Research Awards


September 30th, 2021 – Jim Janetka, PhD, Professor of Biochemistry and Molecular Biophysics, Makedonka Mitreva, Professor of Medicine and Genetics, and Sara Lustigman, Professor and Head, Laboratory of Molecular Parasitology Member, Lindsley F. Kimball Research Institute, New York Blood Center have received a new multi-PI R01 award from the National Institutes of Health, National Eye Institute entitled “Integrative approach for accelerating filarial worm drug discovery to treat river blindness”.

September 17th, 2021 – Roberto Galletto, PhD, Associate Professor in the department of biochemistry and molecular biophysics was awarded a new five year MIRA grant from the National Institute of General Medical Sciences for his research entitled “Functions of DNA helicases at hard-to-replicate sites and telomere regulation”.

September 15th, 2021 – Daniel Griffith, BS, Pre-Doc Trainee in the department of Biochemistry and Molecular Biophysics, and the laboratory of Alex Holehouse, PhD, received a new three-year Graduate Research Fellowship award from the National Science Foundation for his research entitled “Investigating the molecular grammar driving the assembly of membraneless-organelles”.

August 24th, 2021 – Benjamin Garcia, PhD, Raymond H. Wittcoff Distinguished Professor and Head of Biochemistry and Molecular Biophysics, along with Matthew D. Weitzman, PhD, Professor of Microbiology, Professor of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine and Children’s Hospital of Philadelphia, received a five year grant renewal from the National Institute of Allergy and Infectious Diseases for their research entitled “Viral modulation of epitranscriptomic mechanisms”.

August 23rd, 2021 – Jhullian Jamille Alston, BA, Pre-Doc Trainee in the department of Biochemistry and Molecular Biophysics, and the laboratories of Alex Holehouse, PhD and Andrea Soranno, PhD, received a Predoctoral to Postdoctoral Fellow Transition Award from the National Cancer Institute for his research entitled “Single Molecule Biophysics of Intrinsically Disordered Proteins in Disease”.

August 18th, 2021 – Alex Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, along with Shahar Sukenik, Assistant Professor, Department of Chemistry & Biochemistry at University of California, Merced, and Thomas Boothby, Assistant Professor, Department of Molecular Biology, University of Wyoming, received a new four year grant award from the National Science Foundation through the new “Integrative Research in Biology” mechanism for their research entitled “Collaborative Research: Functional Synergy Between Disordered Proteins and their Environment in Desiccation Protection”.

August 17th, 2021 – Matthew A Cruz, BS, Pre-Doc Trainee in the department of Biochemistry and Molecular Biophysics, and the laboratory of Gregory Bowman, PhD, received a new three-year fellowship award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases for his research entitled “Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments”.

August 17th, 2021 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, Carl Frieden, PhD, Professor of Biochemistry and Molecular Biophysics, and Rui Zhang, PhD, Assistant Professor of Biochemistry and Molecular Biophysics will collaborate in the Project named “ApoE isoform-specific structure: insights on biology and pathobiology”. The Project is part of the newly awarded five-year U19 Research Program from the National Institutes of Health, National Institute of Aging, entitled “Biology and pathobiology of apoE in aging and Alzheimer’s disease”, helmed by Dr. David Holtzman, Professor and Chair of the Department of Neurology at Washington University, in St Louis, and Dr. Guojun Bu, Professor of Medicine and Chair of the Department of Neuroscience, Mayo Clinic.

August 17th, 2021 – Greg Bowman, PhD, Associate Professor of Biochemistry and Molecular Biophysics, along with Guojun Bu, Professor of Medicine and chair of the Department of Neuroscience, Mayo Clinic, received a five-year U19 Research Program – Cooperative Agreement Award from the National Institutes of Health, National Institute on Aging, entitled “Biology and pathobiology of apoE in aging and Alzheimer’s disease”. Dr. Bowman is leader of the project’s biochemical & structural biology core.

August 16th, 2021 – Benjamin Garcia, PhD, Raymond H. Wittcoff Distinguished Professor and Head of Biochemistry and Molecular Biophysics, along with Philip A Cole, MD, PhD, Professor Biological Chemistry & Molecular Pharmacology at Harvard Medical School, received a new three year grant award from The National Science Foundation for their research entitled “Collaborative Research: MFB: Deciphering the Logic of PTM Crosstalk via Novel Chemical Technology: Histones and Beyond”.

August 2nd, 2021 – Janice L Robertson, PhD, assistant professor of biochemistry and molecular biophysics received a four year renewal from the National Institute of General Medical Sciences for her research entitled “Driving forces of membrane protein assembly in membranes”.

