Spotlight on Research – Marshall Lab

The Marshall Lab performs a synergistic application of organic synthesis (solution- and solid-phase chemistry), enzymatic assays (electrophoretic mobility shift assays (EMSA) and surface plasmon resonance (SPR)), and computational chemistry techniques (homology modeling, molecular docking, molecular dynamics simulations, QSAR and 3D QSAR models) to rationally develop novel isoform-selective Lysine Deacetylases Inhibitors (KDACIs) as new therapeutics for the treatment of cancer, HIV-1, schistosomiasis and malaria.