Category Archives: Holehouse Publications
Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator
Meaghan S Jankowski, Daniel Griffith, Divya G Shastry, Jacqueline F Pelham, Garrett M Ginell, Joshua Thomas, Pankaj Karande, Alex S Holehouse & Jennifer M Hurley (2024). “Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian … Continue reading
Phase transition of GvpU regulates gas vesicle clustering in bacteria
Zongru Li, Qionghua Shen, Emery T Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai & George J Lu (2024). “Phase transition of GvpU regulates gas vesicle … Continue reading
Labile assembly of a tardigrade protein induces biostasis
S Sanchez-Martinez, K Nguyen, S Biswas, V Nicholson, A V Romanyuk, J Ramirez, S Kc, A Akter, C Childs, E K Meese, E T Usher, G M Ginell, F Yu, E Gollub, M Malferrari, F Francia, G Venturoli, E W … Continue reading
Direct prediction of intrinsically disordered protein conformational properties from sequence
Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker & Alex S Holehouse (2024). “Direct prediction of intrinsically disordered protein conformational properties from sequence” Nat Methods. 2024 Mar;21(3):465-476. doi: 10.1038/s41592-023-02159-5. Epub 2024 Jan 31. (Abstract)
Helicity of a tardigrade disordered protein contributes to its protective function during desiccation
Sourav Biswas, Edith Gollub, Feng Yu, Garrett Ginell, Alex Holehouse, Shahar Sukenik & Thomas C Boothby 1 (2024). “Helicity of a tardigrade disordered protein contributes to its protective function during desiccation” Protein Sci. 2024 Feb;33(2):e4872. doi: 10.1002/pro.4872. (Abstract)
Structural biases in disordered proteins are prevalent in the cell
David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse & Shahar Sukenik (2024). “Structural biases in disordered proteins are prevalent … Continue reading
The molecular basis for cellular function of intrinsically disordered protein regions
Alex S Holehouse & Birthe B Kragelund (2024). “The molecular basis for cellular function of intrinsically disordered protein regions” Nat Rev Mol Cell Biol. 2024 Mar;25(3):187-211. doi: 10.1038/s41580-023-00673-0. Epub 2023 Nov 13. (Abstract)
Dissecting the biophysics and biology of intrinsically disordered proteins
Priya R Banerjee, Alex S Holehouse, Richard Kriwacki, Paul Robustelli, Hao Jiang, Alexander I Sobolevsky, Jennifer M Hurley & Joshua T Mendell (2024). “Dissecting the biophysics and biology of intrinsically disordered proteins” Trends Biochem Sci. 2024 Feb;49(2):101-104. doi: 10.1016/j.tibs.2023.10.002. Epub … Continue reading
Intrinsically disordered regions are poised to act as sensors of cellular chemistry
David Moses, Garrett M Ginell, Alex S Holehouse & Shahar Sukenik (2023). “Intrinsically disordered regions are poised to act as sensors of cellular chemistry” Trends Biochem Sci. 2023 Dec;48(12):1019-1034. doi: 10.1016/j.tibs.2023.08.001. Epub 2023 Aug 31. (Abstract)
Using graphs and charts in scientific figures
Karol Buda, Katerina Cermakova, H Courtney Hodges, Eugenio F Fornasiero, Shahar Sukenik & Alex S Holehouse (2023). “Using graphs and charts in scientific figures” Trends Biochem Sci. 2023 Nov;48(11):913-916. doi: 10.1016/j.tibs.2023.08.011. (Abstract)