FOCUS on RESEARCH
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Carl Frieden's lab is working on protein folding, aggregation, intrinsically disordered proteins, fluorescence methods and fluorine NMR.
Dr. Peter Burgers' lab is working on the biochemistry and genetics of yeast DNA replication and repair.
Dr. John Cooper’s lab studies molecular mechanisms of cell motility and cytoskeleton assembly.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Kathleen Hall's lab is working on NMR and biochemical studies of RNA and RNA-protein complexes.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
- Jim Janetka’s work featured in The Source
Congratulations to Jim Janetka, whose work on UTI treatments was featured in The Source.
Dr. Janetka helped with a new study that may prevent the common problem of recurrent urinary tract infections with the use of a molecular decoy that targets e. coli bacteria.
You can read more about the work in the The Source by clicking HERE or on the picture of e. coli.
- Whitney Grither awarded 2017 DeGutis Prize in Chemical Biology/Medicinal Chemistry
On May 5th, 2017, Whitney Grither was awarded the 2017 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry. Whitney presented her research entitled: Selective Small Molecule Inhibition of Discoidin Domain Receptor 2. Whitney graduated this Spring from the Biochemistry graduate program. She finished her PhD work in the laboratory of Dr. Greg Longmore with the express purpose of identifying novel modes of inhibiting an underappreciated collagen receptor, DDR2, which they had just shown was critical for breast cancer metastasis in experimental mouse models and humans (Nature Cell Biology, 2013). (more...)
- Dr. Galletto Receives Tenure
Congratulations to Roberto Galletto, whose promotion with tenure was officially approved by the Board of Trustees on March 3, 2017.
More in the News Archive…
- Pedal the Cause – Happy Hour Fundraiser
Please join us for a Happy Hour at itap in the Central West End to raise money for cancer research! Sixty percent of sales of the designated beer will be donated (beer TBA). Feel free to stay around after Happy Hour for itap’s weekly trivia night too!
The event will be on Thursday, June 15th, from 4 PM to 7 PM.
More information and links can be found on HERE.
- 3rd Annual Chili Cook-off (2017)
- 2017 Carl and Gerty Cori Lecture
Dr. Taekjip Ha presented this year’s Carl and Gerty Cori Lecture on February 28, 2017 in Connor Auditorium, Farrell Learning and Teaching Center.
Dr. Taekjip Ha is a Bloomberg Distinguished Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University and an investigator of the Howard Hughes Medical Institute. (more...)
More in the Events Archive…
April 6th, 2017 – Roberto Galletto, PhD, Associate Professor of Biochemistry and Molecular Biophysics, received a four year grant award renewal from the National Institute of General Medical Sciences for his research entitled “Helicase Activity and its Role in Telomere and Telomerase Regulation”.
January 30th, 2017 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics and Chemistry Adjunct, along with Scott Hultgren, PhD, Helen L. Stoever Professor of Molecular Microbiology received and a four year grant award from the National Institute of Diabetes and Digestive and Kidney Diseases for his research entitled “Small Molecule Bacterial Lectin Antagonists for UTI Treatment and Prevention”.
December 19th, 2016 – Timothy M. Lohman, PhD, professor of biochemistry and molecular biophysics received a four year grant award from the National Institute of General Medical Sciences for his research entitled “Helicase Catalyzed DNA Unwinding”.
Kunkel T.A. and Burgers P.M.
Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication.
Bioessays. 39(8). (2017) (Abstract)
Albert B.J., Niu A., Ramani R., Marshall G.R., Wender P.A., Williams R.M., Ratner L., Barnes A.B., and Kyei G.B.
Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.
Sci Rep. 7(1):7456. (2017) (Abstract)
Kozlov A.G., Shinn M.K., Weiland E.A., and Lohman T.M.
Glutamate promotes SSB protein-protein Interactions via intrinsically disordered regions.
J Mol Biol. pii: S0022-2836(17)30371-6. (2017) (Abstract)
- Dr. Galletto Receives Tenure