forum for new data, new ideas and works in progress
2023
2023-09-08 – Emery Usher (Holehouse lab) – De-mystifying NIH pre-/post-doctoral
fellowships (F30/F31/F32)2023-11-10 – Mingzhou Zhou – Discovery of MP-4222: a potent small
molecule antagonist of gastrin-releasingpeptide receptor for the treatment of pruritus
— and why we discontinued this molecule2023-11-13 – Arlene Taich (Professionalism) – Understanding Transferable Skills
2023-09-29 – Ben Garcia – An unexpected journey and career in science
2023-10-06 – Chun-Kan Chen (Chen lab) – The Functional Role and
Applications of CircRNA Translation2023-09-22 – Aidan Flynn (Off Topic) – Summer at the Marine Biological Laboratory:
a retrospective2023-10-13 – Tessa Lochetto (Niemi lab) – Deciphering the role of mitochondrial
protein phosphorylation across models of cardiac function2023-10-20 – Tom Lin (Garcia lab) – Activity-based Arginylation Profiling
(ABAP) Opens New Frontiers in Biology and Drug Discovery2023-03-23 – Jennifer Hurley – Circadian Post-Transcriptional
Regulation: The Role of Intrinsic Protein Disorder2023-05-19 – Isaac Plutzer (Major lab) – Probabilistic Scoring of
Protein-Protein Proximity Data Illuminates the Function of Dark Kinases2023-03-31 – Kyle LaPak (Major lab) – Proximal proteomics of NRF2
reveals ZNF746/PARIS as a novel regulator of NRF2 signaling2023-03-24 – Mike Marcinkowski – Grant Proposal Writing Tips
2023-02-24 – Tom Lin (Garcia lab) – The first unbiased
proteomics method for arginylation site discovery2023-02-24 – Joanna Lempiainen (Garcia lab) – Characterizing the role of
SUZ12 and EED in the epigenetic reprogramming of MPNST2023-02-10 – Amy Heath-Carpentier – CVs and Resumes: Tailoring Materials
for your Search2023-03-03 – Kai Loell (Cohen lab) – Transcription factor interactions
explain the context-dependent activity of CRX binding sites2023-03-03 – Ryan Friedman (Cohen lab) – Rational mutagenesis and deep learning
reveals differences between “evil twin” cis-regulatory sequences2023-05-19 – Anoop Kooner (Janetka lab) – Optimizing Calcium Dependent
Protein Kinase 1 Inhibitors for the Treatment of Toxoplasmosis2023-05-19 – Victoria Banas (Janetka lab) – New Therapeutics for
Parasitic Nematode Infections2023-04-07 – Rofaida Gaballa (Li lab) – CD53 promotes B lymphocyte migration
via microtubule stabilization regulated by stathmin/PP2A2023-04-07 – Jin Ye (Li lab) – Molecular mechanism of substrate and
inhibitorrecognition by human vesicular monoaminetransporter2023-04-12 – Lianjie (Jerry) Wei (Niemi lab) – The role of mitochondrial
phosphatase PPTC7 on regulation of receptor-mediated mitophagy2023-05-12 – Tessa Lochetto (Niemi lab) – The underappreciated
role of phosphorylation influencing myoblast differentiation2023-04-28 – James McCarter, Celine St. Pierre, Alyssa Labonte (50th Anniversary) – YOUNG
SCIENTIST PROGRAM: PAST, PRESENT, FUTURE2023-04-14 – Kornelia Skowron (Heemstra lab) – Stimuli-responsive peptide
nucleic acids (PNAs): a novel bilingual assembly system2023-04-14 – Eleonora Grandi (Heemstra lab) – Repurposing and enhancing
Endonuclease V as a tool for studying and tracking A-to-I RNA editing2023-01-27 – Aiden Flynn (Holehouse lab) – Methods for Optimizing
Disordered Protein Biochemistry2023-01-27 – Emery Usher (Holehouse lab) – Control of disordered
protein function through phosphorylation2023-05-05 – Erin Stampp, Jeramia Ory – Growing Inclusion By Expanding
Our Understanding of Ability2023-06-30 – Lianjie (Jerry) Wei (Niemi lab) – A brief history of π: an intertwined
chronicle of mathematical discoveries and major world events2023-06-16 – Nikita Gupta (Rotation Talk) – Temperature
Dependence of Polyampholyte Dimensions2023-06-16 – Krill Miachin (Rotation Talk) – Identifying drivers
of oncogenesis in Malignant Peripheral Nerve Sheath tumor2023-06-16 – Madison Stringer (Rotation Talk) – The Impact of
Crowding on the Conformations and Interactions of a Disordered Tail2023-06-09 – Ramiz Somjee (Rotation Talk) – PMA1’s intrinsically
disordered region as a putative pH sensor2023-06-09 – Emily Harrelson (Rotation Talk) – L-AHA Labeling in
Pptc7 Knockout Cells2023-07-21 – Eric Tomko (Seed Grant) – Cov2 N-protein mediated
compaction of Cov2 sub- genomic RNA sequences2023-07-21 – Greg DeKoster (Seed Grant) – Alternative Approaches to
Protein Labeling with Protein Ligation2023-07-18 – Alex Holehouse PI Career Story
2023-07-14 – Benjamin Garcia – PI Career Story
2023-08-11 – Drake Jensen (Seed Grant) – Mechanisms of sigma-factor-dependent
transcriptional control in Mycobacterium tuberculosis2023-08-11 – Andrzel Krezel (Seed Grant) – Essential enzyme for biotin synthesis
in Helicobacter pylor2023-08-11 – Melissa Brereton (Seed Grant) – Single-molecule investigation of
