Gregory R. Bowman, Ph.D.

Assistant Professor

Biochemistry and Molecular Biophysics

Lab Website
Publications (PubMed / NIH)

Office: 2915 South Building
Phone: 314-362-7433
Email: g.bowman(at)wustl.edu
 

Research

We combine simulation and experiment to understand protein conformational changes, their role in signaling, and opportunities they present for drug design. For example, the movie shows the opening of an unexpected binding pocket that we have demonstrated may be a valuable drug target for combating antibiotic resistance. We are also interested in understanding the roles such conformational changes play in signaling cascades, such as those responsible for vision.

gb_animation

Publications

  • Hart K.M., Moeder K.E., Ho C.M.W., Zimmerman M.I., Frederick T.E., and Bowman G.R.
    Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators.
    PLoS One. 12(6):e0178678. doi: 10.1371/journal.pone.0178678. eCollection. (2017) (Abstract)

  • Sun X., Laroche G., Wang X., Ågren H., Bowman G.R., Giguère P.M., and Tu Y.
    Propagation of the Allosteric Modulation Induced by Sodium in the δ-Opioid Receptor.
    Chemistry 23(19):4615-4624 (2017) (Abstract)

  • Sukrit Singh and Gregory R. Bowman
    Quantifying allosteric communication via both concerted structural changes and conformational disorder with CARDS
    J. Chem. Theory Comput. (2017) (Abstract)

  • Chris A. Brosey, Chris Ho, Winnie Z. Long, Sukrit Singh, Kathryn Burnett, Greg L. Hura, Jay C. Nix, Gregory R. Bowman, Tom Ellenberger, and John A. Tainer
    Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor
    Structure. 24(12):2067-2079. (2016) (Abstract)

  • Shen G., Cui W., Zhang H., Zhou F., Huang W., Liu Q., Yang Y., Li S., Bowman G.R., Sadler J.E., Gross M.L., and Li W.
    Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer.
    Nat Struct Mol Biol. 24(1):69-76. (2017). (Abstract)
    Featured in News and Views, Nature Structural & Molecular Biology 24, 5–6. (2017)

  • Kathryn M. Hart, Chris M. W. Ho, Supratik Dutta, Michael L. Gross & Gregory R. Bowman
    Modelling proteins’ hidden conformations to predict antibiotic resistance
    Nature Communications 7, Article number: 12965 (2016) (Abstract)

  • Pascolutti, R., Sun, X., Kao, J., Maute, R., Ring, A.M., Bowman, G.R. and Kruse, A.C.
    Structure and Dynamics of PD-L1 and an Ultra High-Affinity PD-1 Receptor Mutant.
    Structure. Oct 4;24(10):1719-1728 (2016) (Abstract)

  • Bowman G.R.
    Accurately modeling nanosecond protein dynamics requires at least microseconds of simulation.
    J Comput Chem. 37(6):558-66. (2016) (Abstract)

  • Zimmerman, M.I. and Bowman, G.R.
    FAST Conformational Searches by Balancing Exploration/Exploitation Trade-Offs
    J. Chem. Theory Comput. 11:5747-5757 (2015). (Abstract)

  • Bowman, G.R.
    Accurately modeling nanosecond protein dynamics requires at least microseconds of simulation.
    J Comput Chem 37:558-566 (2016) (Abstract)