The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding.
Macdonald-Obermann J.L. & Pike L.J. (2009). “The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding.” J Biol Chem. 2009 May 15;284(20):13570-6. doi: 10.1074/jbc.M109.001487. Epub 2009 Mar 31. (Abstract)