F. Scott Mathews, Ph.D.

Scott Mathews
Professor Emeritus

Biochemistry and Molecular Biophysics

Publications (PubMed / NIH)

Office: 2617 Cancer Research Building

Email: mathews22@wustl.edu



X-ray structure and analysis of macromolecules

Select Publications

Chen Z.W., Vignaud C., Jaafar A., Levy B., Gueritte F., Guenard D., Lederer F., and Mathews, F.S.
High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.
Biochimie. 94(5):1172-9. doi: 10.1016/j.biochi.2012.02.003. (2012). (Abstract)

Kommoju P.R., Chen Z.W., Bruckner R.C., Mathews F.S., and Jorns, M.S.
Probing oxygen activation sites in two flavoprotein oxidases using chloride as an oxygen surrogate.
Biochemistry. 50(24):5521-34. doi: 10.1021/bi200388g. (2011). (Abstract)

Li, J., Gan, J.H., Mathews, F.S. and Xia, Z.X.
The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase.
Biochem Biophys Res Commun 406:621-626 (2011). (Abstract)

Choi, M., Sukumar, N., Mathews, F.S., Liu, A. and Davidson, V.L.
Proline 96 of the copper ligand loop of amicyanin regulates electron transfer from methylamine dehydrogenase by positioning other residues at the protein-protein interface.
Biochemistry 50:1265-1273 (2011). (Abstract)

Niu, W., Shu, Q., Chen, Z., Mathews, F.S., Di Cera, E. and Frieden, C.
The role of Zn2+ on the structure and stability of murine adenosine deaminase.
J Phys Chem B 114:16156-16165 (2010). (Abstract)

Chen, Z., Datta, S., Dubois, J.L., Klinman, J.P. and Mathews, F.S.
Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.
Biochemistry 49:7393-7402 (2010). (Abstract)

Jorns, M.S., Chen, Z.W. and Mathews, F.S.
Structural characterization of mutations at the oxygen activation site in monomeric sarcosine oxidase.
Biochemistry 49:3631-3639 (2010). (Abstract)

Sukumar N., Mathews F.S., Langan P., and Davidson V.L.
A joint x-ray and neutron study on amicyanin reveals the role of protein dynamics in electron transfer.
Proc Natl Acad Sci U S A. 107(15):6817-22. (2010) (Abstract)

Sukumar, N., Mathews, F.S., Gordon, M.M., Ealik, S.E. and Alpers, D.H.
Postcrystallization Analysis of the Irreproducibility of the Human Intrinsic Factor-Cobalamin Complex Crystals.
Cryst Growth Des. 9(1):348-351. (2009). (Abstract)

Kommoju, P.R., Bruckner, R.C., Ferreira, P., Carrell, C.J., Mathews, F.S., and Jorns, M.S.
Factors that affect oxygen activation and coupling of the two redox cycles in the aromatization reaction catalyzed by NikD, an unusual amino acid oxidase.
Biochemistry. 48(40):9542-55. doi: 10.1021/bi901056a. (2009). (Abstract)