard University, Cambridge, MA – Phosphorylation-Mediated Activation of Bacterial Response Regulator Transcription Factors

Gary Brouhard – 2/7/08 – Max Plack Institute, Dresden, Germany – The Yin and the Yang of Microtubules

Michael Shirts – 2/13/08 – Columbia University, New York, NY – Towards Noncovalent Molecular Design: Making Ligand Binding Predictions Quantitative

Eric Galburt – 2/19/08 – Max Planck Institute, Dresden, Germany – Backtracking and Beyond: Single Molecules of RNA Polymerase II

Athan Kuliopulos – 3/12/08 – Tufts-New England Med Ctr, Boston, MA – Protease Receptor Dimerization in Thrombin Signaling and Sepsis

Neil Lue – 3/26/08 – Cornell University, New York, NY – The Mechanisms and Evolution of Telomere Maintenance Machinery in Budding Yeast

Klaus Schulten – 4/2/08 – University of Illinois, Urbana, IL – How Directional Translocation is Regulated by a DNA Helicase Motor

Andreas Matouschek – 4/9/08 – Northwestern University, Evanston, IL – Protein Unfolding in the Cell

Johannes Walter – 4/16/08 – Harvard University, Boston, MA – The Eukaryotic Replisome: Genomic Copyist and Caretaker Extraordinaire

Melanie Cobb – 4/23/08 – UT Southwestern, Dallas, TX – MAPKs – Nuclear Import and Transcriptional Regulation in Pancreatic Beta Cells

Ann Stock – 4/30/08 – UMDNJ-Robert Wood Johnson Med School, Piscataway, NJ – Phosphorylation Mediated Activation of Bacterial Response Regulator Transcription Factors

Leslie Parise – 5//07/08 – University of North Carolina, Chapel Hill, NC – CIB1 Signaling Networks in Cardiovascular Disease and Cancer

Charles Esmon – 5/14/08 – Oklahoma Med Res Foundation, Oklahoma City, OK – The Protein C Pathway in Health and Disease

David D. Thomas – 5/21/08 – University of Minnesota, Minneapolis, MN – Disorder-Order Transitions Regulate Muscle Contraction and Relaxation

George Rose – 10/8/08 – John Hopkins University, Baltimore, MD – Protein Folding – Inverting the Paradigm

Peter Wright – 10/29/08 – Scripps Research Institute, La Jolla, CA – Exploring the Energy Landscape: Disorder, Dynamics, and Protein Function

Xiaowei Zhuang – 11/12/08 – Harvard University, Cambridge, MA – Nanoscopic Imaging of Enzymes, Cells and Tissues: Super-resolution Imaging and Single Molecule FRET

Titia de Lange – 11/19/08 – Rockefeller University, New York, NY – How Telomeres Protect Chromosome Ends

Matthew Cordes – 12/3/08 – University of Arizona, Tucson, AZ – The Remarkable Evolution of Cro Proteins


2007

Gang Dong – 1/16/07 – Yale University School of Medicine, New Haven, CT – Structural Insights into the Last Stages of Exocytosis: The Architecture and Assembly of the Exocyst

Takanori Otomo – 1/23/07 – UTSWMC at Dallas, Texas – Structural Analysis of Formins: Actin Nucleators Regulated by Rho GTPases

Jin-Der Wen – 1/31/07 – UC, Berkeley, CA – Single-Molecule Translation Using Optical Tweezers

Andy VanDemark – 2/5/07 – University of Utah, Salt Lake City, UT – Structural and Functional Insights into the Chromatin Modifying Complexes RSC and FACT

Samara Reck-Peterson – 2/14/07 – UC, San Francisco, CA – The Molecular Mechanism of Dynein-Based Transport

Xuewu Zhang – 2/19/07 – UC, Berkeley, CA – Autoinhibiton, Allosteric Activation and Feedback Inhibition of the EGFR Kinase Domain

Roberto Galletto – 2/21/07 – UC, Davis, CA – Assembly and Disassembly of Individual RecA Nucleoprotein Filaments

Alan d’Andrea – 2/28/07 – Harvard School of Medicine, Baltimore, MD – The Fanconi Anemia/BRCA Pathway and the DNA Damage Response

Andres Leschziner – 3/12/07 – UC, Berkeley, CA – Structural Studies of ATP-dependent Chromatin Remodeling

James Berger – 3/21/07 – UC, Berkeley, CA – Structural Mechanisms of Initiating DNA Replication

Leslie Z. Benet – 3/28/07 – UC, San Francisco, CA – Drug Absorption and Disposition: Characterization of Transporters Important in Uptake/Elimination

Vadim Gladyshev – 9/19/07 – University of Nebraska, Lincoln, NE – Selenoproteins: Roles in Redox Biology and Human Health

Yann Chemla – 9/26/07 – University of Illinois, Urbana, IL – Viral DNA Packaging One Step at a Time

Patrick Loria – 10/24/07 – Yale University, New Haven, CT – Biophysical Characterization of Functional Enzyme Motions

David Kovar – 11/07/07 – University of Chicago, Chicago, IL – Formin Actin Filaments for Cell Division

John Hunt – 11/14/07 – Columbia University, New York, NY – The ABC’s of Structure-Based Function Elucidation

Leemor Joshua-Tor – 11/28/07 – Cold Spring Harbor Laboratory, Cold Spring Harbor, NY – DNA Translocation in a Replicative Hexameric Helicase

David Cafiso – 12/05/07 – University of Virginia, Charlottesville, VA – Dynamics and Conformational Changes in a Membrane Transport Protein: Applications of Site-Directed Spin Labeling

Mark C. Williams – 12/12/07 – Northeastern Univesity, Boston, MA – Force-induced DNA-ligand Interactions: From Small Molecule Binding to HIV Replication

Paul Selvin – 12/19/07 – University of Illinois, Urbana, IL – Single Molecule Mechanics of Motor Proteins, In vitro and In vivo


2006

Wei Cheng – 1/23/06 – UC, Berkeley, CA – Breaking an RNA ‘Ladder’ Molecular Mechanisms of the Hepatitis C Virus NS3 Helicase

Klaus Fütterer – 2/6/06 – University of Birmingham – UK – Structural Studies of Signaling Proteins in Man and Bacteria

Keir Neuman – 2/10/06 – Ecole Normale Supérieure, France – How does Topoisomerase IV Distinguish Left from Right?

Yuxin Mao – 2/21/06 – Yale University, New Haven, CT – Deubiquitinating Function of Ataxin-3: Insights from the Solution Structure of the Josephin Domain

Sin Urban – 2/23/06 – Harvard Medical School, Boston, MA – Mechanistic Analysis of Rhomboid Intramembrane Proteolysis Reveals Diverse Biological Functions

Sungchul Hohng – 2/27/06 – University of Illinois Champaign-Urbana, Urbana, IL – Advances in Single-molecule Spectroscopy and Biological Applications

Frank Murphy – 3/1/06 – MRC Laboratory of Mol. Biology, Cambridge – UK – Structural Details of Decoding

Myron F. Goodman – 3/08/06 – USC, Los Angeles, CA – Biochemical Basis of Human and Bacterial Hyper-mutation

Haijuan Yang – 3/16/06 – Memorial Sloan Kettering, New York, NY – BRCA2 Structure and Function in DNA Double-strand Break Repair

Kevin Slep – 3/20/06 – UC, San Francisco, CA – Molecular Mechanisms of Microtubule Plus End Tracking Proteins

Dan Sackett – 3/22/06 – NIH/NICHD, Bethesda, MD – Natural Product Antimitotic Peptides Induce Ring Oligomers of Tubulin

Ronald T. Raines – 3/29/06 – University of Wisconsin, Madison, WI – Chemical Forces that Stabilize Proteins

Dorothee Kern – 4/05/06 – Brandeis University, Waltham, MA – Proteins in Action: Dynamics during Datalysis and Signaling

Taekjip Ha – 4/12/06 – University of Illinois, Urbana-Champaign, Urbana, IL – Single Molecule Dynamics of RecA Filament and SSB5

Robert Landick – 4/19/06 – University of Wisconsin, Madison, WI – The Mechanism of Pausing by RNA Polymerase and Its Role in Transcriptional Regulation

James Stivers – 4/26/06 – John Hopkins, Baltimore, MD – Rapid Assembly of Enzyme Inhibitors from Substrate Fragments and Molecular Pieces

J. Andrew McCammon – 5/03/06 – UCSD, San Diego, CA – Integrated Computational Biology: From the Molecule to the Cell

Olke C. Uhlenbeck – 5/10/06 – Northwestern University, Evanston, IL – Why tRNAs are Different

Steve Sligar – 5/17/06 – University of Illinois-Urbana-Champaign, Urbana, IL – Self-assemble Nanometer Scale Lipid Bilayers For Elucidating the Structure and Function of Membrane Proteins

Christopher Hill – 9/13/06 – University of Utah School of Medicine, Salt Lake City, UT – Proteasome Activation: Opening the Gate to Nature’s Molecule of Mass Destruction

James H. Hurley – 9/27/06 – NIDDK, Bethesda, MD – Ubiquitin Recognition and Ubiquitin-dependent Sorting

Enrique De La Cruz – 10/11/06 – Yale University, New Haven, CT – How to Break an Actin Filament: Insights from Cofilin

Barry Stoddard – 10/18/06 – Fred Hutchinson Cancer Center, Seattle, WA – Structure, Evolution and Engineering of Homing Endonucleases: Reagents for Gene Specific Applications

Gabriel Waksman – 10/25/06 – UCL/Birbeck, London, UK – Structural Biology of Pilius Biogenesis and Bacterial Attachment Biology

Roger Woodgate – 11/15/06 – NICHHD, NIH, Baltimore, MD – Role of Y-family Polymerases in Preventing or Promoting Mutagenesis and Carcinogenesis

Natalie Strynadka – 11/29/06 – University of British Columbia, Vancouver, Canada – Structure-based Antibiotic Discovery on the Bacterial Membrane

Erec Stebbins – 12/13/06 – Rockefeller University, New York, NY – Bacterial Reprogramming of Eukaryotic Cell Biochemistry


2005

Scott Auerbach – 2/14/05 – University of Texas, Austin, TX – Decouping ATPase Activity from Microtubule Binding in Conventional Kinesin

Edward A. Dennis – 2/17/05 – UCSD, La Jolla, CA – Phospholipase A2 Regulation and the Lipid MAPS Approach to Eicosanoid Lipidomics

Bertrand Garcia-Moreno – 2/23/05 – John Hopkins, Baltimore, MD – How Do Proteins Accommodate Charge in Their Hydrophobic Interior?

Dennis Winge – 3/2/05 – University of Utah, Salt Lake City, UT – Metal Ion Sensing in Yeast: Transcriptional Regulation by Copper, Iron and Zinc Ions

Mark Goulian – 3/9/05 – University of Pennsylvania, Philadelphia, PA – Imaging, Perturbing, and Modeling Two-component Signaling in E. coli

Linda Pike – 3/23/05 – Washington University, St. Louis, MO – Defining the Interaction of the EGF Receptor with Lipid Rafts Using Lipidomics and Live Cell Fluorescence Cluster Analysis

Marc S. Wold – 3/30/05 – University of Iowa, Iowa City, IA – Replication Protein A: Regulation of Multiple Domains and Multiple Interactions

Trevor P. Creamer – 4/6/05 – University of Kentucky, Lexington, KY – Unfolded is Not Unstructured

Patricia J. Kiley – 4/13/05 – University of Wisconsin, Madison, WI – Using Fe-S Proteins to Program Bacterial Metabolism Under Anaerobic Conditions

Scott Hultgren – 4/20/05 – Washington University, St. Louis, MO – Intracellular Bacterial Communities in Pathogenesis: A Tactic for Subverting Innate Defenses

R. Andrew Byrd – 4/27/05 – NCI-Frederick, Frederick, MD – New Insights into STAT Tetramerization Derived from the Solution Structure of STAT5-NT

Gordon S. Rule – 5/4/05 – University of Pennsylvania, Pittsburgh, PA – Role of Protein Dynamics in Enzymatic Catalysis: Lessons from Human Detoxification Enzymes

Michael S. Kolodney – 5/6/05 – UCLA, Los Angeles, CA – Mechanical Mechanism of Cotricosteroids in the Treatment of Epidermal Blistering Diseases

Donald W. Pettigrew – 5/11/05 – Texas A&M, College Station, TX – Control of Sugar Kinase/hsp70/actin Superfamily Catalysis: Does Coupling of a Distal Allosteric Binding Site to the Conserved ATPase Core Involve Tuning of Backbone Motion?

