dept of biochemistry and molecular biophysics




Faculty

picture of scott mathews
F. Scott Mathews
 Professor of Biological Chemistry
Dept. of Biochemistry and
Molecular Biophysics

Office: 2210 Cancer Research
Phone: 314-362-1080
Fax: 314-362-7183
Email: mathews@biochem.wustl.edu

Lab Website
Research Opportunities

Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110

Research Interests

X-ray structure and analysis of macromolecules



Selected Publications

  • Hassan-Abadallah, A., Zhao, G., Chen, Z., Mathews, F.S. and Schuman Jorns, M. Arginine 49 is a bifunctional residue important in catalysis and biosynthesis of monomeric sarcosine oxidase: A context-sensitive model for the electrostatic impact of arginine to lysine mutations. Biochemistry (E-pub ahead of print.) (2008).

  • Gandhi, P.S., Chen, Z., Mathews, F.S. and Di Cera, E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A. 105:1832-1837 (2008).

  • Ma, J.K., Wang, Y., Carrell, C.J., Mathews, F.S. and Davidson, V.L. A single methionine residue dictates the kinetic mechanism of interprotein electron transfer from methylamine dehydrogenase to amicyanin(,). Biochemistry 46:11137-11146 (2007).

  • Carrell, C.J., Bruckner, R.C., Venci, D., Zhao, G., Jorns, M.S. and Mathews, F.S. NikD, an unusual amino acid oxidase essential for nikkomycin biosynthesis: Structures of closed and open forms at 1.15 and 1.90 A resolution. Structure 15:928-941 (2007).

  • Bush-Pelc, L.A., Marino, F., Chen, Z., Pineda, A.O. Mathews, F.S. and Di Cera, E. Important role of the Cys-191: Cys-220 disulfide bond in thrombin function and allostery. J Biol Chem 282:27165-27170 (2007).

  • Bah, A., Chen, Z., Bush-Pelc, L.A., Mathews, F.S. and Di Cera, E. Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc Natl Acad Sci U S A. 104:11603-11608 (2007).

  • Ma, J.K., Mathews, F.S. and Davidson, V.L. Correlation of rhombic distortion of the type 1 copper site of M98Q amicyanin with increased electron transfer reorganization energy. Biochemistry 46:8561-8568 (2007).

  • Marino, F., Chen, Z., Ergenekan, C.E., Bush-Pelc, L.A., Mathews, F.S. and Di Cera, E. Structural basis of Na+ activation mimicry in murine thrombin. J Biol Chem. 282L16355-16361 (2007).

  • Pineda, A.O., Chen, Z.W., Marino, F., Mathews, F.S., Mosesson, M.W. and Di Cera, E. Crystal structure of thrombin in complex with fibrinogen gamma' peptide. Biophys Chem 125:556-559 (2007).

 

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