Postdoctoral Positions – Department of Biochemistry and Molecular Biophysics

Fellowship Programs:

Regular Postdoctoral Positions:

Peter Burgers

Post-doctoral positions are available to study DNA-protein interactions in eukaryotic DNA replication and DNA damage response mechanisms. Our studies integrate biochemical with genetic analysis using Saccharomyces cerevisiae as a model organism. Applicants should possess a strong background in biochemistry, and have experience in protein purification and analysis. Experience in genetic analysis is preferred. Please, see the lab’s home page for more information.

Interested candidates should send their c.v. and three letters of reference to:

Dr. Peter Burgers
Professor of Biochemistry and Molecular Biophysics
Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8231
St. Louis, MO 63110
E-mail: burgers@wustl.edu

Carl Frieden

ApoE4, a protein of 299 amino acids, is the major risk factor for the development of late-onset Alzheimer’s disease while apoE3, which differs by a single amino acid, is not. A post-doctoral position is immediately available to study the properties of apoE isoforms by sophisticated biophysical techniques to discern why apoE3 is functionally different from apoE4. Of particular interest is the interaction of apoE with small molecules including amyloid-beta and compounds that affect the behavior of apoE. Applicants should possess a strong background in biochemistry, with experience in protein purification and functional characterization of proteins.

Interested candidates should send their c.v. and three letters of reference to:

Dr. Carl Frieden
Professor of Biochemistry and Molecular Biophysics
Box 8231
Washington University School of Medicine
660 S. Euclid Ave
St. Louis, MO 63110
Email: friedenc@wustl.edu
Phone: 314-362-3344

Michael J. Greenberg

The Greenberg Lab at Washington University School of Medicine in St. Louis is seeking a postdoctoral fellow to study the mechanism of disease-causing mutations associated with familial cardiomyopathies, the leading cause of sudden cardiac death in young people. The lab utilizes an array of cutting-edge techniques including single molecule optical trapping, protein expression and purification, stopped-flow rapid kinetics, genome editing, stem cell technologies, mathematical modeling, and tissue engineering to better understand how these point mutations lead to the disease phenotype across multiple scales of organization. Interested candidates should have a background in biophysics, protein biochemistry, cell biology, biomedical engineering, or a closely related field. Experience with single molecule biophysics is preferred. Excellent verbal and written communication skills are required. This is an excellent opportunity for trainees interested in both academic and non-academic positions to get involved in basic biophysical research with direct medical relevance.

For additional information, please see the Greenberg Lab website at glab.biochem.wustl.edu.

Interested candidates should send a cover letter, C.V., a brief research statement (i.e., 1 page describing their past research accomplishments and goals for their postdoctoral training), and the contact information for three references to Michael Greenberg at greenberg@wustl.edu.

James W. Janetka

Postdoctoral Research Associate-Cancer Research
Description: Immediate opening for a postdoctoral appointment in the areas of medicinal, computational and synthetic organic chemistry. This exciting research project is focused on chemical biology and drug discovery including rational structure-based design, synthesis, and optimization of bioactive small-molecule inhibitors for the development of chemical tools and novel therapeutics targeting proteases, growth factors and cell-signaling pathways in cancer.

Requirements: Recent Ph.D. in organic or medicinal chemistry with a strong publication record. Extensive experience with synthetic organic chemistry and use of modern techniques and instrumentation for purification and structural elucidation required. Ability to work independently, communicate data and results clearly coupled with strong analytical and problem-solving abilities are necessary. Experience with peptides, peptidomimetics and heterocyclic chemistry plus working in a collaborative team environment preferred. Computational docking and modeling experience is a huge plus.

Please submit applications enclosing a cover letter with copies of current curriculum vitae/resume and summary of research experience to: Dr. James W. Janetka, Washington University School of Medicine, 660 S. Euclid Ave., Box 8231, St. Louis, MO 63110, or email at janetkaj@wustl.edu.

Postdoctoral Research Associate-Infectious Disease Research
Description: Immediate opening for a postdoctoral appointment in the areas of medicinal, computational and synthetic organic chemistry. This exciting research program is focused on chemical biology and drug discovery including rational structure-based design, synthesis, and optimization of bioactive small-molecule and glycoside inhibitors for the development of chemical tools and novel therapeutics targeting lectins and proteases in Gram-negative bacteria, parasitic kinases and other enzymes in Toxoplasma and Nematode worms, as well as protein-protein interactions in Tuberculosis.

Requirements: Recent Ph.D. in organic or medicinal chemistry with a strong publication record. Extensive experience with synthetic organic chemistry and use of modern techniques and instrumentation for purification and structural elucidation required. Ability to work independently, communicate data and results clearly coupled with strong analytical and problem-solving abilities are necessary. Experience with carbohydrate chemistry and heterocyclic chemistry plus working in a collaborative team environment preferred. Computational docking and modeling experience is a huge plus.

Washington University School of Medicine is an equal opportunity/affirmative action employer.