isoform- specific ApoE interaction with ABCA12023-08-04 – Jacqueline Pelham (Cori Fellow) – Deciphering the contributions
of protein disorder to the core circadian clock2023-08-04 – Samaneh Ghassabi Kondalaji (Cori Fellow) – Neuroepigenetics of
developmental and mental disorders: Rahman Syndrome and a forgotten histone
2022
2022-10-18 – Danfeng Cai – Uncovering the roles of biomolecular
condensates in homeostasis and in cancer2022-10-07 – Amy Heath‐Carpentier – Developing your Networking Style
and Strategy2022-09-23 – Roland Dolle, Maxene Ilagan – An Introduction to the Center for Drug
Discovery: What’s in it for you?2022-09-30 – Lisa Moscoso – Safe Training
2022-11-04 – Sheila Stewart, Qihao Ren, Jennnifer Ye – Cancer: getting
old stinks!”2022-10-21 – Kaining Zhang (Tavoni lab) – Identifying optimal
strategies for memory retrieval2022-10-21 – Masha Khoshkhou (Tavoni lab) – A data-driven dynamic
model conomic decision making2022-09-16 – Yuna Ayala (Alumni) – Walking the tight rope: RNA binding proteins
in neurodegeneration2022-12-02 – Jeramia Ory – A straightforward theory that can be difficult
in practice2022-12-09 – Sayan Roy Chow dhury (Burgers lab) – Structure/function of Mec1ATR checkpoint kinase
2022-12-16 – DeHaven McCrary (Jansen lab) – Understanding the role of
Coronin-7 in actin-driven cellular processes2022-12-16 – Samantha Chin (Jansen lab) – Regulation of the actin
cytoskeleton by Coronins and Plastins2022-09-09 – Jonathan Tai (Pagliarini lab) – Hem25p is a
mitochondrial isoprene transporter2022-09-09 – Abigail Bartlett (Pagliarini lab) – Discovery of novel
enzymatic functions in hydroxylated lipid catabolism2022-09-09 – Dave Pagliarini (Pagliarini lab) – Mitochondrial
Proteins, Pathways, and Pathogenesis2022-11-18 – Matthew King (Pappu lab) – Uncovering molecular grammars
of intrinsically disordered regions that organize nucleolar fibrillar centers2022-11-18 – Mina Farag (Pappu lab) – Interfacial organization of
simulated biomolecular condensates2022-04-22 – Jerry Wei (Niemi lab) – Mitochondrial Mysteries: PPTC7 & The Disappearing
Mito-Proteome – Suspect 2: Excessive Mitophagy and BNIP32022-04-22 – Emily Hunter (Niemi lab) – Mitochondrial Mysteries: PPTC7 & The Disappearing
Mito-Proteome – Suspect 1: Biogenesis Defects2022-05-13 – Jasmine Cubuk (Soranno lab) – Single-molecule spectroscopy of the
SARS-CoV-2 Nucleocapsid protein2022-05-13 – Melissa D. Stuchell-Brereton (Soranno lab) – Apolipoprotein E4 has extensive
conformational heterogeneity in lipid free and lipid bound forms2022-03-03 – Alex Holehouse – How to Give a Good Talk
2022-01-21 – Ryan Emenecker (Holehouse lab) – DRs can determine promoter selection
and occupancy in vivo2022-01-21 – Alex Holehouse (Holehouse lab) – New tools for analyzing large protein
datasets2022-02-11 – Tugba Ozturk (Robertson lab) – The role of the membrane in driving
CLC-ec1 dimerization2022-02-11 – Melanie Ernst (Robertson lab) – Sodium binding is not required for
fluoride channel Fluc dimerization but stabilizes the active state2022-06-24 – Rick Searfoss – Method Optimization of Histone
Propionylation for LCMS Identification2022-06-24 – Youmian Yan – C2C12 Differentiation as a
Model System to Study Mitochondrial Biogenesis2022-06-24 – Hannah Pletcher – Establishing a system
to study individual protein turnover in the mitochondria2022-05-06 – Karen O’Malley (Ombudsman Representative) – Cutting edge science requires workplace
norms to combat stress and burnout2022-05-27 – Jingying Zhang, Jonathan Mount (Yuan lab) – Structural Basis of Mechanotransduction
in Ion Channels2022-04-08 – Michelle DeLair – Career Action Planning: Mapping the
Next Steps of your Job Search2022-04-01 – Miranda Wallace (Dantas lab) – Engineered probiotics as carriers of
next-generation immune checkpoint inhibitor therapies2022-04-01 – Kevin Blake (Dantas lab) – Sequence-structure-function
relationships of tetracycline-inactivating enzymes2022-04-15 – Jianwei Zeng (Zhang lab) – Cryo-EM studies of ciliary complexes
from different organisms2022-04-15 – Rui Zhang (Zhang lab) – Cryo-EM structures of natively decorated
ciliary doublet microtubule and associated complexes from Chlamydomonas2022-02-04 – Michael Ward (Bowman lab) – Predicting protein cryptic pockets using
graph neural networks2022-02-04 – Justin Miller (Bowman lab) – A quantitative model of structure and
disorder in monomeric ApoE4 from single molecule experiments and simulationss2022-03-11 – Drake Jensen (Galburt lab) – Quasi-high-throughput in vitro
measurements of steady-state transcript flux2022-03-11 – Ankita Chadda (Galburt lab) – A redox-sensitive DNA repair helicase is
activated by multiple mechanisms2022-03-25 – Ankit Garg (Greenberg lab) – Defining the mechanism of dilated