May 14th, 2021 – Peter M. Burgers, PhD, Marvin A. Brennecke Professor of Biological Chemistry, department of biochemistry and molecular biophysics was awarded a five-year MIRA grant renewal from the National Institute of General Medical Sciences for his research entitled “Mechanisms of DNA replication and maintenance in eukaryotes”.

April 15th, 2021 – Linda J. Pike, PhD, Professor of Biochemistry and Molecular Biophysics, along with Alexander S. Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, and Gary J. Patti, PhD, Professor of Chemistry and of Genetics and Medicine, received a new four year grant award from the National Institute of General Medical Sciences for their research entitled “Intrinsic Disorder and Agonist Bias in EGF Receptor Signaling”.

March 18th, 2021 – Jim Janetka, PhD, Professor of Biochemistry and Molecular Biophysics, Makedonka Mitreva, Professor of Medicine and Genetics, and Raffi Aroian, Professor of Molecular Medicine at the University of Massachusetts Medical School have received a new multi-PI R01 award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases entitled “Development of small molecule inhibitors of metabolic enzymes as broad-spectrum anthelmintic drugs”.

March 17th, 2021 – Jim Janetka, PhD, Professor of Biochemistry and Molecular Biophysics, along with Scott Hultgren, Helen L. Stoever Professor of Molecular Microbiology, Michael Caparon, Professor of Molecular Microbiology, Peng Yuan, Associate Professor of Cell Biology and Physiology, and Ali Ellebedy, Associate Professor of Pathology and Immunology received a five-year U19 Research Program–Cooperative Agreement Award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases entitled “Innovative Strategies to Combat Antibiotic-resistant Infections”. Dr. Janetka is leader of the project scientific core named “Rational Design and Synthesis of Small Molecule Inhibitors Targeting Unique Pathogenic Mechanisms in Gram- and Gram+ Bacteria Important in UTI”.

February 9th, 2021 – Natalie M. Niemi, PhD, Assistant Professor in the department of Biochemistry and Molecular Biophysics, received a one-year pilot and feasibility grant award from the Washington University Diabetes Research Center (DRC), sponsored by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for her research entitled “The role of the mitochondrial phosphatase Pptc7 in enabling metabolic flexibility”.

February 2nd, 2021 – Samantha Kirstin Barrick, PhD, Postdoctoral Scholar in the department of Biochemistry and Molecular Biophysics, and the laboratory of Dr. Michael J. Greenberg, PhD, received a new three year fellowship award from the National Institutes of Health, National Heart, Lung, and Blood Institute for her research entitled “Multiscale investigation of cardiomyopathy-associated mutations in metavinculin”.

January 22nd, 2021 – Weikai Li, PhD, Associate Professor of Biochemistry and Molecular Biophysics, along with Michael L. Gross, PhD, Professor of Chemistry, Immunology, and Medicine, and Michael J. Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a new three-year grant award from American Heart Association for their research entitled “Interdisciplinary structural studies of iron homeostasis in cardiovascular health”.

January 11th, 2021 – Alex Holehouse, Ph.D., Assistant Professor of Biochemistry and Molecular Biophysics, received a new one year grant award from Dewpoint Therapeutics for his research entitled “Bioinformatic tools for the analysis of phase separating proteins”.

December 15th, 2020 – Michael S Kinch, Ph.D., Associate Vice Chancellor, Director, Centers for Research Innovation in Biotechnology & Drug Discovery, and Professor of Biochemistry and Molecular Biophysics, received a new one-year grant award from Arnold Ventures for his research entitled “CDEK: Clinical Data Experience Knowledge-base”.

October 6th, 2020 – Alex Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a new one year grant award from Longer Life Foundation for his research entitled “Predicting the functional impact of genetic variation within intrinsically disordered protein regions”

August 21st, 2020 – Carl Frieden, PhD, Professor of Biochemistry and Molecular Biophysics, received a new one year grant award from BrightFocus Foundation for his research entitled “Understanding apoE”.

July 10th, 2020 – Rui Zhang, PhD, assistant professor of biochemistry and molecular biophysics received a new five year grant award from the National Institute of General Medical Sciences for his research entitled “Structural and functional studies of axonemal microtubule inner proteins (MIPs)”.

April 24th, 2020 – Timothy M. Lohman, PhD, Marvin A. Brennecke Professor of Biophysics and professor of biochemistry and molecular biophysics received a new five year MIRA grant award from National Institute of General Medical Sciences for his research entitled “Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome Maintenance”.

January 17th, 2020 – Weikai Li, PhD, Associate Professor of Biochemistry and Molecular Biophysics, along with Laura Schuettpelz, MD, PhD, Associate Professor of Pediatrics, received an Interdisciplinary Research Initiatives grant award from the Children’s Discovery Institute for their work entitled “Regulation of normal and malignant B cells by the tetraspanin CD53”.

