Tom Ellenberger, D.V.M., Ph.D.


Biochemistry and Molecular Biophysics





Research in the Ellenberger laboratory focuses on the molecular structures and cellular functions of proteins that replicate DNA, repair chemical damage, and regulate chromatin structure. These enzymes and regulatory proteins ensure the faithful transmission of our genetic blueprint to future generations.


Select Publications

Brosey C.A., Ho C., Long W.Z., Singh S., Burnett K., Hura G.L., Nix J.C., Bowman G.R., Ellenberger T., & Tainer J.A. (2016). “Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor” Structure. 2016 Dec 6;24(12):2067-2079. doi: 10.1016/j.str.2016.09.012. Epub 2016 Nov 3. (Abstract)

Kukshal V., Kim I.K., Hura G.L., Tomkinson A.E., Tainer J.A., & Ellenberger T. (2015). “Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.” Nucleic Acids Res. 2015 Aug 18;43(14):7021-31. doi: 10.1093/nar/gkv652. Epub 2015 Jun 29. (Abstract)

Chen X., Kim I.K., Honaker Y., Paudval S.C., Koh W.K., Sparks M., Lis S., Piwnica-Worms H., Ellenberger T., & You Z. (2015). “14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. J Biol Chem. 2015 May 8;290(19):12300-12. doi: 10.1074/jbc.M115.644005. Epub 2015 Apr 1. (Abstract)

Pascal J.M., & Ellenberger T. (2015). “The rise and fall of poly(ADP-ribose): An enzymatic perspective. DNA Repair (Amst). 2015 Aug;32:10-6. doi: 10.1016/j.dnarep.2015.04.008. Epub 2015 May 1. (Abstract)

Ghisays F., Brace C.S., Yackly S.M., Kwon H.J., Mills K.F., Kashentseva E., Dmitriev I.P., Curiel D.T., Imai S.I., & Ellenberger T. (2015). “The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs.” Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00182-5. doi: 10.1016/j.celrep.2015.02.036. (Abstract)

Kim I.K., Stegeman R.A., Brosey C.A., & Ellenberger T. (2015). “A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase.” J Biol Chem. 2015 Feb 6;290(6):3775-83. doi: 10.1074/jbc.M114.624718. Epub 2014 Dec 4. (Abstract)

Wallen J.R., Majka J., & Ellenberger T. (2013). “Discrete interactions between bacteriophage T7 primase-helicase and DNA polymerase drive the formation of a priming complex containing two copies of DNA polymerase.” Biochemistry. 2013 Jun 11;52(23):4026-36. doi: 10.1021/bi400284j. Epub 2013 May 31. (Abstract)

Della-Maria J., Hegde M.L., McNeill D.R., Matsumoto Y., Tsai M.S., Ellenberger T., Wilson D.M., Mitra S., & Tomkinson, A.E. (2012). “The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites.” J Biol Chem. 2012 Nov 9;287(46):39233-44. doi: 10.1074/jbc.M112.369975. Epub 2012 Sep 19. (Abstract)

Kim I.K., Kiefer J.R., Ho C.M., Stegeman R.A., Classen S., Tainer J.A., & Ellenberger, T. (2012). “Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.” Nat Struct Mol Biol. 2012 May 20;19(6):653-6. doi: 10.1038/nsmb.2305. (Abstract)

Ellenberger, T. (2012). “An arresting development in transcription.” Mol Cell. 2012 Apr 13;46(1):3-4. doi: 10.1016/j.molcel.2012.03.025. (Abstract)

Sperry, J.B., Smith, C.L., Caparon, M.G., Ellenberger, T. and Gross, M.L.
Mapping the protein-protein interface between a toxin and its cognate antitoxin from the bacterial pathogen Streptococcus pyogenes.
Biochem 50:4038-4045 (2011). (Abstract)

Smith, C.L., Ghosh, J., Elam, J.S., Pinkner, J.S., Hultgren, S.J., Caparon, M.G. and Ellenberger, T.
Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.
Structure 19:192-202 (2011). (Abstract)

Cotner-Gohara, E., Kim, I.K., Tainer, J.A., Tomkinson, A.E. and Ellenberger, T.
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.
Biochemistry 49:6165-6176 (2010). (Abstract)

Perry, J.J. and Cotner-Gohara, E., Ellenberger, T. and Tainer, J.A.
Structural dynamics in DNA damage signaling and repair.
Curr Opin Struct Biol 20:283-294 (2010). (Abstract)

Han, Z., Pinkner, J.S., Ford, B., Obermann, R., Nolan, W., Wildman, S.A., Hobbs, D., Ellenberger, T., Cusumano, C.K., Hultgren, S.J. and Janetka, J.W.
Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
J Med Chem. 53(12):4779-92. doi: 10.1021/jm100438s. (2010) (Abstract)