Thomas T. Perkins – 9/21/05 – JILA, NIST & CU Boulder, Boulder, CO – Watching Enzymes Move Along DNA One Molecule at a Time

Sonya J. Franklin – 10/5/05 – University of Iowa, Iowa City, IA – Chimeric Metallopeptide Nucleases: The Helix-turn-helix as a Scaffold for DeNovo Design

Jon R. Lorsch – 10/26/05 – John Hopkins, Baltimore, MD – Probing the Molecular Mechanics of Start-Site Recognition During Eukaryotic Translation

Rob Phillips – 11/2/05 – CIT, Pasadena, CA – DNA in a Tight Squeeze: A Twisted Story of Bacterial Transcription

Michael Cox – 11/9/05 – University of Wisconsin, Madison, WI – Regulation of Recombinase Function

George Makhatadze – 11/16/05 – Penn State College of Medicine, Hershey, PA – Interactions on Protein Surface and Stability: A Charged Relationship

Piero Bianco – 11/30/05 – University of Buffalo, Buffalo, NY – dsDNA Translocases: Energetics and Translocation

Silvia Cavagnero – 12/7/05 – University of Wisconsin, Madison, WI – Mechanistic Explorations on Cotranslational Protein Folding


2004

Amnon Horowitz – 1/12/04 – Rehovot, Israel – Allostery in the Chaperonin GroEL

Thomas Kunkel – 1/28/04 – NIH, Bethesda, MD – Signaling Events that Determine DNA Replication Fidelity

David E. Draper – 2/4/04 – John Hopkins, Baltimore, MD – Getting the Charge Out of RNA: How Ions Help RNA Fold

Hong Qian – 2/11/04 – University of Washington, Seattle, WA – Toward Systems Biology of Cells: Metabolism and Signaling; Thermodynamics and Kinetics

M. Thomas Record, Jr. – 2/25/04 – University of Wisconsin, Madison, WI – Solution Studies of Large-scale Conformational Changes in the Mechanism of Formation of an Open Promoter Complex by E. coli RNA Polymerase

James L. Keck – 3/10/04 – University of Wisconsin, Madison, WI – Structural Dissection of E. coli RecQ DNA Helicase: Insights into the Physical Basis of Cancer and Premature Aging in Three Human Diseases

Muriel Maurer – 3/17/03 – University of Louisville, Louisville, KY – Probing Activation of Factor XIII: Studies on the Blood Clot Stabilizing Factor

David P. Giedroc – 3/31/04 – Texas A&M, College Station, TX – Metal Ion Selectivity and Allosteric Switching in Bacterial Metal Sensor Proteins

Ken Prehoda – 4/7/04 – University of Oregon, Eugene, OR – Protein Interactions in Cell Polarity: Specificity and Regulation

Thomas Bruice – 5/5/04 – UC, Santa Barbara, CA – Importance of Ground State Conformations and Transition State Stabilization in Enzymatic Reactions

Michael Maroney – 5/12/03 – University of Massachusetts, Amherst, MA – Metallobiochemistry: A Nickel Tour

Hilal Lashuel – 7/26/04 – Boston, MA – Protein Fibrillogenesis in Parkinson’s and Alzheimer’s Disease from Biophysics to Therapeutic Strategies

Arthur Kornberg – 9/21/04 – Stanford University, Palo Alto, CA – The Ten Commandments of Enzymology and the Importance of Inorganic Polyphosphate.
(Cori Lecture)

Ron Wetzel – 9/22/04 – University of Tennessee, Knoxville, TN – Polyglutamine Folding and Fibril Formation and Its Relationship to Huntington’s Disease

Dennis Discher – 9/29/04 – University of Pennsylvania, Philadelphia, PA – Compliant Underpinnings in Cell Adhesion and Differentiation

Stephen Kowalczylowski – 10/6/04 – UC, Davis, CA – Single-Molecule Visualization of Protein-DNA Interactions

Daniel M. Quinn – 10/20/04 – University of Iowa, Iowa City, IA – Energetics of Cholinesterase Catalysis – The Mighty Shall Be Brought Low

Kenneth A. Dill – 10/27/04 – UC, San Francisco, CA – Protein Folding in the Fast Lane: A New Twist on the Transition State Idea

Frederick Dahlquist – 11/3/04 – UC, Santa Barbara, CA – A Structural and Dynamic View of Signal Transduction in Bacteria

Samuel E. Butcher – 11/10/04 – University of Wisconsin, Madison, WI – Structure and Dynamics of snRNA

Homme W. Hellinga – 12/1/04 – Duke University, Durham, NC – Computational Design of Biologically Active Proteins

Doug Barrick – 12/8/04 – John Hopkins, Baltimore, MD – An Experimentally Determined Protein Energy Landscape

Wayne Hubbell – 12/15/04 – UCLA, Los Angeles, CA – Beyond Crystallography: Functional Protein Dynamics From Site-directed Spin Labeling


2003

David Mathews – 1/9/03 – University of Rochester, Rochester, NY – Predicting RNA Secondary Structure

Victor Guallar – 1/29/03 – New York, NY – Proton Transfer Mechanism in Biological Systems: Theoretical Studies of DNA Photoinduced Mutations and Enzymatic Catalysis

Wei Wang – 2/3/03 – Stanford University, Stanford, CA – Reconstructing Transcription Networks of the Cell Using Computational Genomics

Gary J. Pielak – 2/5/03 – University of North Carolina, Chapel Hill, NC – An Unfolded Protein that Folds in Cells

Randall Burton – 2/10/03 – MIT, Cambridge, MA – Energy-dependent Protein Unfolding by the Clp/Hsp100 Family of Molecular Machines

Tomasz Heyduk – 2/12/03 – Washington University, St. Louis, MO – Protein-protein and Protein-DNA Interactions in Transcription Initiation

Timothy A. Springer – 3/12/03 – Harvard University, Boston, MA – Integrin Dynamics on Leukocytes, lCAM-1 on Endothelium and the Transmigratory Cup

Renhao Li – 3/13/03 – University of Pennsylvania, Philadelphia, PA – A Structural and Functional Study on the Transmembrane and Cytoplasmic Domains of Integrin allbbe3

Tobin Sosnick – 3/19/03 – The University of Chicago, Chicago, IL – Hydrogen Bond Formation and Pathway Heterogeneity in Protein Folding

Josh E. Baker – 3/20/03 – University of Vermont, Burlington, VT – Multi-scale Studies of Motor Enzyme Mechanochemistry

Wlodzimierz M. Bujalowski -3/26/03 – University of Texas, Galveston, TX – Mechanisms of Damaged-DNA Recognition by DNA Repair Polymerase

Joyce Hamlin – 4/2/03 – University of Virginia, Charlottesville, VA – Controlling Replication in Higher Eukaryotic Chromosomes: Paradigms Lost

Glenn F. King – 4/9/03 – University of Connecticut Health Center, Farmington, CT – How Do Bacteria Decide When and Where to Divide?

Alexander Grosberg – 4/16/03 – University of Minnesota, Minneapolis, MN – How Does A Molecular Machine Work?

Amy L. Davidson – 4/23/03 – Houston, TX – Molecular Mechanism of Maltose Transport in E. coli, a Model for ABC Transport

Harry Noller – 4/30/03 – UC, Santa Cruz, CA – Crystal Structure of the Ribosome, and its Interactions with mRNA and tRNA
(Cori Lecture)

Thomas Blumenthal – 5/7/03 – University of Colorado, Denver, CO – Animal Operons: Processing of Multigene C. elegans pre-mRNAs

Robert Clegg – 5/14/03 – University of Illinois Champaign Urbana, Urbana, IL – Radicals and Reactive Oxygen Species (ROS) and their Effects in Biological Systems: Can Fluorescence Quantify Them?

Tom Alber – 5/21/03 – UC, Berkeley, CA – Dynamic Control in Allosteric Regulation

Isaac Wong – 9/17/03 – Lexington, KY – Retroviral Integrase: From Function to Structure and Back

Steven Almo – 9/24/03 – Einstein College of Medicine, Bronx, NY – Structural Biology in the Third Millennium

Lawrence Brass – 10/1/03 – University of Pennsylvania, Philadelphia, PA – Mechanisms of Platelet Activation: Borrowing Molecules From Neurons

D. Wayne Bolen – 10/8/03 – University of Texas, Galveston, TX – Protein Folding in Organic Osmolytes: The Medium is the Message

William Brownell – 10/15/03 – Baylor College of Medicine, Houston, TX – Piezoelectric Membrane-based Motors in the Outer Hair Cell

Jeff Gelles – 10/22/03 – Brandeis University, Waltham, MA – How Kinesin Keeps Its Grip: The Mechanism of a Processive Motor Enzyme

Robert W. Woody – 10/29/03 – Colorado State University, Fort Collins, CO – Circular Dichroism of Proteins: Analysis and Prediction

John Yin – 11/5/03 – University of Wisconsin, Madison, WI – From Genome to Organism – A Virus-world View

Petra Levin – 11/12/03 – Washington University, St. Louis, MO – Balancing Act: Modulators of Cell Division in Bacillus subtilis


2002

Doug Barrick – 1/16/02 – Johns Hopkins, Baltimore, MD – Stability and Cooperativity in a Modular Signaling Protein

Taekjip Ha – 1/23/02 – University of Illinois Champaign Urbana, Urbana, IL – Single Molecular Dynamics of Nucleic Acids and Helicases

Eaton E. Lattman – 1/30/02 – John Hopkins, Baltimore, MD – What is the Dielectric Constant Inside a Protein?

Erec Stebbins – 2/13/02 – Rockefeller University, New York, NY – Structural Insights into Type III Bacterial Pathogenesis

Mark A. Lemmon – 2/20/02 – University of Pennsylvania, Philadelphia, PA – Membrane Targeting by Specific Recognition of Inositol Phospholipids

Nir Ben-Tal – 2/27/02 – Tel Aviv, Israel – The Identification of Functional Regions in Proteins by Surface-Mapping of Phylogenetic Information

Kevin W. Plaxco – 3/13/02 – UC, Santa Barbara, CA – Theory and Experiment Meet in the Folding of the Simplest Proteins

Jeffrey W. Kelly – 3/27/02 – Scripps Institute, La Jolla, CA – Kinetic-vs Thermodynamic Control of Misfolding Explains Amyloid Disease Diversity

Sunney X. Xie – 4/17/02 – Harvard University, Cambridge, MA – Single Molecule Enzymatic and Conformational Dynamics

S. Mazumdar – 4/19/02 – Princeton University, Princeton, NJ – Time-resolved Fluorescence in the Study of Conformational Properties of Proteins

James Hudspeth – 4/22/02 – Rockefeller University, New York, NY – How the Ear’s Works Work: Mechanoelectrical Transduction and Amplification by Hair Cells
(Cori Lecture)

Anna Marie Pyle – 4/24/02 – Columbia University, New York, NY – A Look Under Hood of the DExH/D RNA Helicase Family

Thomas S. Leyh – 5/14/02 – Einstein University, Bronx, NY – Catalytic Strategies for the Synthesis of Activated Sulfate

Jeremy Edwards – 6/25/02 – University of Delaware, Newark, DE – What Can We Learn From Systems Biology?

