FOCUS on RESEARCH
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
This week, the Research Infrastructure Services (RIS) group – part of Washington University Information Technology – will begin piloting WashU ELN, an electronic lab notebook service powered by LabArchives. The LabArchives Electronic Lab Notebook is a cloud-based application that facilitates the creation, storage, sharing and management of research data. (more…)
Dr. Elliot Elson will be awarded the 2020 Ignacio Tinoco Award from the Biophysics Society. The award will be presented to Dr. Elson at the Annual Meeting of the Biophysical Society in San Diego, California on February 15-19, 2020.
Congratulations to Dr. Elson for being selected to receive this honor! (more…)
Melanie Ernst has been elected chair of the 2021 Mechanisms of Membrane Transport GRS.
The GRS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
More in the News Archive…
On September 20th, 2019, the department held a special seminar to recognize the recipient of the 2018 Elliot Elson Fellowship. Ms. Sarah Clippinger shared her research on “Assembly and Binding of E. coli RecOR Proteins to SSB C-terminal tails”. For more information on Sarah, please click here.
You can click here to view photos from the event.
On July 19th, 2019, the department held a special seminar to recognize the recipient of the 2019 MilliporeSigma Fellowship. Mr. Sukrit Singh shared his research on “Allostery in cellular signaling: Capturing biological switches in action”. For more information on Sukrit Singh, please click here.
You can click here to view photos from the event.
On June 7, 2019, Dr. Josh Rackers was awarded the 2019 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Dr. Rackers presented his research entitled “HIPPO: A physics-based model for biomolecular interactions”. Dr. Rackers was a graduate student in the Computational and Molecular Biophysics Program. Mr. Rackers was nominated by his thesis mentor Dr. Jay Ponder. In Dr. Ponder’s lab, Josh’s work focused on using the tools of applied quantum mechanics to predict the behavior and interactions of biological molecules. This work is motivated by a deeply held belief that physics holds the answers to many of biology’s most important problems. (more…)
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September 16th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Inhibitors of pro-HGF activation overcome resistance to anti-EGFR therapy”.
July 23rd, 2019 – Eric Galburt, PhD, Associate Professor, Department of Biochemistry and Molecular Biophysics, received a new four year grant award from the National Institute of General Medical Sciences for his research entitled “Kinetic regulation of mycobacterial transcription”.
June 14th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, received a two-year Siteman Investment Program (SIP) award from the Siteman Cancer Center and Foundation for Barnes Jewish-Hospital for his research entitled “The role of pericellular serine proteases in tumor progression and resistance to anticancer therapy”.
April 29th, 2019 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a new five year grant award from the National Institute on Aging for his research entitled “Conformational and functional analysis of Apolipoprotein E”.
January 31st, 2019 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Michael L. Gross, PhD, professor of chemistry, immunology, and medicine, received a new four year grant award from the National Institute of General Medical Sciences for their research entitled “New chemical probes enable Mass Spectrometry-based footprinting of human protein structure in lipid membranes and cells”.
Weisz D.A., Johnson V.M., Niedzwiedzki D.M., Shinn M.K., Liu H., Klitzke C.F., Gross M.L., Blankenship R.E., Lohman T.M., & Pakrasi H.B. (2019). “A novel chlorophyll protein complex in the repair cycle of photosystem II.” Proc Natl Acad Sci U S A. 2019 Oct 8. pii: 201909644. doi: 10.1073/pnas.1909644116. [Epub ahead of print] (Abstract)
Clippinger S.R., Cloonan P.E., Greenberg L., Ernst M., Stump W.T., & Greenberg M.J. (2019). “Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy” Proc Natl Acad Sci U S A. 2019 Aug 19. pii: 201910962. doi: 10.1073/pnas.1910962116. [Epub ahead of print] (Abstract)
Ordabayev Y.A., Nguyen B., Kozlov A.G., Jia H., & Lohman T.M. (2019). “UvrD helicase activation by MutL involves rotation of its 2B subdomain.” Proc Natl Acad Sci U S A. 2019 Jul 30. pii: 201905513. doi: 10.1073/pnas.1905513116. [Epub ahead of print] (Abstract)
Sparks M.A., Singh S.P, Burgers P.M., & Galletto R. (2019). “Complementary roles of Pif1 helicase and single stranded DNA binding proteins in stimulating DNA replication through G-quadruplexes.” Nucleic Acids Res. 2019 Jul 24. pii: gkz608. doi: 10.1093/nar/gkz608. [Epub ahead of print] (Abstract)
Shinn M.K., Kozlov A.G., Nguyen B., Bujalowski W.M., & Lohman T.M. (2019). “Are the intrinsically disordered linkers involved in SSB binding to accessory proteins?” Nucleic Acids Res. 2019 Jul 22. pii: gkz606. doi: 10.1093/nar/gkz606. [Epub ahead of print] (Abstract)