cardiomyopathy due to a mutation in skeletal muscle actin2022-03-25 – Samantha Barrick (Greenberg lab) – Characterization of human and python
myosin MYH7b2022-04-29 – Jianwei Zeng (Henderson lab) – Identification of Mutasynthetic
Inhibitors of Yersiniabactin Production in Uropathogenic E. coli2022-04-29 – Lindsey Steinberg (Henderson lab) – Human metabolites increase the
antibacterial potency and spectrum of mammalian siderocalin2022-01-14 – Libby Porter (Garcia lab) – The Role of Histone H3.3 in Novel
Neurodevelopmental Disorder2022-01-14 – Mariel Mendoza (Garcia lab) – Enzymatic transfer of acetate on histones
from lysine reservoir sites to lysine activating sites2022-09-05- Robyn Mahoney-Kruszka (Robertson lab) – Conservation and Reintroduction of the
American Burying Beetle2022-09-19 – Young Ah Goo (Mass Spec Center) – Mass Spectrometry Technology Access
Center2022-09-26 – Sarah Schulte, Ryan Emenecker, Katherine Basore (Alumni) – Recently graduated, where are you now and
how did you get there?2022-07-09 – Tugba Ozturk (Off Topic Talk) – Things you wanted to know but were
afraid to ask
2021
2021-04-16 – Mike Onken (Cooper lab) – Inhibition of constitutively active
Gq/11 in cancer cells2021-01-22 – Erin Heckler, Alex Holehouse, Ron Dolle, Michael Kinch – Career Panel Discussion:
How to apply for jobs in Academia and Industry2021-05-21 – Roseane R. Silva (Ponder lab) – Development of the HIPPO
force field2021-04-09 – Victoria Ismail (Kast Lab) – The GTPase activity of DFCP1
regulates lipid droplet metabolism.2021-05-07 – Aidan Cole (Amarasinghe Lab) – Multivalent Engineered Antibodies
Against Viral and Host Targets2021-04-30 – Jonathan Mount (Yuan lab) – Structural Insights into an
Uncharacterized Bacterial Mechanosensitive Channel2021-07-16 – Fengbo (Harvey) Zhou (DBBS Alumni) – A programmable Cas affinity tag for multiplex
protein isolation and purification.2021-06-25 – Lindsey Steinberg (Henderson lab) – Mechanisms and Evasion of the
Innate Immune Protein Siderocalin2021-03-19 – Mick Ward (Bowman lab) – Deep learning the structural determinants of
proteins biochemical properties by comparing structural ensembles with DiffNets2021-09-17 – Samantha Barrick (Greenberg lab) – A troponin T variant linked with pediatric dilated
cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding2021-05-14 – Nicholas Morffy (Strader Lab – Department of Biology – Duke University) – A High-Throughput Screen for
Identifying ARF Transcriptional Activation Domains2021-06-11 – Dr. John Cooper – Research Integrity – Data
Preservation2021-08-27 – Garrett Ginell (Holehouse lab) – Residue clustering as a key sequence
feature for function in intrinsically disordered proteins2021-06-04 – Larry Page (Managing Director, Lewis & Clark AgriFood) – Investing at the Intersection of Food,
Agriculture, and Technology. An introduction toLewis & Clark AgriFood2021-06-23 – Kyusik Kim (Zaher lab) – Investigating non-canonical
translation initiation2021-07-02 – Michael Greenberg – Off Topic: Fighting crime with
probability distributions2021-09-24 – Artur Meller (Bowman lab) – Signatures of allosteric modulator
specificity are encoded in myosin motor domain equilibrium fluctuations2021-11-05 – Olivia Murray (Cooper lab) – Regulating Capping Protein by
Conformational Changes2021-08-06 – Billy Kang (Silva lab) – Interaction of Disease-associated Calmodulin Variants
with the KCNQ1 Potassium Channel2021-03-26 – Ryan Emenecker (Holehouse lab) – Rational design of IDRs to understand
their impact on condensate properties2021-08-20 – Melanie Ernst (Robertson Lab) – Equilibrium Dimerization Reaction of
the Fluoride Channel Fluc in Membranes. What’s the role of ions?2021-12-03 – Daniel Griffith (Cooper Lab) – An assay to decode how IDPs selectively
partition into biomolecular condensates2021-10-08 – Drake Jensen (Galburt Lab) – Steady-state kinetic analysis of
transcription2021-12-10 – Dr. Ben Garcia – Use of Social Media in Academia
2021-04-02 – Shixuan Liu (Li Lab) – Termini Restraining enables structure
determination of small membrane proteins2021-04-28 – Krista Jarvis – Evidence-based Practices that Support
Mental and Emotional Well-being2021-01-15 – George L. Katumba (Henderson Lab) – Metal-mediated Regulation of a
Uropathogenic E. coli Metallophore2021-05-28 – Eric Tomko (Galburt Lab) – Promoter DNA opening during Pol II
transcription initiation in yeast and humans2021-02-12 – Cameron Sargent (Zhang Lab) – The Tale of Titanic Titin and
its Microbial Synthesis for High-performance Materials2021-07-23 – Kyusik Kim (Zaher Lab) – Investigating non-canonical translation initiation
2021-04-30 – Jonathan Mount (Yuan Lab) – Structural Insights into an
Uncharacterized Bacterial Mechanosensitive Channel2021-04-23 – Tugba Ozturk (Robertson Lab) – How do tryptophans modulate protein association in membranes?
