John A. Cooper, M.D., Ph.D.

Head of Biochemistry and Molecular Biophysics

Lab Website
Publications (PubMed / NIH)

Office: 2901 South
Phone: 314-362-0287

Select Publications

Kiehart D.P. & Cooper J.A. (2018). “Contractile protein biochemistry in the Pollard Lab in Baltimore.” Biophys Rev. 2018 Nov 8. doi: 10.1007/s12551-018-0477-5. [Epub ahead of print] (Abstract)

Yen M., Qi Z., Chen X., Cooper J.A., Mitra R.D., & Onken M.D. (2018). “Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma.” BMC Med Genomics. 2018 Nov 6;11(1):97. doi: 10.1186/s12920-018-0424-0. (Abstract)

Johnston A.B., Hilton D.M., McConnell P., Johnson B., Harris M.T., Simone A., Amarasinghe G.K., Cooper J.A., & Goode B.L. (2018). “A novel mode of capping protein-regulation by twinfilin.” Elife. 2018 Oct 23;7. pii: e41313. doi: 10.7554/eLife.41313. (Abstract)

Onken M.D., Makepeace C.M., Kaltenbronn K.M., Kanai S.M., Todd T.D., Wang S., Broekelmann T.J., Rao P.K., Cooper J.A., & Blumer K.J. (2018). “Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells.” Sci Signal. 2018 Sep 4;11(546). pii: eaao6852. doi: 10.1126/scisignal.aao6852. (Abstract)

Michael D. Onken, Carol M. Makepeace, Shiqi Wang, Kevin M. Kaltenbronn, Stanley M. Kanai, Tom J. Broekelmann, John A. Cooper, & Kendall J. Blumer (2018). “Pharmacologic targeting of Gq reveals new pathways in uveal melanoma” AACR, July 2018, Volume 78, Issue 13 Supplement (Abstract)

Johnson B., McConnell P., Kozlov A.G., Mekel M., Lohman T.M., Gross M.L., Amarasinghe G.K., & Cooper J.A. (2018). “Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.” Cell Rep. 2018 May 29;23(9):2795-2804. doi: 10.1016/j.celrep.2018.04.096. (Abstract)

Kim J. & Cooper J.A. (2019). “Septins regulate junctional integrity of endothelial monolayers.” Mol Biol Cell. 2018 Jul 15;29(13):1693-1703. doi: 10.1091/mbc.E18-02-0136. Epub 2018 May 17. (Abstract)

Stark B.C., Lanier M.H., & Cooper J.A. (2017). “CARMIL family proteins as multidomain regulators of actin-based motility.” Mol Biol Cell. 2017 Jul 1;28(13):1713-1723. doi: 10.1091/mbc.E17-01-0019. (Abstract)

Stewart-Hutchinson P.J., Szasz T.P., Jaeger E.R., Onken M.D., Cooper J.A., & Morley S.C. (2017). “Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate.” J Leukoc Biol. 2017 Sep;102(3):941-948. doi: 10.1189/jlb.1TA0117-008R. Epub 2017 Jun 21. (Abstract)

Santiago-Tirado F.H., Onken M.D., Cooper J.A., Klein R.S., & Doering T.L. (2017). “Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.” MBio. 2017 Jan 31;8(1). pii: e02183-16. doi: 10.1128/mBio.02183-16. (Abstract)

Zhou J.Y., Szasz T.P., Stewart-Hutchinson P.J., Sivapalan J., Todd E.M., Deady L.E., Cooper J.A., Onken M.D., & Morley S.C. (2016). “L-Plastin promotes podosome longevity and supports macrophage motility.” Mol Immunol. 2016 Oct;78:79-88. doi: 10.1016/j.molimm.2016.08.012. Epub 2016 Sep 7. (Abstract)

Xu X., Wang X., Todd E.M., Jaeger E.R., Vella J.L., Mooren O.L., Feng Y., Hu J., Cooper J.A., Morley S.C., & Huang Y.H. (2016). “Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.” J Immunol. 2016 Sep 1;197(5):1683-91. doi: 10.4049/jimmunol.1600874. Epub 2016 Jul 27. (Abstract)

Wang X., Galletta B.J., Cooper J.A., & Carlsson A.E. (2016). “Actin-Regulator Feedback Interactions during Endocytosis.”
Biophys J. 2016 Mar 29;110(6):1430-43. doi: 10.1016/j.bpj.2016.02.018. (Abstract)

Stark B.C. & Cooper J.A. (2015). “Differential expression of CARMIL-family genes during zebrafish development.” Cytoskeleton (Hoboken). 2015 Oct;72(10):534-41. doi: 10.1002/cm.21257. Epub 2015 Oct 23. (Abstract)

Canton D.A., Olsten M.E., Niederstrasser H., Cooper J.A., & Litchfield D.W. (2006). “The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.” J Biol Chem. 2006 Nov 24;281(47):36347-59. Epub 2006 Sep 20. (Abstract)