The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.

Adak S., Deandrade D., & Pike L.J. (2012). “The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.” J Biol Chem. 2011 Jan 14;286(2):1545-55. doi: 10.1074/jbc.M110.182899. Epub 2010 Nov 3. (Abstract)