2020
2020-09-10 – Peder Lund (Garcia lab) – Stable isotope tracing in vivo reveals a
metabolic bridge linking the microbiota to host histone acetylation2020-10-23 – Josh Rackers (DBBS Alumni) – What’s Machine Learning good for
anyway?2020-06-18 – Nicole Fazio (Lohman lab) – The RecBCD nuclease domain regulates DNA binding
and dsDNA unwinding, but not ssDNA translocation2020-10-01 – Verena Burtscher (Chanda lab) – Identification of propofol binding site
in HCN1 channel2020-10-15 – Soumendranath Bhakat – Outsiders in Science
2021-07-30 – Kathleen Hall – Lost wax and bronze sculpture
2016
2016-11-18 – Xianqiang Sun (Bowman Lab) – Molecular mechanism of GDP release by G proteins
2016-10-28 – Robb Welty (Hall Lab)
2016-10-14 – Melissa Brereton (Frieden Lab) – Examining the role of ApoE oligomerization in lipid binding
2016-08-05 – Partha Karmaka – (Janetka Lab) – Development of Selective Protease Inhibitors
2016-07-08 – Michael Greenberg (Greenberg Lab) – Speak Loudly and Carry a Small Laser Pointer: How to Give a Successful Seminar
2016-06-24 – Yansel Nuñez (Pike Lab) – Tyrosine Kinase Inhibitors and Intrinsic Disorder in the EGF Receptor
2016-06-17 – Greg DeKoster – (Hall and Frieden Lab) – Being Dynamic May Make You or Break You
2016-06-03 – Yihu Yang (Li Lab) – Structural Study of the DGGGP Synthase
2016-05-27 – Nicholas Bodmer (Havranek Lab) – Creating a Molecular Toolkit for Next-Generation Protein Sequencing
2016-05-13 – Grace Ramena (Pike Lab) – Understanding ErbB2/ErbB3 Heterodimerization
2016-05-06 – Benjamin Stark (Cooper Lab) – CARMIL Isoform-Specific Expression and Function During Zebrafish Development
2016-04-29 – Sarem Hailemariam (Burgers Lab) – Activation of the Yeast Kinase Tel1 by DNA and the Mre11, Rad50 and Xrs2 (MRX) Complex
2016-04-22 – Rotation Talks:
Drake Jensen – Repetitive Translocation of SF1 Helicases
Lindsey Steinberg – Investigating Interactions Between the Urine Metabolome and Siderocalin2016-04-15 – Shannon Ohlemacher (Henderson Lab) – Characterization of YbtT, a Type II Thioesterase in Yersiniabactin Biosynthesis
2016-04-08 – Binh Nguyen (Lohman Lab) – Conformational Dynamics of DNA Helicases
2016-04-01 – Alex Holehouse (Pappu Lab) – Unstructured Self-Assembly: The Biophysics of Membrane-less Organelles
2016-03-25 – Chris Ho – The Development and Application of Novel Ligand Design Methodologies…25 Years in the Making
2016-03-18 – Shixuan Liu (Li Lab) – Structural Study on Membrane Protein Vitamin K Epoxide Reductase (VKOR)
2016-03-11 – Rotation Talks:
George Katumba – CueO: A Multicopper Oxidase with a Role in Cu Homeostasis in
E. coli
Justin Miller – Dissecting the Role of RNA Polymerase Binding Protein A in Mycobacteria2016-03-04 – Qin Shu (Frieden Lab) – Solution NMR Structure CsgE: Structural Insights into a Chaperone and Regulator Protein in Curli Secretion and Biogenesis
2016-02-26 – Rotation Talks:
Patrick Judge – Calculating Binding Energies and Distribution Coefficients with the AMOEBA Force Field
Cameron Sargent – Modifying the Target Specificity of VCre Recombinase for Recombination Mediated Cassette Exchange of the Huntington Locus2016-02-12 – Jayan Rammohan (Galburt Lab) – Cooperative Stabilization of Mycobacterial Transcription Open-Complexes
2016-01-29 – Saurabh Singh (Galletto Lab) – Role of 2B Domain in Pif1
2016-01-15 – Anne Robinson (Henzler-Wildman / Henderson Lab)– Developing an Alternative Coupling Model for Secondary Active Transporters
2015
JANUARY 16, 2015 – BARNES (Wayne Barnes) – Klentaq1 for PCR, Strand-Displacement, Reverse Transcriptase, and Resistance to Chocolate
JANUARY 23, 2015 – LI (Shixuan Liu) – Structural Study of VKOR Proteins
FEBRUARY 20, 2015 – ELSON (Yanfei Jiang) – Landscape of Gene Regulation Network Probed with Light-inducible Perturbations
MARCH 6, 2015 – MARSHALL (Flavio Ballante) – Lysine Deacetylases (KDACs): Combining in vitro and in silico Strategies in Epigenetics
MARCH 13, 2015 – ROTATION TALKS: (Maxwell Zimmerman) – A General Method for Accelerating Conformational Searches
(McKenna Feltes) – Double TPP: Probing the EmrE Transport Mechanism
MARCH 20, 2015 – LOHMAN (Alex Kozlov) – Intrinsically Disordered C-terminal Tails of E. coli SSB Regulate Cooperative Binding to ss-DNA
