Biochemistry and Molecular Biophysics
E-mail: mdonken@wustl.edu
Select Publications
Michael D. Onken, Carol M. Makepeace, Kevin M. Kaltenbronn, Joelle Choi, Leonel Hernandez-Aya, Katherine N. Weilbaecher, Kisha D. Piggott, P. Kumar Rao, Carla M. Yuede, Alethia J. Dixon, Patrick Osei-Owusu, John A. Cooper, & Kendall J. Blumer (2021). “Targeting primary and metastatic uveal melanoma with a G protein inhibitor” J Biol Chem. 2021 Feb 9;100403. doi: 10.1016/j.jbc.2021.100403. Online ahead of print. (Abstract)
Michael D. Onken, Kendall J. Blumer, & John A. Cooper (2021). “Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium” Mol Biol Cell. 2021 Jan 6;mbcE20040241. doi: 10.1091/mbc.E20-04-0241. Online ahead of print. (Abstract)
Yen M., Qi Z., Chen X., Cooper J.A., Mitra R.D., & Onken M.D. (2018). “Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma.” BMC Med Genomics. 2018 Nov 6;11(1):97. doi: 10.1186/s12920-018-0424-0. (Abstract)
Onken M.D., Makepeace C.M., Kaltenbronn K.M., Kanai S.M., Todd T.D., Wang S., Broekelmann T.J., Rao P.K., Cooper J.A., & Blumer K.J. (2018). “Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells.” Sci Signal. 2018 Sep 4;11(546). pii: eaao6852. doi: 10.1126/scisignal.aao6852. (Abstract)
Michael D. Onken, Carol M. Makepeace, Shiqi Wang, Kevin M. Kaltenbronn, Stanley M. Kanai, Tom J. Broekelmann, John A. Cooper, & Kendall J. Blumer (2018). “Pharmacologic targeting of Gq reveals new pathways in uveal melanoma” AACR, July 2018, Volume 78, Issue 13 Supplement (Abstract)
Stewart-Hutchinson P.J., Szasz T.P., Jaeger E.R., Onken M.D., Cooper J.A., & Morley S.C. (2017). “Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate.” J Leukoc Biol. 2017 Sep;102(3):941-948. doi: 10.1189/jlb.1TA0117-008R. Epub 2017 Jun 21. (Abstract)
Santiago-Tirado F.H., Onken M.D., Cooper J.A., Klein R.S., & Doering T.L. (2017). “Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.” MBio. 2017 Jan 31;8(1). pii: e02183-16. doi: 10.1128/mBio.02183-16. (Abstract)
Zhou J.Y., Szasz T.P., Stewart-Hutchinson P.J., Sivapalan J., Todd E.M., Deady L.E., Cooper J.A., Onken M.D., & Morley S.C. (2016). “L-Plastin promotes podosome longevity and supports macrophage motility.” Mol Immunol. 2016 Oct;78:79-88. doi: 10.1016/j.molimm.2016.08.012. Epub 2016 Sep 7. (Abstract)