Maxene Ilagan

Maxene Ilagan
Director HTS Core, Biology Director Center for Drug Discovery

Lab Website
Publications (PubMed / NIH)

Office: 2603 Cancer Research Building
Phone: 314-362-4445
Email: ilaganmg@wustl.edu
 

Select Publications

Whitney R Grither, Breanna Baker, Vasilios A Morikis, Ma Xenia G Ilagan, Katherine C Fuh, & Gregory D Longmore (2024). “ROR2/Wnt5a Signaling Regulates Directional Cell Migration and Early Tumor Cell Invasion in Ovarian Cancer” Mol Cancer Res. 2024 May 2;22(5):495-507. doi: 10.1158/1541-7786.MCR-23-0616. (Abstract)

Sofia V Salvatore, Ma Xenia G Ilagan, Hongjin Shu, Peter M Lambert, Ann Benz, Mingxing Qian, Douglas F Covey, Charles F Zorumski, & Steven Mennerick (2024). “Neuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model” Sci Rep. 2024 Jan 10;14(1):1042. doi: 10.1038/s41598-024-51582-x. (Abstract)

James Brett Case, Paul W Rothlauf, Rita E Chen, Zhuoming Liu, Haiyan Zhao, Arthur S Kim, Louis-Marie Bloyet, Qiru Zeng, Stephen Tahan, Lindsay Droit, Ma Xenia G Ilagan, Michael A Tartell, Gaya Amarasinghe, Jeffrey P Henderson, Shane Miersch, Mart Ustav, Sachdev Sidhu, Herbert W Virgin, David Wang, Siyuan Ding, Davide Corti, Elitza S Theel, Daved H Fremont, Michael S Diamond, & Sean P J Whelan (2020). “Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2” bioRxiv. 2020 May 18;2020.05.18.102038. doi: 10.1101/2020.05.18.102038. Preprint (Abstract)

Maybruck B.T., Lam W.C., Specht C.A., Ilagan M.X.G., Donlin M.J., & Lodge J.K. (2019). “The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans.” mBio. 2019 Dec 17;10(6). pii: e02264-19. doi: 10.1128/mBio.02264-19. (Abstract)

Boyle, S., D’Eustachio, P., Egan, S.E., Haw, R., Ilagan, M.X.G., Jassal, B., Joutel, A., & Orlic-Milacic, M. (2019). “Signaling by NOTCH” Reactome. R-HSA-157118 (Abstract)

Heitmeier M.R., Hresko R.C., Edwards R.L., Prinsen M.J., Ilagan M.X.G., Odom John A.R, & Hruz P.W. (2019). “Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.” PLoS One. 2019 May 9;14(5):e0216457. doi: 10.1371/journal.pone.0216457. eCollection 2019. (Abstract)

Liu G., Nash P.J., Johnson B., Pietzsch C., Ilagan M.X., Bukreyev A., Basler C.F., Bowlin T.L., Moir D.T., Leung D.W., & Amarasinghe G.K. (2017). “A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.” ACS Infect Dis. 2017 Mar 10;3(3):190-198. doi: 10.1021/acsinfecdis.6b00209. Epub 2017 Feb 9. (Abstract)

Kraft T.E., Heitmeier M.R., Putanko M., Edwards R.L., Ilagan M.X., Payne M.A., Autry J.M., Thomas D.D., Odom A.R., and Hruz P.W. (2016) “A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters.” Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. Print 2016 Dec. (Abstract)

Thomas J.J., Abed M., Heuberger J., Novak R., Zohar Y., Beltran Lopez A.P., Trausch-Azar J.S., Ilagan M.X., Benhamou D., Dittmar G., Kopan R., Birchmeier W., Schwartz A.L., and Orian A. (2016) “RNF4-Dependent Oncogene Activation by Protein Stabilization.” Cell Rep. 2016 Sep 20;16(12):3388-3400. doi: 10.1016/j.celrep.2016.08.024. (Abstract)

Ilagan M.X. and Kopan R. (2014) “Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays.” Methods Mol Biol. 2014;1187:155-68. doi: 10.1007/978-1-4939-1139-4_12. (Abstract)

Yang K.S., Ilagan M.X., Pinica-Worms D. and Pike L.J. (2009) “Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor.” J Biol Chem. 2009 Mar 20;284(12):7474-82. doi: 10.1074/jbc.M808041200. Epub 2009 Jan 26. (Abstract)