Recent Publications

Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections.

Victoria Banas, Mostafa A Elfawal, Bruce A Rosa, Matthew Mahoney, Jacquelyn Kauffman, Emily Goetz, Paulina Chen, Raffi V Aroian, Makedonka Mitreva, James W Janetka

ACS Infect Dis. 2025 Jan 19. doi: 10.1021/acsinfecdis.4c00864. Online ahead of print.

Das M, Hile SE, Brewster J, Boer JL, Bezalel-Buch R, Guo Q, Yang W, Burgers PM, Eckert KA, Freudenreich CH. “DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion. ” Nucleic Acids Res. 2024 Dec 27:gkae1254. doi: 10.1093/nar/gkae1254. Online ahead of print. PMID: 39727171(Abstract)

Henze E, Ehrlich JJ, Robertson JL, Gelsleichter E, Kawate T. “The C-terminal activating domain promotes pannexin 1 channel opening.” Proc Natl Acad Sci U S A. 2024 Dec 17;121(51):e2411898121. doi: 10.1073/pnas.2411898121. Epub 2024 Dec 13. PMID: 39671183. (Abstract)

Walker EC, Javati S, Todd EM, Matlam JP, Lin X, Bryant M, Krone E, Ramani R, Chandra P, Green TP, Anaya EP, Zhou JY, Alexander KA, Tong RS, Yuasi L, Boluarte S, Yang F, Greenberg L, Nerbonne JM, Greenberg MJ, Clemens RA, Philips JA, Wilson LD, Halabi CM, DeBosch BJ, Blyth CC, Druley TE, Kazura JW, Pomat WS, Morley SC. “Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease.” Nat Immunol. 2024 Dec;25(12):2247-2258. doi: 10.1038/s41590-024-01998-4. Epub 2024 Nov 4. PMID: 39496954 (Abstract)

Ernst M, Mahoney-Kruszka R, Zelt NB, Robertson JL. “A roadmap to cysteine specific labeling of membrane proteins for single-molecule photobleaching studies.” Methods. 2024 Nov 23;234:21-35. doi: 10.1016/j.ymeth.2024.10.013. Epub ahead of print. PMID: 39586432.(Abstract)

Gao M, Chen L, Yang J, Dong S, Cao Q, Cui Z, Dong Y, Liu H, Shen Y, Yang H, Hao Z, Zhang L, Li W, Tie JK, Shen G. “Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B”. Blood Adv. 2024 Aug 13;8(15):3893-3905. doi: 10.1182/bloodadvances.2023012432. PMID: 38820490

Matthew W Mahoney, Jonathan Helander, Anoopjit S Kooner, Mariah Norman, Vishnu C Damalanka, Paolo De Bona, Paulina Kasperkiewicz, Wioletta Rut, Marcin Poreba, Maithri M Kashipathy, Kevin P Battaile, Scott Lovell, Anthony J O’Donoghue, Charles S Craik, Marcin Drag & James W Janetka (2024). “Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin” Protein Sci. 2024 Aug;33(8):e5110. doi: 10.1002/pro.5110. (Abstract)

Michael J Greenberg (2024). “Super Relaxed or Super Stressed: Modeling Length-Dependent Activation in Cardiac Muscle” Biophys J.2024 Jul 26:S0006-3495(24)00492-2. doi: 10.1016/j.bpj.2024.07.033. (Abstract)

Meng Gao, Long Chen, Jinlong Yang, Shixia Dong, Qing Cao, Zihan Cui, Yanyan Dong, Hongli Liu, Yan Shen, Haiping Yang, Zhenyu Hao, Lei Zhang, Weikai Li, Jian-Ke Tie & Guomin Shen (2024). “Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B” Blood Adv.2024 Aug 13;8(15):3893-3905. doi: 10.1182/bloodadvances.2023012432. (Abstract)

Jiyeon Lee, Julie M Dimitry, Jong Hee Song, Minsoo Son, Patrick W Sheehan, Melvin W King, G Travis Tabor, Young Ah Goo, Mitchell A Lazar, Leonard Petrucelli, Erik S Musiek (2023). “Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice” Nat Commun. 2023 Aug 25;14(1):5197. doi: 10.1038/s41467-023-40927-1. (Abstract)

Abhay K Singh, Calvin D Lewis, Cristian A W V Boas, Philipp Diebolder, Prashant N Jethva, Aaron Rhee, Jong Hee Song, Young Ah Goo, Shunqian Li, Michael L Nickels, Yongjian Liu, Buck E Rogers, Vaishali Kapoor & Dennis E Hallahan (2024). “Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library” Clin Cancer Res. 2024 Apr 1;30(7):1293-1306. doi: 10.1158/1078-0432.CCR-23-3647. (Abstract)

Tusar Giri, Susan E Maloney, Saswat Giri, Young Ah Goo, Jong Hee Song, Minsoo Son, Eric Tycksen, Sara B Conyers, Annie Bice, Xia Ge, Joel R Garbow, James D Quirk, Adam Q Bauer & Arvind Palanisamy (2024). “Oxytocin-induced birth causes sex-specific behavioral and brain connectivity changes in developing rat offspring” iScience. 2024 Jan 22;27(2):108960. doi: 10.1016/j.isci.2024.108960. eCollection 2024 Feb 16. (Abstract)