Yoav Henis – 7/11/02 – Tel Aviv, Israel – Ras Proteins: Activation-dependent Interactions with Raft and Non-raft Sites and Disruption of TGF-β Signaling

Carlos E. Catalano – 9/18/02 – University of Colorado Health Sciences Center, Denver, CO – Biochemical and Structural Studies on a Viral Genome Packaging Machine

Eric Smart – 9/25/02 – University of Kentucky, Lexington, KY – Regulation of Endothelial Nitric Oxide Synthase by HDL, SR-BI, CD36, Estrogen, and Caveolae

David Shortle – 10/16/02 – John Hopkins, Baltimore, MD – The Expanded Denatured State: An Ensemble of Conformations Trapped in a Locally-Encoded Topological Space

David A. Case – 10/30/02 – Scripps Institute, La Jolla, CA – The Use of Continuum Solvent Models in Biomolecular Simulations

T. Joseph Kappock – 11/6/02 – Washington University, St. Louis, MO – An Acid Test for Enzymes

Steven Almo – 11/13/02 – Einstein College of Medicine, Bronx, NY – Structural Biology in the Third Millennium

Joseph Jez – 11/18/02 – St. Louis, MO – Exploring Polyketide Biosynthesis: Structure, Mechanism, and Engineering

Gary Ackers – 11/20/02 – Washington University, St. Louis, MO – Subunit Interfaces and Cooperativity in Hemoglobins: A Surprising Role Reversal

Karen Anderson – 12/9/02 – Yale University, New Haven, CT – Mechanistic Studies on HIV Reverse Transcriptase: Insights Into Inhibitor Design, Drug Resistance, and Toxicity

Dale Edmondson – 12/11/02 – Emory University, Atlanta, GA – Structure and Mechanism of Human Monoamine Oxidase B


2001

David Benson – 1/17/01 – Durham, NC – Rational Design of Protein Function: From Oxygen Activation to Biosensing

Cynthia Wolberger – 1/31/01 – John Hopkins, Baltimore, MD – Structural Studies of Ets1 and Pax5: Combinatorial Regulation and Autoinhibition of DNA Binding

Kenneth Keiler – 2/14/01 – Stanford University, Stanford, CA – A Stable RNA Coordinates Cell Cycle Progression

Enrique De La Cruz – 2/28/01 – University of Pennsylvania, Philadelphia, PA – Kinetic Mechanism of Myosin V, A Processive Actin-based Motor

Carlos Bustamante – 3/7/00 – UC, Berkeley, CA – Following DNA Replication One Molecule at a Time

David Eisenberg – 3/14/01 – UCLA, Los Angeles, CA – From Genome Sequences to Protein Interactions
(Cori Lecture)

Luis B. Agellon – 3/28/01 – Canada Institutes of Health, Edmonton, Canada – Insights into the Physiological Functions of Intracellular Lipid Binding Proteins

Lewis E. Kay – 4/4/01 – University of Toronto, Toronto, Canada – New NMR Approaches to Studying Protein Structure and Dynamics

Arthur G. Palmer – 4/18/01 – Columbia University – New York, NY – Protein Motions and Folding Characterized by NMR Spectroscopy

Michael P. Sheetz – 5/2/01 – Columbia University, New York, NY – Molecular Basis of Pilus Retraction

Martin J. Stone – 10/3/01 – Indiana University, Bloomington, IN – Interplay of Protein Dynamics with Structural Stability and Ligand Binding

Nathan A. Baker – 10/10/01 – UCSD, La Jolla, CA – Computational Evaluation of the Electrostatic Properties for Cellular Components

James Bartles – 10/24/01 – Northwestern, Chicago, IL – What Can the Jerker Deafness Mutation Tell Us About the Espin Actin-bundling Proteins?

Evan R. Kantrowitz – 11/7/01 – Boston College, Chestnut Hill, MA – New Insights into the Function of the Allosteric Aspartate Transcarbamyolase from Mutants, Hybrids, X-ray Scattering and Crystallography

David O’Callaghan – 11/9/01 – INSERM, Nimes, France – Type IV Secretion and Virulence of the Intracellular Pathogen Brucella

Richard G.W. Anderson – 11/14/01 – UT Southwestern, Dallas, TX – A Role for Caveolae in the Spatial Control of Signal Transduction

David Lilley – 11/19/01 – University of Dundee, Dundee, Scotland – RNA Folding and Catalytic Activity

William A. Frazier – 11/28/01 – Washington University, St. Louis, MO – Integrin Modulation by Thrombospondins and Their Receptor IAP/CD47

John Tainer – 12/5/01 – Scripps Institute, La Jolla, CA – A Unified Structural Biology for DNA Repair: From Proteins to Pathways

David Agard – 12/12/01 – UCSF, San Francisco, CA – Impact of Protein Folding Landscapes on Biological Function: Longevity Through Kinetic Stability


2000

Steve Schultz – 1/5/00 – University of Colorado, Boulder, CO – Structure of O. nova Telomeric Protein-ssDNA Complexes

Siegfried Musser – 1/6/00 – Brandeis University, Brandeis, MA – The Delta pH/Tat Machinery: Antiport Coupling of a Proton Gradient to Transport of Folded Proteins

Taekjip Ha – 1/20/00 – Stanford University, Stanford, CA – Watching Single Biological Molecules Work by Fluorescence

Marc Vidal – 1/26/00 – Charlestown, MA – Protein Interaction Mapping in C. elegans
(CANCELLED)

Hernando Sosa – 1/27/00 – UCSD, San Diego, CA – Structural Studies on the Molecular Motor Kinesin by Cryo-electron Microscopy and Fluorescence Spectroscopy

Alexander Sytnik – 2/3/00 – University of Pennsylvania, Philadelphia, PA – New Insights into tRNA, Ribosomes, and Light-Harvesting Complexes via Single Molecule Fluorescence Studies

Christopher Lima – 3/1/00 – Sloan-Kettering, New York, NY – Functional and Structural Analysis of the SUMO Protein Modification System

Rajeev Aurora – 3/8/00 – Washington University, St. Louis, MO – Protein Fold Recognition from Genomic Sequences: Optimizing the Drug Discovery Process

Jonathan Widom – 3/15/00 – Northwestern, Evanston, IL – Chromosome Structure and Gene Regulation

Thomas Poulos – 3/22/00 – UCI, Irvine, CA – Structural Studies on Nitric Oxide Synthase and a P450 Electron Transfer Complex

Carol Fierke – 3/29/00 – University of Michigan, Ann Arbor, MI – tRNA Processing: Synergy of the Protein and RNA Subunits in the Mechanism of Ribonuclease P

Steven VanDoren – 4/5/00 – University of Missouri, Columbia, MO – Structure and Motion in a Few Proteins with Roles in Cancer Progression: TIMP, MMP, & Viral Co-Chaperone

Karen S. Anderson – 4/12/00 – Yale University, New Haven, CT – Detection and Characterization of Enzyme Intermediates in PEP-Utilizing Enzymes

David P. Giedroc – 4/19/00 – Texas A&M, Collage Sta., TX – Structure and Stability of Translational Regulatory RNA Pseudoknots

Thomas D. Pollard – 4/26/00 – UCSD, La Jolla, CA – Regulation of Actin Filaments Dynamics at the Leading Edge of Motile Cells by Arp2/3 Complex and WASP-family Proteins

Lawrence Shapiro – 5/3/00 – New York, NY – The Big Picture: Investigating Obesity Through Structure-Based Functional Genomics

Harold Sheraga – 5/10/00 – Cornell University, Ithaca, NY – Prediction of Protein Structure by Global Optimization of a Potential Energy Function

Michael Dustin – 5/10/00 – Washington University, St. Louis, MO – Molecular Interactions in the Immunological Synapse and Other Specialized Cell-cell Junctions

Alan Schechter – 9/20/00 – NIDDK, Bethesda, MD – The Binding and Turnover of Nitric Oxide by Human Hemoglobin

George Rose – 9/27/00 – Harvard University, Baltimore, MD – Protein Folding – As Simple As Possible (But No Simpler)

Adam Zlotnick – 10/4/00 – University of Oklahoma, Oklahoma City, OK – Protein Polymerization in the Round: Experimental and Theoretical Approaches to Virus Capsid Assembly

Charles E. Bell – 10/6/00 – University of Pennsylvania, Philadelphia, PA – Structural Studies of the Lambda Repressor C-terminal Domain and Its Interaction with the E. coli RecA Protein

Christopher Miller – 10/11/00 – Brandeis University, Waltham, MA – Chloride Channels: Unusual Mechanism, Unprecedented Architecture

Harald Schwalbe – 10/18/00 – MIT, Cambridge, MA – NMR Studies of Structure and Dynamics of Proteins and Oligonucleotides

Carlos Bustamante – 10/25/00 – UC, Berkeley, CA – Following DNA Replication One Molecular at a Time
CANCELLED

Ernesto Freire – 11/8/00 – John Hopkins, Baltimore, MD – New Strategies for HIV-1 Protease Inhibitor Design: Minimizing Susceptibility to Mutations Causing Drug Resistance

Zucai (Mark) Suo – 11/10/00 – Indianapolis, IN – Biosynthesis of the Plague Iron Chelator Yersiniabactin by a Mixed Nonribosomal Peptide Synthetase-Polyketide Synthase System

Martin Stone – 11/15/00 – Indiana University, Bloomington, IN – Interplay of Protein Dynamics with Structure, Stability, and Ligand Binding
CANCELLED

Shao Q Yao – 11/17/00 – Scripps Institute, La Jolla, CA – Exploring the Interface of Chemistry and Biology: From Chemical Evolution of Peptides and Proteins to Developing New Biochemical Tools

Bill Weis – 12/6/00 – Stanford University, Stanford, CA – Structural Studies of Intracellular Vesicle Trafficking

Thomas Hollis – 12/13/00 – Boston, MA – Structural Insights into DNA Alkylation Repair by BER Glycosylases

William Wikoff – 12/21/00, Scripps Institute, La Jolla, CA – Structure and Dynamics in the Maturation of a dsDNA Virus


1999

Christopher J. Carrell – 1/26/99 – W. Lafayette, IN – Structures of the Subunits of the Cytochrome b6f Complex: Putting Together a Complex Bits at a time

Jeremy Murray – 1/29/99 – Leeds, U.K. – Changing the Color of E. coli Copper Amine Oxidase: Unexpected Consequences of the Structural Investigation of Copper Amine Oxidase Catalytic Mechanism

Gregory A. Petsko – 2/1/99 – Brandeis University, Waltham, MA – Protein Crystallography in Four Dimensions

Andrej Sali – 2/3/99 – New York, NY – Comparative Protein Structure Modeling in Genomics

Robert H. White – 3/3/99 – Blacksburg, VA – The Dark Side of Archaeal Metabolism

Ruben A. Abagyan – 3/10/99 – Skirball Institute, New York, NY – Challenges of Biomolecular Structure Prediction and Drug Design

Dan Herschlag – 3/31/99, Stanford University, Stanford, CA – Biological Catalysis: Insights from Comparison of RNA and Protein Enzymes

David Millar – 4/7/99 – Scripps Institute, La Jolla, CA – Application of Time-resolved Fluorescence Spectroscopy to Studies of DNA-protein Interactions and RNA Folding

David L. Beveridge – 4/21/99 – Middletown, CT – Molecular Dynamics of DNA: Structure Solvation and Confirmational Transitions

Robert Sauer – 4/28/99 – MIT, Cambridge, MA – Protein Folding and Degradation

Michael Garavito – 5/5/99 – Michigan State University, E. Lansing, MI – Structural Biology at the Membrane Interface: Prostaglandin H Synthase and Mammalian Hexokinases

I. Robert. Lehman – 5/12/99 – Stanford University, Stanford, CA – Replication of Herpes Virus DNA

Ram Sasisekharan – 5/19/99 – MIT, Cambridge, MA – Heparin-like Glycosaminoglycans

Ernesto Fuentes – 6/18/99 – Philadelphia, PA – Global and Subglobal Stabilities of Apocytochrome b562 from the Dependence of Hydrogen Exchange on Denaturant and Pressure

