FOCUS on RESEARCH
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
November 4th, 2019 – Research by Dr. Carl Frieden appeared on the Alzforum site in the article “Can an ApoE Mutation Halt Alzheimer’s Disease?”
One of Dr. Frieden’s previous publications was also cited by the article.
Click here to view the article on the Alzform site.
To view Dr. Frieden’s publication mentioned in the article, you can click here to view it on the NIH site.
This week, the Research Infrastructure Services (RIS) group – part of Washington University Information Technology – will begin piloting WashU ELN, an electronic lab notebook service powered by LabArchives. The LabArchives Electronic Lab Notebook is a cloud-based application that facilitates the creation, storage, sharing and management of research data. (more…)
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On September 20th, 2019, the department held a special seminar to recognize the recipient of the 2018 Elliot Elson Fellowship. Ms. Sarah Clippinger shared her research on “Assembly and Binding of E. coli RecOR Proteins to SSB C-terminal tails”. For more information on Sarah, please click here.
You can click here to view photos from the event.
On July 19th, 2019, the department held a special seminar to recognize the recipient of the 2019 MilliporeSigma Fellowship. Mr. Sukrit Singh shared his research on “Allostery in cellular signaling: Capturing biological switches in action”. For more information on Sukrit Singh, please click here.
You can click here to view photos from the event.
On June 7, 2019, Dr. Josh Rackers was awarded the 2019 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Dr. Rackers presented his research entitled “HIPPO: A physics-based model for biomolecular interactions”. Dr. Rackers was a graduate student in the Computational and Molecular Biophysics Program. Mr. Rackers was nominated by his thesis mentor Dr. Jay Ponder. In Dr. Ponder’s lab, Josh’s work focused on using the tools of applied quantum mechanics to predict the behavior and interactions of biological molecules. This work is motivated by a deeply held belief that physics holds the answers to many of biology’s most important problems. (more…)
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September 16th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Inhibitors of pro-HGF activation overcome resistance to anti-EGFR therapy”.
August 1st, 2019 – Together with Kory Lavine and Kathleen Simpson, the Greenberg lab received a Large Scale Interdisciplinary Research Initiative Grant from the Children’s Discovery Institute. The project, “Redefining Pediatric Dilated Cardiomyopathy through Precision Medicine” brings together a team of basic scientists and physician scientists to better understand pediatric heart failure and to develop novel therapeutics.
July 23rd, 2019 – Eric Galburt, PhD, Associate Professor, Department of Biochemistry and Molecular Biophysics, received a new four year grant award from the National Institute of General Medical Sciences for his research entitled “Kinetic regulation of mycobacterial transcription”.
June 14th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, received a two-year Siteman Investment Program (SIP) award from the Siteman Cancer Center and Foundation for Barnes Jewish-Hospital for his research entitled “The role of pericellular serine proteases in tumor progression and resistance to anticancer therapy”.
April 29th, 2019 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a new five year grant award from the National Institute on Aging for his research entitled “Conformational and functional analysis of Apolipoprotein E”.
Yang B., Hird A.W., Bodnarchuk M.S., Zheng X., Dakin L., Su Q., Daly K., Godin R., Hattersley M.M., Brassil P., Redmond S., John Russell D., & Janetka J.W. (2020). “Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254).” Bioorg Med Chem. 2020 Jan 15;28(2):115227. doi: 10.1016/j.bmc.2019.115227. Epub 2019 Dec 11. (Abstract)
Greenberg Z.J., Monlish D.A., Bartnett R.L., Yang Y., Shen G., Li W., Bednarski J.J., & Schuettpelz L.G. (2020). “The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.” J Immunol. 2020 Jan 1;204(1):58-67. doi: 10.4049/jimmunol.1900539. Epub 2019 Nov 20. (Abstract)
Singh S.P., Soranno A., Sparks M.A., & Galletto R. (2019). “Branched unwinding mechanism of the Pif1 family of DNA helicases.” Proc Natl Acad Sci U S A. 2019 Nov 19. pii: 201915654. doi: 10.1073/pnas.1915654116. [Epub ahead of print] (Abstract)
Jordan E Ezekian, Sarah R Clippinger, Jackie Garcia, Susan W Denfield, Aamir Jeewa, William Dreyer, Wenxin Zou, Yuxin Fan, Hugh D Allen, Jeffrey Kim, Michael Greenberg, & Andrew P Landstrom (2019). “The Mutation R94C InTNNT2-encoded Troponin T Predisposes to Restrictive Cardiomyopathy and Pediatric Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction” American Heart Association, Inc. 11 Nov 2019, Circulation. 2019;140:A12139 (Abstract)
Yates L.A., Williams R.M., Hailemariam S., Ayala R., Burgers P., & Zhang X. (2019). “Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations.” Structure. 2019 Nov 4. pii: S0969-2126(19)30353-3. doi: 10.1016/j.str.2019.10.012. [Epub ahead of print] (Abstract)