September 16th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Inhibitors of pro-HGF activation overcome resistance to anti-EGFR therapy”.

August 1st, 2019 – Together with Kory Lavine and Kathleen Simpson, the Greenberg lab received a Large Scale Interdisciplinary Research Initiative Grant from the Children’s Discovery Institute. The project, “Redefining Pediatric Dilated Cardiomyopathy through Precision Medicine” brings together a team of basic scientists and physician scientists to better understand pediatric heart failure and to develop novel therapeutics.

July 23rd, 2019 – Eric Galburt, PhD, Associate Professor, Department of Biochemistry and Molecular Biophysics, received a new four year grant award from the National Institute of General Medical Sciences for his research entitled “Kinetic regulation of mycobacterial transcription”.

June 14th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, received a two-year Siteman Investment Program (SIP) award from the Siteman Cancer Center and Foundation for Barnes Jewish-Hospital for his research entitled “The role of pericellular serine proteases in tumor progression and resistance to anticancer therapy”.

April 29th, 2019 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a new five year grant award from the National Institute on Aging for his research entitled “Conformational and functional analysis of Apolipoprotein E”.

January 31st, 2019 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Michael L. Gross, PhD, professor of chemistry, immunology, and medicine, received a new four year grant award from the National Institute of General Medical Sciences for their research entitled “New chemical probes enable Mass Spectrometry-based footprinting of human protein structure in lipid membranes and cells”.

January 23rd, 2019 – Justin Porter, a Computational & Systems Biology student in the Bowman laboratory, received a three year National Research Service Award from the National Heart, Lung, and Blood Institute for his research entitled “Physics-based precision medicine: computationally phenotyping myosin isoforms and cardiomyopathy mutations”.

January 17th, 2019 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a new three year Research Grant Award from the Alzheimer’s Association (AARG) for his work entitled “Conformational analysis of ApoE isoforms and their role in AD mechanism”.

January 9th, 2019 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics received a four year renewal from the National Heart, Lung, and Blood Institute for his research entitled “Structural and Functional Basis of the Vitamin K Cycle”.

December 27th, 2018 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Rui Zhang, PhD, assistant professor of biochemistry and molecular biophysics received a new three year, grant award from the W. M. Keck foundation for their research entitled “Terminal coupling enabled structure determination of human membrane proteins at atomic resolution”.

October 19th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a New Investigator Award in Alzheimer’s Disease from the American Federation for Aging Research (AFAR), Inc. for his work entitled “Identifying Neurotoxic Conformers in the Structural Ensemble of apoE”.

May 2nd, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a Knight ADRC Pilot Grant award from the Alzheimer’s Disease Research Center (ADRC) for his work entitled “Conformational analysis of ApoE and its role in AD mechanism”.

April 9th, 2018 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Targeting Hepatocyte Growth Factor with Protease Inhibitors in Lung Cancer”.

April 2nd, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a five-year grant award from the National Heart, Lung, and Blood Institute for his work entitled “Regulation of cardiac power output in health and disease”.

March 26th, 2018 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a two year Extramural Award from the Ruth K. Broad Biomedical Research Foundation, Inc. for his work entitled “Structural plasticity of ApoE and its role in AD”.

February 27th, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, received a two year, Basil O’Connor Starter Scholar Research grant award from the March of Dimes for his work entitled “Understanding Congenital Heart Disease from the Ground Up”.

February 26th, 2018 – Weikai Li, PhD, assistant professor of biochemistry and molecular biophysics, along with Jayne S. Weiss, MD, Professor and Chair, Department of Ophthalmology, LSU Health Sciences Center received a new two year, grant award from the National Eye Institute for his research entitled “Structural basis of Schnyder corneal dystrophy”.

January 26th, 2018 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, along with Kory Lavine, MD, PhD, Assistant Professor of Medicine, and Christopher M. Sturgeon, PhD, Assistant Professor of Medicine, received a 2018 Center of Regenerative Medicine (CRM) seed grant for their work entitled “Leveraging macrophage ontogeny to engineer human cardiac tissues to model cardiomyopathy”.

December 20th, 2017 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a 2018 CIMED P&F award from the Center for the Investigation of Membrane Excitability Diseases for his work entitled “Effects of Mechanical Forces on Cardiac Excitability in Heart Disease”.

