FOCUS on RESEARCH
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Congratulations to John LeClair and Meng’ou (Mary) Zhu for receiving the 2018 David F. Silbert Summer Fellowship Award.
John LeClair worked with Drs. Lisa D McKenzie and Milan G Chheda on a project entitled “Characterizing the role of CHD4 in glioblastoma treatment response”, and Meng’ou (Mary) Zhu worked with Drs. Matthew J Walter and Michael O Alberti on a project entitled “Mutant U2AF1(Q157P) expression alters hematopoiesis in vivo.” (more…)
Dr. Linda Pike and Dr. Kathleen Hall have been selected as new fellows by the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society.
The AAAS selects fellows in recognition of their distinguished efforts to advance science and its applications, and has selected eleven faculty members at Washington University in St. Louis – the most in a decade-and-a-half. (more…)
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The winner with the best Chili was the Robertson lab! The Lohman lab won best costume – they all “dressed up” as Dr. Lohman!
On Friday, October 19th, 2018, a symposium in remembrance of Dr. John Majors was held in Moore Auditorium on the medical campus of Washington University. Many colleagues, friends and family members from the university community, as well as from across the country, were in attendance. Drs. Peter Burgers, Mark Johnston, Charlie Rice, and Harold Varmus all gave heartfelt talks about John’s influence in biophysics as well as speaking about the different hobbies (i.e., backpacking and golf) and interests John had outside of the lab. It was great to hear about the many sides of John that were not widely known. By the end of the day, everyone had learned something new about John. (more…)
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January 31st, 2019 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Michael L. Gross, PhD, professor of chemistry, immunology, and medicine, received a new four year grant award from the National Institute of General Medical Sciences for their research entitled “New chemical probes enable Mass Spectrometry-based footprinting of human protein structure in lipid membranes and cells”.
January 17th, 2019 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a new three year Research Grant Award from the Alzheimer’s Association (AARG) for his work entitled “Conformational analysis of ApoE isoforms and their role in AD mechanism”.
January 9th, 2019 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics received a four year renewal from the National Heart, Lung, and Blood Institute for his research entitled “Structural and Functional Basis of the Vitamin K Cycle”.
December 27th, 2018 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Rui Zhang, PhD, assistant professor of biochemistry and molecular biophysics received a new three year, grant award from the W. M. Keck foundation for their research entitled “Terminal coupling enabled structure determination of human membrane proteins at atomic resolution”.
October 19th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a New Investigator Award in Alzheimer’s Disease from the American Federation for Aging Research (AFAR), Inc. for his work entitled “Identifying Neurotoxic Conformers in the Structural Ensemble of apoE”.
Frieden C. (2019). “Protein oligomerization as a metabolic control mechanism. Application to apoE.” Protein Sci. 2019 Jan 30. doi: 10.1002/pro.3583. [Epub ahead of print] (Abstract)
Porter J.R., Zimmerman M.I., & Bowman G.R. (2019). “Enspara: Modeling molecular ensembles with scalable data structures and parallel computing.” J Chem Phys. 2019 Jan 28;150(4):044108. doi: 10.1063/1.5063794. (Abstract)
Makurath M.A., Whitley K.D., Nguyen B., Lohman T.M., & Chemla Y.R. (2019). “Regulation of Rep helicase unwinding by an auto-inhibitory subdomain.” Nucleic Acids Res. 2019 Jan 23. doi: 10.1093/nar/gkz023. [Epub ahead of print] (Abstract)
Singh S.P., Kukshal V., & Galletto R. (2019). “A stable tetramer is not the only oligomeric state that mitochondrial single-stranded DNA binding proteins can adopt.” J Biol Chem. 2019 Jan 7. pii: jbc.RA118.007048. doi: 10.1074/jbc.RA118.007048. [Epub ahead of print] (Abstract)
Kawaguchi M., Yamamoto K., Takeda N., Fukushima T., Yamashita F., Sato K., Kitamura K., Hippo Y., Janetka J.W., & Kataoka H. (2019). “Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine.” Commun Biol. 2019 Jan 4;2:11. doi: 10.1038/s42003-018-0255-8. eCollection 2019. (Abstract)