Isoform-selective lysine deacetylase inhibitors
Title: Isoform-selective lysine deacetylase inhibitors
Patent #: US20180230181
Kind: A1
Inventor(s): Garland R. Marshall, George B. Kyei, Michael D. Onken, Lee Ratner, Nandarapu Damodara Reddy
Abstract:
Isoform-selective lysine deacetylase inhibitors are described. Inhibitors of the lysine deacetylase enzyme are useful as antitumor drugs and for treating addiction, asthma, cardio-vascular disease, immunosuppression, neurodegenerative diseases, sepsis, sickle-cell disease, uveal melanoma and termination of viral latency, particularly HIV-1 latency.