Andrea Soranno, Ph.D.

Assistant Professor

Biochemistry and Molecular Biophysics

Lab Website
Publications (PubMed / NIH)

Office: 2913 South Building
Phone: 314-273-1632


We combine single-molecule fluorescence spectroscopy and concepts from polymer physics to investigate intrinsically disordered proteins; we develop innovative methods to study macromolecular conformations and dynamics within cells and in membraneless organelles.

Select Publications

Jasmine Cubuk, Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell-Brereton, Michael D. Ward, Maxwell I. Zimmerman, Neha Vithani, Daniel Griffith, Jason A. Wagoner, Gregory R. Bowman, Kathleen B. Hall, Andrea Soranno, & Alex S. Holehouse. (2021). “The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA” Nat Commun. 2021 Mar 29;12(1):1936. doi: 10.1038/s41467-021-21953-3. (Abstract)

Martin E.W., Holehouse A.S., Peran I., Farag M., Incicco J.J., Bremer A., Grace C.R., Soranno A., Pappu R.V., & Mittag T. (2020). “Valence and patterning of aromatic residues determine the phase behavior of prion-like domains.” Science. 2020 Feb 7;367(6478):694-699. doi: 10.1126/science.aaw8653. (Abstract)

Singh S.P., Soranno A., Sparks M.A., & Galletto R. (2019). “Branched unwinding mechanism of the Pif1 family of DNA helicases.” Proc Natl Acad Sci U S A. 2019 Nov 19. pii: 201915654. doi: 10.1073/pnas.1915654116. [Epub ahead of print] (Abstract)

Felicia Gibson, Andrea Soranno, Wenwei Zheng, & Sara M. Vaiana. (2019). “Extracting Sequence-Dependent Intra-Protein Interaction Parameters from Photo-Induced Electron Transfer Measurements of IDPs” Biophysical Journal. Volume 116, Issue 3, Supplement 1, 15 February 2019, Page 202a. (Abstract)

Andrea Soranno, Jeremias Incicco, Paolo De Bona, Eric Tomko, Eric Galburt, & Roberto Galletto. (2019). “Shelterin Components Modulate the Phase-Separation Propensity of Telomeres” Biophysical Journal. Volume 116, Issue 3, Supplement 1, 15 February 2019, Pages 467a-468a. (Abstract)

Melissa D. Stuchell-Brereton, Berevan Baban, Greg DeKoster, Carl Frieden, & Andrea Soranno. (2019). “Single-Molecule Conformational Analysis of Apolipoprotein E” Biophysical Journal. Volume 116, Issue 3, Supplement 1, 15 February 2019, Page 167a. (Abstract)

Rezaei-Ghaleh N., Parigi G., Soranno A., Holla A., Becker S., Schuler B., Luchinat C., & Zweckstetter M. (2018). “Local and Global Dynamics in Intrinsically Disordered Synuclein.” Angew Chem Int Ed Engl. 2018 Sep 5. doi: 10.1002/anie.201808172. [Epub ahead of print] (Abstract)

Soranno A., Zosel F., & Hofmann H. (2018). “Internal friction in an intrinsically disordered protein-Comparing Rouse-like models with experiments.” J Chem Phys. 2018 Mar 28;148(12):123326. doi: 10.1063/1.5009286. (Abstract)

Borgia A., Borgia M.B., Bugge K., Kissling V.M., Heidarsson P.O., Fernandes C.B., Sottini A., Soranno A., Buholzer K.J., Nettels D., Kragelund B.B., Best R.B., & Schuler B. (2018). “Extreme disorder in an ultrahigh-affinity protein complex.” Nature. 2018 Mar 1;555(7694):61-66. doi: 10.1038/nature25762. Epub 2018 Feb 21. (Abstract)

Zosel F., Haenni D., Soranno A., Nettels D., & Schuler B. (2017). “Combining short- and long-range fluorescence reporters with simulations to explore the intramolecular dynamics of an intrinsically disordered protein.” J Chem Phys. 2017 Oct 21;147(15):152708. doi: 10.1063/1.4992800. (Abstract)

Soranno A., Holla A., Dingfelder F., Nettels D., Makarov D.E., & Schuler B. (2017). “Integrated view of internal friction in unfolded proteins from single-molecule FRET, contact quenching, theory, and simulations.” Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1833-E1839. doi: 10.1073/pnas.1616672114. Epub 2017 Feb 21. (Abstract)

Borgia A., Zheng W., Buholzer K., Borgia M.B., Schüler A., Hofmann H., Soranno A., Nettels D., Gast K., Grishaev A., Best R.B., & Schuler B. (2016). “Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods.” J Am Chem Soc. 2016 Sep 14;138(36):11714-26. doi: 10.1021/jacs.6b05917. Epub 2016 Sep 1. (Abstract)

Schuler B., Soranno A., Hofmann H., & Nettels D. (2016). “Single-Molecule FRET Spectroscopy and the Polymer Physics of Unfolded and Intrinsically Disordered Proteins.” Annu Rev Biophys. 2016 Jul 5;45:207-31. doi: 10.1146/annurev-biophys-062215-010915. Epub 2016 May 2. (Abstract)