Crick, S.L., Ruff, K.M., Garai, K., Frieden, C. and Pappu, R.V.
Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.
PNAS 110:20075-20080 (2013). (Abstract)
Verghese, P.B., Castellano, J.M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C. and Holtzmann, D.M.
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
PNAS 110:E1807-1816 (2013). (Abstract)
Garai, K. and Frieden, C.
Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ.
PNAS 110:3321-3326 (2013). (Abstract)
Frieden C. & Garai K. (2012). “Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer’s disease.” Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8913-8. doi: 10.1073/pnas.1207022109. Epub 2012 May 21. (Abstract)
Shu Q., Crick S.L., Pinkner J.S., Ford B., Hultgren S.J., & Frieden C. (2012). “The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.” Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6502-7. doi: 10.1073/pnas.1204161109. Epub 2012 Apr 9. (Abstract)
Huang R.Y., Garai K., Frieden C., & Gross M.L. (2011). “Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization.” Biochemistry. 2011 Nov 1;50(43):9273-82. doi: 10.1021/bi2010027. Epub 2011 Oct 5. (Abstract)
Gau B.C., Garai K., Frieden C., & Gross M.L. (2011). “Mass spectrometry-based protein footprinting characterizes the structures of oligomeric apolipoprotein E2, E3, and E4.” Biochemistry. 2011 Sep 27;50(38):8117-26. doi: 10.1021/bi200911c. Epub 2011 Sep 2. (Abstract)
Garai K., Baban B., & Frieden C. (2011). “Self-association and stability of the ApoE isoforms at low pH: implications for ApoE-lipid interactions.” Biochemistry. 2011 Jul 26;50(29):6356-64. doi: 10.1021/bi2006702. Epub 2011 Jun 29. (Abstract)
Garai K., Baban B., & Frieden C. (2011). “Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles.” Biochemistry. 2011 Apr 5;50(13):2550-8. doi: 10.1021/bi1020106. Epub 2011 Feb 28. (Abstract)
Niu W., Shu, Q., Chen Z., Mathews F.S., Di Cera E., & Frieden C. (2010). “The role of Zn2+ on the structure and stability of murine adenosine deaminase.” J Phys Chem B. 2010 Dec 16;114(49):16156-65. doi: 10.1021/jp106041v. Epub 2010 Sep 3. (Abstract)