FOCUS on RESEARCH
Dr. Roberto Galletto's lab is working on the roles of DNA helicases in maintaining telomere structure.
Dr. Weikai Li's lab is working on structural and biochemical studies of membrane proteins supporting blood coagulation.
Dr. Eric Galburt's lab focuses on mechanistic and single-molecule studies of transcription initiation in eukaryotes and pathogenic bacteria.
Dr. Michael Greenberg's lab focuses on generation and transduction of forces by molecular motors, with an emphasis on human disease.
Dr. Greg Bowman's lab combines computer simulation and biochemical experiments to understand the role of proteins' conformational heterogeneity in antibiotic resistance and vision.
Dr. Linda Pike's lab is working on mechanism of action of growth factors; polyphosphoinositide metabolism.
Dr. Timothy Lohman's lab is working on equilibria and kinetics of DNA-protein interactions; DNA motor proteins (helicases) and helix destabilizing proteins.
Folding@home’s fight against COVID-19 enlists big tech, gamers, pro soccer
When the crowdsourced supercomputing project Folding@home first announced a shift to coronavirus research and asked for new volunteers to run its software and expand its computing capacity, organizations and citizen scientists from all walks of life heeded the call. Now, about four months later, the number of volunteers has increased a hundredfold. To continue reading, click here.
Jonathan Lin completed his PhD thesis in the lab of Dr. Rajendra Apte in the Department of Ophthalmology and Visual Sciences. His research led to the discovery that NAD+ intermediate molecules can enhance the metabolism of the neurosensory retina and thus has therapeutic potential for preventing photoreceptor neurodegeneration. He graduated from Washington University in St. Louis this past May with an MD/PhD as a student in the Medical Scientist Training Program (MSTP). He will pursue postgraduate education in the Transitional Year Residency at MetroWest Medical Center followed by Ophthalmology Residency at Harvard Medical School/Mass. Eye and Ear Infirmary.
Ms. Cohan is a Ph.D. Candidate in Biomedical Engineering at the McKelvey School of Engineering. Ms. Cohan was nominated for this award by her thesis mentor, Dr. Rohit Pappu. In her thesis work, she utilizes a variety of computational and experimental techniques to understand how intrinsically disordered regions (IDRs) might impact the molecular functions of bacterial proteins.
More in the News Archive…
On June 12, 2020, Ms. Megan Cohan and Dr. Jonathan Lin were awarded the 2020 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.
Ms. Cohan presented her research entitled “Small but mighty! Intrinsically disordered domains as key regulators of bacterial processes” followed by Dr. Jonathan Lin who presented his research entitled “The Role of NAD+ in Retinal Neurodegeneration”. If you want to learn more about these fellows please click here.
On March 5th the Department held a half day retreat at the Eric P. Newman Center located on the WU Medical Campus. All of the labs in the department introduced their lab members and questions their lab is working on in their lab.
You can click here to view photos from the event.
On September 20th, 2019, the department held a special seminar to recognize the recipient of the 2018 Elliot Elson Fellowship. Ms. Sarah Clippinger shared her research on “Dissecting the Molecular and Cellular Mechanisms of Familial Cardiomyopathy”. For more information on Sarah, please click here.
You can click here to view photos from the event.
More in the Events Archive…
July 10th, 2020 – Rui Zhang, PhD, assistant professor of biochemistry and molecular biophysics received a new five year grant award from the National Institute of General Medical Sciences for his research entitled “Structural and functional studies of axonemal microtubule inner proteins (MIPs)”
April 24th, 2020 – Timothy M. Lohman, PhD, Marvin A. Brennecke Professor of Biophysics and professor of biochemistry and molecular biophysics received a new five year MIRA grant award from National Institute of General Medical Sciences for his research entitled “Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome Maintenance”.
January 17th, 2020 – Weikai Li, PhD, Associate Professor of Biochemistry and Molecular Biophysics, along with Laura Schuettpelz, MD, PhD, Associate Professor of Pediatrics, received an Interdisciplinary Research Initiatives grant award from the Children’s Discovery Institute for their work entitled “Regulation of normal and malignant B cells by the tetraspanin CD53”.
September 16th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Inhibitors of pro-HGF activation overcome resistance to anti-EGFR therapy”.
August 1st, 2019 – Together with Kory Lavine and Kathleen Simpson, the Greenberg lab received a Large Scale Interdisciplinary Research Initiative Grant from the Children’s Discovery Institute. The project, “Redefining Pediatric Dilated Cardiomyopathy through Precision Medicine” brings together a team of basic scientists and physician scientists to better understand pediatric heart failure and to develop novel therapeutics.
Rachel Bezalel-Buch, Young K. Cheun, Upasana Roy, Orlando D. Schärer, & Peter M. Burgers (2020). “Bypass of DNA interstrand crosslinks by a Rev1-DNA polymerase ζ complex” Nucleic Acids Res. 2020 Jul 7;gkaa580. doi: 10.1093/nar/gkaa580. Online ahead of print. (Abstract)
Maxwell I. Zimmerman, Justin R. Porter, Michael D. Ward, Sukrit Singh, Neha Vithani, Artur Meller, Upasana L. Mallimadugula, Catherine E. Kuhn, Jonathan H. Borowsky, Rafal P. Wiewiora, Matthew F. D. Hurley, Aoife M. Harbison, Carl A. Fogarty, Joseph E. Coffland, Elisa Fadda, Vincent A. Voelz, John D. Chodera, & Gregory R. Bowman (2020). “Citizen Scientists Create an Exascale Computer to Combat COVID-19” bioRxiv. 2020 Jun 28;2020.06.27.175430. doi: 10.1101/2020.06.27.175430. Preprint (Abstract)
Shuang Li, Shixuan Liu, Xiaoran Roger Liu, Mengru Mira Zhang, and Weikai Li. (2020). “Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy” Blood Adv. 2020 May 26; 4(10): 2202–2212. Published online 2020 May 20. doi: 10.1182/bloodadvances.2020001750 (Abstract)
Jason D Fernandes, Sarvenaz Sarabipour, Christopher T Smith, Natalie M Niemi, Nafisa M Jadavji, Ariangela J Kozik, Alex S Holehouse, Vikas Pejaver, Orsolya Symmons, Alexandre W Bisson Filho, & Amanda Haage (2020). “A survey-based analysis of the academic job market” Elife. 2020 Jun 12;9:e54097. doi: 10.7554/eLife.54097. Online ahead of print. (Abstract)
Justin R Porter, Artur Meller, Maxwell I Zimmerman, Michael J Greenberg, & Gregory R Bowman (2020). “Conformational Distributions of Isolated Myosin Motor Domains Encode Their Mechanochemical Properties” Elife. 2020 May 29;9:e55132. doi: 10.7554/eLife.55132. (Abstract)