FOCUS on RESEARCH
Dr. Peter Burgers' Lab studies DNA replication and DNA damage response mechanisms in yeast, using a combination of biochemical, biophysical and genetic approaches.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Sarah Clippinger in Dr. Michael Greenberg's Lab is culturing human stem cell derived cardiomyocytes to model heart disease.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Anna Damato is a fifth-year PhD candidate in Neuroscience in the Department of Biology. Anna was nominated for this award by her thesis mentor, Dr. Erik Herzog, in whose lab she is connecting the bench to the bedside by investigating mechanisms of glioblastoma brain tumor circadian rhythms and how they impact the efficacy of chemotherapy. Anna uses real-time bioluminescence reporters of circadian gene expression to analyze the effects of timed treatment, with the goal of maximizing anti-tumor effects and minimizing side effects of chemotherapy in treating an otherwise dismal disease. In addition to cellular and molecular studies, Anna collaborates with physicians at the Siteman Cancer Center to assess benefits of timed chemotherapy in patients with brain cancer. (more…)
Congratulations to Dr. Jim Janetka who was named a Senior member of the National Academy of Inventors. Dr. Janetka was named among six researchers from Washington University in St. Louis.
Richard Axelbaum, PhD; David T. Curiel, MD, PhD; James W. Janetka, PhD; Gregory M. Lanza, MD, PhD; Robi D. Mitra, PhD; and Jennifer N. Silva, MD — are being recognized for their success in patents, licensing and commercialization, and for producing technologies that have the potential to have a significant impact on the welfare of society. (more…)
Jennette received her bachelor’s degree from Kenyon College in Gambier, Ohio. In 2016 she joined the Plant and Microbial Biosciences Program in the Division of Biology and Biomedical Sciences at Washington University. She is completing her thesis research in the laboratory of Dr. Elizabeth Haswell, where she works to elucidate mechanical signal transduction pathways in plants. Using a combination of proteomic and genetic screens in the model plant Arabidopsis thaliana, Jennette uncovered a novel connection between a plasma membrane mechanosensitive ion channel, MSL10, and proteins that tether the ER and the plasma membrane together. She has shown that MSL10 influences the morphology of ER-plasma membrane contact sites. (more…)
Ryan went to the University of Minnesota – Twin Cities for undergrad where he completed a double major in Plant Biology and Genetics, Cell Biology, & Development. Ryan joined the Plant and Microbial Biosciences program in the Division of Biology and Biomedical Sciences at Washington University in St. Louis in 2017. Ryan joined the lab of Dr. Lucia Strader for his thesis work. Upon the Strader Lab moving to Duke in 2020, Ryan became co-advised by Dr. Alex Holehouse. Ryan’s thesis work covered a wide-range of areas including plant hormone crosstalk, biomolecular condensates in plants, and the role of protein disorder in condensate formation. Ryan finished his Ph.D. in December 2021. (more…)
Drs. Jim Janetka and Makedonka Mitreva received two grants from the National Institutes of Health (NIH) totaling more than $5.5 million to develop new treatments for two types of devastating parasitic infections common in sub-Saharan Africa and Central and South America: river blindness and intestinal worm infections.
You can read the press release by clicking here (medicine.wustl.edu).
More in the News Archive…
On April 28th, 2021, the Department hosted a special session entitled “Evidence-based Practices that Support Mental and Emotional Well-being”. Mrs. Krista Jarvis, Clinical Case Manager and Program Manager in the Department of Psychiatry at Washington University, walks the group through five different evidence-based practices for our mental and emotional well-being. These practices are designed to help each individual feel empowered to utilize a variety of simple techniques for stress-reduction in these challenging times.
If you would like to view this, just click here.
On March 5th, 2021, Dr. Thi Nguyen presented on “Working Smarter – Strategic Planning & Time Management Basics”. To watch this presentation, please click here.
On January 22nd, 2021, the department hosted a Career Panel Discussion on how to apply for jobs in academia and industry. Panelist included: Dr. Erin Heckler, Director, Office of Postdoctoral Affairs; Dr. Alex Holehouse, Assistant Professor, Biochemistry and Molecular Biophysics; Dr. Ron Dolle, Chemistry Director, Center for Drug Discovery; Dr. Michael Kinch, Director, Center for Drug Discovery.
