Peter M. Burgers, Ph.D.

Brennecke Professor of Biological Chemistry

Biochemistry and Molecular Biophysics

Lab Website
Graduate Programs (DBBS)
Publications (PubMed / NIH)

Office: 1911 South Building
Phone: 314-362-3872


The Burgers Lab studies DNA replication and DNA damage response in eukaryotic cells. Using yeast as a model organism, the lab integrates the biochemical analysis of DNA-protein interactions in purified model systems with the genetic analysis of targeted yeast mutants. Specific areas of interest are lagging strand DNA replication and Okazaki fragment maturation, damage induced mutagenesis, and DNA damage cell cycle checkpoints.

DNA replication fork and Okazaki fragment maturation

Select Publications

Burgers, P.M. (2019). “Solution to the 50-year-old Okazaki-fragment problem.” Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3358-3360. doi: 10.1073/pnas.1900372116. Epub 2019 Feb 15. (Abstract)

Mondol T., Stodola J.L., Galletto R., & Burgers P.M. (2019). “PCNA accelerates the nucleotide incorporation rate by DNA polymerase δ.” Nucleic Acids Res. 2019 Jan 3. doi: 10.1093/nar/gky1321. [Epub ahead of print] (Abstract)

Stodola J.L. & Burgers P.M. (2017). “Mechanism of Lagging-Strand DNA Replication in Eukaryotes.” Adv Exp Med Biol. 2017;1042:117-133. doi: 10.1007/978-981-10-6955-0_6. (Abstract)

Bartels P.L., Stodola J.L., Burgers P.M.J., & Barton J.K. (2017). “A Redox Role for the [4Fe4S] Cluster of Yeast DNA Polymerase δ.” J Am Chem Soc. 2017 Dec 20;139(50):18339-18348. doi: 10.1021/jacs.7b10284. Epub 2017 Dec 6. (Abstract)

Kunkel T.A. & Burgers P.M. (2017). “Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication.” Bioessays. 2017 Aug;39(8). doi: 10.1002/bies.201700070. (Abstract)

Burgers P.M. & Kunkel T.A. (2017). “Eukaryotic DNA Replication Fork.” Annu Rev Biochem. 2017 Jun 20;86:417-438. doi: 10.1146/annurev-biochem-061516-044709. Epub 2017 Mar 1. (Abstract)

Kochenova O.V., Bezalel-Buch R., Tran P., Makarova A.V., Chabes A., Burgers P.M., & Shcherbakova P.V. (2016). “Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.” Nucleic Acids Res. 2017 Feb 17;45(3):1200-1218. doi: 10.1093/nar/gkw1149. (Abstract)

Stojkovic G., Makarova A.V., Wanrooij P.H., Forslund J., Burgers P.M., & Wanrooij S. (2016). “Oxidative DNA damage stalls the human mitochondrial replisome.” Sci Rep. 2016 Jul 1;6:28942. doi: 10.1038/srep28942. (Abstract)

Cho J.E., Huang S.N., Burgers P.M., Shuman S., Pommier Y., & Jinks-Robertson S. (2016). “Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo.” Nucleic Acids Res. 2016 Sep 19;44(16):7714-21. doi: 10.1093/nar/gkw495. Epub 2016 Jun 1. (Abstract)

Stodola J.L., Stith C.M., & Burgers P.M. (2016). “Proficient Replication of the Yeast Genome by a Viral DNA Polymerase.” J Biol Chem. 2016 May 27;291(22):11698-705. doi: 10.1074/jbc.M116.728741. Epub 2016 Apr 12. (Abstract)

Stodola J.L. & Burgers P.M. (2016). “Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale.” Nat Struct Mol Biol. 2016 May;23(5):402-8. doi: 10.1038/nsmb.3207. Epub 2016 Apr 11. (Abstract)

Koc K.N., Singh S.P., Stodola J.L., Burgers P.M., & Galletto R. (2016). “Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ.” Nucleic Acids Res. 2016 May 5;44(8):3811-9. doi: 10.1093/nar/gkw181. Epub 2016 Mar 21. (Abstract)

Sawicka, M., Wanrooij, P.H., Darbari, V.C., Tannous, E., Hailemariam, S., Bose, D., Makarova, A.V., Burgers, P.M. and Zhang, X.
The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization.
J Biol Chem 291:13436-47 (2016) (Abstract)

Burgers, P.M., Gordenin, D. and Kunkel, T.A.
Who Is Leading the Replication Fork, Pol ε or Pol δ?
Mol Cell. 61:492-493 (2016). (Abstract)

Wanrooij, P.H, Tannous, E., Kumar, S., Navadgi-Patil, V.M. and Burgers, P.M.
Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.
J Biol Chem 291:1076-1091 (2016). (Abstract)