Biochemistry and Molecular Biophysics
The Burgers lab studies DNA replication and DNA damage response in eukaryotic cells. Using yeast as a model organism, the lab integrates the biochemical analysis of DNA-protein interactions in purified model systems with the genetic analysis of targeted yeast mutants. Specific areas of interest are lagging strand DNA replication and Okazaki fragment maturation, damage induced mutagenesis, and DNA damage cell cycle checkpoints.
Kochenova O.V., Bezalel-Buch R., Tran P., Makarova A.V., Chabes A., Burgers P.M., and Shcherbakova P.V.
Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.
Nucleic Acids Res. (2016) (Abstract)
Koc, K.N., Singh, S.P., Stodola, J.L., Burgers, P.M. and Galletto, R.
Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ.
Nucleic Acids Res. 44:3811-3819 (2016). (Abstract)
Burgers, P.M., Gordenin, D. and Kunkel, T.A.
Who Is Leading the Replication Fork, Pol ε or Pol δ?
Mol Cell. 61:492-493 (2016). (Abstract)
Wanrooij, P.H, Tannous, E., Kumar, S., Navadgi-Patil, V.M. and Burgers, P.M.
Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.
J Biol Chem 291:1076-1091 (2016). (Abstract)