F. Scott Mathews, Ph.D.

Scott Mathews
Professor Emeritus

Biochemistry and Molecular Biophysics

Publications (PubMed / NIH)

Office: 2617 Cancer Research Building

Email: mathews22@wustl.edu

 

Research

X-ray structure and analysis of macromolecules

Publications

  • Chen, Z.W., Vignaud, C., Jaafar, A., Levy, B., Gueritte, F., Guenard, D., Lederer, F. and Mathews, F.S.
    High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.
    Biochimie 94:1172-1179 (2012). (Abstract)

  • Kommoju, P.R., Chen, Z.W., Bruckner, R.C., Mathews, F.S. and Jorns, M.S.
    Probing oxygen activation sites in two flavoprotein oxidases using chloride as an oxygen surrogate.
    Biochemistry 50:5521-5534 (2011). (Abstract)

  • Li, J., Gan, J.H., Mathews, F.S. and Xia, Z.X.
    The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase.
    Biochem Biophys Res Commun 406:621-626 (2011). (Abstract)

  • Choi, M., Sukumar, N., Mathews, F.S., Liu, A. and Davidson, V.L.
    Proline 96 of the copper ligand loop of amicyanin regulates electron transfer from methylamine dehydrogenase by positioning other residues at the protein-protein interface.
    Biochemistry 50:1265-1273 (2011). (Abstract)

  • Niu, W., Shu, Q., Chen, Z., Mathews, F.S., Di Cera, E. and Frieden, C.
    The role of Zn2+ on the structure and stability of murine adenosine deaminase.
    J Phys Chem B 114:16156-16165 (2010). (Abstract)

  • Chen, Z., Datta, S., Dubois, J.L., Klinman, J.P. and Mathews, F.S.
    Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.
    Biochemistry 49:7393-7402 (2010). (Abstract)

  • Jorns, M.S., Chen, Z.W. and Mathews, F.S.
    Structural characterization of mutations at the oxygen activation site in monomeric sarcosine oxidase.
    Biochemistry 49:3631-3639 (2010). (Abstract)

  • Sukumar N., Mathews F.S., Langan P., and Davidson V.L.
    A joint x-ray and neutron study on amicyanin reveals the role of protein dynamics in electron transfer.
    Proc Natl Acad Sci U S A. 107(15):6817-22. (2010) (Abstract)

  • Sukumar, N., Mathews, F.S., Gordon, M.M., Ealik, S.E. and Alpers, D.H.
    Postcrystallization Analysis of the Irreproducibility of the Human Intrinsic Factor-Cobalamin Complex Crystals.
    Cryst Growth Des. 9:348-351 (2009). (Abstract)

  • Kommoju, P.R., Bruckner, R.C., Ferreira, P., Carrell, C.J., Mathews, F.S., and Jorns, M.S.
    Factors that affect oxygen activation and coupling of the two redox cycles in the aromatization reaction catalyzed by NikD, an unusual amino acid oxidase.
    Biochemistry 48:9542-9555 (2009). (Abstract)