FOCUS on RESEARCH
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Linda Pike and Dr. Kathleen Hall have been selected as new fellows by the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society.
The AAAS selects fellows in recognition of their distinguished efforts to advance science and its applications, and has selected eleven faculty members at Washington University in St. Louis – the most in a decade-and-a-half. (more…)
On November 15th, the Distinguished Service Teaching Awards ceremony was to honor faculty that exhibited exemplary teaching skills from the 2017-2018 school year. The Class of 2021 awarded Dr. Linda Pike with Professor of the Year. Congratulations Dr. Pike!
Ms. Sarah Clippinger received her B.S. in Biochemistry from the Ohio State University in 2016. After graduation, Ms. Clippinger joined the Division of Biological and Biomedical Sciences at Washington University in St. Louis as part of the Biochemistry, Biophysics and Structural Biology program. (more…)
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The winner with the best Chili was the Robertson lab! The Lohman lab won best costume – they all “dressed up” as Dr. Lohman!
On Friday, October 19th, 2018, a symposium in remembrance of Dr. John Majors was held in Moore Auditorium on the medical campus of Washington University. Many colleagues, friends and family members from the university community, as well as from across the country, were in attendance. Drs. Peter Burgers, Mark Johnston, Charlie Rice, and Harold Varmus all gave heartfelt talks about John’s influence in biophysics as well as speaking about the different hobbies (i.e., backpacking and golf) and interests John had outside of the lab. It was great to hear about the many sides of John that were not widely known. By the end of the day, everyone had learned something new about John. (more…)
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January 17th, 2019 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a new three year Research Grant Award from the Alzheimer’s Association (AARG) for his work entitled “Conformational analysis of ApoE isoforms and their role in AD mechanism”.
January 9th, 2019 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics received a four year renewal from the National Heart, Lung, and Blood Institute for his research entitled “Structural and Functional Basis of the Vitamin K Cycle”.
December 27th, 2018 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Rui Zhang, PhD, assistant professor of biochemistry and molecular biophysics received a new three year, grant award from the W. M. Keck foundation for their research entitled “Terminal coupling enabled structure determination of human membrane proteins at atomic resolution”.
October 19th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a New Investigator Award in Alzheimer’s Disease from the American Federation for Aging Research (AFAR), Inc. for his work entitled “Identifying Neurotoxic Conformers in the Structural Ensemble of apoE”.
May 2nd, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a Knight ADRC Pilot Grant award from the Alzheimer’s Disease Research Center (ADRC) for his work entitled “Conformational analysis of ApoE and its role in AD mechanism”.
Knoverek C.R., Amarasinghe G.K., & Bowman G.R. (2018). “Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities.” Trends Biochem Sci. 2018 Dec 13. pii: S0968-0004(18)30248-2. doi: 10.1016/j.tibs.2018.11.007. [Epub ahead of print] (Abstract)
Maddirala A., Klein R.D., Pinkner J., Kalas V., Hultgren S.J., & Janetka J.W. (2018). “Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through iterative rational drug design.” J Med Chem. 2018 Dec 12. doi: 10.1021/acs.jmedchem.8b01561. [Epub ahead of print] (Abstract)
Dubiel K., Myers A.R., Kozlov A.G., Yang O., Zhang J., Ha T., Lohman T.M., & Keck J.L. (2018). “Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins.” J Mol Biol. 2018 Nov 22. pii: S0022-2836(18)31046-5. doi: 10.1016/j.jmb.2018.11.019. [Epub ahead of print] (Abstract)
Galburt E.A. (2018). “The calculation of transcript flux ratios reveals single regulatory mechanisms capable of activation and repression.” Proc Natl Acad Sci U S A. 2018 Nov 21. pii: 201809454. doi: 10.1073/pnas.1809454115. [Epub ahead of print] (Abstract)
Zimmerman M.I., Porter J.R., Sun X., Silva R.R., & Bowman G.R. (2018). “Choice of Adaptive Sampling Strategy Impacts State Discovery, Transition Probabilities, and the Apparent Mechanism of Conformational Changes.” J Chem Theory Comput. 2018 Nov 13;14(11):5459-5475. doi: 10.1021/acs.jctc.8b00500. Epub 2018 Oct 23. (Abstract)