FOCUS on RESEARCH

BMB NEWS

Congratulations to Darrell Baldwin!

On May 24, 2018, Mr. Darrell Baldwin received the Washington University School of Medicine 2018 Operations Staff Service Award.
The Operations Staff Service award is given to a staff member who has demonstrated outstanding leadership, exceptional performance in their position and superior service.
The department surprised Darrell with an award ceremony and celebration in the seminar room where Dr. David Perlmutter, Dean of the Medical School, said a few words and presented Darrell with his award.

Ms. Melissa Budelier and Ms. Lucy Li were awarded the 2018 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.

On May 22nd, 2018, Ms. Melissa Budelier and Ms. Lucy Li were awarded the 2018 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.

Ms. Budelier presented her research entitled “Mapping Ligand Binding Sites in Integral Membrane Proteins”. Ms. Budelier was a graduate student in the Biochemistry, Biophysics and Structural Biology Program. Ms. Budelier was nominated by her thesis mentor Dr. Alex Evers. In Dr. Evers lab, Melissa’s work focused on developing chemical biology tools and mass spectrometric (MS) methods to sequence the transmembrane domains (TMDs) of integral membrane proteins (IMPs) and identified the sites at which sterol analogue photoaffinity labeling reagents modify these proteins. (more…)

Dr. Frazier to Be Honored for Innovation and Entrepreneurship

Dr. William Frazier will receive the Chancellor’s Award for Innovation and Entrepreneurship. Chancellor Mark S. Wrighton will present Dr. Frazier and two others with awards during a ceremony October 5th, 2018 at The Ritz-Carlton Hotel in Clayton.

Dr. Frazier

“Professors Achilefu, Elgin and Frazier represent the very best of Washington University and join the distinguished company of previous winners who have worked creatively and diligently to discover and disseminate new knowledge that brings great benefit to society,” Wrighton said.

You can read more about this at The Source.

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BMB EVENTS

2018 – International Potluck

On April 20, 2018, the department hosted its very first international potluck. We have many people bring in their favorite home cooked dishes from all over the world. Everything was very delicious!

Click on the following to view more photos or a slideshow of the photos taken at the event.

2017 BMB Holiday Party

On December 16th, 2017, the BMB Department celebrated its annual Holiday Party at the Saint Louis Zoo. Everyone enjoyed the Zoo Wild Lights display, great food and a game of Rudolf the red-nose reindeer.

Click on the following to view more photos or a slideshow of the photos taken at the event.

Single Molecule Workshop: Structural Dynamics of Biomolecules and 34th Robert E. Olson Lecture

The Single Molecule Workshop will be held at Saint Louis University, in the Education Union Auditorium, on Wednesday, December 6th, 2017.

5th Annual Workshop: Structural Dynamics of Biomolecules
10:00 am – 2:30 pm

Frontiers in Molecular Medicine and 34th Robert E. Olson Lecture
3:00 – 4:00 pm

Speakers include Enrico Di Cera, M.D., Colin Nichols, Ph.D., Frances Yap, Ph.D., Yann Chemla, Ph.D., Kathleen Hall, Ph.D., and Beniamino Barbieri, Ph.D.

More information and registration can be found on HERE (slu.edu).

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Research Awards

May 2nd, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a Knight ADRC Pilot Grant award from the Alzheimer’s Disease Research Center (ADRC) for his work entitled “Conformational analysis of ApoE and its role in AD mechanism”.

April 9th, 2018 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Targeting Hepatocyte Growth Factor with Protease Inhibitors in Lung Cancer”.

April 2nd, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a five-year grant award from the National Heart, Lung, and Blood Institute for his work entitled “Regulation of cardiac power output in health and disease”.

March 26th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a two year Extramural Award from the Ruth K. Broad Biomedical Research Foundation, Inc. for his work entitled “Structural plasticity of ApoE and its role in AD”.

February 27th, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a two year, Basil O’Connor Starter Scholar Research grant award from the March of Dimes for his work entitled “Understanding Congenital Heart Disease from the Ground Up”.

More Research Awards

 

Recent Publications

Song J.G., King M.R., Zhang R., Kadzik R.S., Thawani A., & Petry S. (2018) “Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules.” J Cell Biol. 2018 Jul 2;217(7):2417-2428. doi: 10.1083/jcb.201711090. Epub 2018 Jun 6. (Abstract)

Weber G., DeKoster G.T., Holton N., Hall K.B., & Wahl M.C. (2018). “Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.” Nat Commun. 2018 Jun 7;9(1):2220. doi: 10.1038/s41467-018-04561-6. (Abstract)

Johnson B., McConnell P., Kozlov A.G., Mekel M., Lohman T.M., Gross M.L., Amarasinghe G.K., & Cooper J.A. (2018). “Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.” Cell Rep. 2018 May 29;23(9):2795-2804. doi: 10.1016/j.celrep.2018.04.096. (Abstract)

Tyagi R., Maddirala A.R., Elfawal M., Fischer C., Bulman C.A., Rosa B.A., Gao X., Chugani R., Zhou M., Helander J., Brindley P.J., Tseng C.C., Greig I.R., Sakanari J., Wildman S.A., Aroian R., Janetka J.W., & Mitreva M. (2018). “Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics.” ACS Infect Dis. 2018 May 14. doi: 10.1021/acsinfecdis.8b00090. (Abstract)

Kinch M.S. & Griesenauer R.H. (2018). “2017 in review: FDA approvals of new molecular entities.” Drug Discov Today. 2018 May 8. pii: S1359-6446(18)30088-6. doi: 10.1016/j.drudis.2018.05.011. (Abstract)

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