FOCUS on RESEARCH
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. John Cooper’s lab studies molecular mechanisms of cell motility and cytoskeleton assembly.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. James Janetka's lab is working on medicinal chemistry, combinatorial and parallel synthesis and chemical biology.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Carl Frieden's lab is working on protein folding, aggregation, intrinsically disordered proteins, fluorescence methods and fluorine NMR.
Dr. Peter Burgers' lab is working on the biochemistry and genetics of yeast DNA replication and repair.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Dr. Kathleen Hall's lab is working on NMR and biochemical studies of RNA and RNA-protein complexes.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. William Frazier will receive the Chancellor’s Award for Innovation and Entrepreneurship. Chancellor Mark S. Wrighton will present Dr. Frazier and two others with awards during a ceremony October 5th, 2018 at The Ritz-Carlton Hotel in Clayton.
“Professors Achilefu, Elgin and Frazier represent the very best of Washington University and join the distinguished company of previous winners who have worked creatively and diligently to discover and disseminate new knowledge that brings great benefit to society,” Wrighton said.
You can read more about this at The Source.
Congratulations to Paige Cloonan (pictured, on the left), an undergraduate researcher in Michael Greenberg’s lab, for winning the Undergraduate Poster Award Competition at the 2018 Biophysical Society Meeting.
Paige is currently in her fourth year, majoring in Biomedical Engineering. The winning poster was entitled “Mechanical and Structural Analysis of Cardiomyopathies at the Single Cell Level”.
Congratulations to Jim Janetka, whose work on UTI treatments was featured in Proceedings of the National Academy of Sciences.
Dr. Janetka helped with a new study that may prevent the common problem of recurrent urinary tract infections with the use of a molecular decoy that targets e. coli bacteria. (more…)
More in the News Archive…
The Single Molecule Workshop will be held at Saint Louis University, in the Education Union Auditorium, on Wednesday, December 6th, 2017.
5th Annual Workshop: Structural Dynamics of Biomolecules
10:00 am – 2:30 pm
Frontiers in Molecular Medicine and 34th Robert E. Olson Lecture
3:00 – 4:00 pm
Speakers include Enrico Di Cera, M.D., Colin Nichols, Ph.D., Frances Yap, Ph.D., Yann Chemla, Ph.D., Kathleen Hall, Ph.D., and Beniamino Barbieri, Ph.D.
More information and registration can be found on HERE (slu.edu).
The Annual BBSB retreat was held on October 20th and 21st, 2017 at the Cedar Creek. This year the keynote speakers were: Drs. Andrea Soranno and Rui Zhang, Assistant Professors in the Department of Biochemistry and Molecular Biophysics. Dr. Soranno presented on “Single-molecule fluorescence spectroscopy of intrinsically disordered proteins”. Dr. Zhang presented on “What can you do with cryo-EM”. Friday evening concluded with a poster session. In addition to the two keynote speakers, various students presented talks on their research during the day on Friday and Saturday. (more…)
More in the Events Archive…
May 2nd, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a Knight ADRC Pilot Grant award from the Alzheimer’s Disease Research Center (ADRC) for his work entitled “Conformational analysis of ApoE and its role in AD mechanism”.
April 9th, 2018 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Targeting Hepatocyte Growth Factor with Protease Inhibitors in Lung Cancer”.
April 2nd, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a five-year grant award from the National Heart, Lung, and Blood Institute for his work entitled “Regulation of cardiac power output in health and disease”.
March 26th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a two year Extramural Award from the Ruth K. Broad Biomedical Research Foundation, Inc. for his work entitled “Structural plasticity of ApoE and its role in AD”.
February 27th, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a two year, Basil O’Connor Starter Scholar Research grant award from the March of Dimes for his work entitled “Understanding Congenital Heart Disease from the Ground Up”.
Prusa J., Jensen D., Santiago-Collazo G., Pope S.S., Garner A.L., Miller J.J., Ruiz Manzano A., Galburt E.A., & Stallings C.L. (2018). “Domains within RbpA serve specific functional roles that regulate the expression of distinct mycobacterial gene subsets.” J Bacteriol. 2018 Apr 23. pii: JB.00690-17. doi: 10.1128/JB.00690-17. (Abstract)
Rocha A.G., Franco A., Krezel A.M., Rumsey J.M., Alberti J.M., Knight W.C., Biris N., Zacharioudakis E., Janetka J.W., Baloh R.H., Kitsis R.N., Mochly-Rosen D., Townsend R.R., Gavathiotis E., & Dorn G.W. 2nd (2018). “MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.” Science. 2018 Apr 20;360(6386):336-341. doi: 10.1126/science.aao1785. (Abstract)
Bodmer N.K. & Havranek J.J. (2018). “Efficient minimization of multipole electrostatic potentials in torsion space.” PLoS One. 2018 Apr 11;13(4):e0195578. doi: 10.1371/journal.pone.0195578. eCollection 2018. (Abstract)
Lohman T.M. & Fazio N.T. (2018) “How Does a Helicase Unwind DNA? Insights from RecBCD Helicase.” Bioessays. 2018 Mar 30. doi: 10.1002/bies.201800009. [Epub ahead of print] (Abstract)
Antony E. & Lohman T.M. (2018) “Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexes.” Semin Cell Dev Biol. 2018 Mar 30. pii: S1084-9521(17)30432-9. doi: 10.1016/j.semcdb.2018.03.017. [Epub ahead of print] (Abstract)