October 2nd, 2017 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics and Chemistry Adjunct received a two year, Career Catalyst Research (CCR) Competitive Renewal Grant Program award from Susan G. Komen for the Cure for his research entitled “Multifunctional inhibitors of MET/RON signaling and cross-talk with EGFR/HER2”. The work is focused on developing new drugs to treat breast cancer by dual targeting of the tumor and its microenvironment.

April 6th, 2017 – Roberto Galletto, PhD, Associate Professor of Biochemistry and Molecular Biophysics, received a four year grant award renewal from the National Institute of General Medical Sciences for his research entitled “Helicase Activity and its Role in Telomere and Telomerase Regulation”.

January 30th, 2017 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics and Chemistry Adjunct, along with Scott Hultgren, PhD, Helen L. Stoever Professor of Molecular Microbiology received and a four year grant award from the National Institute of Diabetes and Digestive and Kidney Diseases for his research entitled “Small Molecule Bacterial Lectin Antagonists for UTI Treatment and Prevention”.

December 19th, 2016 – Timothy M. Lohman, PhD, professor of biochemistry and molecular biophysics received a four year grant award from the National Institute of General Medical Sciences for his research entitled “Helicase Catalyzed DNA Unwinding”.

November 1st, 2016 – Dr. Gregory Bowman, Assistant Professor of Biochemistry and Molecular Biophysics received a two year subcontract from the National Institute of Allergy and Infectious Diseases. This project is a subcontract with Drs. Gaya Amarsinghe (Wash U) and Christopher Basler (Georgia State University) for his project entitled “Therapeutics Targeting Filoviral Interferon-Antagonist and Replication Functions”.

October 14th, 2016 – Dr. Gregory Bowman, Assistant Professor of Biochemistry and Molecular Biophysics, has been chosen to receive a 2016 Packard Fellowship for Science and Engineering in support of his research entitled “Energy-landscape engineering: exploiting proteins uncharted conformations”. (more…)

October 13th, 2016 – Michael Greenberg, PhD, assistant professor of biochemistry and molecular biophysics received received an award from the CDI hPSC Pilot Grant Program to develop models of familial cardiomyopathies using stem cells.

October 10th, 2016 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics has been awarded a CDI Micro-Grant from the Washington University Center for Cellular Imaging to use high-resolution imaging techniques to study familial cardiomyopathies in stem cell-derived cardiomyocytes.

September 27th, 2016 – Jim Janetka, PhD, Associate Professor, Department of Biochemistry and Molecular Biophysics, received a new two year grant award from the Alvin J. Siteman Cancer Research Fund for his research entitled “Inhibitors of growth factor activation as new adjunct chemotherapy for cancer”.

More information here: “Siteman fund grants $300,000 for unique approaches to fighting cancer

May 27th, 2016 – Gregory Bowman, PhD, assistant professor of biochemistry and molecular biophysics received a new five year grant award from the National Science Foundation for his research entitled “CAREER: FAST methods for protein folding and design”.

May 20th, 2016 – Gregory Bowman, PhD, assistant professor of biochemistry and molecular biophysics received a BWF Ad Hoc grant in support of a workshop entitled “The 2016 Workshop on Kinetics and Markov State Models (MSMs) in Drug Design” held on May 19-20 at the Novartis Institutes for Biomedical Research in Cambridge, Massachusetts.

April 27th, 2016 – Peter M. Burgers, PhD, Marvin A. Brennecke Professor of Biological Chemistry, department of biochemistry and molecular biophysics received a five year MIRA grant award from the National Institute of General Medical Sciences for his research entitles “Mechanisms of DNA Replication and Maintenance in Eukaryotes”.

April 20th, 2016 – John A Cooper, MD, PhD, Wittcoff Professor and Head of biochemistry and molecular biophysics received a new five year MIRA grant award from National Institute of General Medical Sciences for his research entitled “Actin Assembly and Cell Motility: Mechanisms and Regulation”.

March 27th, 2016 – Thomas Ellenberger, DVM, PhD, professor of biochemistry and molecular biophysics, along with Darin E. Jones, PhD, assistant professor of organic, pharmaceutical, and biochemistry at the University of Arkansas at Little Rock, received a new five year grant award from National Cancer Institute of the National Institutes of Health (NIH) for their research entitled “Pharmacological modulation of poly(ADP-ribose) metabolism”.

February 27th, 2016 – Michael Greenberg, PhD, assistant professor of biochemistry and molecular biophysics received received an award from the CDI hPSC Pilot Grant Program to develop models of familial cardiomyopathies using stem cells.

February 20th, 2016 – Timothy M. Lohman, PhD, Marvin A. Brennecke Professor of Biophysics, department of biochemistry and molecular biophysics received a four year grant award from the National Institute of General Medical Sciences for his research entitled “SSB Protein/DNA Interactions”.