MARCH 27, 2015 – Student Revisit with speaker TOLIA (Jooyoung Park) – The Role of the Malaria Parasite Sugar Phosphatase, PfHAD1, in Fosmidomycin Resistance and Methylerythritol Phosphate (MEP) Pathway Regulation
APRIL 3, 2015 – FRIEDEN (Tridib Mondal) – The Binding of Small Molecules (SM) to Human Apolipoprotein E
APRIL 10, 2015 – ROTATION TALKS: (Sukrit Singh) – Dynamic Correlation: A Novel Method to Identify Allosteric Communication
(Tyson Todd) – Cellular Extraction from Microfluidic Devices for the Quantification of RNA Expression in the Tumor Microenvironment
APRIL 17, 2015 – PIKE (Kamaldeep Gill) – Studying the Recruitment of Signaling Proteins to the Intrinsically Disordered tail of the EGF Receptor
MAY 1, 2015 – PAPPU (Alex Holehouse) – Decoding the Driving Forces for the Complex Phase Behavior of Polyampholytic Septal Pore Proteins
MAY 8, 2015 – GALBURT (Eric Galburt) – TFIIH and Transcription Initiation
MAY 15, 2015 – LOHMAN (Yerdos Ordabayev) – Regulation of DNA Unwinding by UvrD Helicase
JUNE 12, 2015 – ELLENBERGER (Chris Brosey) – Out of the Mitochondria: Investigating the Mechanistic Basis for AIF Dimerization and Release Following PARP-1 Hyperactivation
JUNE 19, 2015 – GALBURT (Jayan Rammohan) – CarD Stabilizes Mycobacterial Open Complexes via a Two-tiered Kinetic Mechanism
JUNE 26, 2015 – ROTATION TALKS: (Yansel Nunez) – A Tumor-associated Mutation in the EGF Receptor May Alter Higher Order Oligomerization of the EGF Receptor
(Theodore Christensen) – Evasion of Cellular Immunity by Rodent Herpesvirus Peru
JULY 10, 2015 – ROTATION TALKS: (Elizabeth DeLassus) – Synthesis of a Charged Substrate Molecule for Near Infra Red (NIR) Imaging of Protein Kinase A Activity in Cancer Cells
(Elisa Murray) – Biochemical and Biophysical Analysis of HER3 C-terminal Tail
JULY 17, 2015 – BOWMAN (Katie Hart) – Combining Simulations and Experiments to Understand beta-lacatamase’s Evolving Functions
JULY 31, 2015 – BEVERLEY (John Robinson) – E6: A Small-Molecule Inhibitor of Leishmania RNA Virus
AUGUST 14, 2015 – LOHMAN (Joshua Sokoloski) – DNA Translocases Can Push Single-Stranded DNA Binding Proteins Along ssDNA
AUGUST 18, 2015 – GALLETTO (Paolo De Bona) – Rap1 Conformational Transition Couple to DNA Binding
SEPTEMBER 11, 2015 – GALBURT (Eric Tomko) – Probing Pol II Transcription Start Scanning Mechanism with Site Specific DNA Cross-Links
SEPTEMBER 18, 2015 – BOWMAN (Maxwell Zimmerman) – Fast Conformational Searches by Balancing Exploration/Exploitation Tradeoffs
SEPTEMBER 25, 2015 – FREMONT (Jabari Elliot) – The Immunomodulatory Cowpox Viral Protein: M2
OCTOBER 2, 2015 – PONDER (Joshua Rackers) – Using Quantum Mechanics to Build a Better Force Field
OCTOBER 9, 2015 – SWAMIDASS (Tyler Hughes) – Modeling Epoxidation of Drug-like Molecules with a Deep Machine Learning Network
OCTOBER 16, 2015 – KREZEL (Andrzej Krezel) – Noroviral Protein NS1/2 Targeting ER Protein VAPA
OCTOBER 30, 2015 – HALL (Robb Welty) – RNA Folding is a Synchronized Affair. Measuring the Kinetics of RNA Tertiary Structure Formation
November 6, 2015 – ROTATION TALKS: (Edward Fisher) – Sequence and Characterization of Amyloidogenic lambda-AL-1
(Brittany Smith) – Challenges and Progress in Simulating Protein-Ligand Complexes
NOVEMBER 20, 2015 – BURGERS (Rachel Bezalel-Buch) – The Control of Eukaryotic Mutagenesis by Rev1 and DNA Polymerase z’
DECEMBER 4, 2015 – HAVRANEK (James Havranek) – Engineering Cre Recombinase for Native-site Genome Editing
2014
JANUARY 10, 2014 – BURGERS (Justin Sparks) – The Role of RNase H2 and Topoisomerase 1 in Ribonucleotide Processing
JANUARY 17, 2014 – BARNES (Wayne Barnes) – Unnatural DNA Polymerase
JANUARY 24, 2014 – LOHMAN (Josh Sokoloski) – Movement of Single Strand Binding Proteins on DNA: Random Walk Diffusion and Chemomechanical Pushing by Translocases
FEBRUARY 7, 2014 – BURGERS (Sjoerd Wanrooij) – Human Mitochondrial DNA Metabolism and Its Role in Disease
FEBRUARY 21, 2014 – ELSON (Artem Melnykov) – Regulation of Yeast Dipeptide Transporter Ptr2: Contribution of Amino Acids
FEBRUARY 28, 2014 – LOHMAN (Vincent Waldman) – Unraveling the ssDNA-SSB Complex: What Can We Learn by Destabilizing the (SSB)65 DNA-binding Mode?
