FOCUS on RESEARCH

BMB NEWS

Congratulations to Paige Cloonan (pictured, on the left), an undergraduate researcher in Michael Greenberg’s lab, for winning the Undergraduate Poster Award Competition at the 2018 Biophysical Society Meeting.

Paige is currently in her fourth year, majoring in Biomedical Engineering. The winning poster was entitled “Mechanical and Structural Analysis of Cardiomyopathies at the Single Cell Level”.

Jim Janetka’s work featured in PNAS

Jim JanetkaCongratulations to Jim Janetka, whose work on UTI treatments was featured in Proceedings of the National Academy of Sciences.

Dr. Janetka helped with a new study that may prevent the common problem of recurrent urinary tract infections with the use of a molecular decoy that targets e. coli bacteria. (more…)

Eric Galburt and Jim Janetka Awarded Tenure
Congratulations to Eric Galburt and Jim Janetka! Both have been awarded tenure by the university!

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BMB EVENTS

2017 BMB Holiday Party

On December 16th, 2017, the BMB Department celebrated its annual Holiday Party at the Saint Louis Zoo. Everyone enjoyed the Zoo Wild Lights display, great food and a game of Rudolf the red-nose reindeer.

Click on the following to view more photos or a slideshow of the photos taken at the event.

Single Molecule Workshop: Structural Dynamics of Biomolecules and 34th Robert E. Olson Lecture

The Single Molecule Workshop will be held at Saint Louis University, in the Education Union Auditorium, on Wednesday, December 6th, 2017.

5th Annual Workshop: Structural Dynamics of Biomolecules
10:00 am – 2:30 pm

Frontiers in Molecular Medicine and 34th Robert E. Olson Lecture
3:00 – 4:00 pm

Speakers include Enrico Di Cera, M.D., Colin Nichols, Ph.D., Frances Yap, Ph.D., Yann Chemla, Ph.D., Kathleen Hall, Ph.D., and Beniamino Barbieri, Ph.D.

More information and registration can be found on HERE (slu.edu).

24th Annual Biochemistry, Biophysics and Structural Biology (BBSB) Graduate Student Retreat

The Annual BBSB retreat was held on October 20th and 21st, 2017 at the Cedar Creek. This year the keynote speakers were: Drs. Andrea Soranno and Rui Zhang, Assistant Professors in the Department of Biochemistry and Molecular Biophysics. Dr. Soranno presented on “Single-molecule fluorescence spectroscopy of intrinsically disordered proteins”. Dr. Zhang presented on “What can you do with cryo-EM”. Friday evening concluded with a poster session. In addition to the two keynote speakers, various students presented talks on their research during the day on Friday and Saturday. (more…)

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Research Awards

April 9th, 2018 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Targeting Hepatocyte Growth Factor with Protease Inhibitors in Lung Cancer”.

April 2nd, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a five-year grant award from the National Heart, Lung, and Blood Institute for his work entitled “Regulation of cardiac power output in health and disease”.

March 26th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a two year Extramural Award from the Ruth K. Broad Biomedical Research Foundation, Inc. for his work entitled “Structural plasticity of ApoE and its role in AD”.

February 27th, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a two year, Basil O’Connor Starter Scholar Research grant award from the March of Dimes for his work entitled “Understanding Congenital Heart Disease from the Ground Up”.

February 26th, 2018 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Jayne S. Weiss, MD, Professor and Chair, Department of Ophthalmology, LSU Health Sciences Center received a new two year, grant award from the National Eye Institute for his research entitled “Structural basis of Schnyder corneal dystrophy”.

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Recent Publications

Lohman T.M. & Fazio N.T. (2018) “How Does a Helicase Unwind DNA? Insights from RecBCD Helicase.” Bioessays. 2018 Mar 30. doi: 10.1002/bies.201800009. [Epub ahead of print] (Abstract)

Antony E. & Lohman T.M. (2018) “Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexes.” Semin Cell Dev Biol. 2018 Mar 30. pii: S1084-9521(17)30432-9. doi: 10.1016/j.semcdb.2018.03.017. [Epub ahead of print] (Abstract)

Soranno A., Zosel F., & Hofmann H. (2018). “Internal friction in an intrinsically disordered protein-Comparing Rouse-like models with experiments.” J Chem Phys. 2018 Mar 28;148(12):123326. doi: 10.1063/1.5009286. (Abstract)

Kalas V., Hibbing M.E., Maddirala A.R., Chugani R., Pinkner J.S., Mydock-McGrane L.K., Conover M.S., Janetka J.W., & Hultgren S.J. (2018). “Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.” Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 201720140. doi: 10.1073/pnas.1720140115. (Abstract)

James W. Janetka & Roseann M. Benson (2018). “Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways” ISBN-13: 978-1119300182, ISBN-10: 1119300185 (Publisher)

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