Jeff Lawton – 7/22/99 – Houston, TX – Structural Studies of the Mechanism of Endogenous Genome Transcription in Rotavirus

Joel Janin – 7/30/99 – Gif-sur-Yvette, France – Common Structural Features in Protein-Protein and Protein-DNA Recognition

Russell F. Doolittle – 9/15/99 – UCSD, La Jolla, CA – X-ray Structure of Principal Fragments from Fibrinogen and Fibrin

Agnes Vignery – 9/29/99 – Yale University, New Haven, CT – Osteoclasts and Giant Cells: Molecular Mechanisms of Macrophage Fusion

David Baker – 10/13/99 – University of Washington, Seattle, WA – How Proteins Fold

Michael Overduin – 10/27/99 – University of Colorado Health Sciences Center, Denver, CO – Structure and Function of Signaling Domains

Norman Pace – 11/3/99 – University of California, Berkeley, CA – Zen Genetics: Phylogenetic Diversity and the Structure of RNase P RNA

M. Thomas Record, Jr. – 11/10/99 – University of Wisconsin, Madison, WI – Coupled Conformational Changes in Protein-DNA Interactions

Micah Dembo – 11/17/99 – Boston University, Boston, MA – Stresses and Forces on the Substratum During Cell Adhesion and Locomotion

Jeffrey Skolnick – 12/1/99 – Scripps Institute – La Jolla, CA – Prediction of Protein Structure and Function on a Genomic Scale


1998

Robert J. Linhardt – 1/14/98 – University of Iowa, Iowa City, IA – Heparin Structure and Activities Mediated Through Its Interaction with Proteins

Michael A. Resnick – 2/9/98 – National Institute of Environmental Health Sciences, Res. Triangle Park, NC – Genome Instability: The Interplay of DNA at-risk Motifs and Altered DNA Metabolism

David S. Kliger – 2/18/98 – University of California, Santa Cruz, CA – Photolysis Intermediates of Native and Artificial Visual Pigments

Gregory D. Reinhart – 3/4/98 – Texas A&M University, College Station, TX – Allosteric Control of Phosphofructokinase – Lessons from Thermodynamics

Charles S. Craik – 3/10/98 – University of California, San Francisco, CA – Reverse Biochemistry: Regulating Complex Biological Processes by Selective Inhibition of Proteases

Tom Ellenberger – 3/11/98, Harvard University, Boston, MA – Crystal Structure of a DNA Replicative Polymerase. An Open and Closed Case for DNA Synthesis?

Douglas Lauffenburger – 3/18/98 – MIT, Cambridge, MA – Integrins, Growth Factors, and Cell Migration

Michael F. Dunn – 3/25/98 – University of California, Riverside, CA – Insulin Allostery: Dynamics, Equilibria, and Modeling

Kenneth P. Murphy – 4/8/98 – University of Iowa, Iowa City, IA – Structural Energetics of Serine Protease Inhibition

Lawrence Leung – 4/15/98 – Stanford University, Stanford, CA – Functional Mapping and Protein Engineering of Thrombin

Wolfram Ruf – 4/22/98 – Scripps Research Institute, La Jolla, CA – Mutagenesis of Factor VIIa, A Cofactor regulated Serine Protease

Michael O’Donnell – 4/29/98 – New York, NY – Interprotein Dynamics Within the Replisome During Chromosome Replication

Ronald T. Raines – 5/6/98 – University of Wisconsin, Madison, WI – Catalysis of Oxidative Protein Folding in vitro and in vivo

Emil Unanue – 5/13/98 – Washington University, St. Louis, MO – Biochemistry of Peptide Selection by Histocompatability Molecules
(CANCELLED)

Jan Oscarsson – 6/29/98 – Sahlgrenska Universitetssjukhuset/S, Goteborg, Sweden – Liver Fatty Acid Binding Protein: Hormonal Regulation and Importance for Secretion of apoB 100-containing Lipoproteins

Narayana S. Sukumar – 7/7/98 – Paris, France – Role of Water in Plasticity, Stability and Action of Proteins

Florence Lederer – 7/22/98 – Gif-sur-Yvette, France – Protein Mobility and Electron Transfer in a Two domain Protein, as Studied by Site-directed Mutagenesis and with a Monoclonal Antibody

Linda Nicholson – 9/16/98 – Cornell University, Ithaca, NY – Structure Dynamics and Thermodynamics of Molecular Switches

Barry Honig – 9/23/98 – Columbia University, New York, NY – Integrating Three Dimensional Structure Information in Genome Analysis

Daved Fremont – 9/30/98 – Washington University, St. Louis, MO – Structural Studies of Antigen Processing and Presentation

Claude Desplan – 10/7/98 – New York University, New York, NY – Patterning the Fly Retina for Color Vision

Michael Levitt – 10/21/98 – Stanford University, Stanford, CA – Computer Simulation of Protein Folding

Stephen K. Burley – 11/4/98 – Rockefeller University, New York, NY – X-ray Crystallographic Studies of Eukaryotic Gene Expression

Hong Qian – 11/11/98 – University of Washington, Seattle, WA – Protein Mechanics and Dynamics. I. From Equilibrium Conformational Fluctuation to Protein-Ligand Dissociation Under External Force

Stephen H. White – 11/18/98 – University of California, Irvine, CA – Protein Folding on Membranes: Mechanism of Secondary Structure Formation

Peter A. Kollman – 12/2/98 – University of California, San Francisco, CA – Molecular Dynamics Simulations on Molecules of Biological Interests

Terrence G. Oas – 12/9/98 – Duke University, Durham, NC – Folding Mechanism of an Ultra-fast Folding Protein: Experiment and Theory


1997

Jean-Pierre Changeux – 1/10/97 – Institut Pasteur, Paris, France – The Nicotinic Receptor: An Allosteric Protein Engaged in Intercellular Communications from Electric Organ to Brain

Michael Glaser – 1/22/97 – University of Illinois-Urbana-Champaign, Urbana, IL – Formation and Function of Protein-induced Membrane Domains

Lynne Regan – 1/29/97 – Yale University, New Haven, CT – Design Approaches to Study Protein Structure and Function

Stanley C. Rall, Jr. – 2/5/97 – University of California, San Francisco, CA – Transgenic Animal Models of Cholesterol Disorders

Sandor Damjanovich – 2/12/97 – University of Debrecen, Debrecen, Hungary – Dynamic Receptor Superstructure at the Plasma Membrane

Thomas Tullius – 2/19/97 – Boston University, Baltimore, MD – A Radical Perspective on DNA

Eric Gouaux – 2/26/97 – Columbia University, New York, NY – Structure and Mechanism of α−hemolysin: A Heptameric Transmembrane Pore

Peter von Hippel – 3/12/97 – University of Oregon, Eugene, OR – Regulatory Mechanism for the Control of Transcription
(Cori Lecture)

Gordon M. Crippen – 3/19/97 – University of Michigan, Ann Arbor, MI – The True Free Energy of Protein Folding is Difficult to Use for Structure Prediction and Sometimes Fails at Fold Recognition

Victor L. Davidson – 3/24/97 – University of Mississippi, Jackson, MS – Catalytic and Electron Transfer Reactions of the Quinoprotein Methylamine Dehydrogenase

Donald A. Hammer – 3/26/97 – Philadelphia, PA – Dynamics of Leukocyte Adhesion

Heidi E. Hamm – 4/2/97 – Northwestern University, Chicago, IL – Structure of a G Protein and Role in Signal Transduction

Elizabeth Luna – 4/2/97 – University of Massachusetts, Worcester, MA – Actin-Membrane Interactions in Motile Cells

Fred E. Cohen – 4/9/97 – University of California, San Francisco, CA – Mad Cows and Englishmen: The Prion Folding Problem

Kenneth G. Mann – 4/16/97 – University of Vermont, Burlington, VT – How Blood Clots

Karl H. Weisgraber – 4/23/97 – University of California, San Francisco, CA – Structure and Function of Apolipoprotein E: Lessons from X-ray Crystallography

Richard Brennan – 4/29/97 – Oregon Health Sciences University, Portland, OR – Towards Understanding the Structural Basis of Specificity and Minor Groove DNA Binding of the Purine Receptor

Joseph Bonaventura – 5/7/97 – San Francisco, CA – The Interaction of Nitric Oxide with Hemoglobin: A Microcosm of the Biology of NO?

Gerald R. Smith – 5/13/97 – Fred Hutchinson Cancer Research Center, Seattle, WA – Megabase and Kilobase Control of Meiotic Recombination in S. pombe

Judith P. Klinman – 10/1/97 – University of California, Berkeley, CA – Beyond the Classics: Hydrogen Tunneling in Enzyme Reactions

Cheng-Wen Wu – 10/8/97 – Taiwan, R.O.C. – Establishment of a Cell Model for the Study of Cancer Metastases and Early Detection of Circulating Tumor Cells

Sankar Ghosh – 10/8/97 – Yale University, New Haven, CT – NF Kappa B – A Mediator of Inducible Gene Expression

Lynne Regan – 10/15/97 – Yale, New Haven, CT – Design Approaches to Study Protein Structure and Function

Pamela A. Silver – 10/22/97 – Harvard University, Boston, MA – Coordinated Movement of Proteins and RNAs In and Out of the Nucleus

Ira Ropson – 10/29/97 – Pennsylvannia State University, Hershey, PA – Exploring Folding Funnels: Similar Structures – Different Folding Kinetics

Linda L. Randall – 11/5/97 – Washington State University, Pullman, WA – Binding by the Chaperone SecB: High Selectivity with Low Specificity

Paul A. Janmey – 11/12/97 – Harvard University – Boston, MA – Cytoskeletal Networks and Their Regulation by Inositol Lipids

Steven M. Block – 11/19/97 – Princeton University, Princeton, NJ – Using Optical Tweezers to Study Biological Motors

Steven K. Hanks – 12/3/97 – Vanderbilt University, Nashville, TN – Focal Adhesion Kinase (FAK) Signaling and Function

Watt W. Webb – 12/10/97 – Cornell University, Ithaca, NY – Biomedical Applications of Multi-photon Laser Microscopy

Jeramia Ory – 12/19/97 – University of Minnesota, Minneapolis, MN – Structural Insights into the Cavity of Apipocyte Lipid Binding Protein


1996

George D. Rose – 1/17/96 – Johns Hopkins Univ., Baltimore, MD – A Hierarchic Procedure to Predict Protein Conformation from Amino Acid Sequence

Steve Hubbard – 1/24/96 – New York University, New York, NY – Crystallographic Studies of the Tyrosine Kinase Domains of the Insulin and Fibroblast Growth Factor Receptors

Kim A. Sharp – 3/6/96 – Univ. of Pennsylvania, Philadelphia, PA – Understanding the Hydrophobic Effect: Water Structure & Heat Capacity Changes

Michael Rossmann – 3/13/96 – Purdue University, W. Lafayette, IN – A Molecular Mechanism of Viral Budding

Nick Tonks – 3/20/96 – Cold Spring Harbor, Cold Spr. Harb., NY – Protein Tyrosine Phosphatases and the
Control of Cellular Signalling Responses

Gary K. Ackers – 3/27/96 – Washington University, St. Louis, MO – Hemoglobin Allostery and Monod’s “2nd Secret of Life”: Where Do We Stand in 1996?

