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Carl Frieden
Professor
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research Interests
Protein folding, aggregation, intrinsically disordered proteins, fluorescence methods, fluorine NMR
Selected Publications
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Zhang, R., Hu, X., Khant, H., Ludtke, S.J., Chiu, W., Schmeid, M.F., Frieden, C. and Lee, J.M. Interprotofiliment interactions between Alzheimer's A{beta}1-42 peptides in amyloid fibrils revealed by cryoEM. PNAS 106:4653-4658 (2009).
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Garai, K., Crick, S.L., Mustafi, S.M. and Frieden, C. Expression and purification of amyloid-beta peptides from Escherichia coli. Protein Expr Purif. 66:107-112 (2009).
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Frieden, C. A lifetime of kinetics. J Biol Chem. 283:19873-19878 (2008).
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Frieden, C. Protein aggregation Processes: In search of the mechanism. Protein Science16:2334-2344 (2007).
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Li, H. and Frieden, C. Observation of sequential steps in the folding of intestinal fatty acid binding protein using a slow folding mutant and 19F NMR. Proc Natl Acad Sci USA 104:11993-11998 (2007).
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Li, H. and Frieden, C. Comparison of C40/82A and P27A C40/82A Barstar mutants using (19)F NMR. Biochemistry 46:4337-4347 (2007).
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Crick, S.L, Jayaraman, M., Frieden, C., Wetzel, R. and Pappu, R.V. Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions. Proc Natl Acad Sci USA 103:16764-16769 (2006).
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Li, H . and Frieden, C. Fluorine-19 NMR studies on the acid state of the intestinal fatty acid binding protein. Biochemistry 45:6272-6278 (2006).
