Recent Publications

Publications by faculty, post-doctoral associates, students, and staff of Biochemistry and Molecular Biophysics.

More can be found in the Archives.

Johnson B., McConnell P., Kozlov A.G., Mekel M., Lohman T.M., Gross M.L., Amarasinghe G.K., & Cooper J.A. (2018). “Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.” Cell Rep. 2018 May 29;23(9):2795-2804. doi: 10.1016/j.celrep.2018.04.096. (Abstract)

Tyagi R., Maddirala A.R., Elfawal M., Fischer C., Bulman C.A., Rosa B.A., Gao X., Chugani R., Zhou M., Helander J., Brindley P.J., Tseng C.C., Greig I.R., Sakanari J., Wildman S.A., Aroian R., Janetka J.W., & Mitreva M. (2018). “Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics.” ACS Infect Dis. 2018 May 14. doi: 10.1021/acsinfecdis.8b00090. (Abstract)

Kinch M.S. & Griesenauer R.H. (2018). “2017 in review: FDA approvals of new molecular entities.” Drug Discov Today. 2018 May 8. pii: S1359-6446(18)30088-6. doi: 10.1016/j.drudis.2018.05.011. (Abstract)

Prusa J., Jensen D., Santiago-Collazo G., Pope S.S., Garner A.L., Miller J.J., Ruiz Manzano A., Galburt E.A., & Stallings C.L. (2018). “Domains within RbpA serve specific functional roles that regulate the expression of distinct mycobacterial gene subsets.” J Bacteriol. 2018 Apr 23. pii: JB.00690-17. doi: 10.1128/JB.00690-17. (Abstract)

Rocha A.G., Franco A., Krezel A.M., Rumsey J.M., Alberti J.M., Knight W.C., Biris N., Zacharioudakis E., Janetka J.W., Baloh R.H., Kitsis R.N., Mochly-Rosen D., Townsend R.R., Gavathiotis E., & Dorn G.W. 2nd (2018). “MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.” Science. 2018 Apr 20;360(6386):336-341. doi: 10.1126/science.aao1785. (Abstract)

Bodmer N.K. & Havranek J.J. (2018). “Efficient minimization of multipole electrostatic potentials in torsion space.” PLoS One. 2018 Apr 11;13(4):e0195578. doi: 10.1371/journal.pone.0195578. eCollection 2018. (Abstract)

Lohman T.M. & Fazio N.T. (2018) “How Does a Helicase Unwind DNA? Insights from RecBCD Helicase.” Bioessays. 2018 Mar 30. doi: 10.1002/bies.201800009. [Epub ahead of print] (Abstract)

Antony E. & Lohman T.M. (2018) “Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexes.” Semin Cell Dev Biol. 2018 Mar 30. pii: S1084-9521(17)30432-9. doi: 10.1016/j.semcdb.2018.03.017. [Epub ahead of print] (Abstract)

Soranno A., Zosel F., & Hofmann H. (2018). “Internal friction in an intrinsically disordered protein-Comparing Rouse-like models with experiments.” J Chem Phys. 2018 Mar 28;148(12):123326. doi: 10.1063/1.5009286. (Abstract)

Kalas V., Hibbing M.E., Maddirala A.R., Chugani R., Pinkner J.S., Mydock-McGrane L.K., Conover M.S., Janetka J.W., & Hultgren S.J. (2018). “Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.” Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 201720140. doi: 10.1073/pnas.1720140115. (Abstract)

James W. Janetka & Roseann M. Benson (2018). “Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways” ISBN-13: 978-1119300182, ISBN-10: 1119300185 (Publisher)

Borgia A., Borgia M.B., Bugge K., Kissling V.M., Heidarsson P.O., Fernandes C.B., Sottini A., Soranno A., Buholzer K.J., Nettels D., Kragelund B.B., Best R.B., & Schuler B. (2018). “Extreme disorder in an ultrahigh-affinity protein complex.” Nature. 2018 Mar 1;555(7694):61-66. doi: 10.1038/nature25762. Epub 2018 Feb 21. (Abstract)

Spaulding C.N., Klein R.D., Schreiber H.L. 4th, Janetka J.W., & Hultgren S.J. (2018). “Precision antimicrobial therapeutics: the path of least resistance?” NPJ Biofilms Microbiomes. 2018 Feb 27;4:4. doi: 10.1038/s41522-018-0048-3. eCollection 2018. (Abstract)