MARCH 7, 2014 – GALLETTO (Katrina Koc) – Biochemical Activity of Rrm3
MARCH 14, 2014 – ELLENBERGER (Jamie Wallen) – The Crystal Structure of the T7 Replisome Reveals Asymmetric Binding of DNA Polymerases to a Helicase Ring
MARCH 21, 2014 – STEWART (Shankar Parajuli) – Role of Flap Endonuclease 1 in Maintaining Telomere Integrity
MARCH 28, 2014 – BRETT (Zeynep Yurtsever) – Mechanism of CLCA1-Regulated CaCC Activity in Chronic Inflammatory Lung Diseases
GALBURT (Jayan Rammohan) – CarD Regulation of Mycobacterial Transcription Initiation
APRIL 4, 2014 – ROTATION STUDENT (Ryan Christman) – Interaction of Abeta42 with Lipid Vesicles
APRIL 18, 2014 – HENZLER-WILDMAN (Chao Wu) – Structure, Dynamics, and Function Relationship Study of a Multidrug Resistance Transporter, EmrE
APRIL 25, 2014 – GALBURT (Eric Tomko) – Yeast Pol II Transcription Initiation, One PIC at a Time
MAY 2, 2014 – HENDERSON (Shannon Ohlemacher) – HPTT: A Second Natural Product of the Yersiniabactin Biosynthetic Pathway
MAY 9, 2014 – LI (Guomin Shen) – Mechanism of Warfarin Inhibiting hVKOR: Learning From Redox Status of hVKOR
MAY 16, 2014 – HALL (Aaztli Coria) – Tale of Two Stem Loops
JUNE 6, 2014 – BURGERS (Paulina Wanrooij) – Structure and Function Studies of the Essential Checkpoint Kinase Mec1
JUNE 20, 2014 – ELLENBERGER (Chris Brosey) – Investigating the Mechanistic Basis for AIF Release During PARP-1 Hyperactivation
JUNE 27, 2014 – ROTATION STUDENT (Josh Rackers) – What Happens When Two Molecules Meet: Improving the AMOEBA Force Field by Including the Charge Penetration Effect
JULY 25, 2014 – GALLETTO (Saurabh Pratap Singh) – More Insight into Mechanism of pif1 Helicase of Saccharomyces cerevisae
AUGUST 1, 2014 – HENZLER-WILDMAN (Josh Brettmann) – NaK Channel as a Model System to Study Ion Selectivity and Channel Gating via Solution NMR
AUGUST 22, 2014 – GALBURT (Eric Galburt) – Helicases, Translocases, and Transcription Initiation
AUGUST 29, 2014 – GALLETTO (Paolo De Bona) – Switching Between Rap1 Binding Modes
SEPTEMBER 12, 2014 – HENZLER-WILDMAN (Supratik Dutta) – Blocking Conformational Dynamics of the Small Multi-drug Resistance (SMR) Transporter EmrE Impairs Efflux Activity
SEPTEMBER 26, 2014 – MARSHALL (Rajasekhar Depatla) – Design, Synthesis of KDAC Inhibitors Carrying a Benzodiazepine Ring and Towards the Synthesis of Dipeptide Nitroxides for EPR Studies
OCTOBER 10, 2014 – KREZEL (Andrzej Krezel) – Norovirus Non-Structural Protein 2 (NS2): What’s it Do?
OCTOBER 24, 2014 – FRAZIER (Katie Liu) – C-terminal BNIP3 Phosphorylation Regulates Mitochondrial Damage and Cell Death
OCTOBER 31, 2014 – HALL (Robb Welty) – Local and Global Folding of a 58mer RNA Revealed by Fluorescent Base Substitutions
NOVEMBER 7, 2014 – ROTATION STUDENTS
Andrew Meiberg-Investigation by Key Residues in the MO Helix of NaK
Nicole Fazio-The Role of the C-terminal Linker of SSB in Diffusion on ssDNA
NOVEMBER 14, 2014 – HENZLER-WILDMAN (Anne Georges (Robinson)) – The Unique Substrate Coupling Mechanism of an Asymmetric Homodimer, EmrE
NOVEMBER 21, 2014 – BOWMAN – guest lecturer (Milo Lin – UC Berkeley) – Statistical Mechanical Protection of Protein Self-Assembly
DECEMBER 2, 2014 – LOHMAN (Michael Simon) – Observing Helicase Activity in RecBCD in the Absence of Canonical Translocation
DECEMBER 12, 2014 – BURGERS (Sarem Hailemariam) – Activation of the Yeast Checkpoint Kinase Tel1 by Mre11, Rad50 and Xrs2 (MRX) Complex
2013
JANUARY 11, 2013 – BURGERS (Alena Makarova) – Biochemistry of DNA Damage-induced Mutagenesis in Eukaryotic Cells
JANUARY 18, 2013 – HALL (Sandra Williams) – 2B or not 2B: Heterotrophic Linkage in snRNPs
FEBRUARY 15, 2013 – ELLENBERGER (Chris Brosey) – Assassination by Nucleic Acid: Exploring the Structural Basis for Cell Death Induced by poly(ADP-ribose)
FEBRUARY 22, 2013 – LOHMAN (Josh Sokoloski) – Single Molecular Fluorescence Studies on Protein-DNA Interactions
MARCH 1, 2013 – GALBURT (Eric Tomko) – Studying Yeast Transcription Initiation One PIC at A Time
MARCH 15, 2013 – LI (Shixuan Liu) – Novel Mechanism of Disulfide Formation and Exchange Cataltyzed by VKOR
MARCH 22, 2013 – ELLENBERGER (Jamie Wallen) – Structural Investigation of a Helicase Polymerase Interaction That is Critical for T7 Replisome Processivity
MARCH 29, 2013 – LOHMAN (Vince Waldman) – Introducing Asymmetry into Symmetric SSB Protein to Study DNA-Binding Modes in vitro and in vivo
APRIL 5, 2013 – HENZLER-WILDMAN (Chao Wu) – Structure and Dynamics of a Multi-Drug Resistance Transporter, EmrE
APRIL 12, 2013 – BURGERS (Paulina Wanrooij) – The Role of Dna2 in Checkpoint Activation
APRIL 26, 2013 – ELSON (Artem Melnykov) – Import of Short Peptides in Yeast as a Bistable Switch
MAY 17, 2013 – HALL (Kim Delaney) – New Ventures in Non Coding RNA
