Faculty

Linda J. Pike
Associate Professor of Biological Chemistry
Dept. of Biochemistry and
Molecular Biophysics

Office: 2201 Cancer Research
Phone: 314-362-9502
Fax: 314-362-7183
Email: pike@biochem.wustl.edu

Lab Website
Research Opportunities

Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110

Macdonald, J.L. and Pike, L.J. Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system. PNAS 105:112-117 (2008).
Saffarian, S., Li, Y., Elson, E.L. and Pike, L.J. Oligomerization of the EGF receptor investigated by live cell fluorescence intensity distribution analysis. Biophys J 93:1021-1031(2007).
Macdonald, J., Li, Z., Su, W. and Pike, L.J. The membrane proximal disulfides of the EGF receptor extracellular domain are required for high affinity binding and signal transduction but do not play a role in localization of the receptor to lipid rafts. Biochim Biophys Acta 1763:870-878 (2006).
Pike, L.J. Rafts defined. J Lipid Res 47:1597-1598 (2006).
Pike, L.J. Growth factor receptors, lipid rafts and caveolae: An evolving story. Biochim Biophys Acta 1746:260-273 (2005).
Macdonald, J.L. and Pike, L.J. A simplified method for the preparation of detergent-free lipid rafts. J Lipid Research 46:1061-1067 (2005).
Pike, L.J., Han, X. and Gross, R.W. EGFR are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: A shotgun lipidomics study. J Biol Chem 280:26796-26804 (2005).