If you would like to view this panel discussion, please click here.
Tom Rapoport, PhD, from Harvard Medical School, presented the 2020 Carl and Gerty Cori Lecture on November 12, 2020, via Zoom.
Dr. Rapoport’s seminar was entitled “Mechanism of ER-Associated Protein Degradation (“ERAD”)”.
For more information on Dr. Tom Rapoport, please click here.
To see a recording of Dr. Rapoport’s lecture, please click here.
On June 12, 2020, Ms. Megan Cohan and Dr. Jonathan Lin were awarded the 2020 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Ms. Cohan presented her research entitled “Small but mighty! Intrinsically disordered domains as key regulators of bacterial processes” followed by Dr. Jonathan Lin who presented his research entitled “The Role of NAD+ in Retinal Neurodegeneration”. If you want to learn more about these fellows please click here.
More in the Events Archive…
April 22nd, 2022 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics along with Kathleen Hall, PhD, Professor of Biochemistry and Molecular Biophysics and Alex Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics have received a new five-year grant from National Institute of Allergy and Infectious Diseases for their research entitled “A multipronged investigation of SARS-CoV-2 genome packaging”
March 16th, 2022 – Alex Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics along with Dolf Weijer, PhD, Associate Professor in Laboratory of Biochemistry from Wageningen University and Research, and Hyun Lee, PhD, Assistant Professor of Biochemistry from University of Toronto, received a new three-year grant award from Human Frontier Science Program for their research entitled “Molecular determinants of evolutionary conservation in disordered protein regions”.
March 2nd, 2022 – Eric Galburt, PhD, Associate Professor in Biochemistry and Molecular Biophysics, received a new five-year MIRA grant award from National Institute of General Medical Sciences for his research entitled “Molecular Mechanisms of Transcription Initiation and DNA Repair”.
March 1st, 2022 – Jim Janetka, PhD, Professor in Biochemistry and Molecular Biophysics and David Sibley, Professor in Molecular Microbiology received a new five-year grant R01 award from the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH totaling 3.9 million dollars for their research entitled “Optimizing CDPK1 inhibitors for chronic toxoplasmosis”.
October 22nd, 2021 – Alex Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a one year renewal grant award from Longer Life Foundation for his research entitled “Predicting the functional impact of genetic variation within intrinsically disordered protein regions”.
Alexander G. Kozlov, Xian Cheng, Hongshan Zhang, Min Kyung Shinn, Elizabeth Weiland, Binh Nguyen, Irina A. Shkel, Emily Zytkiewicz, Ilya J. Finkelstein, M. Thomas Record Jr., & Timothy M. Lohman (2022). “How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein” J Mol Biol. 2022 Mar 26;434(9):167562. doi: 10.1016/j.jmb.2022.167562. Online ahead of print.
Jie Sun, Weikai Li, & Michael L. Gross (2022). “Advances in mass spectrometry-based footprinting of membrane proteins” Proteomics. 2022 Apr;22(8):e2100222. doi: 10.1002/pmic.202100222. (Abstract)
Upasana L. Mallimadugula & Eric A. Galburt (2022). “Parallel path mechanisms lead to nonmonotonic force-velocity curves and an optimum load for molecular motor function” Phys Rev E. 2022 Mar;105(3-1):034405. doi: 10.1103/PhysRevE.105.034405. (Abstract)
Shixuan Liu, Shuang Li, Andrzej M. Krezel, & Weikai Li (2022). “Stabilization and structure determination of integral membrane proteins by termini restraining” Nat Protoc. 2022 Jan 17. doi: 10.1038/s41596-021-00656-5. Online ahead of print. (Abstract)
Jie Sun, Xiaoran Roger Liu, Shuang Li, Peng He, Weikai Li, & Michael L. Gross (2021). “Nanoparticles and photochemistry for native-like transmembrane protein footprinting” Nat Commun. 2021 Dec 14;12(1):7270. doi: 10.1038/s41467-021-27588-8. (Abstract)