Andrea Soranno, Ph.D.

Assistant Professor

Biochemistry and Molecular Biophysics

Lab Website
Publications (PubMed / NIH)

Office: 2913 South Building
Phone: 314-273-1632


We combine single-molecule fluorescence spectroscopy and concepts from polymer physics to investigate intrinsically disordered proteins; we develop innovative methods to study macromolecular conformations and dynamics within cells and in membraneless organelles.

Select Publications

Soranno A., Zosel F., & Hofmann H. (2018). “Internal friction in an intrinsically disordered protein-Comparing Rouse-like models with experiments.” J Chem Phys. 2018 Mar 28;148(12):123326. doi: 10.1063/1.5009286. (Abstract)

Borgia A., Borgia M.B., Bugge K., Kissling V.M., Heidarsson P.O., Fernandes C.B., Sottini A., Soranno A., Buholzer K.J., Nettels D., Kragelund B.B., Best R.B., & Schuler B. (2018). “Extreme disorder in an ultrahigh-affinity protein complex.” Nature. 2018 Mar 1;555(7694):61-66. doi: 10.1038/nature25762. Epub 2018 Feb 21. (Abstract)

Zosel F., Haenni D., Soranno A., Nettels D., & Schuler B. (2017). “Combining short- and long-range fluorescence reporters with simulations to explore the intramolecular dynamics of an intrinsically disordered protein.” J Chem Phys. 2017 Oct 21;147(15):152708. doi: 10.1063/1.4992800. (Abstract)

Soranno A., Holla A., Dingfelder F., Nettels D., Makarov D.E., & Schuler B. (2017). “Integrated view of internal friction in unfolded proteins from single-molecule FRET, contact quenching, theory, and simulations.” Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1833-E1839. doi: 10.1073/pnas.1616672114. Epub 2017 Feb 21. (Abstract)

Borgia A., Zheng W., Buholzer K., Borgia M.B., Schüler A., Hofmann H., Soranno A., Nettels D., Gast K., Grishaev A., Best R.B., & Schuler B. (2016). “Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods.” J Am Chem Soc. 2016 Sep 14;138(36):11714-26. doi: 10.1021/jacs.6b05917. Epub 2016 Sep 1. (Abstract)

Schuler B., Soranno A., Hofmann H., & Nettels D. (2016). “Single-Molecule FRET Spectroscopy and the Polymer Physics of Unfolded and Intrinsically Disordered Proteins.” Annu Rev Biophys. 2016 Jul 5;45:207-31. doi: 10.1146/annurev-biophys-062215-010915. Epub 2016 May 2. (Abstract)