Burgers Lab Yeast DNA replication and DNA repair
Peter M. Burgers, Professor Programs: Biochemistry Molecular Genetics Molecular Cell Biology Department of Biochemistry & Molecular Biophysics Washington University School of Medicine 660 South Euclid St. Louis, MO 63110 Office: 314-362-3872 Lab: 314-362-3182 E-mail Lab Members Positions Research Projects Publications	Our laboratory is studying nuclear DNA replication and DNA repair in the yeast Saccharomyces cerevisiae. Current biochemical and genetic efforts focus on the mechanisms which ensures genome fidelity and integrity during DNA replication and the DNA damage response.	Models Replication Fork PCNA Loading by RFC Okazaki Fragment Synthesis Nick Translation Nick Maintenance DNA damage checkpoint Translesion Synthesis Protein Complexes Replicational DNA polymerases Structure of PCNA-RFC Complex Alternative Clamp Loaders