M. Thomas Record – 4/3/96 – University of Wisconsin, Madison, WI – Lac Repressor-lac Operator Interactions in vitro and in vivo: Functional Complexity and Simplicity of a Classical Gene Regulatory System

Robert M. Clegg – 4/9/96 – Max-Planck Inst., Goettingen, Ger. – A Fluorophore’s Portrayal of Nucleic Acids: Photophysical Reporters of Molecular Structures, Physical Properties, and Protein-DNA Interactions

Wlodzimierz Bujalowski – 4/10/96 – University of Texas, Galveston, TX – E. coli Primary Replicative Helicase the DnaB Protein. Structure and Mechanisms of Interactions with DNA

David Cistola – 4/17/96 – Washington University, St. Louis, MO – Recent Insights into the Ligand Entry Mechanism for Intestinal Fatty Acid-Binding Protein

Ruth A. Steele – 4/19/96 – Univ. of Pennsylvania, Philadelphia, PA – Progress in the Structure Determination of a Bacterial Mercury Detoxification Protein, MerP

Lorena Beese – 4/24/96 – Duke University, Durham, NC – Structure and Function of DNA Polymerases

Tomasz Heyduk – 5/1/96 – St. Louis University, St. Louis, MO – Probing Macromolecules of Transcription Initiation Complexes Using Protein Footprinting and Fluorescence Spectroscopy

Ada Yonath – 5/8/96 – Weizmann Inst., Rehovot, Israel – X-ray Studies of Ribosomes

Thomas Spiro – 5/8/96 – Princeton University, Princeton, NJ – Protein Dynamics in Hemoglobin from Resonance Raman Spectroscopy

Lynn F. Ten Eyck – 5/15/96 – Univ of California, San Diego, La Jolla, CA – Molecular Docking the Elegant Way: Brute Force

Andrew Lockhart – 5/16/96 – Marie Curie Institute, Oxted, England – Biochemical Studies with Microtubule Motors

Takehisa Matsuda – 6/7/96 – National Cardiovascular Center Research Institute, Osaka, Japan – Mechanical- and Surface-induced Vascular Cell Alignment in vitro and Cardiovascular Tissue Remodeling of Hybrid Tissue in vivo

Michael Hecht – 7/22/96 – Princeton University, Princeton, NJ – De Novo Protein Design

Gregory DeKoster – 7/25/96 – University of Iowa, Iowa City, IA – Thermodynamcs of Unfolding for Kazal-type Serine Protease Inhibitors: Stabilization of Ovomucoid First Domain by Glycosylation

Geoffrey Turner – 8/22/96 – University of Sheffield, Sheffield, U.K. – Genetic Analysis of Penicillin Biosynthesis in Aspergillus and Penicillium

Peter J. Newman – 9/11/96 – Medical College of Wisconsin, Milwaukee, WI – The Role of the Cell Adhesion and Cell Signaling Molecule, PECAM-1, in Vascular Cell Biology

David D. Moore – 10/2/96 – Boston, MA – Proteins Interacting With Nuclear Hormone Receptors

Marc S. Wold – 10/16/96 – University of Iowa, Iowa City, IA – Structure and Function of Replication Protein A: A Human Single-Stranded Binding Protein Involved in DNA Metabolism

Jeff Gelles – 10/23/96 – Brandeis University, Waltham, MA – Studying Transcription One Molecule at a Time

Thomas L. Innerarity – 10/30/96 – University of California, San Francisco, CA – ApoB mRNA Editing

James Williamson – 11/6/96 – Cambridge, MA – RNA-Protein Interactions in the HIV Rev-RRE Complex

Julie Forman-Kay – 11/13/96 – Unviersity of Toronto, Toronto, Canada – Correlation Between Motion and Binding in SH2 Domain-Phosphopeptide Interactions

Elizabeth A. Komives – 11/20/96 – University of California San Diego, La Jolla, CA – Structure/Function of the 4th and 5th EGF-like Domains of Thrombomodulin

Douglas H. Turner – 12/4/96 – University of Rochester, Rochester, NY – RNA Folding

Judy Storch – 2/11/96 – Rutgers University, New Brunswick, NJ – Structure-Function Analysis of Intracellular Fatty Acid Binding Proteins


1995

William Bachovchin – 1/18/95 – Tufts Univ., Boston, MA – Usefulness of the 15N Chemical Shifts of His57 for Studying Structures and Mechanisms Within the Active Site of Serine Proteinases

George J. Thomas – 1/25/95 – Univ. of Missouri, Kansas City, MO – Structure and Dynamics of a Packaged Viral Chromosome Probed by Laser Raman Spectroscopy

Brian Sykes – 2/1/95 – Univ. of Alberta, Edmonton, Ala Can. – NMR Studies of the Structural Trigger for Muscle Contraction

Dmitry Vassylyev – 2/15/95 – Protein Engineering Inst., Osaka, Japan – Atomic Structure of ruvC Resolvase: The Holliday Junction Endonuclease from E. coli

John A. Cooper – 2/22/95 – Washington Univ., St. Louis, MO – Interactions of Actin and Capping Protein in vivo and in vitro

Ruth Spolar – 3/1/95 – Univ. of Wisconsin, Madison, WI – Thermodynamic Signatures of Conformational Changes Induced by Site Specific Protein-DNA Association

Paula Schlax – 3/3/95 – Univ. of Wisconsin, Madison, WI – Repression of Transcription of the lac Operon by lac Repressor

Elinor T. Adman – 3/8/95 – Univ. of Washington, Seattle, WA – Pseudoazurin/Nitrite Reductase: Structural Studies in Electron Transfer

David D. Hackney – 3/15/95 – Carnegie Mellon Univ., Pittsburgh, PA – Alternating Head Catalysis by Kinesin and Processive Movement Along Microtubules

B. Garcia Moreno E. – 3/22/95 – Johns Hopkins Univ., Baltimore, MD – Regulation of Macromolecules by Electrostatic Forces

David Cowburn – 3/29/95 – Rockefeller Univ., New York, NY – Some Protein Domains in Intracellular Signal Transduction: Their Appearances, Affinities, and Interactions

Kenneth Marians – 4/5/95 – Mem. Sloan-Kettering Can. Ctr., New York, NY – Topoisomerases & DNA Replication

Daniel J. Leahy – 4/12/95 – Johns Hopkins Univ., Baltimore, MD – Crystal Structure of a Multi-Domain Fragment of Human Fibronectin

Richard Brennan – 4/17/95 – Oregon Health Sci. Univ., Portland, OR – Crystal Structure of PurR Bound to DNA: Minor Groove Binding by α Helices

Morris F. White – 4/19/95 – Joslin Diabetes Ctr., Boston, MA – The IRS-Signaling System and Insulin Action

John W. Little – 4/26/95 – Univ. of Ariz., Tucson, AZ – Mechanism of Lex A Repressor Self-Cleavage
(CANCELED)

Peter D. Munro – 4/26/95 – Washington Univ., St. Louis, MO – Interpretation of Heparin-Thrombin Binding Data: The Parking Problem et al.

Austen Riggs – 4/28/95 – Univ. of Texas, Austin, TX – Gigantic Hemoglobins of Invertebrates: Structure, Function, and Evolution

Sanjeev Jain – 5/3/95 – St. Louis Univ., St. Louis, MO – Molecular Structure of Human β-Glucuronidase and Its Biomedical Implications

Joel Gottesfeld – 5/10/95 – Scripps Res. Inst., La Jolla, CA – Protein Factors Involved in RNA Polymerase III Transcription

Andrew D. Robertson – 5/17/95 – Univ. of Iowa, Iowa City, IA – Structural Pathways for Coupling and Transmission of Interactions Within Proteins

Mark Wardell – 6/22/95 – Univ. of Cambridge, Cambridge, U.K – New Insights from the Crystal Structures of Apolipoprotein E and Antithrombin: The Expected and The Unexpected
(faculty Candidate)

Donald Winzor – 8/3/95 – Univ. of Queensland, Brisbane, Aust. – The Study of Interactions by Sensor Technology

John W. Little – 9/20/95 – Univ. of Arizona, Tucson, AZ – Mechanism of LexA Repressor Self-Cleavage

Jim Sun – 9/22/95 – Carnegie-Mellon Inst., Pittsburgh, PA – 19F-NMR Studies of a Membrane Associated D-Lactate Dehydrogenase

John W. Shriver – 9/27/95 – Southern Illinois Univ., Carbondale, IL – Structure and Stability of a DNA-Binding Protein from a Hyperthermophile

Smita Patel – 10/4/95 – Ohio State Univ., Columbus, OH – Mechanistic Studies of a Hexameric DNA Helicase

David Draper – 10/11/95 – Johns Hopkins Univ., Baltimore, MD – RNA Folding: What are the Alternatives?

Wujian Xian – 10/12/95 – Univ. of Nebraska, Lincoln, NE – Conformational Studies of the Interaction between Gelsolin (150-169) and Phosphatidylinositol Phosphates

Steven O. Smith – 10/18/95 – Yale Univ., New Haven, CT – How Light is Converted into a Chemical Signal in Rhodopsin, a G-Protein Coupled Receptor

Martha Ludwig – 10/25/95 – Univ. of Michigan, Ann Arbor, MI – B12-Dependent Methionine Synthase: Piecing Together the Structure of a Multidomain Enzyme

Craig Kundrot – 11/1/95 – Univ. of Colorado, Boulder, CO – New Insights into Protein Engineering and Hemoglobin Function from the Blood Substitute rHb1.1

Jeffrey Pessin – 11/8/95 – Univ. of Iowa, Iowa City, IA – Feedback Regulation of Insulin-Stimulated Ras Signaling Pathways

Arthur Horwich – 11/15/95 – Yale Univ., New Haven, CT – Chaperonin-Mediated Protein Folding: Structure and Function Studies

John A. Gerlt – 11/29/95 – Univ. of Illinois, Urbana, IL – How Enzymes Abstract Protons from Carbon

Joseph M. Beechem – 12/6/95 – Vanderbilt Univ., Nashville, TN – Real-Time Kinetics of Protein-DNA Interactions Using Fluorescence-Based and Interferometer-Based Spectroscopy: Application to Transcription Factors and DNA Polymerases

Frederic M. Richards – 12/13/95 – Yale University, New Haven, CT – Empty Space and the Structure of Proteins
(Cori Lecture)

George Broze – 12/20/95 – Washington University, St. Louis, MO – The Regulation of Coagulation


1994

A. Joshua Wand – 1/19/94 – Univ. of Illinois, Urbana, IL – Structural Studies of Calmodulin-Peptide Complexes

John Kuriyan – 1/26/94 – Rockefeller Univ., New York, NY – Crystal Structures of DNA Polymerase Clamps: β Subunit of E. coli POL III and Yeast PCNA

Craig Pikaard – 2/2/94 – Washington Univ., St. Louis, MO – RNA Polymerase I Transcription and Enhancer Function in Higher Eukaryotes

Daniel R. Marshak – 2/3/94 – Cold Spring Harbor Lab, Cold Spr. Har., NY – Ser/Thr Protein Kinases and Their Role in Cell Growth

Lihua Jin – 2/7/94 – Princeton Univ., Princeton, NJ – Thermodynamics of Ligand Binding to Wild Type and L75F Trp Repressor

Rageev Aurora & Rajgopal Srinivasan – 2/16/94 – Washington Univ., St. Louis, MO – Unravelling the Code for α-helix Termination by Glycine or The Reggie and Raj Show Does St. Louis

Daniel Goldberg – 3/2/94 – Washington Univ., St. Louis, MO – The Biochemistry of Hemoglobin Degradation in the Malaria Parasite Plasmodium Falciparum

Tomasz Kowalewski – 3/4/94 – Washington Univ., St. Louis, MO – Atomic Force Microscopy – Potentials for Applications in Biosciences

Doug Rees – 3/9/94 – C.I.T., Pasadena, CA – Nitrogenase Structure and Function

Joseph Avruch – 3/23/94 – Mass. General Hospital, Charlestown, MA – Insulin Signal Transduction

Brian W. Matthews – 3/30/94 – Univ. of Oregon, Eugene, OR – Glycosidases, Large and Small: T4 Lysozyme and E. coli β-Galactosidase

Kathleen S. Matthews – 4/6/94 – Rice University, Houston, TX – Physical and Genetic Studies of Lactose Repressor Protein

Richard L. Karpel – 4/7/94 – Univ. of Maryland, Baltimore, MD – Domains and Interactions in a Nucleic Acid Binding Protein: First Principles and LAST Motifs

Jung Ja Kim – 4/11/94 – Medical Coll. of Wisconsin, Milwaukee, WI – Three-Dimensional Structure of Fatty Acyl CoA Dehydrogenase: Structural Basis for Substrate Specificity

