FOCUS on RESEARCH
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Melanie Ernst has been elected chair of the 2021 Mechanisms of Membrane Transport GRS.
The GRS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
Congratulations to Maxwell Zimmerman for being awarded the Dr. Philip Needleman Pharmacology Prize.
The award is presented annually from the Department of Developmental Biology to a graduating student demonstrating outstanding achievements it the field of Pharmacology. Maxwell is a PhD student in the Computational and Molecular Biophysics Program – he is completing his thesis research in the lab of Dr. Gregory Bowman. (more…)
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On June 7, 2019, Dr. Josh Rackers was awarded the 2019 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Dr. Rackers presented his research entitled “HIPPO: A physics-based model for biomolecular interactions”. Dr. Rackers was a graduate student in the Computational and Molecular Biophysics Program. Mr. Rackers was nominated by his thesis mentor Dr. Jay Ponder. In Dr. Ponder’s lab, Josh’s work focused on using the tools of applied quantum mechanics to predict the behavior and interactions of biological molecules. This work is motivated by a deeply held belief that physics holds the answers to many of biology’s most important problems. (more…)
On February 22nd, 2019, the department held a special seminar to recognize the recipients of the 2017 Elliot Elson Fellowship. Ms. Min Kyung Shinn shared her research on “Assembly and Binding of E. coli RecOR Proteins to SSB C-terminal tails”. Mr. Drake Jensen shared his research on “Mechanisms of transcription represivation in Mycobacterium tuberculosis”. For more information on these two Elson fellows, please click here.
You can click here to view more photos from the event.
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June 14th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, received a two-year Siteman Investment Program (SIP) award from the Siteman Cancer Center and Foundation for Barnes Jewish-Hospital for his research entitled “The role of pericellular serine proteases in tumor progression and resistance to anticancer therapy”.
April 29th, 2019 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a new five year grant award from the National Institute on Aging for his research entitled “Conformational and functional analysis of Apolipoprotein E”.
January 31st, 2019 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Michael L. Gross, PhD, professor of chemistry, immunology, and medicine, received a new four year grant award from the National Institute of General Medical Sciences for their research entitled “New chemical probes enable Mass Spectrometry-based footprinting of human protein structure in lipid membranes and cells”.
January 23rd, 2019 – Justin Porter, a Computational & Systems Biology student in the Bowman laboratory, received a three year National Research Service Award from the National Heart, Lung, and Blood Institute for his research entitled “Physics-based precision medicine: computationally phenotyping myosin isoforms and cardiomyopathy mutations”.
January 17th, 2019 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a new three year Research Grant Award from the Alzheimer’s Association (AARG) for his work entitled “Conformational analysis of ApoE isoforms and their role in AD mechanism”.
Tyagi R., Elfawal M.A., Wildman S.A., Helander J., Bulman C.A., Sakanari J., Rosa B.A., Brindley P.J., Janetka J.W., Aroian R.V., & Mitreva M. (2019). “Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics.” Sci Rep. 2019 Jun 24;9(1):9085. doi: 10.1038/s41598-019-45548-7. (Abstract)
Dennis X. Zhu, Ashley L. Garner, Eric A. Galburt, & Christina L. Stallings (2019). “CarD contributes to diverse gene expression outcomes throughout the genome of Mycobacterium tuberculosis” PNAS. June 19, 2019 doi.org/10.1073/pnas.1900176116 (Abstract)
Nguyen B., Ciuba M.A., Kozlov A.G., Levitus M., & Lohman T.M. (2019). “Protein Environment and DNA Orientation Affect Protein-Induced Cy3 Fluorescence Enhancement.” Biophys J. 2019 Jun 7. pii: S0006-3495(19)30448-5. doi: 10.1016/j.bpj.2019.05.026. [Epub ahead of print] (Abstract)
Jensen D., Ruiz Manzano A., Rammohan J., Stallings C.L., & Galburt E.A. (2019). “CarD and RbpA modify the kinetics of initial transcription and slow promoter escape of the Mycobacterium tuberculosis RNA polymerase.” Nucleic Acids Res. 2019 May 25. pii: gkz449. doi: 10.1093/nar/gkz449. [Epub ahead of print] (Abstract)
Dyson H.J., Hall K.B., & Piston D.W. (2019). “Economics and Politics of Publishing in Our Mission-Driven Society.” Biophys J. 2019 May 21;116(10):E1-E2. doi: 10.1016/j.bpj.2019.04.019. Epub 2019 May 1. (Abstract)