Carl Frieden, Ph.D.

Carl Frieden

Biochemistry and Molecular Biophysics

Lab Website
Graduate Programs (DBBS)
Publications (PubMed / NIH)

Office: 215 McDonnell Science Building
Phone: 314-362-3344
Email: friedenc(at)


Protein folding, aggregation, intrinsically disordered proteins, fluorescence methods, ApoE lipoproteins and Alzheimer’s disease

Carl Frieden lab research

Select Publications

Wang H., Rempel D.L., Giblin D., Frieden C., & Gross M.L. (2017). “Peptide-Level Interactions between Proteins and Small-Molecule Drug Candidates by Two Hydrogen-Deuterium Exchange MS-Based Methods: The Example of Apolipoprotein E3.” Anal Chem. 2017 Oct 17;89(20):10687-10695. doi: 10.1021/acs.analchem.7b01121. Epub 2017 Sep 25. (Abstract)

Wang H., Shu Q., Rempel D.L., Frieden C., & Gross M.L. (2017). “Understanding Curli Amyloid-Protein Aggregation by Hydrogen-Deuterium Exchange and Mass Spectrometry.” Int J Mass Spectrom. 2017 Sep;420:16-23. doi: 10.1016/j.ijms.2016.10.006. Epub 2016 Oct 11. (Abstract)

Frieden C., Wang H., and Ho C.M.W.
A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions.
Proc Natl Acad Sci U S A. 114(24):6292-6297. (2017) (Abstract)

Wang H., Shu Q., Frieden C., and Gross M.L.
Deamidation slows Curli Amyloid-Protein Aggregation.
Biochemistry. (2017) (Abstract)

Shu, Q., Krezel, A.M., Cusumano, Z.T., Pinkner, J.S., Klein, R., Hultgren, S.J. and Frieden, C.
Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.
Proc Natl Acad Sci USA 113:7130-7135 (2016) (Abstract)

Mondal, T., Wang, H., DeKoster, G.T., Baban, B., Gross, M.L. and Frieden, C.
ApoE: In Vitro Studies of a Small Molecule Effector.
Biochemistry 55:2613-2621 (2016). (Abstract)

Wang, H., Shu, Q., Rempel, D.L., Frieden, C. and Gross, M.L.
Continuous and pulsed hydrogen-deuterium exchange and mass spectrometry characterize CsgE oligomerization.
Biochemistry 54:6475-6481 (2015). (Abstract)

Frieden, C.
ApoE: the role of conserved residues in defining function.
Protein Sci 24:138-144 (2015). (Abstract)

Garai, K., Verghese, P.B., Baban, B., Holtzman, D.M. and Frieden, C.
The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation.
Biochemistry 53:6323-6331 (2014). (Abstract)

Hammes, G. and Frieden, C.
Robert A. Alberty“.
Biographical Memoirs Natl Acad of Sci. (2014). (Abstract)