FOCUS on RESEARCH
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
On Friday, November 2nd, 2018, the Saint Louis Section of the American Chemical Society will hold an Award Symposium honoring Dr. Jim Janetka.
The afternoon will have several speakers, followed by a reception.
Make sure to send in your reservation by October 30th if you wish to attend!
On May 24, 2018, Mr. Darrell Baldwin received the Washington University School of Medicine 2018 Operations Staff Service Award.
The Operations Staff Service award is given to a staff member who has demonstrated outstanding leadership, exceptional performance in their position and superior service.
The department surprised Darrell with an award ceremony and celebration in the seminar room where Dr. David Perlmutter, Dean of the Medical School, said a few words and presented Darrell with his award.
On May 22nd, 2018, Ms. Melissa Budelier and Ms. Lucy Li were awarded the 2018 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Ms. Budelier presented her research entitled “Mapping Ligand Binding Sites in Integral Membrane Proteins”. Ms. Budelier was a graduate student in the Biochemistry, Biophysics and Structural Biology Program. Ms. Budelier was nominated by her thesis mentor Dr. Alex Evers. In Dr. Evers lab, Melissa’s work focused on developing chemical biology tools and mass spectrometric (MS) methods to sequence the transmembrane domains (TMDs) of integral membrane proteins (IMPs) and identified the sites at which sterol analogue photoaffinity labeling reagents modify these proteins. (more…)
More in the News Archive…
On Friday, October 19th, 2018, a symposium in remembrance of Dr. John Majors was held in Moore Auditorium on the medical campus of Washington University. Many colleagues, friends and family members from the university community, as well as from across the country, were in attendance. Drs. Peter Burgers, Mark Johnston, Charlie Rice, and Harold Varmus all gave heartfelt talks about John’s influence in biophysics as well as speaking about the different hobbies (i.e., backpacking and golf) and interests John had outside of the lab. It was great to hear about the many sides of John that were not widely known. By the end of the day, everyone had learned something new about John. (more…)
On Sunday, June 3rd the department held a faculty reception to congratulate Drs. Jim Janetka and Eric Galburt being awarded tenure in March, 2018.
The reception was held at the Moonrise Hotel in the Delmar Loop.
More in the Events Archive…
October 19th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a New Investigator Award in Alzheimer’s Disease from the American Federation for Aging Research (AFAR), Inc. for his work entitled “Identifying Neurotoxic Conformers in the Structural Ensemble of apoE”.
May 2nd, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a Knight ADRC Pilot Grant award from the Alzheimer’s Disease Research Center (ADRC) for his work entitled “Conformational analysis of ApoE and its role in AD mechanism”.
April 9th, 2018 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Targeting Hepatocyte Growth Factor with Protease Inhibitors in Lung Cancer”.
April 2nd, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a five-year grant award from the National Heart, Lung, and Blood Institute for his work entitled “Regulation of cardiac power output in health and disease”.
March 26th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a two year Extramural Award from the Ruth K. Broad Biomedical Research Foundation, Inc. for his work entitled “Structural plasticity of ApoE and its role in AD”.
Axelrod D., Elson E.L., Schlessinger J., & Koppel D.E. (2018). “Reminiscences on the “Classic” 1976 FRAP Article in Biophysical Journal.” Biophys J. 2018 Oct 2;115(7):1156-1159. doi: 10.1016/j.bpj.2018.08.037. Epub 2018 Sep 4. (Abstract)
Welty R., Pabit S.A., Katz A.M., Calvey G.D., Pollack L., & Hall K.B. (2018). “Divalent ions tune the kinetics of a bacterial GTPase Center rRNA folding transition from secondary to tertiary structure.” RNA. 2018 Sep 25. pii: rna.068361.118. doi: 10.1261/rna.068361.118. [Epub ahead of print] (Abstract)
Woody M.S., Greenberg M.J., Barua B., Winkelmann D.A., Goldman Y.E., & Ostap E.M. (2018). “Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke.” Nat Commun. 2018 Sep 21;9(1):3838. doi: 10.1038/s41467-018-06193-2. (Abstract)
Geronimo C.L., Singh S.P., Galletto R., & Zakian V.A. (2018). “The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity.” Nucleic Acids Res. 2018 Sep 19;46(16):8357-8370. doi: 10.1093/nar/gky655. (Abstract)
Rezaei-Ghaleh N., Parigi G., Soranno A., Holla A., Becker S., Schuler B., Luchinat C., & Zweckstetter M. (2018). “Local and Global Dynamics in Intrinsically Disordered Synuclein.” Angew Chem Int Ed Engl. 2018 Sep 5. doi: 10.1002/anie.201808172. [Epub ahead of print] (Abstract)