MAY 31, 2013 – ROTATION STUDENT (Anne Georges) – EmrE-Lipid Interactions: Investigating the Role of Lipids in EmrE Global Dynamics and Ligand Binding
JUNE 7, 2013 – ROTATION STUDENT (Mariah Lawler) – Do You Know Your Favorite Protein’s History? An Eye Opening Look at the Past
JUNE 14, 2013 – LOHMAN (Fuqian Xie) – Asymmetric Regulation of Bipolar Single-Stranded DNA Translocation by the Two Motors with Escherichia coli RecBCD Helicase
JUNE 28, 2013 – HENZLER-WILDMAN (Supratik Dutta) – Role of Structural Flexibility on the Conformational Exchange of a Bacterial Small Multi-Drug Resistance (SMR) Transporter, EmrE
JULY 12, 2013 – HRUZ (Thomas Kraft) – Structural, Dynamic and Functional Studies of the Mammalian Glucose Transporter GLUT4
JULY 26, 2013 – BOSE (Koby Sarpong) – EGFR Family Kinase Domain Dimerization
AUGUST 2, 2013 – LOHMAN (Alex Kozlov) – E. coli SSB: Exploring DNA Binding Modes and Cooperativities by Mutational Studies
AUGUST 9, 2013 – HENZLER-WILDMAN (Joshua Brettmann) – Investigating the Role of Selectivity Filter Flexibility on Ion Selectivity
AUGUST 23, 2013 – HAVRANEK (Ben Borgo) – Computational Redesign of Enzyme Specificity Using Native Motifs
AUGUST 30, 2013 – LI (Wei Cheng) – Structures of the Membrane-Embedded Enzyme UbiA
SEPTEMBER 13, 2013 – MARSHALL (Garland Marshall) – Epigenetic Control of HIV-1 Expression
SEPTEMBER 20, 2013 – PIKE (Linda Pike) – Ligand-Specific Differences in Allosteric Interactions of the EGF Receptor
SEPTEMBER 27, 2013 – GALLETTO (Erik Feldmann) – Architecture and Regulation of the Yeast ‘Shelterin-Like’ Complex
OCTOBER 4, 2013 – Harald Schwalbe – John Wolfgang Goethe-Universitat, Frankfurt, Germany – NMR of RNA
OCTOBER 11, 2013 – GALBURT (Jayan Rammohan) – The Effect of CarD on Mycobacterial Transcription Initiation
OCTOBER 18, 2013 – FRAZIER (Katie Liu) – C-terminal BNIP3 Phosphorylation Regulates Mitochondrial Damage, Autophagy, and Cell Death
NOVEMBER 1, 2013 – KREZEL (Andrzej Krezel) – Norovirus NS1-2 Protein
NOVEMBER 8, 2013 – BURGERS (Joe Stodola) – Kinetic Analysis of the Yeast DNA Polymerase Delta Holoenzyme
NOVEMBER 15, 2013 – WILDMAN (Scott Wildman) – Using a Wide Net to Catch Tiny Things
NOVEMBER 22, 2013 – ELLENBERGER (Vandna Kukshal) – Insight into Intermolecular DNA Ligation Mechanism of Human DNA Ligase III
December 6, 2013 – HENZLER-WILDMAN (Emma Morrison) – Mechanism of Multidrug Transport
December 13, 2013 – LOHMAN (Michael Simon) – The Kinetics of DNA Blunt-End Melting by RecBCD
2012
MARCH 2, 2012 – ELSON (Elliot Elson) and FRIEDEN (Carl Frieden)
MARCH 16, 2012 – FREMONT (Vince Luca) and FRAZIER (William Frazier)
MARCH 30, 2012 – GALBURT (Eric Tomko) and BARNES (Wayne Barnes)
APRIL 13, 2012 – BURGERS (Sandeep Kumar) and GALLETTO (Roberto Galletto)
APRIL 27, 2012 – HALL (Kathleen Hall) and JANETKA (Peter Harris)
MAY 11, 2012 – HENZLER-WILDMAN (Supratik Dutta) and LOHMAN (Alex Kozlov)
MAY 18, 2012 – LI (Wei Cheng) and MARSHALL (Garland Marshall)
JUNE 15, 2012 – COHEN (Robert Zeigler) – Decoding Combinatorial cis-regulation Using Synthetic Promoters
JUNE 22, 2012 – BURGERS (Sara Binz) – Modulation of Translesion Synthesis by Rev1
JUNE 29, 2012 – ELSON (Yanfei Jiang) – Study of the Phase Separation in a Binary Membrane System with Fluorescence Techniques and AFM
JULY 6, 2012 – HALL (Kim Delaney) – Induced Folding of the U2AF35 RRM Upon Binding to U2AF65* – *Kellenberger, et al. – FEBS (2002) 528:171-176
JULY 13, 2012 – HAVRANEK (Benjamin Borgo) – Engineering a Molecular Toolkit for Single Molecule Sequencing
JULY 20, 2012 – LOHMAN (Edwin Antony) – Chimeric Single Strand DNA Binding Proteins Reveal Surprising Properties of the Disordered C-Terminal Tails
JULY 27, 2012 – JANETKA (Cassie Jarvis) – Improving the PK Profile of Mannose Glycoside FimH Inhibitors
AUGUST 3, 2012 – PIKE (Linda Pike) – Imaging ErbB Receptor Family Interactions
AUGUST 10, 2012 – GALBURT (Jayan Rammohan) – Throughtput: The Achilles’ Heel of Single Molecule Force Spectroscopy
AUGUST 17, 2012 – SKEATH (Mark Snee) – CDK1 Regulation of Dis3 Ribonuclease Activity
AUGUST 24, 2012 – HENZLER-WILDMAN (Josh Brettmann) – Purification and Early Structural Studies of the BK Ion Channel Pore
AUGUST 31, 2012 – ELLENBERGER (In-Kwon Kim) – Structure and Mechanism of Mammalian poly(ADP-ribose) Glycohydrolase
SEPTEMBER 14, 2012 – LOHMAN (Michael Simon) – Exploring the Kinetics of DNA Blunt End Melting by RecBC and RecBCD
SEPTEMBER 21, 2012 – HAVRANEK (Chi Zhang) – Engineering Cre Recombinase for Genome Editing
SEPTEMBER 28, 2012 – BURGERS (Justin Sparks) – Exo5: Sliding Bi-Directional Exonuclease Required for Genome Stability
OCTOBER 4, 2012 – ELSON (Artem Melnykov) – Import of Short Peptides in Yeast as a Bi-stable Switch
OCTOBER 12, 2012 – FRAZIER (William Frazier) – Is CD47 the Answer to Cancer?