Alan D. Frankel – 4/13/94 – Univ. of California, San Francisco, CA – Using Peptides to Study RNA-Protein Recognition

Lila M. Gierasch – 4/20/94 – Univ. of Texas, Dallas, TX – Protein Folding and How Molecular Chaperones May Facilitate It

Lynn Ten Eyck – 4/26/94 – Univ. of California, San Diego, CA – Conformational Changes in Proteins

Bruno Zimm – 4/27/94 – La Jolla, CA – How DNA Moves Through Gels in Electrophoresis
(SHAFFER LECTURE)

Donald M. Engelman – 5/4/94 – Yale Univ., New Haven, CT – Helix Interactions in Membrane Protein Folding and Oligomerization

Sarina Bromberg – 5/11/94 – Univ. of California, San Francisco, CA – A Protein Folding Packing Puzzle

Chien Ho – 5/11/94 – Carnegie Mellon Univ., Pittsburgh, PA – Designing Hemoglobin: A Model for Allosteric Proteins

John E. Hearst – 5/18/94 – Univ. of California, Berkeley, CA – Transcription of Inner Membrane Proteins in E. coli

Scott Hultgren – 5/25/94 – Washington Univ, St. Louis, MO – Molecular Basis of Periplasmic Chaperones and Ushers in Microbial Pathogens

Yoshio Fukui – 5/31/94 – Northwestern Univ. Med. Sch., Chicago, IL – Dynamics of the Actomyosin System in Dictyostelium

Andrzej Krezel – 7/19/94 – Harvard Med. Sch., Boston, MA – Solution Structure of Decorsin: Conserved Motif and Distinct Function in Leech Antihemostatic Proteins

Donald J. Winzor – 7/20/94 – Univ. of Queensland, Brisbane, Aust. – Thermodynamic Nonideality as a Probe of Conformational Changes

Frank Ling – 8/23/94 – Univ. of California, Berkeley, CA – Statistical Phase Space Rate Theory of Isomerization

David Chu – 8/24/94 – Univ. of California, Riverside, CA – Spin Glass Dynamics and the Memory Effect

Christin Carter-Su – 9/21/94 – Univ. of Michigan, Ann Arbor, MI – The Role of JAK2 Tyrosine Kinase in Signaling by Growth Hormone & Prolactin

Michael Zuker – 9/28/94 – Washington Univ., St. Louis, MO – Assessing the Reliability of RNA Secondary Structure Predictions

Jeffrey Milbrandt – 10/5/94 – Washington Univ., St. Louis, MO – Immediate-Early Genes: The Biological Seismograph

Michael Cusanovich – 10/12/94 – Univ. of Arizona, Tucson, AZ – Biological Electron Transfer. Site Directed Mutagenesis of Cytochrome C2

Edward Eisenstein – 10/19/94 – Univ. of Maryland, Rockville, MD – Molecular Control Mechanisms Studied with Single Amino Substitutions in Allosteric Threonine Deaminase and GroES/GroEL Molecular Chaperones

Alexander Tulinsky – 10/26/94 – Michigan State Univ., E. Lansing, MI – Domain Structure of Prothrombin

Donald Abraham – 11/2/94 – Virginia Commonwealth Univ., Richmond, VA – Allosteric Effectors of Hemoglobin: As Tools to Understand Allosteric Mechanisms at the Molecular Level

Steven W. Matson – 11/9/94 – Univ. of North Carolina, Chapel Hill, NC – DNA Helicases: Enzymes with Essential Roles in DNA Metabolism

Stephen C. Harrison – 11/16/94 – Harvard Univ., Cambridge, MA – Structures of Viruses and Virus-Receptor Interactions

Ulrich Hubscher – 11/21/94 – Univ. Zurich-Irchel, Zurich, Switz. – Mechanisms at the DNA Replication Fork

Ernst Helmreich – 11/30/94 – Univ. of Wurzburg, Wurzburg, Ger. – Interaction of β, γ Subunits of G Proteins with Receptors

Patrick Connelly – 12/7/94 – Vertex Pharm., Cambridge, MA – Experimental Thermodynamics in a Structure-Based Drug Design Program
(CANCELED)

Hazel Holden – 12/14/94 – Univ. of Wisconsin, Madison, WI – Structural Studies of Biotin Carboxylase and Phosphotriesterase

Ivan Rayment – 12/14/94 – Univ. of Wisconsin, Madison, WI – Structural Studies of Myosin Subfragment-1


1993

Rashmi Hegde – 1/12/93 – Yale Univ., New Haven, CT – Crystal Structure of Bovine Papilloma Virus E2 DNA Binding Domains
(faculty candidate)

Gabriel Waksman – 1/25/93 – Rockefeller Univ, New York, NY – Crystallographic Studies of Phosphatyrosyl Peptides Bound to the SH2 Domain
(faculty candidate)

John Law – 1/27/93 – Univ. of Arizona, Tucson, AZ – Biochemical Models from Insects

Kenneth A. Johnson – 2/3/93 – Penn. State Univ., University Park, PA – Mechanism & Inhibition of HIV Reverse Transcriptase

Neil Greenspan – 2/8/93 – Case Western Univ., Cleveland, OH – Epitopes, Paratopes, and Other Topes: Do Immunologists Know What They Are Talking About?

Robert Callender – 2/10/93 – City Univ. of New York, New York, NY – Protein Ligand Binding and Enzymatic Catalysis Studied by Vibrational Spectroscopy

David Baker – 2/11/93 – Univ. of California, San Francisco, CA – A Protein Folding Reaction Under Kinetic Control

Seunghyon Choe – 2/14/93 – UCLA, Los Angeles, CA – The Crystal Structure of Diphtheria Toxin

Emil Pai – 2/17/93 – Univ. of Toronto, Toronto, Canada – Ha-ras Oncogene Product p21: Structure and Function

Thomas M. Jovin – 2/22/93 – Max-Plank Inst., Gottingen, Ger. – Atomic Force Microscopy of Molecules and Cells

Millie Georgiadis – 2/22/93 – Columbia Univ., New York, NY – Crystal Structure of the Nitrogenase Iron Protein from Azotobacter Vinelandii
(faculty candidate)

Daniel Carter – 3/3/93 – Marshall Space Ctr., Huntsville, AL – Three-Dimensional Structure of Human Serum Albumin

Jirong Lu – 3/12/93 – Univ. of Oregon, Eugene, OR – Folding Pathway of Bacteriophage T4 Lysozyme

Douglas C. Rees – 3/17/93 – C.I.T., Pasadena, CA – Structure and Function of Nitrogenase
(canceled)

Richard Wolfenden – 3/24/93 – Chapel Hill, NC – Protein-Ligand Binding Discrimination: Are There Limits?

Manny Ares – 3/31/93 – Univ. of California, Santa Cruz, CA – How Works a snRNP? Structure-Function Studies of U2 snRNA in Yeast

Steven T. Olson – 4/7/93 – Henry Ford Hospital, Detroit, MI – Role of Protein Conformational Changes, Surface Catalysis and Protein Cofactors in Heparin-Accelerated Antithrombin-Proteinase Reactions

Harold A. Scheraga – 4/8/93 – Cornell Univ., Ithaca, NY – Theoretical Aspects of Protein Folding

John T. Edsall – 4/21/93 – Harvard Univ., Cambridge, MA – Maintenance of Scientific Integrity: Questions and Some Case Histories

Tyler Jacks – 4/28/93 – M.I.T., Cambridge, MA – Rb and p53 Knockout Mice

Francine B. Perler – 5/12/93 – New England Biolabs, Beverly, MAb – Mobile Protein-Splicing Introns in Archaebacteria

Michele Perrella – 5/13/93 – Univ. of Milano, Milano, Italy – Hemoglobin Cooperativity as Seen from the Intermediates

Michel Frey – 8/5/93 – Institut de Biologie Struc., Grenoble, France – Electron Transfer in Grenoble. A Progress Report

Jannette L. Carey – 10/1/93 – Princeton Univ., Princeton, NJ – Tandem Binding in New Cocrystals of trp Repressor with DNA

Rowena G. Matthews – 10/6/93 – Univ. of Michigan, Ann Arbor, MI – Inactivation of Cobalamin-Dependent Methionine Synthase by Nitrous Oxide: Death by Laughing

Hong Qian – 10/7/93 – C.I.T., Pasadena, CA – α-Helix Formation by Small Peptides

Lynn F. Ten Eyck – 10/14/93 – Univ. of California, La Jolla, CA – Conformational Changes in Cyclic-AMP Dependent Protein Kinase on Binding Substrates

Stephen J. Benkovic – 10/20/93 – Penn. St. Univ., Univ. Park, PA – Molecular Complexes in Transcription and Replication

A. Clay Clark – 10/22/93 – Texas A&M, Bryan, TX – Protein-Protein Interactions: Thermodynamics vs. Kinetic Control of Folding/Assembly

Roger L. McMacken – 10/27/93 – Johns Hopkins, Baltimore, MD – Biochemical Mechanisms in the Initiation of Bacteriophage λ DNA Replication

George M. Carman – 11/3/93 – Rutgers Univ., New Brunswick, NJ – Regulation of Yeast Phosphatidate Phosphatase

Ignacio Tinoco, Jr. – 11/10/93 – Univ. of California, Berkeley, CA – Non-Watson-Crick Base Pairs and RNA Structure

Richard Wolfenden – 11/17/93 – Univ. of North Carolina, Chapel Hill, NC – Transition States in Pieces: Results of Substrates and Enzyme Modification

Gordon L. Hager – 12/1/93 – Natl. Cancer Inst./NIH, Bethesda, MD – The Interaction of Steroid Receptors with Chromatin

Krzysztof Appelt – 12/2/93 – Agouron Pharm., San Diego, CA – Crystal Structure of Human Proteoglycanase-Stromelysin

Joyce Bischoff – 12/6/93 – Harvard Med. Sch., Boston, MA – A Role for Sialyl Lewis-X/A Glycoconjugates in Capillary Blood Vessel Formation

Howard Schachman – 12/6/93 – UC, Berkeley, CA – Maintaining Integrity in Science Requires Vigilance Not Vigilantes

Howard Schachman – 12/7/93 – UC, Berkeley, CA – Formation of Active Enzyme from Defective, Incomplete and Rearranged Polypeptide Chains: Aspartate Trans-carbamylase
(Cori Lecture)

Robert Landick – 12/15/93 – Washington Univ., St. Louis, MO – Dissection of RNA Polymerase-Elongation Control Site Interactions: From Fundamental Mechanism to the Action of HIV TAT

Michael Johnson – 12/16/93 – Univ. of Virginia, Charlottesville, VA – Methods for Numerical Analysis of Experimental Data


1992

Shirley Tilghman – 1/8/92 – Princeton, NJ – Genomic Imprinting in the Mouse

Van Moudrianakis – 1/15/92 – Baltimore, MD – Molecular Shapes and Chemical Forces at the Core of the Chromosome

Roy Curtiss, III – 2/5/92 – St. Louis, MO – Mechanisms of Salmonella Pathogenicity

Satya Prakash – 2/12/92 – Rochester, NY – DNA Repair Genes and Proteins of Yeast and Human

Paul Srere – 2/19/92 – Dallas, TX – The Krebs TCA Cycle Metabolon

Michael Brenowitz – 2/26/92 – Bronx, NY – Protein-Mediated DNA Loops-Modulation by Homotropic and Heterotropic Interactions

Bryan Cullen – 3/4/92 – Durham, NC – Regulation of HIV-1 Replication

Lizbeth K. Hedstrom – 3/10/92 – San Francisco, CA – Converting Trypsin to Chymotrypsin
(faculty candidate)

Carlos Bustamante – 3/11/92 – Eugene, OR – Recent Developments in the Imaging of Nucleic Acids by Scanning Force Microscopy

Steven L. Roderick – 3/13/92 – Eugene, OR – Crystal Structure of Methonine Aminopeptidase
(faculty candidate)

Joan Brugge – 3/18/92 – Philadelphia, PA – Regulation of Tyrosine Phosphorylation in Platelets

