Kathleen Hall, Ph. D.

Kathleen Hall
Professor

Biochemistry and Molecular Biophysics

Lab Website
Graduate Programs (DBBS)
Publications (PubMed / NIH)

Office: 2816 North Building
Phone: 314-362-4196
Email: hallkathleen@wustl.edu
 

Research

We study RNA molecules and their interactions with protein partners in order to understand their biology. We use biochemistry, molecular biology, and molecular biophysics to understand the properties of these molecules.

Kathleen Hall's research

Select Publications

Welty R., Pabit S.A., Katz A.M., Calvey G.D., Pollack L., & Hall K.B. (2018). “Divalent ions tune the kinetics of a bacterial GTPase Center rRNA folding transition from secondary to tertiary structure.” RNA. 2018 Dec;24(12):1828-1838. doi: 10.1261/rna.068361.118. Epub 2018 Sep 25. (Abstract)

Weber G., DeKoster G.T., Holton N., Hall K.B., & Wahl M.C. (2018). “Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.” Nat Commun. 2018 Jun 7;9(1):2220. doi: 10.1038/s41467-018-04561-6. (Abstract)

Hayatshahi H.S., Roe D.R., Galindo-Murillo R., Hall K.B., & Cheatham T.E. 3rd (2017). “Computational Assessment of Potassium and Magnesium Ion Binding to a Buried Pocket in the GTPase-Associating Center RNA.” J Phys Chem B. 2017 Jan 26;121(3):451-462. doi: 10.1021/acs.jpcb.6b08764. Epub 2017 Jan 17. (Abstract)

Welty R. & Hall K.B. (2016). “Nucleobases Undergo Dynamic Rearrangements during RNA Tertiary Folding.” J Mol Biol. 2016 Nov 6;428(22):4490-4502. doi: 10.1016/j.jmb.2016.09.015. Epub 2016 Sep 29. (Abstract)

Bergonzo C., Hall K.B, & Cheatham T.E. (2016). “Divalent Ion Dependent Conformational Changes in an RNA Stem-Loop Observed by Molecular Dynamics.” J Chem Theory Comput. 2016 Jul 12;12(7):3382-9. doi: 10.1021/acs.jctc.6b00173. Epub 2016 Jun 28. (Abstract)

Bergonzo C., Hall K.B., & Cheatham T.E. 3rd. (2015). “Stem-Loop V of Varkud Satellite RNA Exhibits Characteristics of the Mg(2+) Bound Structure in the Presence of Monovalent Ions.” J Phys Chem B. 2015 Sep 24;119(38):12355-64. doi: 10.1021/acs.jpcb.5b05190. Epub 2015 Sep 14. (Abstract)

Rau M.J., Welty R., Stump T.W., & Hall K.B. (2015). “Formation of Tertiary Interactions during rRNA GTPase Center Folding.” J Mol Biol. 2015 Aug 28;427(17):2799-815. doi: 10.1016/j.jmb.2015.07.013. Epub 2015 Jul 22. (Abstract)

Hall K.B. (2015). “Mighty tiny.” RNA. 2015 Apr;21(4):630-1. doi: 10.1261/rna.050567.115. (Abstract)

Melnykov A.V., Nayak R.K., Hall K.B., & Van Orden A. (2015). “Effect of loop composition on the stability and folding kinetics of RNA hairpins with large loops.” Biochemistry. 2015 Mar 17;54(10):1886-96. doi: 10.1021/bi5014276. Epub 2015 Mar 4. (Abstract)

Rau M.J. & Hall K.B. (2015). “2-Aminopurine Fluorescence as a Probe of Local RNA Structure and Dynamics and Global Folding.” Methods Enzymol. 2015;558:99-124. doi: 10.1016/bs.mie.2015.01.006. Epub 2015 Mar 3. (Abstract)

DeKoster G.T., Delaney K.J., & Hall K.B. (2014). “A compare-and-contrast NMR dynamics study of two related RRMs: U1A and SNF.” Biophys J. 2014 Jul 1;107(1):208-19. doi: 10.1016/j.bpj.2014.05.026. (Abstract)

Williams S.G. & Hall K.B. (2014). “Binding affinity and cooperativity control U2B″/snRNA/U2A’ RNP formation.” Biochemistry. 2014 Jun 17;53(23):3727-37. doi: 10.1021/bi500438e. Epub 2014 Jun 5. (Abstract)

Williams S.G. & Hall K.B. (2014). “Linkage and allostery in snRNP protein/RNA complexes.” Biochemistry. 2014 Jun 10;53(22):3529-39. doi: 10.1021/bi500192a. Epub 2014 May 29. (Abstract)

Delaney K.J., Williams S.G., Lawler M., & Hall K.B. (2014). “Climbing the vertebrate branch of U1A/U2B″ protein evolution.” RNA. 2014 Jul;20(7):1035-45. doi: 10.1261/rna.044255.114. Epub 2014 May 19. (Abstract)

Hall K.B. (2014). “Molecular biology: Protein binding cannot subdue a lively RNA.” Nature. 2014 Feb 20;506(7488):303-4. doi: 10.1038/nature13055. Epub 2014 Feb 12. (Abstract)