Linda J. Pike, Ph.D.

Jennifer L Macdonald-Obermann & Linda J Pike (2024). “Extracellular domain mutations of the EGF receptor differentially modulate high-affinity and low-affinity responses to EGF receptor ligands” J Biol Chem. 2024 Mar;300(3):105763. doi: 10.1016/j.jbc.2024.105763. Epub 2024 Feb 16. (Abstract)

Macdonald-Obermann J.L. & Pike L.J. (2018). “Allosteric regulation of epidermal growth factor (EGF) receptor ligand binding by tyrosine kinase inhibitors.” J Biol Chem. 2018 Aug 31;293(35):13401-13414. doi: 10.1074/jbc.RA118.004139. (Abstract)

Gill K., Macdonald-Obermann J.L., & Pike L.J. (2017). “Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent.” J Biol Chem. 2017 Dec 15;292(50):20744-20755. doi: 10.1074/jbc.M117.802553. Epub 2017 Oct 26. (Abstract)

Needham S.R., Roberts S.K., Arkhipov A., Mysore V.P., Tynan C.J., Zanetti-Domingues L.C., Kim E.T., Losasso V., Korovesis D., Hirsch M., Rolfe D.J., Clarke D.T., Winn M.D., Lajevardipour A., Clayton A.H., Pike L.J., Perani M., Parker P.J., Shan Y., Shaw D.E., & Martin-Fernandez M.L. (2016). “EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.” Nat Commun. 2016 Oct 31;7:13307. doi: 10.1038/ncomms13307. (Abstract)

Ronan T., Macdonald-Obermann J.L., Huelsmann L., Bessman N.J., Naegle K.M., & Pike L.J. (2016). “Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins.” J Biol Chem. 2016 Mar 11;291(11):5528-40. doi: 10.1074/jbc.M115.710087. Epub 2016 Jan 19. (Abstract)

Macdonald-Obermann J.L. & Pike L.J. (2014). “Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.” J Biol Chem. 2014 Sep 19;289(38):26178-88. doi: 10.1074/jbc.M114.586826. Epub 2014 Aug 1. (Abstract)

Macdonald-Obermann J.L., Adak S., Landgraf R., Piwnica-Worms D., & Pike L.J. (2013). “Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging.” J Biol Chem. 2013 Oct 18;288(42):30773-84. doi: 10.1074/jbc.M113.489534. Epub 2013 Sep 6. (Abstract)

Li Y., Macdonald-Obermann J., Westfall C., Piwnica-Worms D., & Pike L.J. (2012). “Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.” J Biol Chem. 2012 Sep 7;287(37):31116-25. doi: 10.1074/jbc.M112.373647. Epub 2012 Jul 20. (Abstract)

Pike L.J. (2012). “Negative co-operativity in the EGF receptor.” Biochem Soc Trans. 2012 Feb;40(1):15-9. doi: 10.1042/BST20110610. (Abstract)

Macdonald-Obermann J.L, Piwnica-Worms D., & Pike L.J. (2012). “Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging.” Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):137-42. doi: 10.1073/pnas.1111316109. Epub 2011 Dec 21. (Abstract)

Adak S., Yang K.S., Macdonald-Obermann J., & Pike L.J. (2011). “The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding.” J Biol Chem. 2011 Dec 30;286(52):45146-55. doi: 10.1074/jbc.M111.274175. Epub 2011 Nov 8. (Abstract)

Adak S., Deandrade D., & Pike L.J. (2012). “The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.” J Biol Chem. 2011 Jan 14;286(2):1545-55. doi: 10.1074/jbc.M110.182899. Epub 2010 Nov 3. (Abstract)

Yang K.S., Macdonald-Obermann J., Piwnica-Worms D., & Pike L.J. (2010). “Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.” J Biol Chem. 2010 Jul 30;285(31):24014-22. doi: 10.1074/jbc.M110.103317. Epub 2010 May 27. (Abstract)

Yang R.Y., Yang K.S., Pike L.J., and Marshall G.R. (2010) “Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors.” Chem Biol Drug Des. 2010 Jul;76(1):1-9. doi: 10.1111/j.1747-0285.2010.00986.x. Epub 2010 May 4. (Abstract)

Macdonald-Obermann J.L. & Pike L.J. (2009). “The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding.” J Biol Chem. 2009 May 15;284(20):13570-6. doi: 10.1074/jbc.M109.001487. Epub 2009 Mar 31. (Abstract)