FOCUS on RESEARCH
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Sarah Clippinger in Dr. Michael Greenberg's Lab is culturing human stem cell derived cardiomyocytes to model heart disease.
Dr. Peter Burgers' Lab studies DNA replication and DNA damage response mechanisms in yeast, using a combination of biochemical, biophysical and genetic approaches.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Jasmine is a fifth-year graduate student in the Biochemistry, Biophysics, and Structural Biology (BBSB) program. She is doing her PhD thesis work in the lab of Dr. Andrea Soranno, where she studies how sequence composition of intrinsically disordered regions within a protein can affect interactions with both proteins and nucleic acids using single-molecule fluorescence spectroscopy.
Jasmine joined the BBSB program after receiving her B.S. from Stockton University in Galloway, New Jersey with a major in biochemistry & molecular biology and a minor in holistic health. Prior to starting her Ph.D. work, Jasmine studied polymer synthesis and how polymer interactions contribute to optimized hydrogel formation. (more…)
Dr. Kathleen Hall was promoted to serve as a senior member of the Washington University School of Medicine Committee on Admissions in recognition of her contributions and dedication to the WUSM Admissions process.
Benjamin A. Garcia, PhD, a noted leader in the field of biochemistry, especially for his work advancing mass spectrometry techniques, has been named head of the Department of Biochemistry and Molecular Biophysics at Washington University School of Medicine in St. Louis. Garcia, whose appointment tentatively is set to begin July 1, also will become the Raymond H. Wittcoff Distinguished Professor. (more…)
More in the News Archive…
On April 28th, 2021, the Department hosted a special session entitled “Evidence-based Practices that Support Mental and Emotional Well-being”. Mrs. Krista Jarvis, Clinical Case Manager and Program Manager in the Department of Psychiatry at Washington University, walks the group through five different evidence-based practices for our mental and emotional well-being. These practices are designed to help each individual feel empowered to utilize a variety of simple techniques for stress-reduction in these challenging times.
If you would like to view this, just click here.
On March 5th, 2021, Dr. Thi Nguyen presented on “Working Smarter – Strategic Planning & Time Management Basics”. To watch this presentation, please click here.
On January 22nd, 2021, the department hosted a Career Panel Discussion on how to apply for jobs in academia and industry. Panelist included: Dr. Erin Heckler, Director, Office of Postdoctoral Affairs; Dr. Alex Holehouse, Assistant Professor, Biochemistry and Molecular Biophysics; Dr. Ron Dolle, Chemistry Director, Center for Drug Discovery; Dr. Michael Kinch, Director, Center for Drug Discovery.
If you would like to view this panel discussion, please click here.
More in the Events Archive…
September 30th, 2021 – Jim Janetka, PhD, Professor of Biochemistry and Molecular Biophysics, Makedonka Mitreva, Professor of Medicine and Genetics, and Sara Lustigman, Professor and Head, Laboratory of Molecular Parasitology Member, Lindsley F. Kimball Research Institute, New York Blood Center have received a new multi-PI R01 award from the National Institutes of Health, National Eye Institute entitled “Integrative approach for accelerating filarial worm drug discovery to treat river blindness”.
September 17th, 2021 – Roberto Galletto, PhD, Associate Professor in the department of biochemistry and molecular biophysics was awarded a new five year MIRA grant from the National Institute of General Medical Sciences for his research entitled “Functions of DNA helicases at hard-to-replicate sites and telomere regulation”.
September 15th, 2021 – Daniel Griffith, BS, Pre-Doc Trainee in the department of Biochemistry and Molecular Biophysics, and the laboratory of Alex Holehouse, PhD, received a new three-year Graduate Research Fellowship award from the National Science Foundation for his research entitled “Investigating the molecular grammar driving the assembly of membraneless-organelles”.
August 24th, 2021 – Benjamin Garcia, PhD, Raymond H. Wittcoff Distinguished Professor and Head of Biochemistry and Molecular Biophysics, along with Matthew D. Weitzman, PhD, Professor of Microbiology, Professor of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine and Children’s Hospital of Philadelphia, received a five year grant renewal from the National Institute of Allergy and Infectious Diseases for their research entitled “Viral modulation of epitranscriptomic mechanisms”.
August 23rd, 2021 – Jhullian Jamille Alston, BA, Pre-Doc Trainee in the department of Biochemistry and Molecular Biophysics, and the laboratories of Alex Holehouse, PhD and Andrea Soranno, PhD, received a Predoctoral to Postdoctoral Fellow Transition Award from the National Cancer Institute for his research entitled “Single Molecule Biophysics of Intrinsically Disordered Proteins in Disease”.
Daniel Griffith & Alex S. Holehouse (2021). “PARROT is a flexible recurrent neural network framework for analysis of large protein datasets” Elife. 2021 Sep 17;10:e70576. doi: 10.7554/eLife.70576. (Abstract)
Nicole R. Wong, Jay Mohan, Benjamin J. Kopecky, Shuchi Guo, Lixia Du, Jamison Leid, Guoshuai Feng, Inessa Lokshina, Oleksandr Dmytrenko, Hannah Luehmann, Geetika Bajpai, Laura Ewald, Lauren Bell, Nikhil Patel, Andrea Bredemeyer, Carla J. Weinheimer, Jessica M. Nigro, Attila Kovacs, Sachio Morimoto, Peter O. Bayguinov, Max R. Fisher, W. Tom Stump, Michael Greenberg, James A. J. Fitzpatrick, Slava Epelman, Daniel Kreisel, Rajan Sah, Yongjian Liu, Hongzhen Hu, & Kory J. Lavine (2021). “Resident cardiac macrophages mediate adaptive myocardial remodeling” Immunity. 2021 Sep 14;54(9):2072-2088.e7. doi: 10.1016/j.immuni.2021.07.003. Epub 2021 Jul 27. (Abstract)
Ishan Taneja & Alex S. Holehouse (2021). “Folded domain charge properties influence the conformational behavior of disordered tails” Curr Res Struct Biol. 2021 Sep 7;3:216-228. doi: 10.1016/j.crstbi.2021.08.002. eCollection 2021. (Abstract)
Linxuan Hao, Rui Zhang, & Timothy M. Lohman (2021). “Heterogeneity in E. coli RecBCD Helicase-DNA Binding and Base Pair Melting” J Mol Biol. 2021 Sep 3;433(18):167147. doi: 10.1016/j.jmb.2021.167147. Epub 2021 Jul 9. (Abstract)
Maria Papadaki, Theerachat Kampaengsri, Samantha K. Barrick, Stuart G. Campbell, Dirk von Lewinski, Peter P. Rainer, Samantha P. Harris, Michael J. Greenberg, & Jonathan A. Kirk (2021). “Myofilament glycation in diabetes reduces contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains” J Mol Cell Cardiol. 2021 Sep 3;162:1-9. doi: 10.1016/j.yjmcc.2021.08.012. Online ahead of print. (Abstract)