FOCUS on RESEARCH
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Carl Frieden's lab is working on protein folding, aggregation, intrinsically disordered proteins, fluorescence methods and fluorine NMR.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Peter Burgers' lab is working on the biochemistry and genetics of yeast DNA replication and repair.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. John Cooper’s lab studies molecular mechanisms of cell motility and cytoskeleton assembly.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Kathleen Hall's lab is working on NMR and biochemical studies of RNA and RNA-protein complexes.
Congratulations to Jim Janetka, whose work on UTI treatments was featured in Proceedings of the National Academy of Sciences. (more…)
On Friday, October 19th, 2018, a symposium in remembrance of Dr. John Majors will be held. To view more information.
More in the News Archive…
The Single Molecule Workshop will be held at Saint Louis University, in the Education Union Auditorium, on Wednesday, December 6th, 2017.
5th Annual Workshop: Structural Dynamics of Biomolecules
10:00 am – 2:30 pm
Frontiers in Molecular Medicine and 34th Robert E. Olson Lecture
3:00 – 4:00 pm
Speakers include Enrico Di Cera, M.D., Colin Nichols, Ph.D., Frances Yap, Ph.D., Yann Chemla, Ph.D., Kathleen Hall, Ph.D., and Beniamino Barbieri, Ph.D.
More information and registration can be found on HERE (slu.edu).
The Annual BBSB retreat was held on October 20th and 21st, 2017 at the Cedar Creek. This year the keynote speakers were: Drs. Andrea Soranno and Rui Zhang, Assistant Professors in the Department of Biochemistry and Molecular Biophysics. Dr. Soranno presented on “Single-molecule fluorescence spectroscopy of intrinsically disordered proteins”. Dr. Zhang presented on “What can you do with cryo-EM”. Friday evening concluded with a poster session. In addition to the two keynote speakers, various students presented talks on their research during the day on Friday and Saturday. (more…)
More in the Events Archive…
February 27th, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a two year, Basil O’Connor Starter Scholar Research grant award from the March of Dimes for his work entitled “Understanding Congenital Heart Disease from the Ground Up”.
February 26th, 2018 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Jayne S. Weiss, MD, Professor and Chair, Department of Ophthalmology, LSU Health Sciences Center received a new two year, grant award from the National Eye Institute for his research entitled “Structural basis of Schnyder corneal dystrophy”.
January 26th, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, along with Kory Lavine, MD, PhD, Assistant Professor of Medicine, and Christopher M. Sturgeon, PhD, Assistant Professor of Medicine, received a 2018 Center of Regenerative Medicine (CRM) seed grant for their work entitled “Leveraging macrophage ontogeny to engineer human cardiac tissues to model cardiomyopathy”.
Kalas V., Hibbing M.E., Maddirala A.R., Chugani R., Pinkner J.S., Mydock-McGrane L.K., Conover M.S., Janetka J.W., & Hultgren S.J. (2018). “Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.” Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 201720140. doi: 10.1073/pnas.1720140115. (Abstract)
James W. Janetka & Roseann M. Benson (2018). “Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways” ISBN-13: 978-1119300182, ISBN-10: 1119300185 (Publisher)
Spaulding C.N., Klein R.D., Schreiber H.L. 4th, Janetka J.W., & Hultgren S.J. (2018). “Precision antimicrobial therapeutics: the path of least resistance?” NPJ Biofilms Microbiomes. 2018 Feb 27;4:4. doi: 10.1038/s41522-018-0048-3. eCollection 2018. (Abstract)