Su Z., Wu C., Shi L., Luthra P., Pintilie G.D., Johnson B., Porter J.R., Ge P., Chen M., Liu G., Frederick T.E., Binning J.M., Bowman G.R., Zhou Z.H., Basler C.F., Gross M.L., Leung D.W., Chiu W., & Amarasinghe G.K. (2018). “Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.” Cell. 2018 Feb 22;172(5):966-978.e12. doi: 10.1016/j.cell.2018.02.009. (Abstract)

Reddy D.N., Singh S., Ho C.M.W., Patel J., Schlesinger P., Rodgers S., Doctor A., & Marshall G.R. (2018). “Design, synthesis, and biological evaluation of stable β6.3-Helices: Discovery of non-hemolytic antibacterial peptides.” Eur J Med Chem. 2018 Apr 10;149:193-210. doi: 10.1016/j.ejmech.2018.02.057. Epub 2018 Feb 20. (Abstract)

Lobysheva E., Taylor C.M., Marshall G.R., & Kisselev O.G. (2018). “Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin.” Exp Eye Res. 2018 Feb 16;170:51-57. doi: 10.1016/j.exer.2018.02.015. (Abstract)

Sarah R. Clippinger, Lina Greenberg, & Michael J. Greenberg (2018). “Dissecting the Molecular Mechanism for Familial Cardiomyopathies” Biophysical Journal. Volume 114, Issue 3, Supplement 1, p139a–140a, 2 February 2018. doi: 10.1016/j.bpj.2017.11.787 (Abstract)

Min Kyung Shinn, Alexander G. Kozlov, & Timothy M. Lohman (2018). “Allosteric Effect of E. coli SSB C-Terminal Tails on RecOR Binding to DNA” Biophysical Journal, Volume 114, Issue 3, Supplement 1, Page 441a (Abstract)

Yang B., Vasbinder M., Hird A.W., Su Q., Wang H., Yu Y., Toader D., Lyne P.D., Read J.A., Breed J., Ioannidis S., Deng C., Grondine M., DeGrace N., Whitston D., Brassil P., & Janetka J.W. (2018). “Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.” J Med Chem. doi: 10.1021/acs.jmedchem.7b01490. (Abstract)

Stodola J.L. & Burgers P.M. (2017). “Mechanism of Lagging-Strand DNA Replication in Eukaryotes.” Adv Exp Med Biol. 2017;1042:117-133. doi: 10.1007/978-981-10-6955-0_6. (Abstract)

Michael Kinch (2018). “Between Hope and Fear: A History of Vaccines and Human Immunity” ISBN-13: 978-1681777511, ISBN-10: 1681777517

Bartels P.L., Stodola J.L., Burgers P.M.J., & Barton J.K. (2017). “A Redox Role for the [4Fe4S] Cluster of Yeast DNA Polymerase δ.” J Am Chem Soc. 2017 Dec 20;139(50):18339-18348. doi: 10.1021/jacs.7b10284. Epub 2017 Dec 6. (Abstract)

Shen G., Li S., Cui W., Liu S., Yang Y., Gross M., & Li W. (2017). “Membrane Protein Structure in Live Cells: Methodology for Studying Drug Interaction by Mass Spectrometry-Based Footprinting.” Biochemistry. 2018 Jan 23;57(3):286-294. doi: 10.1021/acs.biochem.7b00874. Epub 2017 Dec 20. (Abstract)

Zimmerman M.I., Hart K.M., Sibbald C.A., Frederick T.E., Jimah J.R., Knoverek C.R., Tolia N.H., & Bowman G.R. (2017). “Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.” ACS Cent Sci. 2017 Dec 27;3(12):1311-1321. doi: 10.1021/acscentsci.7b00465. Epub 2017 Nov 21. (Abstract)

Halstead A.M., Kapadia C.D., Bolzenius J., Chu C.E., Schriefer A., Wartman L.D., Bowman G.R., & Arora V.K. (2017). “Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.” Elife. 2017 Nov 16;6. pii: e30862. doi: 10.7554/eLife.30862. (Abstract)

More can be found in the Archives.