PCR methods; Aptamer selection to counter neurological diseases
Postdoc candidate profile: Mouse management experience and willing certification for vertebrate research. Interest in the power of aptamers. Biostatistics. Homemade NGS (next gen sequencing). Single-cell NGS. Neuroscience.
The role of DNA helicases in facilitating progression of DNA replication at barriers. The assembly of telomeric nucleoprotein complexes.
Postdoc candidate profile: Expertise in molecular biology methods, protein expression, purification and characterization, and preferably one or more quantitative methods to study macromolecular interactions and function. These include, but are not limited to, fluorescence spectroscopy, stopped-flow/quench flow and steady-state methods to study enzymatic activities, single molecule imaging, analytical ultracentrifugation.
High-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.
Postdoc candidate profile: Broad cell biology and biochemistry skills, experience with any mass spectrometry would be a plus but not needed. Interests in neuroscience or cancer.
Molecular and cellular biophysics of heart disease, with the goal of engineering disease models and precision therapeutics.
Postdoc candidate profile: Background in molecular/cellular biophysics, mechanobiology, biomedical engineering, muscle biology, cardiovascular sciences, or a closely related field. Experience with single molecule techniques, protein biochemistry, muscle biophysics, cell culture, cellular/tissue engineering, and/or cardiac biology are preferred.
Structure and function of membrane proteins in hematological and cardiovascular systems.
Postdoc candidate profile: Structure biology (cryo-EM preferred, or crystallography), biochemistry or mass spectrometry skills. Membrane protein structures and interactions. Membrane protein degradation, cell adhesion and migration.
How mitochondria are built, regulated, and maintained across physiological contexts.
Postdoc candidate profile: Metabolism, mass spectrometry (including, but not limited to metabolomics, and/or quantitative phosphoproteomics), molecular biology, biochemistry, mouse modeling of complex diseases, yeast genetics, or CRISPR screening.