Publications List from the Past Ten Years

Abstracts available for recent papers

  • Shu, Q., Krezel, A.M., Cusumano, Z.T., Pinkner, J.S., Klein, R., Hultgren, S.J. and Frieden, C. (2016) Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation. Proc Natl Acad Sci USA 113, 7130-7135 [Abstract]


  • Mondal, T., Wang, H., DeKoster, G.T., Baban, B., Gross, M.L. and Frieden, C. (2016) ApoE: In vitro studies of a small molecule effector. Biochemistry 55 2613-2621. [Abstract]


  • Wang, H., Shu, Q., Remple, D.L., Frieden, C. and Gross, M.L. (2015) Continuous and pulsed hydrogen-deuterium exchange and mass spectrometry characterize CsgE oligomerizaton Biochemistry 54, 6475-6481 [Abstract]


  • Frieden, C. (2015) ApoE: The role of conserved residues in defining function Protein Science 24, 138-144 [Abstract]


  • Hammes, G. and Frieden, C. (2014) "Robert A. Alberty". Biographical Memoirs Natl Acad Sci. On-line publication. [Article]


  • Garai, K., Verghese, P.B., Baban, B., Holtzman, D.M. and Frieden, C. (2014) The binding of apoE to oligomers and fibrils of amyloid-beta alters the kinetics of amyloid aggregation Biochemistry 53, 6323-6331 [Abstract]


  • Crick, S.L., Ruff, K.M., Garai, K., Frieden, C. and Pappu, R.V. (2013) Unmasking the roles of N- and C-terminal flanking sequences from Exon 1 of Huntingtin as modulators of polyglutamine aggregation PNAS 110, 20075-20080 [Abstract]


  • Frieden, C. and Garai, K. (2013) Concerning the structure of apoE. Protein Sci. 22, 1820-1825 [Abstract]


  • Verghese, P.B., Castellano, J.M., Garai, K., Wang, Y., Jiang, H., Shah, A, Bu, G., Frieden, C. and Holtzman, D.M. (2013) ApoE influences amyloid-Aβ (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. PNAS 110, E1807-1816 [Abstract]


  • Garai, K. and Frieden, C. (2013) Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetrmethylrhodamine-labeled Aβ. PNAS 110, 3321-3326 [Abstract]


  • Frieden, C. and Garai, K. (2012) Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease. PNAS 18, 8913-8919 [Abstract]


  • Shu, Q., Crick, S.L., Pinkner, J.S., Ford, B., Hultgren, S.J. and Frieden, C. (2012) The E. coli CsgB nucleator of curli assembles to beta-sheet oligomers that alter the CsgA fibrillization mechanism. PNAS 109, 6502-6507. [Abstract]


  • Huang, R.Y., Garai, K., Frieden, C. and Gross, M.L. (2011) Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization. Biochemistry 50, 9273-9282. [Abstract]


  • Gau, B.C., Garai, K., Frieden, C. and Gross, M.L. (2011) Mass spectrometry-based protein footprinting characterizes the structures of oligomeric apolipoprotein E2, E3 and E4. Biochemistry 50, 8117-8126. [Abstract]


  • Garai, K., Baban, B. and Frieden, C. (2011) The self-association and stability of the APOE isoforms at low pH: Implications for APOE-lipid interactions. J Mol Biol 50, 6356-6364. [Abstract]


  • Garai, K., Baban, B. and Frieden, C. (2011) Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity bidning to phospholipid vescicles. Biochemistry 50, 2550-2558. [Abstract]


  • Garai, K. and Frieden, C. (2010) The association-dissociation behavior fo the ApoE proteins: Kinetic and equilibrium Studies Biochemistry 49, 9533-9541. [Abstract]


  • Frieden, C. (2010) Sidney Frederick Velick Biogr Mem Natl Acad Sci National Academy of Sciences, Washington, D.C. [Chapter]

  • Niu, W., Shu, Q., Chen, Z., Mathews, S., Di Cera, E. and Frieden, C. (2010) The role of Zn(2+) on the structure and stability of murine adenosine deaminase J Phys Chem B 114, 16156-16165 [Abstract]


  • Baldwin, R.L., Frieden, C. and Rose, G.D. (2010) Dry molten globule intermediates and the mechanism of protein unfolding. Proteins 78, 2725-2737 [Abstract]


  • Mustafi, S.M., Garai, K., Crick, S.L., Baban, B. and Frieden, C. (2010) Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide. Biochem Biophys Res Commun, 397, 509-512 [Abstract]


  • Garai, K., Mustafi, S.M., Baban, B. and Frieden, C. Structural differences between apolipoprotein E3 and E4 as measured by (19)F NMR. Protein Sci. 19, 66-74. (2010). [Abstract]


  • Garai, K., Mustafi, S.M., Baban, B. and Frieden, C. (2009) Structural differences between apoli poprotein E3 and E4 as measured by (19)F- NMR Protein Sci, 106, 20324-20329 [Abstract]

  • Hu, X., Crick, S.L., Bu, G., Frieden, C., Pappu, R.V. and Lee, J.M. (2009) Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta paptide. PNAS, 106, 20324-20329 [Abstract]

  • Zhang, R., Hu, X., Khant, H., Ludtke, S.J., Chiu, W., Schmeid, M.F., Frieden, C. and Lee, J.M. (2009) Interprotofiliment interactions between Alzheimer's A{beta}1-42 peptides in amyloid fibrils revealed by cryoEM. PNAS, 103, 4653-4658.
  • Gerai, K., Crick, S.L., Mustafi, S.M. and Frieden, C. (2009) Expression and purification of amyloid-beta peptides from Escherichia coli Protein Expr Purif, 66, 107-112.
  • Frieden, C. (2008) A lifetime of kinetics J Biol Chem, 283, 19873-19878.

  • Frieden, C. (2007) Protein aggregation processes: In search of the mechanism. Protein Science, 16, 2334-2344.
  • Li, H. and Frieden, C. (2007) Observation of sequential steps in the folding of intestinal fatty acid binding protein using a slow folding mutant and 19F NMR. Proc Natl Acad Sci USA, 104, 11993-11998.
  • Li, H. and Frieden, C. (2007) Comparison of C40/82A and P27A C40/82A barstar mutants using 19F NMR Biochemistry, 46, 4337-4347.
  • Crick, S.L., Jayaraman, M., Frieden, C., Wetzel, R. and Pappu, R. (2006) Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions. Proc Natl Acad Sci USA 103, 16764-16769.
  • Li, H. and Frieden, C. (2006) Fluorine-19 NMR studies on the acid state of the intestinal fatty acid binding protein Biochemistry 45, 6272-6278.
  • Chattopadhyay, K. and Frieden, C. (2006) Steady-state and time-resolved fluorescence studies of the intestinal fatty acid binding protein. Proteins 63 327-335.