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Eric A. Galburt
Assistant Professor
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research
Eric Galburt’s laboratory research focuses on the use of single molecule biophysical approaches (primarily optical tweezers) to study mechanistic aspects of eukaryotic transcription by RNA polymerase II and cotranscriptional RNA folding.
Selected Publications
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Galburt, E.A., Grill, S.W. and Bustamante, C. Single molecule transcription elongation. Methods 48:323-332 (2009).
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Depken, M, Galburt, E.A. and Grill, S.W. The origin of short transcriptional pauses. Biophys J 96:2189-2193 (2009).
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Galburt. E.A., Grill, S.W., Wiedmann, A., Lubkowska, L., Choy, J., Nogales, E., Kashlev, M., and Bustamante, C.
Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner.
Nature, 446:820-823 (2007).
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Galburt. E.A. and Jurica, M.S. "His-Cys box homing endonucleases" in Nucleic Acids and Molecular Biology, Volume 16 Homing Endonucleases and Inteins ©Springer Verlag Berlin Heidelberg (2005).
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Galburt, E.A. and Stoddard, B.L. Catalytic mechanisms of restriction and homing endonucleases.
Biochemistry 41:13851-3860 (2002).
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Galburt, E.A., Pelletier, J., Wilson, G. and Stoddard, B.L.
Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase.
Structure 10:1249-1260 (2002).
