A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity.

Lin, T., Greenberg, M.J., Moore, J.R. and Ostap, E.M.
A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity.
Biochemistry 50:1831-1838 (2011). (Abstract)