Research Interests

Mechanisms of DNA-protein interactions; DNA motor proteins (helicases) and SSB proteins

Selected Publications

• Lohman, T.M., Tomko, E.J. and Wu, C.G. Non-hexameric DNA helicases and translocases: Mechanisms and regulation. Nat Rev Mol Cell Biol. 9:391-401 (2008).

• Wong, C.J. and Lohman, T.M. Kinetic control of Mg(2+)-dependent melting of duplex DNA ends by Escherichia coli RecBC. J Mol Biol. 378:759-775 (2008).

• Niedziela-Majka, A., Chesnik, M.A., Tomko, E.J. and Lohman, T.M. B\. Stearothermophilus PCRA monomer is a single stranded DNA translocase but not a processive helicase in vitro. J Biol Chem 282:27076-27085 (2007)

• Tomko, E.J., Fischer, C.J., Niedziela-Majka, A. and Lohman, T.M. A nonuniform stepping mechanism for E. coli UvrD monomer translocation along single-stranded DNA. Mol Cell 26:335-347 (2007).

• Roy, R., Kozlov, A.G., Lohman, T.M. and Ha, T. Dynamic structural rearrangements between DNA binding modes of E. coli SSB protein. J Mol Biol 369:1244-1257 (2007).

• Eggington, J.M., Kozlov, A.G., Cox, M.M. and Lohman, T.M. Polar destabilization of DNA duplexes with single-stranded overhangs by the Deinococcus radiodurans SSB protein. Biochemistry 45:14490-14502 (2006).

• Kumaran, S., Kozlov, A. G. and Lohman, T. M. Saccharomyces cerevisiae replication protein A binds to single-stranded DNA in multiple salt-dependent modes. Biochemistry 45:11958-11973 (2006).

• Wong, C.J., Rice, R.L., Baker, N.A., Ju, T. and Lohman, T.M. Probing 3'-ssDNA loop formation in E. coli RecBCD/RecBC-DNA complexes using non-natural DNA: A model for "chi" recognition complexes. J Mol Biol 362:26-43 (2006).

• Kozlov, A.G. and Lohman, T.M. Effects of monovalent anions on a temperature-dependent heat capacity change for excherichia coli SSB tetramer binding to single-stranded DNA. Biochemistry 45:5190-5205 (2006).