Spotlight on Research – Holehouse Lab

The Holehouse Lab works to understand how intrinsically disordered regions – protein regions that lack a stable 3D structure – facilitate molecular and cellular function. The lab combines computational and experimental approaches to elucidate how disordered regions behave in isolation, how they interact with partners, how they evolve, and how mutations in disordered regions impact their normal cellular function in the context of human disease. The lab explores these questions in various contexts, combining synthetic biology and protein design to decode the underlying principles that relate sequence to function.