FOCUS on RESEARCH
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Carl Frieden's lab is working on protein folding, aggregation, intrinsically disordered proteins, fluorescence methods and fluorine NMR.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Peter Burgers' lab is working on the biochemistry and genetics of yeast DNA replication and repair.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. John Cooper’s lab studies molecular mechanisms of cell motility and cytoskeleton assembly.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Kathleen Hall's lab is working on NMR and biochemical studies of RNA and RNA-protein complexes.
On Friday, October 19th, 2018, a symposium in remembrance of Dr. John Majors will be held. Click here to view more information on the symposium.
On May 24, 2018, Mr. Darrell Baldwin received the Washington University School of Medicine 2018 Operations Staff Service Award.
The Operations Staff Service award is given to a staff member who has demonstrated outstanding leadership, exceptional performance in their position and superior service.
The department surprised Darrell with an award ceremony and celebration in the seminar room where Dr. David Perlmutter, Dean of the Medical School, said a few words and presented Darrell with his award.
On May 22nd, 2018, Ms. Melissa Budelier and Ms. Lucy Li were awarded the 2018 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Ms. Budelier presented her research entitled “Mapping Ligand Binding Sites in Integral Membrane Proteins”. Ms. Budelier was a graduate student in the Biochemistry, Biophysics and Structural Biology Program. Ms. Budelier was nominated by her thesis mentor Dr. Alex Evers. In Dr. Evers lab, Melissa’s work focused on developing chemical biology tools and mass spectrometric (MS) methods to sequence the transmembrane domains (TMDs) of integral membrane proteins (IMPs) and identified the sites at which sterol analogue photoaffinity labeling reagents modify these proteins. (more…)
Dr. William Frazier will receive the Chancellor’s Award for Innovation and Entrepreneurship. Chancellor Mark S. Wrighton will present Dr. Frazier and two others with awards during a ceremony October 5th, 2018 at The Ritz-Carlton Hotel in Clayton.
“Professors Achilefu, Elgin and Frazier represent the very best of Washington University and join the distinguished company of previous winners who have worked creatively and diligently to discover and disseminate new knowledge that brings great benefit to society,” Wrighton said.
You can read more about this at The Source.
More in the News Archive…
On Sunday, June 3rd the department held a faculty reception to congratulate Drs. Jim Janetka and Eric Galburt being awarded tenure in March, 2018.
The reception was held at the Moonrise Hotel in the Delmar Loop.
More in the Events Archive…
May 2nd, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a Knight ADRC Pilot Grant award from the Alzheimer’s Disease Research Center (ADRC) for his work entitled “Conformational analysis of ApoE and its role in AD mechanism”.
April 9th, 2018 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Targeting Hepatocyte Growth Factor with Protease Inhibitors in Lung Cancer”.
April 2nd, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a five-year grant award from the National Heart, Lung, and Blood Institute for his work entitled “Regulation of cardiac power output in health and disease”.
March 26th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a two year Extramural Award from the Ruth K. Broad Biomedical Research Foundation, Inc. for his work entitled “Structural plasticity of ApoE and its role in AD”.
February 27th, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a two year, Basil O’Connor Starter Scholar Research grant award from the March of Dimes for his work entitled “Understanding Congenital Heart Disease from the Ground Up”.
Macdonald-Obermann J.L. & Pike L.J. (2018). “Allosteric regulation of EGF receptor ligand binding by tyrosine kinase inhibitors.” J Biol Chem. 2018 Jul 11. pii: jbc.RA118.004139. doi: 10.1074/jbc.RA118.004139. (Abstract)
Song J.G., King M.R., Zhang R., Kadzik R.S., Thawani A., & Petry S. (2018) “Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules.” J Cell Biol. 2018 Jul 2;217(7):2417-2428. doi: 10.1083/jcb.201711090. Epub 2018 Jun 6. (Abstract)
Singh S.P., Kukshal V., De Bona P., Antony E., & Galletto R. (2018). “The mitochondrial single-stranded DNA binding protein from S. cerevisiae, Rim1, does not form stable homo-tetramers and binds DNA as a dimer of dimers.” Nucleic Acids Res. 2018 Jun 21. doi: 10.1093/nar/gky530. (Abstract)
Shen G., Li S., Cui W., Liu S., Liu Q., Yang Y., Gross M., & Li W. (2018). “Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition.” J Thromb Haemost. 2018 Jun;16(6):1164-1175. doi: 10.1111/jth.14127. Epub 2018 May 20. (Abstract)
Weber G., DeKoster G.T., Holton N., Hall K.B., & Wahl M.C. (2018). “Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.” Nat Commun. 2018 Jun 7;9(1):2220. doi: 10.1038/s41467-018-04561-6. (Abstract)