Alexander Kozlov

Alexander Kozlov
Research Instructor

Biochemistry and Molecular Biophysics

Lab Website

Room: 2803 North Building
Phone: 314-362-4394
Email: kozlov@wustl.edu
 

Select Publications

Dubiel K., Myers A.R., Kozlov A.G., Yang O., Zhang J., Ha T., Lohman T.M., & Keck J.L. (2018). “Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins.” J Mol Biol. 2018 Nov 22. pii: S0022-2836(18)31046-5. doi: 10.1016/j.jmb.2018.11.019. [Epub ahead of print] (Abstract)

Johnson B., McConnell P., Kozlov A.G., Mekel M., Lohman T.M., Gross M.L., Amarasinghe G.K., & Cooper J.A. (2018). “Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.” Cell Rep. 2018 May 29;23(9):2795-2804. doi: 10.1016/j.celrep.2018.04.096. (Abstract)

Min Kyung Shinn, Alexander G. Kozlov, & Timothy M. Lohman (2018). “Allosteric Effect of E. coli SSB C-Terminal Tails on RecOR Binding to DNA” Biophysical Journal, Volume 114, Issue 3, Supplement 1, 2 February 2018, Page 441a (Abstract)

Kozlov A.G., Shinn M.K., Weiland E.A., & Lohman T.M. (2017). “Glutamate promotes SSB protein-protein Interactions via intrinsically disordered regions.” J Mol Biol. 2017 Sep 1;429(18):2790-2801. doi: 10.1016/j.jmb.2017.07.021. Epub 2017 Aug 3. (Abstract)

Waldman V.M., Weiland E., Kozlov A.G., & Lohman T.M. (2016). “Is a fully wrapped SSB-DNA complex essential for Escherichia coli survival?” Nucleic Acids Res. 2016 May 19;44(9):4317-29. doi: 10.1093/nar/gkw262. Epub 2016 Apr 15. (Abstract)

Sokoloski J.E., Kozlov A.G., Galletto R., & Lohman T.M. (2016). “Chemo-mechanical pushing of proteins along single-stranded DNA.” Proc Natl Acad Sci U S A. 2016 May 31;113(22):6194-9. doi: 10.1073/pnas.1602878113. Epub 2016 May 16. (Abstract)

Suksombat S., Khafizov R., Kozlov A.G., Lohman T.M., & Chemla Y.R. (2015). “Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways.” Elife. 2015 Aug 25;4. doi: 10.7554/eLife.08193. (Abstract)

Kozlov A.G., Weiland E., Mittal A., Waldman V., Antony E., Fazio N., Pappu R.V., & Lohman T.M. (2015). “Intrinsically disordered C-terminal tails of E. coli single-stranded DNA binding protein regulate cooperative binding to single-stranded DNA.” J Mol Biol. 2015 Feb 27;427(4):763-74. doi: 10.1016/j.jmb.2014.12.020. Epub 2015 Jan 3. (Abstract)

Lee K.S., Marciel A.B., Kozlov A.G., Schroeder C.M., Lohman T.M., & Ha T. (2014). “Ultrafast redistribution of E. coli SSB along long single-stranded DNA via intersegment transfer.” J Mol Biol. 2014 Jun 26;426(13):2413-21. doi: 10.1016/j.jmb.2014.04.023. Epub 2014 May 2. (Abstract)

Antony E., Weiland E., Yuan Q., Manhart C.M., Nguyen B., Kozlov A.G., McHenry C.S., & Lohman T.M. (2013). “Multiple C-terminal tails within a single E. coli SSB homotetramer coordinate DNA replication and repair.” J Mol Biol. 2013 Nov 29;425(23):4802-19. doi: 10.1016/j.jmb.2013.08.021. Epub 2013 Sep 7. (Abstract)

Kozlov A.G., Galletto R., & Lohman T.M. (2012). “SSB-DNA binding monitored by fluorescence intensity and anisotropy.” Methods Mol Biol. 2012;922:55-83. doi: 10.1007/978-1-62703-032-8_4. (Abstract)

Kozlov A.G. & Lohman T.M. (2012). “SSB binding to ssDNA using isothermal titration calorimetry.” Methods Mol Biol. 2012;922:37-54. doi: 10.1007/978-1-62703-032-8_3. (Abstract)

Antony E., Kozlov A.G., Nguyen B., & Lohman T.M. (2012). “Plasmodium falciparum SSB tetramer binds single-stranded DNA only in a fully wrapped mode.” J Mol Biol. 2012 Jul 20;420(4-5):284-95. doi: 10.1016/j.jmb.2012.04.022. Epub 2012 Apr 26. (Abstract)

Ha T., Kozlov A.G., & Lohman T.M. (2012). “Single-molecule views of protein movement on single-stranded DNA.” Annu Rev Biophys. 2012;41:295-319. doi: 10.1146/annurev-biophys-042910-155351. Epub 2012 Feb 23. (Abstract)

Zhou R., Kozlov A.G., Roy R., Zhang J., Korolev S., Lohman T.M., & Ha T. (2011). “SSB functions as a sliding platform that migrates on DNA via reptation.” Cell. 2011 Jul 22;146(2):222-32. doi: 10.1016/j.cell.2011.06.036. (Abstract)