Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.

Chen Z., Datta S., Dubois J.L., Klinman J.P., & Mathews F.S. (2010). “Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.” Biochemistry. 2010 Aug 31;49(34):7393-402. doi: 10.1021/bi100643y. (Abstract)