Category: Janetka Publications

Dr. Janetka’s Publications

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.

Yang B., Vasbinder M., Hird A.W., Su Q., Wang H., Yu Y., Toader D., Lyne P.D., Read J.A., Breed J., Ioannidis S., Deng C., Grondine M., DeGrace N., Whitston D., Brassil P., and Janetka J.W.
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
J Med Chem. doi: 10.1021/acs.jmedchem.7b01490. (2018) (Abstract)

Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii.

Rutaganira F.U., Barks J., Dhason M.S., Wang Q., Lopez M.S., Long S., Radke J.B., Jones N.G., Maddirala A.R., Janetka J.W., El Bakkouri M., Hui R., Shokat K.M., and Sibley L.D.
Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii.
J Med Chem. doi: 10.1021/acs.jmedchem.7b01192. (2017) (Abstract)

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Spaulding C.N., Klein R.D., Ruer S., Kau A.L., Schreiber H.L., Cusumano Z.T., Dodson K.W., Pinkner J.S., Fremont D.H., Janetka J.W., Remaut H., Gordon J.I., and Hultgren S.J.
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Nature. 546(7659):528-532. doi: 10.1038/nature22972. (2017) (Abstract, Article)

Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation

Owusu B.Y., Thomas S., Venukadasula P., Han Z., Janetka J.W., Galemmo R.A. Jr., and Klampfer L.
Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation
Oncotarget. 8(38):63014-63025. doi: 10.18632/oncotarget.18260. (2017) (Abstract)

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1

Melissa M Budelier, Wayland WL Cheng, Lucie Bergdoll, Zi-Wei Chen, James W Janetka, Jeff Abramson, Kathiresan Krishnan, Laurel Mydock-McGrane, Douglas F Covey, Julian P Whitelegge, and Alex S Evers
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1
Journal of Biological Chemistry (2017) (Abstract)

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

Vasilios Kalas, Jerome S. Pinkner, Thomas J. Hannan, Michael E. Hibbing, Karen W. Dodson, Alex S. Holehouse, Hao Zhang, Niraj H. Tolia, Michael L. Gross, Rohit V. Pappu, James Janetka and Scott J. Hultgren
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions
Science Advances Vol. 3, no. 2 (2017) (Abstract)

Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins

Melissa M. Budelier, Wayland W. L. Cheng, Lucie Bergdoll, Zi-Wei Chen, Jeff Abramson, Kathiresan Krishnan, Mingxing Qian, Douglas F. Covey, James W. Janetka, and Alex S. Evers
Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins
Analytical Chem. (2017) (Abstract)

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

Mydock-McGrane L., Cusumano Z., Han Z., Binkley J., Kostakioti M., Hannan T., Pinkner J.S., Klein R., Kalas V., Crowley J., Rath N.P., Hultgren S.J., and Janetka J.W.
Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections
J Med Chem. (2016) (Abstract)