F. Scott Mathews, Ph.D.

Scott Mathews
Professor Emeritus

Biochemistry and Molecular Biophysics

Publications (PubMed / NIH)

Office: 2617 Cancer Research Building

Email: mathews22@wustl.edu



X-ray structure and analysis of macromolecules

Select Publications

Sukumar N., Liu S., Li W., Mathews F.S., Mitra B., & Kandavelu P. (2018). “Structure of the monotopic membrane protein (S)-mandelate dehydrogenase at 2.2Å resolution.” Biochimie. 2018 Jul 30. pii: S0300-9084(18)30212-8. doi: 10.1016/j.biochi.2018.07.017. (Abstract)

Chen Z.W., Vignaud C., Jaafar A., Levy B., Gueritte F., Guenard D., Lederer F., & Mathews F.S. (2012). “High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.” Biochimie. 2012 May;94(5):1172-9. doi: 10.1016/j.biochi.2012.02.003. Epub 2012 Feb 9. (Abstract)

Kommoju P.R., Chen Z.W., Bruckner R.C., Mathews F.S., & Jorns, M.S. (2011). “Probing oxygen activation sites in two flavoprotein oxidases using chloride as an oxygen surrogate.” Biochemistry. 2011 Jun 21;50(24):5521-34. doi: 10.1021/bi200388g. Epub 2011 May 26. (Abstract)

Li J., Gan J.H., Mathews F.S., & Xia Z.X. (2011). “The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase.” Biochem Biophys Res Commun. 2011 Mar 25;406(4):621-6. doi: 10.1016/j.bbrc.2011.02.107. Epub 2011 Feb 26. (Abstract)

Choi M., Sukumar N., Mathews F.S., Liu A., & Davidson V.L. (2011). “Proline 96 of the copper ligand loop of amicyanin regulates electron transfer from methylamine dehydrogenase by positioning other residues at the protein-protein interface.” Biochemistry. 2011 Feb 22;50(7):1265-73. doi: 10.1021/bi101794y. Epub 2011 Jan 26. (Abstract)

Niu W., Shu, Q., Chen Z., Mathews F.S., Di Cera E., & Frieden C. (2010). “The role of Zn2+ on the structure and stability of murine adenosine deaminase.” J Phys Chem B. 2010 Dec 16;114(49):16156-65. doi: 10.1021/jp106041v. Epub 2010 Sep 3. (Abstract)

Chen Z., Datta S., Dubois J.L., Klinman J.P., & Mathews F.S. (2010). “Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.” Biochemistry. 2010 Aug 31;49(34):7393-402. doi: 10.1021/bi100643y. (Abstract)

Jorns M.S., Chen Z.W., & Mathews F.S. (2010). “Structural characterization of mutations at the oxygen activation site in monomeric sarcosine oxidase.” Biochemistry. 2010 May 4;49(17):3631-9. doi: 10.1021/bi100160j. (Abstract)

Sukumar N., Mathews F.S., Langan P., & Davidson V.L. (2010). “A joint x-ray and neutron study on amicyanin reveals the role of protein dynamics in electron transfer.” Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6817-22. doi: 10.1073/pnas.0912672107. Epub 2010 Mar 29. (Abstract)

Sukumar N., Mathews F.S., Gordon M.M., Ealik S.E., & Alpers D.H. (2009). “Postcrystallization Analysis of the Irreproducibility of the Human Intrinsic Factor-Cobalamin Complex Crystals.” Cryst Growth Des. 2009;9(1):348-351. (Abstract)

Kommoju P.R., Bruckner R.C., Ferreira P., Carrell C.J., Mathews F.S., & Jorns M.S. (2009). “Factors that affect oxygen activation and coupling of the two redox cycles in the aromatization reaction catalyzed by NikD, an unusual amino acid oxidase.” Biochemistry. 2009 Oct 13;48(40):9542-55. doi: 10.1021/bi901056a. (Abstract)

Sukumar N., Dewanti A., Merli A., Rossi G.L., Mitra B., & Mathews F.S. (2009). “Structures of the G81A mutant form of the active chimera of (S)-mandelate dehydrogenase and its complex with two of its substrates.” Acta Crystallogr D Biol Crystallogr. 2009 Jun;65(Pt 6):543-52. doi: 10.1107/S0907444909010270. Epub 2009 May 15. (Abstract)

Sukumar N., Chen Z.W., Ferrari D., Merli A., Rossi G.L., Bellamy H.D., Chistoserdov A., Davidson V.L., & Mathews F.S. (2006). “Crystal structure of an electron transfer complex between aromatic amine dehydrogenase and azurin from Alcaligenes faecalis.” Biochemistry. 2006 Nov 14;45(45):13500-10. (Abstract)

Pineda A.O., Chen Z.W., Bah A., Garvey L.C., Mathews F.S., & Di Cera E (2006). “Crystal structure of thrombin in a self-inhibited conformation.” J Biol Chem. 2006 Oct 27;281(43):32922-8. Epub 2006 Sep 5. (Abstract)

Hynson R.M., Mathews F.S., & Schuman Jorns M. (2006). “Identification of a stable flavin-thiolate adduct in heterotetrameric sarcosine oxidase.” J Mol Biol. 2006 Sep 29;362(4):656-63. Epub 2006 Jul 29. (Abstract)