Meaghan S Jankowski, Daniel Griffith, Divya G Shastry, Jacqueline F Pelham, Garrett M Ginell, Joshua Thomas, Pankaj Karande, Alex S Holehouse & Jennifer M Hurley (2024). “Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator” Nat Communn. 2024 Apr 25;15(1):3523. doi: 10.1038/s41467-024-47761-z. (Abstract)

Zongru Li, Qionghua Shen, Emery T Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai & George J Lu (2024). “Phase transition of GvpU regulates gas vesicle clustering in bacteria” Nat Microbiol. 2024 Apr;9(4):1021-1035. doi: 10.1038/s41564-024-01648-3. Epub 2024 Mar 29. (Abstract)

S Sanchez-Martinez, K Nguyen, S Biswas, V Nicholson, A V Romanyuk, J Ramirez, S Kc, A Akter, C Childs, E K Meese, E T Usher, G M Ginell, F Yu, E Gollub, M Malferrari, F Francia, G Venturoli, E W Martin, F Caporaletti, G Giubertoni, S Woutersen, S Sukenik, D N Woolfson, A S Holehouse & T C Boothby (2024). “Labile assembly of a tardigrade protein induces biostasis” Protein Sci.2024 Apr;33(4):e4941. doi: 10.1002/pro.4941. (Abstract)

Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker & Alex S Holehouse (2024). “Direct prediction of intrinsically disordered protein conformational properties from sequence” Nat Methods. 2024 Mar;21(3):465-476. doi: 10.1038/s41592-023-02159-5. Epub 2024 Jan 31. (Abstract)

Sourav Biswas, Edith Gollub, Feng Yu, Garrett Ginell, Alex Holehouse, Shahar Sukenik & Thomas C Boothby 1 (2024). “Helicity of a tardigrade disordered protein contributes to its protective function during desiccation” Protein Sci. 2024 Feb;33(2):e4872. doi: 10.1002/pro.4872. (Abstract)

David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse & Shahar Sukenik (2024). “Structural biases in disordered proteins are prevalent in the cell” Nat Struct Mol Biol. 2024 Feb;31(2):283-292. doi: 10.1038/s41594-023-01148-8. Epub 2024 Jan 4. (Abstract)

Alex S Holehouse & Birthe B Kragelund (2024). “The molecular basis for cellular function of intrinsically disordered protein regions” Nat Rev Mol Cell Biol. 2024 Mar;25(3):187-211. doi: 10.1038/s41580-023-00673-0. Epub 2023 Nov 13. (Abstract)

Priya R Banerjee, Alex S Holehouse, Richard Kriwacki, Paul Robustelli, Hao Jiang, Alexander I Sobolevsky, Jennifer M Hurley & Joshua T Mendell (2024). “Dissecting the biophysics and biology of intrinsically disordered proteins” Trends Biochem Sci. 2024 Feb;49(2):101-104. doi: 10.1016/j.tibs.2023.10.002. Epub 2023 Nov 8. (Abstract)

David Moses, Garrett M Ginell, Alex S Holehouse & Shahar Sukenik (2023). “Intrinsically disordered regions are poised to act as sensors of cellular chemistry” Trends Biochem Sci. 2023 Dec;48(12):1019-1034. doi: 10.1016/j.tibs.2023.08.001. Epub 2023 Aug 31. (Abstract)

Karol Buda, Katerina Cermakova, H Courtney Hodges, Eugenio F Fornasiero, Shahar Sukenik & Alex S Holehouse (2023). “Using graphs and charts in scientific figures” Trends Biochem Sci. 2023 Nov;48(11):913-916. doi: 10.1016/j.tibs.2023.08.011. (Abstract)

Gretchen A Meyer, Jeremie L A Ferey, James A Sanford, Liam S Fitzgerald, Akiva E Greenberg, Kristoffer Svensson, Michael J Greenberg & Simon Schenk (2024). “Insights into posttranslational regulation of skeletal muscle contractile function by the acetyltransferases, p300 and CBP” J Appl Physiol (1985). 2024 Jun 1;136(6):1559-1567. doi: 10.1152/japplphysiol.00156.2024. Epub 2024 May 9. (Abstract)

Venecia Valdez, Meisheng Ma, Bernardo Gouveia, Rui Zhang & Sabine Petry (2024). “HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2” bioRxiv. [Preprint]. 2023 Dec 18:2023.12.18.571906. doi: 10.1101/2023.12.18.571906. (Abstract)

Kiarash Jamali, Lukas Käll, Rui Zhang, Alan Brown, Dari Kimanius & Sjors H W Scheres (2024). “Automated model building and protein identification in cryo-EM maps” Nature. 2024 Apr;628(8007):450-457. doi: 10.1038/s41586-024-07215-4. Epub 2024 Feb 26. (Abstract)