Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.

Yang B., Hird A.W., Russell D.J., Fauber B.P., Dakin L.A., Zheng X., Su Q., Godin R., Brassil P., Devereaux E., and Janetka J.W. (2012) “Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.” Bioorg Med Chem Lett. 2012 Jul 15;22(14):4907-11. doi: 10.1016/j.bmcl.2012.04.104. Epub 2012 Apr 30. (Abstract)