Category: Pike Publications

Dr. Pike’s Publications

Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent.

Gill K., Macdonald-Obermann J.L., and Pike L.J.
Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent.
J Biol Chem. pii: jbc.M117.802553. doi: 10.1074/jbc.M117.802553. (2017) (Abstract)

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.

Needham S.R., Roberts S.K., Arkhipov A., Mysore V.P., Tynan C.J., Zanetti-Domingues L.C., Kim E.T., Losasso V., Korovesis D., Hirsch M., Rolfe D.J., Clarke D.T., Winn M.D., Lajevardipour A., Clayton A.H., Pike L.J., Perani M., Parker P.J., Shan Y., Shaw D.E., and Martin-Fernandez M.L.
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Nat Commun. 7:13307 (2016) (Abstract)

Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins.

Ronan, T., Macdonald-Obermann, J.L., Huelsmann, L., Bessman, N.J., Naegle, K.M. and Pike, L.J.
Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins.
J. Biol Chem 291:5528-5540 (2016). (Abstract)

Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.

Macdonald-Obermann, J.L. and Pike, L.J.
Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.
J. Biol Chem 289:26178-26188 (2014). (Abstract)

Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging.

Macdonald-Obermann, J.L., Adak, S., Landgraf, R., Piwnica-Worms, D. and Pike, L.J.
Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging.
J. Biol Chem 288:30773-30784 (2013). (Abstract)

The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding.

Adak, S., Yang, K.S., Macdonald-Obermann, J. and Pike, L.J.
The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding.
J Biol Chem 286:45146-45155 (2011). (Abstract)