Peter M. Burgers, Ph.D.

Brennecke Professor of Biological Chemistry

Biochemistry and Molecular Biophysics

Lab Website
Graduate Programs (DBBS)
Publications (PubMed / NIH)

 

Office: 1911 South Building
Phone: 314-362-3872
Email: burgers(at)wustl.edu
 

Research

The Burgers lab studies DNA replication and DNA damage response in eukaryotic cells. Using yeast as a model organism, the lab integrates the biochemical analysis of DNA-protein interactions in purified model systems with the genetic analysis of targeted yeast mutants. Specific areas of interest are lagging strand DNA replication and Okazaki fragment maturation, damage induced mutagenesis, and DNA damage cell cycle checkpoints.

Peter Burgers' Replication Fork

Publications

  • Kochenova O.V., Bezalel-Buch R., Tran P., Makarova A.V., Chabes A., Burgers P.M., and Shcherbakova P.V.
    Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.
    Nucleic Acids Res. (2016) (Abstract)

  • Stojkovic, G., Makarova, A.V., Wanrooij, P.H., Forslund, J., Burgers, P.M. and Wanrooij, S.
    Oxidative DNA damage stalls the human mitochondrial replisome.
    Sci Rep. (2016) (Abstract)

  • Cho, J.E., Huang, S.N., Burgers, P.M., Shuman, S., Pommier, Y. and Jinks-Robertson, S.
    Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo.
    Nucleic Acids Research, Volume 44, Issue 16, Pages 7714-7721 (2016) (Abstract)

  • Stodola, J.L., Stith, C.M. and Burgers, P.M.
    Proficient Replication of the Yeast Genome by a Viral DNA Polymerase.
    J Biol Chem 291:11698-11705 (2016) (Abstract)

  • Stodola, J.L. and Burgers, P.M.
    Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale.
    Nat Struct Mol Biol 23:402-408 (2016) (Abstract)

  • Koc, K.N., Singh, S.P., Stodola, J.L., Burgers, P.M. and Galletto, R.
    Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ.
    Nucleic Acids Res. 44:3811-3819 (2016). (Abstract)

  • Koc, K.N., Singh, S.P., Stodola, J.L., Burgers, P.M. and Galletto, R.
    Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ.
    Nucleic Acids Res 44:3811-3819 (2016). (Abstract)

  • Sawicka, M., Wanrooij, P.H., Darbari, V.C., Tannous, E., Hailemariam, S., Bose, D., Makarova, A.V., Burgers, P.M. and Zhang, X.
    The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization.
    J Biol Chem 291:13436-47 (2016) (Abstract)

  • Burgers, P.M., Gordenin, D. and Kunkel, T.A.
    Who Is Leading the Replication Fork, Pol ε or Pol δ?
    Mol Cell. 61:492-493 (2016). (Abstract)

  • Wanrooij, P.H, Tannous, E., Kumar, S., Navadgi-Patil, V.M. and Burgers, P.M.
    Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.
    J Biol Chem 291:1076-1091 (2016). (Abstract)