OCTOBER 19, 2012 – FRIEDEN (Kanchan Garai) – Targeting apoE4 by High Throughput Screening
NOVEMBER 9, 2012 – HENZLER-WILDMAN (Emma Morrison) – Broad Ligand Specificity in the Small Multidrug Resistance Transporter EmrE
NOVEMBER 16, 2012 – GALLETTO (Katrina Koc) – Rrm3: Not a Helicase?
DECEMBER 7, 2012 – ELLENBERGER (Vandna Kukshal) – How Does a Zinc Finger Promote DNA End Joining?
DECEMBER 14, 2012 – LOHMAN (Binh Nguyen) – Dynamics of Human Replication Protein A (RPA) Bound to Single Strand DNA
2011
FEBRUARY 25, 2011 – FRIEDEN (Kanchan Garai) and CHIVERS (Peter Chivers)
MARCH 4, 2011 – ELLENBERGER (In-Kwon Kim) and ELSON (Elliot Elson)
MARCH 18, 2011 – FRAZIER (Katie Lindstrand) and BURGERS (Sandeep Kumar)
APRIL 1, 2011 – HALL (Kathleen Hall) and GALLETTO (Roberto Galletto)
APRIL 15, 2011 – GALBURT (Eric Tomko) and HENZLER-WILDMAN (Katie Henzler-Wildman)
APRIL 29, 2011 – JANETKA (Zhenfu Han) and KREZEL (Andrzej Krezel)
MAY 13, 2011 – LI (Weikai Li) and LOHMAN (Fuqian Xie)
MAY 27, 2011 – MARSHALL (Garland Marshall) and PIKE (Sangeeta Adak)
JUNE 10, 2011 – PONDER (Justin Xiang) and SCHINDLER (John Schindler)
JUNE 24, 2011 – WILDMAN (Scott Wildman) and BARNES (Wayne Barnes)
SEPTEMBER 16, 2011 – FRIEDEN (Scott Crick) and ELLENBERGER (Tom Ellenberger)
SEPTEMBER 30, 2011 – ELSON (Artem Melnykov) and FRAZIER ( William Frazier)
OCTOBER 14, 2011 – BURGERS (Sandeep Kumar) and GALBURT (Tina Bradford)
NOVEMBER 4, 2011 – HENZLER-WILDMAN (Katie Henzler-Wildman) and HALL (Sandra Williams)
NOVEMBER 11, 2011 – GALLETTO (Roberto Galletto) and JANETKA (Jim Janetka)
DECEMBER 2, 2011 – LI (Weikai Li) and LOHMAN (Binh Nguyen)
DECEMBER 9, 2011 – ROTONS – Zeynep Yurtsever, Chao Wu, Lu Yu, Shankar Parajuli
DECEMBER 16, 2011 – MARSHALL (Xiange Zheng) and PIKE (Linda Pike)
2010
JANUARY 8, 2010 – BAKER (Brett Olsen) and CHIVERS (Peter Chivers)
JANUARY 22, 2010 – LOHMAN (Colin Wu) and FRIEDEN (Scott Crick)
FEBRUARY 5, 2010 – ELLENBERGER (Fiorella Ghisays) and PIKE (Linda Pike)
FEBRUARY 26, 2010 – BURGERS (Sara Binz) and HALL (Artem Melnykov)
MARCH 12, 2010 – GALLETTO (Roberto Galletto) and SCHLESINGER (Olen Ivanshyna)
MARCH 26, 2010 – JANETKA (Francisco Franco) and RUIZ MANZANO (Ana Ruiz Manzano)
APRIL 9, 2010 – WILDMAN (Scott Wildman)
APRIL 23, 2010 – ELLENBERGER (Jamie Wallen) and MARSHALL (Xiange Zheng)
MAY 7, 2010 – HENZLER-WILDMAN (Emma Morrison) and FRAZIER (Bill Frazier)
MAY 14, 2010 – PIKE (Sangeeta Adak) and ELSON (Yanfei Jiang)
SEPTEMBER 24, 2010 – ELLENBERGER (Beth Gohara) and BURGERS (Peter Burgers)
OCTOBER 22, 2010 – HALL (Sandra Williams) and HENZLER-WILDMAN (Greg DeKoster)
NOVEMBER 5, 2010 – BARNES (Wayne Barnes)
NOVEMBER 19, 2010 – ROTONS
DECEMBER 3, 2010 – LOHMAN (Edwin Antony) and GALBURT (Christina Bradford)
DECEMBER 17, 2010 – BURGERS (Justin Sparks) and HENZLER-WILDMAN (Supratik Dutta)