Roberto Galletto, Ph.D.

Roberto Galletto
Associate Professor

Biochemistry and Molecular Biophysics

Graduate Programs (DBBS)
Publications (PubMed / NIH)

Office: 2808 North Building
Phone: 314-362-4368
Email: galletto@wustl.edu
 

Research

Mechanistic studies of DNA motor proteins.

Galletto lab research

Select Publications

Singh S.P., Kukshal V., & Galletto R. (2019). “A stable tetramer is not the only oligomeric state that mitochondrial single-stranded DNA binding proteins can adopt.” J Biol Chem. 2019 Mar 15;294(11):4137-4144. doi: 10.1074/jbc.RA118.007048. Epub 2019 Jan 7. (Abstract)

Andrea Soranno, Jeremias Incicco, Paolo De Bona, Eric Tomko, Eric Galburt, & Roberto Galletto. (2019). “Shelterin Components Modulate the Phase-Separation Propensity of Telomeres” Biophysical Journal. Volume 116, Issue 3, Supplement 1, 15 February 2019, Pages 467a-468a. (Abstract)

Mondol T., Stodola J.L., Galletto R., & Burgers P.M. (2019). “PCNA accelerates the nucleotide incorporation rate by DNA polymerase δ.” Nucleic Acids Res. 2019 Jan 3. doi: 10.1093/nar/gky1321. [Epub ahead of print] (Abstract)

Dahan D., Tsirkas I., Dovrat D., Sparks M.A., Singh S.P., Galletto R., & Aharoni A. (2018). “Pif1 is essential for efficient replisome progression through lagging strand G-quadruplex DNA secondary structures.” Nucleic Acids Res. 2018 Dec 14;46(22):11847-11857. doi: 10.1093/nar/gky1065. (Abstract)

Geronimo C.L., Singh S.P., Galletto R., & Zakian V.A. (2018). “The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity.” Nucleic Acids Res. 2018 Sep 19;46(16):8357-8370. doi: 10.1093/nar/gky655. (Abstract)

Singh S.P., Kukshal V., De Bona P., Antony E., & Galletto R. (2018). “The mitochondrial single-stranded DNA binding protein from S. cerevisiae, Rim1, does not form stable homo-tetramers and binds DNA as a dimer of dimers.” Nucleic Acids Res. 2018 Aug 21;46(14):7193-7205. doi: 10.1093/nar/gky530. (Abstract)

Sokoloski J.E., Kozlov A.G., Galletto R., & Lohman T.M. (2016). “Chemo-mechanical pushing of proteins along single-stranded DNA.” Proc Natl Acad Sci U S A. 2016 May 31;113(22):6194-9. doi: 10.1073/pnas.1602878113. Epub 2016 May 16. (Abstract)

Koc K.N., Singh S.P., Stodola J.L., Burgers P.M., & Galletto R. (2016). “Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ.” Nucleic Acids Res. 2016 May 5;44(8):3811-9. doi: 10.1093/nar/gkw181. Epub 2016 Mar 21. (Abstract)

Singh, S.P., Koc, K.N., Stodola, J.L. and Galletto, R.
A Monomer of Pif1 Unwinds Double-Stranded DNA and It Is Regulated by the Nature of the Non-Translocating Strand at the 3′-End.
J Mol Biol 428:1053-1067 (2016). (Abstract)

Feldmann, E.A., De Bona, P. and Galletto, R.
The wrapping loop and Rap1 C-terminal (RCT) domain of yeast Rap1 modulate access to different DNA binding modes.
Journal of Biological Chemistry 290:11455-11466 (2015). (Abstract)

Koc, K.N., Stodola, J.L, Burgers, P.M. and Galletto, R.
Regulation of yeast DNA polymerase δ-mediated strand displacement synthesis by 5′-flaps.
Nucleic Acid Research 43:4179-4190. (2015). (Abstract)

Koc, K.N., Stodola, J.L., Burgers, P.M., and Galletto, R.
Regulation of yeast DNA polymerase δ-mediated strand displacement synthesis by 5′-flaps.
Nucleic Acid Research 43:4179-4190 (2015). (Abstract)

Feldmann, E.A., Koc, K.N. and Galletto, R.
Alternative arrangements of telomeric recognition sites regulate the binding mode of the DNA-binding domain of yeast Rap1.
Biophysical Chemistry 198:1-8 (2015). (Abstract)

Feldmann, E.A. and Galletto, R.
The DNA-binding domain of yeast Rap1 interacts with double-stranded DNA in multiple binding modes.
Biochemistry 33:7471-7483 (2014). (Abstract)

Nguyen B., Sokoloski J.E., Galletto R., Elson E.L., Wold M.S., & Lohman T.M. (2014). “Diffusion of human replication protein A along single-stranded DNA.” J Mol Biol. 2014 Sep 23;426(19):3246-3261. doi: 10.1016/j.jmb.2014.07.014. Epub 2014 Jul 22. (Abstract)