FOCUS on RESEARCH
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Sarah Clippinger in Dr. Michael Greenberg's Lab is culturing human stem cell derived cardiomyocytes to model heart disease.
Dr. Peter Burgers' Lab studies DNA replication and DNA damage response mechanisms in yeast, using a combination of biochemical, biophysical and genetic approaches.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Benjamin A. Garcia, PhD, a noted leader in the field of biochemistry, especially for his work advancing mass spectrometry techniques, has been named head of the Department of Biochemistry and Molecular Biophysics at Washington University School of Medicine in St. Louis. Garcia, whose appointment tentatively is set to begin July 1, also will become the Raymond H. Wittcoff Distinguished Professor. (more…)
The 2020 John E. Majors Award goes to two individuals – Sarah Clippinger and Emma Winkler.
Ms. Sarah Clippinger was nominated by her advisor, Dr. Michael Greenberg. Ms. Clippinger is a graduate student in the Biochemistry, Biophysics, and Structural Biology Program. She is completing her thesis work on the study of mutations in the protein troponin T that lead to familial cardiomyopathies.
Ms. Emma Winkler was nominated by her advisor, Dr. Michael Diamond. Ms. Winkler is an MSTP student in the Immunology program. She is completing her thesis work on understanding how the intestinal microbiome modulates systemic immune responses to virus infection, specifically mosquito-born alphaviruses such as Chikungunya virus. (more…)
More in the News Archive…
On March 5th, 2021, Dr. Thi Nguyen presented on “Working Smarter – Strategic Planning & Time Management Basics”. To watch this presentation, please click here.
On January 22nd, 2021, the department hosted a Career Panel Discussion on how to apply for jobs in academia and industry. Panelist included: Dr. Erin Heckler, Director, Office of Postdoctoral Affairs; Dr. Alex Holehouse, Assistant Professor, Biochemistry and Molecular Biophysics; Dr. Ron Dolle, Chemistry Director, Center for Drug Discovery; Dr. Michael Kinch, Director, Center for Drug Discovery.
If you would like to view this panel discussion, please click here.
Tom Rapoport, PhD, from Harvard Medical School, presented the 2020 Carl and Gerty Cori Lecture on November 12, 2020, via Zoom.
Dr. Rapoport’s seminar was entitled “Mechanism of ER-Associated Protein Degradation (“ERAD”)”.
For more information on Dr. Tom Rapoport, please click here.
To see a recording of Dr. Rapoport’s lecture, please click here.
More in the Events Archive…
April 15th, 2021 – Linda J. Pike, PhD, Professor of Biochemistry and Molecular Biophysics, along with Alexander S. Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, and Gary J. Patti, PhD, Professor of Chemistry and of Genetics and Medicine, received a new four year grant award from the National Institute of General Medical Sciences for their research entitled “Intrinsic Disorder and Agonist Bias in EGF Receptor Signaling”.
March 18th, 2021 – Jim Janetka, PhD, Professor of Biochemistry and Molecular Biophysics, Makedonka Mitreva, Professor of Medicine and Genetics, and Raffi Aroian, Professor of Molecular Medicine at the University of Massachusetts Medical School have received a new multi-PI R01 award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases entitled “Development of small molecule inhibitors of metabolic enzymes as broad-spectrum anthelmintic drugs”.
March 17th, 2021 – Jim Janetka, PhD, Professor of Biochemistry and Molecular Biophysics, along with Scott Hultgren, Helen L. Stoever Professor of Molecular Microbiology, Michael Caparon, Professor of Molecular Microbiology, Peng Yuan, Associate Professor of Cell Biology and Physiology, and Ali Ellebedy, Associate Professor of Pathology and Immunology received a five-year U19 Research Program–Cooperative Agreement Award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases entitled “Innovative Strategies to Combat Antibiotic-resistant Infections”. Dr. Janetka is leader of the project scientific core named “Rational Design and Synthesis of Small Molecule Inhibitors Targeting Unique Pathogenic Mechanisms in Gram- and Gram+ Bacteria Important in UTI”.
February 9th, 2021 – Natalie M. Niemi, PhD, Assistant Professor in the department of Biochemistry and Molecular Biophysics, received a one-year pilot and feasibility grant award from the Washington University Diabetes Research Center (DRC), sponsored by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for her research entitled “The role of the mitochondrial phosphatase Pptc7 in enabling metabolic flexibility”.
February 2nd, 2021 – Samantha Kirstin Barrick, PhD, Postdoctoral Scholar in the department of Biochemistry and Molecular Biophysics, and the laboratory of Dr. Michael J. Greenberg, PhD, received a new three year fellowship award from the National Institutes of Health, National Heart, Lung, and Blood Institute for her research entitled “Multiscale investigation of cardiomyopathy-associated mutations in metavinculin”.
Ming Cheng, Chunyang Guo, Weikai Li, & Michael L. Gross (2021). “Free-Radical Membrane Protein Footprinting by Photolysis of Perfluoroisopropyl Iodide Partitioned to Detergent Micelle by Sonication” Angew Chem Int Ed Engl. 2021 Mar 10. doi: 10.1002/anie.202014096. Online ahead of print. (Abstract)
Weikai Li (2021). “Targeting multiple enzymes in vitamin K metabolism for anticoagulation” J Thromb Haemost. 2021 Mar;19(3):633-636. doi: 10.1111/jth.15212. (Abstract)
Michael J. Greenberg & Jil C. Tardiff (2021). “Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine” J Gen Physiol. 2021 Mar 1;153(3):e202012662. doi: 10.1085/jgp.202012662. (Abstract)
Adam L. Bailey, Oleksandr Dmytrenko, Lina Greenberg, Andrea L. Bredemeyer, Pan Ma, Jing Liu, Vinay Penna, Lulu Lai, Emma S. Winkler, Sanja Sviben, Erin Brooks, Ajith P. Nair, Kent A. Heck, Aniket S. Rali, Leo Simpson, Mehrdad Saririan, Dan Hobohm, W. Tom Stump, James A. Fitzpatrick, Xuping Xie, Pei-Yong Shi, J. Travis Hinson, Weng-Tein Gi, Constanze Schmidt, Florian Leuschner, Chieh-Yu Lin, Michael S. Diamond, Michael J. Greenberg, & Kory J. Lavine (2021). “SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis” JACC Basic Transl Sci. 2021 Feb 26. doi: 10.1016/j.jacbts.2021.01.002. Online ahead of print. (Abstract)
Min Kyung Shinn, Alexander G. Kozlov, & Timothy M. Lohman (2021). “Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins” Nucleic Acids Res. 2021 Feb 26;49(4):1987-2004. doi: 10.1093/nar/gkaa1291. (Abstract)