FOCUS on RESEARCH
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Sarah Clippinger in Dr. Michael Greenberg's Lab is culturing human stem cell derived cardiomyocytes to model heart disease.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Peter Burgers' Lab studies DNA replication and DNA damage response mechanisms in yeast, using a combination of biochemical, biophysical and genetic approaches.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Congratulations to Dr. Jim Janetka, whose promotion to Professor was officially approved on September 11, 2020.
For more information on Dr. Jim Janetka, click here.
Dr. Natalie Niemi joined the Department on July 1, 2020, as an Assistant Professor on the Investigator Track. Her lab will investigates how mitochondria are built, regulated, and maintained across physiological contexts. We blend biochemistry, systems biology, and physiology to understand mechanisms of mitochondrial regulation and how they influence metabolism and organellar function. Using insights gained from our molecular studies, we aim to understand how mitochondrial dysfunction contributes to mammalian pathophysiology, with the long-term goal of translating our discoveries into new therapeutic options to restore mitochondrial function in human disease.
For more information on Dr. Natalie Niemi, click here.
Dr. Alex Holehouse joined the Department on January 1, 2020, as an Assistant Professor on the Investigator track. His lab will explore how intrinsically disordered protein regions confer biological function and how this goes wrong in disease. The lab integrates physics-based models (all-atom and coarse-grained simulations) with informatics and machine learning to develop sequence-specific predictions. They then test those predictions either within the lab or with collaborators around the world.
For more information on Dr. Alex Holehouse, click here.
More in the News Archive…
On June 12, 2020, Ms. Megan Cohan and Dr. Jonathan Lin were awarded the 2020 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Ms. Cohan presented her research entitled “Small but mighty! Intrinsically disordered domains as key regulators of bacterial processes” followed by Dr. Jonathan Lin who presented his research entitled “The Role of NAD+ in Retinal Neurodegeneration”. If you want to learn more about these fellows please click here.
On March 5th the Department held a half day retreat at the Eric P. Newman Center located on the WU Medical Campus. All of the labs in the department introduced their lab members and questions their lab is working on in their lab.
You can click here to view photos from the event.
On September 20th, 2019, the department held a special seminar to recognize the recipient of the 2018 Elliot Elson Fellowship. Ms. Sarah Clippinger shared her research on “Dissecting the Molecular and Cellular Mechanisms of Familial Cardiomyopathy”. For more information on Sarah, please click here.
You can click here to view photos from the event.
More in the Events Archive…
August 21st, 2020 – Carl Frieden, PhD, Professor of Biochemistry and Molecular Biophysics, received a new one year grant award from BrightFocus Foundation for his research entitled “Understanding apoE”.
July 10th, 2020 – Rui Zhang, PhD, assistant professor of biochemistry and molecular biophysics received a new five year grant award from the National Institute of General Medical Sciences for his research entitled “Structural and functional studies of axonemal microtubule inner proteins (MIPs)”.
April 24th, 2020 – Timothy M. Lohman, PhD, Marvin A. Brennecke Professor of Biophysics and professor of biochemistry and molecular biophysics received a new five year MIRA grant award from National Institute of General Medical Sciences for his research entitled “Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome Maintenance”.
January 17th, 2020 – Weikai Li, PhD, Associate Professor of Biochemistry and Molecular Biophysics, along with Laura Schuettpelz, MD, PhD, Associate Professor of Pediatrics, received an Interdisciplinary Research Initiatives grant award from the Children’s Discovery Institute for their work entitled “Regulation of normal and malignant B cells by the tetraspanin CD53”.
September 16th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Inhibitors of pro-HGF activation overcome resistance to anti-EGFR therapy”.
Elias A. Tannous, Luke A. Yates, Xiaodong Zhang, & Peter M. Burgers (2020). “Mechanism of auto-inhibition and activation of Mec1 ATR checkpoint kinase” Nat Struct Mol Biol. 2020 Nov 9. doi: 10.1038/s41594-020-00522-0. Online ahead of print. (Abstract)
Joanna Kim & John A. Cooper (2020). “Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers” Arterioscler Thromb Vasc Biol. 2020 Nov 5;ATVBAHA120315472. doi: 10.1161/ATVBAHA.120.315472. Online ahead of print. (Abstract)
Shixuan Liu, Shuang Li, Guomin Shen, Narayanasami Sukumar, Andrzej M. Krezel, & Weikai Li (2020). “Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation” Science. 2020 Nov 5;eabc5667. doi: 10.1126/science.abc5667. Online ahead of print. (Abstract)
Adam L. Bailey, Oleksandr Dmytrenko, Lina Greenberg, Andrea L. Bredemeyer, Pan Ma, Jing Liu, Vinay Penna, Lulu Lai, Emma S. Winkler, Sanja Sviben, Erin Brooks, Ajith P. Nair, Kent A. Heck, Aniket S. Rali, Leo Simpson, Mehrdad Saririan, Dan Hobohm, W. Tom Stump, James A. Fitzpatrick, Xuping Xie, Pei-Yong Shi, J. Travis Hinson, Weng-Tein Gi, Constanze Schmidt, Florian Leuschner, Chieh-Yu Lin, Michael S. Diamond, Michael J. Greenberg, & Kory J. Lavine (2020). “SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis” bioRxiv. 2020 Nov 5;2020.11.04.364315. doi: 10.1101/2020.11.04.364315. Preprint (Abstract)
Melanie A. Sparks, Peter M. Burgers, & Roberto Galletto. (2020). “Pif1, RPA and FEN1 modulate the ability of DNA polymerase δ to overcome protein barriers during DNA synthesis” J Biol Chem. 2020 Sep 10;jbc.RA120.015699. doi: 10.1074/jbc.RA120.015699. Online ahead of print. (Abstract)