FOCUS on RESEARCH
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Peter Burgers' Lab studies DNA replication and DNA damage response mechanisms in yeast, using a combination of biochemical, biophysical and genetic approaches.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Sarah Clippinger in Dr. Michael Greenberg's Lab is culturing human stem cell derived cardiomyocytes to model heart disease.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
The 2020 John E. Majors Award goes to two individuals – Sarah Clippinger and Emma Winkler.
Dr. Sarah Clippinger was nominated by her advisor, Dr. Michael Greenberg. Ms. Clippinger is a graduate student in the Biochemistry, Biophysics, and Structural Biology Program. She is completing her thesis work on the study of mutations in the protein troponin T that lead to familial cardiomyopathies.
Dr. Emma Winkler was nominated by her advisor, Dr. Michael Diamond. Ms. Winkler is an MSTP student in the Immunology program. She is completing her thesis work on understanding how the intestinal microbiome modulates systemic immune responses to virus infection, specifically mosquito-born alphaviruses such as Chikungunya virus. (more…)
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Tom Rapoport, PhD, from Harvard Medical School, presented the 2020 Carl and Gerty Cori Lecture on November 12, 2020, via Zoom.
Dr. Rapoport’s seminar was entitled “Mechanism of ER-Associated Protein Degradation (“ERAD”)”.
For more information on Dr. Tom Rapoport, please click here.
To see a recording of Dr. Rapoport’s lecture, please click here.
On June 12, 2020, Ms. Megan Cohan and Dr. Jonathan Lin were awarded the 2020 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Ms. Cohan presented her research entitled “Small but mighty! Intrinsically disordered domains as key regulators of bacterial processes” followed by Dr. Jonathan Lin who presented his research entitled “The Role of NAD+ in Retinal Neurodegeneration”. If you want to learn more about these fellows please click here.
On March 5th the Department held a half day retreat at the Eric P. Newman Center located on the WU Medical Campus. All of the labs in the department introduced their lab members and questions their lab is working on in their lab.
You can click here to view photos from the event.
More in the Events Archive…
January 11th, 2021 – Alex Holehouse, Ph.D., Assistant Professor of Biochemistry and Molecular Biophysics, received a new one year grant award from Dewpoint Therapeutics for his research entitled “Bioinformatic tools for the analysis of phase separating proteins”.
August 21st, 2020 – Carl Frieden, PhD, Professor of Biochemistry and Molecular Biophysics, received a new one year grant award from BrightFocus Foundation for his research entitled “Understanding apoE”.
July 10th, 2020 – Rui Zhang, PhD, assistant professor of biochemistry and molecular biophysics received a new five year grant award from the National Institute of General Medical Sciences for his research entitled “Structural and functional studies of axonemal microtubule inner proteins (MIPs)”.
April 24th, 2020 – Timothy M. Lohman, PhD, Marvin A. Brennecke Professor of Biophysics and professor of biochemistry and molecular biophysics received a new five year MIRA grant award from National Institute of General Medical Sciences for his research entitled “Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome Maintenance”.
January 17th, 2020 – Weikai Li, PhD, Associate Professor of Biochemistry and Molecular Biophysics, along with Laura Schuettpelz, MD, PhD, Associate Professor of Pediatrics, received an Interdisciplinary Research Initiatives grant award from the Children’s Discovery Institute for their work entitled “Regulation of normal and malignant B cells by the tetraspanin CD53”.
Michael D. Onken, Kendall J. Blumer, & John A. Cooper (2021). “Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium” Mol Biol Cell. 2021 Jan 6;mbcE20040241. doi: 10.1091/mbc.E20-04-0241. Online ahead of print. (Abstract)
Vishnu C. Damalanka, Amarendar Reddy Maddirala, & James W. Janetka (2020). “Novel approaches to glycomimetic design: Development of small molecular weight lectin antagonists” Expert Opin Drug Discov. 2020 Dec 18. doi: 10.1080/17460441.2021.1857721. Online ahead of print. (Abstract)
Elias A. Tannous, Luke A. Yates, Xiaodong Zhang, & Peter M. Burgers (2020). “Mechanism of auto-inhibition and activation of Mec1 ATR checkpoint kinase” Nat Struct Mol Biol. 2020 Nov 9. doi: 10.1038/s41594-020-00522-0. Online ahead of print. (Abstract)
Joanna Kim & John A. Cooper (2020). “Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers” Arterioscler Thromb Vasc Biol. 2020 Nov 5;ATVBAHA120315472. doi: 10.1161/ATVBAHA.120.315472. Online ahead of print. (Abstract)
Shixuan Liu, Shuang Li, Guomin Shen, Narayanasami Sukumar, Andrzej M. Krezel, & Weikai Li (2020). “Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation” Science. 2020 Nov 5;eabc5667. doi: 10.1126/science.abc5667. Online ahead of print. (Abstract)