Thomas R. Hynes – 3/20/92 – S. San Francisco, CA – A Crystallographic and Genetic Examination of Molecular Recognition
(faculty candidate)

Michelle F. Browner – 3/30/92 – San Francisco, CA – Engineering Allosteric Function
(faculty candidate)

Donald Small – 3/25/92 – Boston, MA – The Physical Properties of Lipids: From Alkanes to Complex Lipids

Charles O. Rock – 4/1/92 – Memphis, TN – Regulation of Fatty Acid Biosynthesis

Jens Birktoft – 4/3/92 – St. Louis, MO – The Second Domain of Tissue Factor Pathway Inhibitor (LACI/EPI): The Crystal Structure and Its Implications for the Design of Blood Coagulation Inhibitors
(faculty candidate)

Giorgio Careri – 4/7/92 – Rome, Italy – Proton Percolation and Emergence of Function in Nearly Dry Biological Systems

Gary Johnson – 4/8/92 – Denver, CO – Mitogenic Pathways Regulated by G Protein Oncogenes

Danny Reinberg – 4/15/92 – Piscataway, NJ – Interactions of the General Initiation Factors and Regulatory Factors Leading to Activation and/or Repression of Polymerase II Transcription

Stephen G. Sligar – 4/22/92 – Urbana, IL – Mechanisms of Macromolecular Recognition

JoAnne Stubbe – 5/6/92 – Cambridge, MA – Assembly of the Dinuclear Iron Center – Tyrosyl Radical Cofactor of Ribonucleotide Reductase

Paul Hagerman – 5/13/92 – Denver, CO – Branched Nucleic Acid Structures: A Case of the Bends

Harden McConnell – 5/19/92 – Stanford, CA – The Cytosensor – A New Tool for Discovery

Susan Taylor – 5/20/92 – La Jolla, CA – Crystal Structure of cAMP-Dependent Protein Kinase: Prototype for a Family of Enzymes

Nigel Scrutton – 6/12/92 – Cambridge, Eng. – Molecular Recognition in the Flavo-Protein Disulphide Oxidoreductases

Angel Lee – 7/16/92 – Bethesda, MD – Signalling by the Receptor for CSF-1: A Tyrosine Kinase of the Immunoglobulin Superfamily
(faculty candidate)

David Roberts – 9/16/92 – Bethesda, MD – Effects of Thrombospondin on Tumor Cell Adhesion, Motility and Metastasis

Robert H. Costa – 9/23/92 – Chicago, IL – Liver Transcription Factor HNF-3 Defines a New Gene Family

James C. Lee – 9/30/92 – Galveston, TX – A Molecular Analysis of the Role of Macromolecular Assembly in Transcription

Rajgopal Srinivasan – 10/2/92 – Indianapolis, IN – Computer Simulations of Turn Mutations in Cytochrome B562

Errol Friedberg – 10/14/92 – Dallas, TX – Nucleotide Excision Repair of DNA in Eukaryotes – What Yeast Has Taught Us

Steve White – 10/21/92 – Irvine, CA – Global Statistics and History of Protein Sequences

Paul Sternberg – 10/28/92 – Pasadena, CA – Molecular Genetics of C. elegans EGF Receptor Homologue let-23

Neville R. Kallenbach – 11/4/92 – New York, NY – The α-Helix (1951-1992): Four More Years

Jorge D. Cortese – 11/6/92 – Chapel Hill, NC – Liposome-Mediated Engineering of Mitochondria: The Lives of Cytochrome C

Paul L. Modrich – 11/11/92 – Durham, NC – DNA Mismatch Repair in Bacteria and Human Cells

Howard Towle – 11/18/92 -Minneapolis, MN – Carbohydrate Metabolism Regulates Gene Expression in the Liver

Steve Hajduk – 12/2/92 – Birmingham, AL – RNA Editing in Trypanosomes

George Hess – 12/9/92 – Ithaca, NY – Determination of the Chemical Mechanism of Neurotransmitter Receptor-mediated Reactions by Rapid Chemical Kinetic Techniques

V. Adrian Parsegian – 12/16/92 – Bethesda, MD – Solvation Forces in Allosteric Regulation


1991

Edmond H. Fischer – 1/30/91 – Seattle, WA – Protein Tyrosine Phosphatases in Signal Transduction and Cell Cycle

Carlos Faerman – 2/6/91 – Montreal, Canada – Towards Accurate Transferable Electrostatic Models for Peptides

John Taylor – 2/13/91 – St. Louis, MO – Unravelling the Molecular Pathway from Sunlight to Skin Cancer

Jay Gralla – 2/20/91 – Los Angeles, CA – Strategies for Transcriptional Control: E. coli Sigma 54, and Sigma 70 and Simple polll Promoters

Sue Goo Rhee – 2/27/91 – Bethesda, MD – Regulation of Phospholipase C Isozymes

Peter von Hippel – 3/6/91 – Eugene, OR – Mechanisms and Regulation of Transcript Elongation and Termination in E. coli

David L. Garbers – 3/27/91 – Dallas, TX – The Guanylyl Cyclase Receptor Family and Its Role in Cell Regulation

Wayne Bolen – 3/28/91 – Carbondale, IL – On Energy Management, Transduction, and Dissection in an Enzyme Catalyzed Reaction

James Hu – 4/1/91 – Cambridge, MA – Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions

Vernon Anderson – 4/3/91 – Providence, RI – Enzyme Catalyzed ß-Eliminations: Correlation Between Structure,
Stereochemistry and Mechanism

S. Walter Englander – 4/10/91 – Philadelphia, PA – Protein Interaction Folding and Function by Hydrogen Exchange and 2D NMR

Charles S. McHenry – 4/17/91 – Denver, CO – DNA Polymerase III Holoenzyme: Mechanism and Regulation of a True Replicative Complex

M. Thomas Record – 4/24/91 – Madison, WI – Studies of Protein-DNA Interactions in vitro and in vivo

Norma M. Allewell – 5/1/91 – Middletown, CT – How Cooperative Enzymes Work: The Energetics of Allosteric Regulation in E. coli Aspartate Transcarbamylase

Dennis A. Torchia – 5/8/91 – Bethesda, MD – NMR Studies of Protein Structure and Dynamics

David Eisenberg – 5/15/91 – Los Angeles, CA – Protein Structures & Profiles

Chien Ho – 5/21/91 – Pittsburgh, PA – Effects of Anions on the Allosteric Properties of Hemoglobin

Richard Brennan – 6/25/91 – Portland, OR – Protein-DNA Conformational Changes in the Crystal Structure of a λ Cro-Operator Complex
(faculty candidate)

Kjeld Norris – 7/17/91 – Copenhagen, Denmark – Cloning and Expression of Human BPTI-Like (Kunitz, Aprotinin) Protease Inhibitor Domains in Yeast

Teruhiko Beppu – 8/8/91 – Tokyo, Japan – Protein Engineering of Several Microbial Enzymes

Michael Cox – 9/11/91 – Madison, WI – RecA Protein as a Recombinational Repair System

Eaton E. Lattman – 9/25/91 – Baltimore, MD – Plasticity and Stability in Protein Structures

C. Nick Pace – 10/2/91 – College Station, TX – Contributions of Hydrogen Bonding and Hydrophobic Interactions to the Conformational Stability of RNase T1

Thomas M. Laue – 10/3/91 – Durham, NH – Real-Time Acquisition and Analysis of Rayleigh Interference Data from the Analytical Ultracentrifuge

Thomas M. Laue – 10/4/91 – Durham, NH – Ca-+-Dependent Interactions in a Soluble Protein C Activation Complex

Albert Mildvan – 10/8/91 – Baltimore, MD – Magnetic Resonance and Mechanistic Studies of Ketosteroid Isomerase

Robert L. Baldwin – 10/16/91 – Stanford, CA – Pathways of Protein Folding

Arthur Spector – 10/23/91 – Iowa City, IA – Hydroxylated Arachidonic Acid Derivatives and Endothelial Function

Craig C. Malbon – 10/30/91 – Stony Brook, NY – G-Protein-Linked Receptors: Analysis from Membrane to Genome

Peter Kim – 11/6/91 – Cambridge, MA – Protein Dissection

James Maller – 11/13/91 – Denver, CO – Control of the Cell Cycle by Protein Kinases

George D. Rose – 11/20/91 – Chapel Hill, NC – Some Thoughts About the α−Helix
(faculty candidate)

D. Lansing Taylor – 12/4/91 – Pittsburgh, PA – Light as a Probe of Cell Dynamics

Paul L. Modrich – 12/11/91 – Durham, NC – Mechanisms of DNA Mismatch Correction


1990

Jean Baum – 2/8/90 – New Brunswick, NJ – NMR Studies on Partially Folded Proteins
(faculty candidate)

Victor Davidson – 4/19/90 – Jackson, MS – Quinoproteins, A New Class of Oxidative Enzymes with Pyrroloquinoline Quinone (PQQ) as Cofactor

Mark Boguski – 5/3/90 – Bethesda, MD – Baroque Periodic Proteins and The Music of The Spheres

Douglas J. Winton – 7/12/90 – Cambridge, Eng. – Stem Cell Organization in Mouse Intestinal Epithelia

Craig M. Jackson – 7/19/90 – Detroit, MI – Modulation of Thrombin Activity by Interaction of Heparin with Fibrin

Lawrence Berliner – 7/24/90 – Columbus, OH – The Use of Spin Labels in Looking at Subtle Conformational Changes in Blood Coagulation Proteins

Lars Petersen – 8/3/90 – Copenhagen, Den. – Are t-PA, Urokinase and Factor VII Genuine Zymogens? How Are They Involved in Protease Cascade Initiation?

Donald J. Winzor – 8/27/90 – Queensland, Aust. – Interactions of Glycolytic Enzymes with Myofibrils and Erythrocyte Membranes: The Concept of a Matrix-Bound Glycolytic Complex

Joachim Seelig – 10/3/90 – Basel, Switzerland – Magnetic Resonance: From Membranes to Man’s Brains

Robert O. Fox – 10/10/90 – New Haven, CT – Biophysical Genetics of ß-Turns

Jan F.C. Glatz – 10/11/90 – Maastricht, Neth. – Heart Fatty Acid Binding Protein and Its Release Upon Injury

Paul R. Schimmel – 10/17/90 – Cambridge, MA – Recognition of Transfer RNA Studied with Dissected RNA and Protein Molecules

Dermot Cooper – 10/24/90 – Denver, CO – Integrated Control of Intracellular Ca2+ in Pituitary Glands

Art Pardi – 10/31/90 – Boulder, CO – Structural Studies of Catalytic RNA

Ralph J. Nossal – 11/7/90 – Bethesda, MD – Gelation and Elasticity of Complex Polymer Networks: Models for Calculating the Viscoelastic Properties of Cytosol

George P. Smith – 11/14/90 – Columbia, MO – Peptide Libraries on Filamentous Phage: What’s Known, What’s Hoped

Enrico Gratton – 11/28/90 – Urbana, IL – Protein Dynamics and Fluorescence of Tryptophan

Elizabeth Howell – 12/5/90 – Knoxville, TN – A Structure-Function Study of Reductase Using Site-Directed Mutagenesis and Genetic Techniques

Robert Stroud – 12/12/90 – San Francisco, CA – Thymidylate Synthetase Structure, Target for Drug Design, and the Control of an Enzyme by Phosphorylation


1989

Carol Post – 2/8/89 – W. Lafayette, IN – NMR and Energetics of Protein-Ligand Complexes
(faculty candidate)

Vernon Anderson – 2/21/89 – Providence, RI – Interaction of CoA Dithioesters with Enzymes Catalyzing Claisen Condensations
(Canceled)

Jay Ponder – 2/22/89 – New Haven, CT – Computational and Experimental Approaches to the Protein Design Problem
(faculty candidate)

Roger Bone – 3/9/89 – San Francisco, CA – The Role of Structural Plasticity in Determining Enzyme Specificity
(faculty candidate)

