Recent Publications


Publications by faculty, post-doctoral associates, students, and staff of Biochemistry and Molecular Biophysics.

More can be found in the Archives.


  • Mydock-McGrane L.K., Hannan T.J., and Janetka J.W.
    Rational Design Strategies for FimH Antagonists: New Drugs on the Horizon for Urinary Tract Infection and Crohn’s Disease.
    Expert Opin Drug Discov. (2017) (Abstract)

  • Wang H., Shu Q., Frieden C., and Gross M.L.
    Deamidation slows Curli Amyloid-Protein Aggregation.
    Biochemistry. (2017) (Abstract)

  • Benjamin Yaw Owusu, Robert Galemmo, James Janetka, and Lidija Klampfer
    Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment
    Cancers 2017, 9(4), 35 (2017) (Abstract)

  • Melissa M Budelier, Wayland WL Cheng, Lucie Bergdoll, Zi-Wei Chen, James W Janetka, Jeff Abramson, Kathiresan Krishnan, Laurel Mydock-McGrane, Douglas F Covey, Julian P Whitelegge, and Alex S Evers
    Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1
    Journal of Biological Chemistry (2017) (Abstract)

  • Sun X., Laroche G., Wang X., Ågren H., Bowman G.R., Giguère P.M., and Tu Y.
    Propagation of the Allosteric Modulation Induced by Sodium in the δ-Opioid Receptor.
    Chemistry 23(19):4615-4624 (2017) (Abstract)

  • Tianyang Liu, Anbang Dai, Yong Cao, Rui Zhang, Meng-Qiu Dong, and Hong-Wei Wang
    Structural insights of WHAMM’s interaction with microtubules by cryo-EM
    Journal of Molecular Biology (2017) (Abstract)

  • Sukrit Singh and Gregory R. Bowman
    Quantifying allosteric communication via both concerted structural changes and conformational disorder with CARDS
    J. Chem. Theory Comput. (2017) (Abstract)

  • Burgers P.M. and Kunkel T.A.
    Eukaryotic DNA Replication Fork.
    Annu Rev Biochem. (2017) (Abstract)

  • Ballante F., Reddy D.R., Zhou N.J., and Marshall G.R.
    Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy.
    Bioorg Med Chem. (2017) (Abstract)

  • Vasilios Kalas, Jerome S. Pinkner, Thomas J. Hannan, Michael E. Hibbing, Karen W. Dodson, Alex S. Holehouse, Hao Zhang, Niraj H. Tolia, Michael L. Gross, Rohit V. Pappu, James Janetka and Scott J. Hultgren
    Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions
    Science Advances Vol. 3, no. 2 (2017) (Abstract)

  • Galburt E.A. and Tomko E.J.
    Conformational selection and induced fit as a useful framework for molecular motor mechanisms.
    Biophys Chem. 223:11-16 (2017) (Abstract)

  • Chang Y.K., Srivastava Y., Hu C., Joyce A., Yang X., Zuo Z., Havranek J.J., Stormo G.D., and Jauch R.
    Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq.
    Nucleic Acids Res. (2017) (Abstract)

  • Santiago-Tirado F.H., Onken M.D., Cooper J.A., Klein R.S., and Doering T.L.
    Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.
    MBio. (2017) (Abstract)

  • Melissa M. Budelier, Wayland W. L. Cheng, Lucie Bergdoll, Zi-Wei Chen, Jeff Abramson, Kathiresan Krishnan, Mingxing Qian, Douglas F. Covey, James W. Janetka, and Alex S. Evers
    Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins
    Analytical Chem. (2017) (Abstract)

  • Istvan E.S., Mallari J.P., Corey V.C., Dharia N.V., Marshall G.R., Winzeler E.A., and Goldberg D.E.
    Esterase mutation is a mechanism of resistance to antimalarial compounds.
    Nat Commun. (2017) (Abstract)

  • Reddy D.R., Ballante F., Zhou N.J., and Marshall G.R.
    Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors.
    Eur J Med Chem. (2016) (Abstract)

  • Galburt E.A. and Rammohan J.
    A Kinetic Signature for Parallel Pathways: Conformational Selection and Induced Fit. Links and Disconnects between Observed Relaxation Rates and Fractional Equilibrium Flux under Pseudo-First-Order Conditions.
    Biochemistry. 7014-7022. (2016) (Abstract)

  • Hayatshahi H.S., Roe D.R., Galindo-Murillo R., Hall K.B., and Cheatham T.E.
    Computational Assessment of Potassium and Magnesium Ion Binding to a Buried Pocket in the GTPase-Associating Center RNA.
    J Phys Chem B. (2016) (Abstract)

  • Galburt E.A. and Rammohan J.
    A Kinetic Signature for Parallel Pathways: Conformational Selection and Induced Fit. Links and Disconnects between Observed Relaxation Rates and Fractional Equilibrium Flux under Pseudo-First-Order Conditions.
    Biochemistry. 20;55(50):7014-7022 (2016) (Abstract)

  • Garner A.L., Rammohan J., Huynh J.P., Onder L.M., Chen J., Bae B., Jensen D., Weiss L.A., Ruiz Manzano A., Darst S.A., Campbell E.A., Nickels B.E., Galburt E.A., and Stallings C.L.
    Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence.
    J Bacteriol. (2016) (Abstract)

  • Shen G., Cui W., Zhang H., Zhou F., Huang W., Liu Q., Yang Y., Li S., Bowman G.R., Sadler J.E., Gross M.L., and Li W.
    Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer.
    Nature Structural & Molecular Biology 24, 69–76 (2017). (Abstract)
    Featured in News and Views, Nature Structural & Molecular Biology 24, 5–6 (2017).

  • Kochenova O.V., Bezalel-Buch R., Tran P., Makarova A.V., Chabes A., Burgers P.M., and Shcherbakova P.V.
    Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.
    Nucleic Acids Res. (2016) (Abstract)

  • Greenberg M.J., Shuman H., and Ostap E.M.
    Measuring the Kinetic and Mechanical Properties of Non-processive Myosins Using Optical Tweezers.
    Methods Mol Biol. 1486:483-509. (2017)

  • Chris A. Brosey, Chris Ho, Winnie Z. Long, Sukrit Singh, Kathryn Burnett, Greg L. Hura, Jay C. Nix, Gregory R. Bowman, Tom Ellenberger, and John A. Tainer
    Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor
    Structure (2016) (Abstract)

  • Needham S.R., Roberts S.K., Arkhipov A., Mysore V.P., Tynan C.J., Zanetti-Domingues L.C., Kim E.T., Losasso V., Korovesis D., Hirsch M., Rolfe D.J., Clarke D.T., Winn M.D., Lajevardipour A., Clayton A.H., Pike L.J., Perani M., Parker P.J., Shan Y., Shaw D.E., and Martin-Fernandez M.L.
    EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
    Nat Commun. 7:13307 (2016) (Abstract)


More can be found in the Archives.