William A. Frazier, Ph.D.

Professor

Biochemistry and Molecular Biophysics

Lab Website
Graduate Programs (DBBS)
Publications (PubMed / NIH)

Office: 1914A South Building

Email: frazier@wustl.edu

 

Research

A Nobel Prize was awarded for the discovery of the physiological role of nitric oxide and NO was named the 1992 “Molecule of the Year” by Science magazine. The Frazier lab discovered that CD47 is a receptor for thrombospondin-1 and that TSP1 ligation of CD47 negates the beneficial effects of NO signaling thereby exacerbating all cardiovascular diseases. We are now studying the molecular details of the TSP1-CD47 binding interaction, the mechanism of CD47 inhibition of NO signaling and discovering new phenotypes of CD47-null mice.

Publications

  • Xia, Z., Banan, B., Xu, M., Jia, J., Manning, P.T., Hiebsch, R.R., Gunasekaran, M., Upadhya, G.A. Frazier, W.A., Mohanakumar, T., Liny, Y. and Chapman, W.C.
    Attenuation of Ischemia-Reperfusion Injury and Improvement of Survival in Recipients of Steatotic Rat Livers Using CD47 Monoclonal Antibody.
    Transplantation 100:1480-1489 (2016) (Abstract)

  • Xiao, Z., Banan, B., Xu, M., Jia, J., Manning, P.T., Hiebsch, R.R., Gunasekaran, M., Upadhya, G.A., Frazier, W.A., Mohanakumar, T., Lin, Y. and Chapman, W.C.
    Attenuation of Ischemia-Reperfusion Injury and Improvement of Survival in Recipients of Steatotic Rat Livers Using CD47 Monoclonal Antibody.
    Transplantation 100:1480-1489 (2016). (Abstract)

  • Liu, X., Pu, Y., Cron, K., Deng, L., Kline, J., Frazier, W.A., Xu, H., Peng, H., Fu, Y.X. and Xu, M.M.
    CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.
    Nat Med 21:1209-1215 (2015). (Abstract)

  • Liu, K.E. and Frazier, W.A.
    Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy.
    PLoS One 10:e0129667 (2015). (Abstract)

  • Xiao, Z.Y., Chung, H., Banan, B., Manning, P.T., Ott, K.C., Lin, S., Capoccia, B.J., Subramanian, V., Hiebsch, R.R., Upadhya, G., Mohanakumar, T., Frazier, W.A., Lin, Y. and Chapman, W.C.
    Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma.
    Cancer Lett. 360:302-309 (2015). (Abstract)

  • Amend, S.R., Uluckan, O., Hurchla, M., Leib, D., Novack, D.V., Silva, M., Frazier, W. and Weilbaecher, K.N.
    Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts.
    J Bone Miner Res. 30:106-115 (2015). (Abstract)

  • Xiao, Z.Y., Banan, B., Jia, J., Manning, P.T., Hiebsch, R.R., Gunasekaran, M., Upadhya, G., Frazier, W.A., Mohanakumar, T. and Chapman, W.C.
    CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model.
    Liver Transplantation 21:468-477 (2015). (Abstract)

  • Lin, Y., Manning, P.T., Jia, J., Gaut, J.P., Xiao, Z., Capoccia, B.J., Chen, C.C., Hiebsch, R.R., Upadhya, G., Mohanakumar, T., Frazier, W.A. and Chapman, W.C.
    CD47 blockade reduces ischemia-reperfusion injury and improves outcomes in a rat kidney transplant model.
    Transplantation 98:394-401 (2014). (Abstract)

  • Zheleznyak, A., Ikotun, O.F., Dimitry, J., Frazier, W.A. and Lapi, S.E.
    Imaging of CD47 expression in xenograft and allograft tumor models.
    Mol Imaging 12:525-534 (2013). (Abstract)

  • Azcutia, V., Routledge, M., Williams, M.R., Newton, G., Frazier, W.A., Manica, A., Croce, K.J., Parkos, C.A., Schmider, A.B., Turman, M.V., Soberman, R.J. and Luscinskas, F.W.
    CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.
    Mol Biol Cell 24:3358-3368 (2013). (Abstract)