Harry Duckworth – 3/10/89 – Winnipeg, Canada – Citrate Synthase: Site-directed Mutagenesis of an Allosteric Enzyme

James Knox – 3/10/89 – Storrs, CT – Drug Target Enzymes in Bacteria Involved in Cell Wall Synthesis: Crystallographic Studies

C. Robert Matthews – 3/21/89 – Univ. Park, PA – Single Amino Acid Replacements as Probes of Protein Folding Mechanisms
(faculty candidate)

Ulrich Hubscher – 3/22/89 – Zurich, Switz – Different Forms of DNA Polymerase from Mammalian Cells

Douglas Ohlendorf – 4/13/89 – Wilmington, DE – Structure and Assembly of Protocatechuate 3,4-Dioxygenase
(faculty candidate)

Timothy Lohman – 4/18/89 – College Stat., TX – E. coli SSB Protein Multiple DNA Binding Modes and Cooperativities
(faculty candidate)

Sam Hwang – 4/26/89 – Basel, Switz. – Import of Natural and Artificial Precursors into Mitochondria

Jeffrey Bolin – 5/8/89 – W. Lafayette, IN – The Metal Clusters of Nitrogenase: Progress Towards a 3-dimensional Structure
(faculty candidate)

James Sacchettini – 5/16/89 – St. Louis, MO – The Three-Dimensional Structure of Intestinal Fatty Acid Binding Protein
(faculty candidate)

David Cistola – 5/18/89 – St. Louis, MO – Toward a Molecular Level View of Fatty Acid Transport
(faculty candidate)

C. Blazynski – 8/1/89 – St. Louis, MO – Biochemical Regulation of Visual Transduction
(faculty candidate)

Michel Frey – 8/8/89 – Marseilles, France – Protein Crystallography in Marseilles Recent Results

Enrico Di Cera – 9/25/89 – Rome, Italy – Linkage Thermodynamics and Macromolecular Interactions
(faculty candidate)

David Draper – 9/28/89 – Baltimore, MD – Protein Recognition of Unusual RNA Structures
(faculty candidate)

Kathleen Hall – 10/3/89 – Waltham, MA – Complex RNA Conformational Variations Probed by NMR Structure Mapping and Specific Mutations
(faculty candidate)

Pearl Tsang – 10/16/89 – La Jolla, CA – Studies of an Antigen-Antibody Complex by Solution NMR Techniques
(faculty candidate)

Yiqing Feng – 11/2/89 – Urbana, IL – Redox Structural Difference of Cytochrome c
(faculty candidate)

Edgar Meyer – 12/14/89 – College Stat., TX – A Broad View of Structural Biochemistry: Crystallographic, Modeling, and Molecular Dynamic Studies of Porcine Pancreatic Elastase
(faculty candidate)


1988

Nien-chu C. Yang – 1/21/88 – Univ. of Chicago – Biophysical Chemistry of Proteins

Raymond Owens – 2/5/88 – Slough, England – Designer Genes: Generation of Human:Mouse Chimeric Anti-tumor Antibodies

Richard E. Pagano – 2/11/88 – Baltimore, MD – Membrane Traffic in Animal Cells: Intracellular Transport of Fluorescent Lipids

Paul B. Sigler – 3/4/88 – Chicago, IL – The Structure and Function of the trp Repressor/Operon System

Lawrence Chan – 3/18/88 – Houston, TX – The Structure and Biosynthesis of Apolipoprotein B

William Lennarz – 3/25/88 – Houston, TX – Studies on the Glycosylation Process in the Endoplasmic Reticulum

Ed Krebs – 4/14/88 – Seattle, WA – Recent Work on Protein Phosphorylation and Signal Transduction
(Cori Lecture)

Alan Horwitz – 4/22/88 – Urbana, IL – The Fibronectin Receptor: Its Family and Neighbors

Sam T. Hwang – 4/27/88 – Basel, Switzerland – Mitochondrial Protein Biosynthesis
(canceled)

Friedrich Spener – 5/18/88 – Munster, W. Germ. – Structure and Function of the Bovine Heart Fatty Acid Binding Protein

Yasuo Konishi – 5/25/88 – St. Louis, MO – Identification of Functional Sites in Peptides and Proteins

Peter Olins – 6/1/88 – St. Louis, MO – Application of a Prokaryotic Translational Enhancer for High-Level Expressions of Foreign Genes in E. coli

Yiqing Feng – 9/30/88 – Philadelphia, PA – Structure of Cytochrome C Studied by High Resolution NMR

John Johnson – 9/30/88 – W. Lafayette, IN – The Structure, Function and Evolution of Small RNA Viruses

Peter Newman – 10/21/88 – Milwaukee, WI – Application of the Polymerase Chain Reaction and Other Novel Molecular Cloning Techniques to the Analysis of Platelet Membrane Glycoprotein Structure

Watt Webb – 11/11/88 – Ithaca, NY – Tracking Individual Molecular Receptors on the Surfaces of Living Cells

Mark Saper – 11/21/88 – Cambridge, MA – 3-D Structure of a Human Histochemistry Antigen: A Close Look at the Peptide Binding Site

Daryl Granner – 12/2/88 – Nashville, TN – Regulation of Gene Expression: A Major Action of Insulin

Ernesto Friere – 12/20/88 – Baltimore, MD – Energetics of Insertion, Folding and Assembly of Membrane Proteins
(faculty candidate)


1987

Paul Engel – 6/17/87 – Sheffield, Eng. – New Insights into the Structure and Evolution of Glutamate Dehydrogenases

Nadia Rosenthal – 7/8/87 – Boston, MA – Muscle-Specific DNA Regulatory Elements of the Myosin Light Chain Genes

Alan A. Aderem – 12/11/87 – New York, NY – Protein Myristoylation as an Intermediate Step in the Regulation of Macrophage Functions


1986

Thomas E. Thompson – 1/14/86 – Charlottesville, VA – The Molecular Arrangement of Glycosphingolipids in Phospholipid Bilayers and Biological Membranes

Bonnie Wallace – 3/3/86 – New York, NY – The Structure of Gramicidin, a Transmembrane Ion Channel

Daniel D. Oprian – 3/10/86 – Cambridge, MA – Total Synthesis of a Gene for Bovine Rhodopsin

Robert Tilton – 3/12/86 – Cambridge, MA – Cavities in Proteins: Studies of the Xenon Binding to Myoglobin

Allen D. Kline – 3/24/86 – Zurich, Switz. – The Determination of Secondary and Tertiary Structures for Globular Proteins in Solution: A 1H NMR Study of Tendamistat

Gordon Ringold – 4/15/86 – Stanford, CA – Gene Regulation During Adipogenesis

Alan Attie – 4/22/86 – Madison, WI – Studies in a Pig Model of Genetic Hyperlipidemia

Margaret Adams – 5/21/86 – Oxford, England – Coenzyme Binding to Phosphogluconate Dehydrogenase

Ross Tellam – 7/18/86 – Canberra, Aust. – Motile and Contractile Systems

Wolfgang Trommer – 8/8/86 – West Germany – Structure-Function Relationships in F1-ATPase and Dehydrogenases as Studied by Spin-Labeled Nucleotides

Hans Jansonius – 9/3/86 – Basel, Switzerland – The Three-Dimensional Structure and Mechanism of Action of Mitochondrial Aspartate Aminotransferase

John J. Holbrook – 9/29/86 – Bristol, England – What If? Mutants of Dehydrogenases

Kenneth A. Johnson – 11/20/86 – Univ. Park, PA – Structure and Mechanism of the Microtubule-Activated Dynein ATPase


1985

John Holbrook – 1/30/85 – Bristol, England – The Role of Protein Conformational Changes in the Dehydrogenase Reaction

Lynna Hereford – 2/11/85 – Boston, MA – Yeast Histone Expression and Localization

Robert D. Simoni – 3/20/85 – Stanford, CA – Biogenesis of HMG-CoA Reductase and Integral Membrane Protein of the Endoplasmic Reticulum

C. A. Pasternak – 4/1/85 – London, England – How Viruses Damage Cells: Interactions with Plasma Membranes

Yoav I. Henis – 6/24/85 – Tel Aviv, Israel – Correlation Between the Mobility of Sendai Virus Glycoproteins on the Erythrocyte Surface and Cell Fusion

K.W.A. Wirtz – 6/26/85 – Utrecht, Neth. – Phospholipid Transfer Proteins

Benjamin Rivnay – 7/16/85 – Rehovot, Israel – Studies on the Phospholipid Associated with the IgE Receptor on RBL Cells and Assessment of the Role of the Receptor in Calcium Gating

Melitta Schachner – 9/25/85 – Heidelberg, Ger – Cell Surfaces and the Development of the Nervous System

Peter L. Jeffrey – 10/18/85 – Camperdown, NSW – The Thy-1 Glycoprotein – A Developmentally Regulated Neural Antigen

David Schubert – 11/12/85 – San Diego, CA – Characterization of a Neural Retina Adhesion and Survival Molecule

Terry Van Dyke – 11/22/85 – Princeton, NJ – Induction of Brain Tumors in a Time and Tissue Specific Fashion in Transgenic Mice

Irina M. Russu – 12/10/85 – Pittsburgh, PA – Conformation and Dynamics at Individual Sites in Proteins: Nuclear Magnetic Resonance Studies of Hemoglobins


1984

F. Michael Hoffman – 2/13/84 – Cambridge, MA – Drosophila Cellular Oncogenes

Randy W. Schekman – 4/16/84 – Berkeley, CA – Secretion and Organelle Assembly in Yeast

Michael P. Yaffe – 5/17/84 – Basel, Switzerland – Molecular and Genetic Analysis of Mitochondrial Protein Import

Alexander Buko – 6/8/84 – Bethesda, MD – Polypeptide Sequencing by Mass Spectrometry

Annemarie Weber – 7/23/84 – Philadelphia, PA – The Effects of Villin on Actin Assembly

Donald Winzor – 7/25/84 – Queensland, Aust. – Quantitative Affinity Chromatography: An Approach to the Study of Metabolite-Dependent Change in the Subcellular Distribution of Enzymes

Jacques Ricard – 7/30/84 – Marseilles, France – Dynamics of Enzyme Reactions at the Surface of Living Cells

Alan Schwartz – 9/10/84 – Boston, MA – Life History of the Asialoglycoprotein Receptor

Enrique J. Rodriguez-Boulan – 10/1/84 – New York, NY – Biogenesis of Epithelial Cell Polarity

James Tam – 10/12/84 – New York, NY – Chemistry and Biology of Transforming Growth Factors

Christian Frelin – 12/4/84 – Nice, France – Sodium Hydrogen Exchange

1983

Joseph Schlessinger – 4/15/83 – Rehovot, Israel – Studies of the Mechanism of Action of Epidermal Growth Factor

L.W. Nichol – 6/3/83 – Canberra, Aust. – Reversible Crosslinking Reactions Involving Proteins

Athanasios Theologis – 7/15/83 – Stanford, CA – Auxin-Regulated Polyadenylated mRNA’s in Pea Epicotyl Tissue

Jeffrey Reidler – 8/18/83 – Stanford, CA – Structure and Dynamics of Mouse Monoclonal Immunoglobulins

Ross Fernley – 9/26/83 – Victoria, Aust. – The Application of Hybridization Histochemistry to the Renin-Angiotensin System

S. Walter Englander – 10/6/83 – Philadelphia, PA – How Does Protein Structure Generate Function: Functional Labeling of Hemoglobin

Sandor Damjanovich – 11/10/83 – Debrecen, Hungary – Cell Surface Dynamics and Information Transfer

Mary Dempsey – 11/10/83 – Minneapolis, MN – Regulation of Lipid Metabolism by a Carrier Protein

Gerhard Isenberg – 12/5/83 – Muchen, FRG – Actin Filament Capping Proteins as Regulators for Actin Assembly in vitro & in vivo


1982

Henry Gale – 7/12/82 – Omaha, NE – Active Muscle Expansion Force: Measurements and Possible Mechanisms