Author: Nicholas Caito

Congratulations to Melanie Ernst!

Melanie ErnstMelanie Ernst has been elected chair of the 2021 Mechanisms of Membrane Transport GRS.

The GRS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Congratulations Melanie!

Mr. Josh Rackers was awarded the 2019 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.

On June 7, 2019, Dr. Josh Rackers was awarded the 2019 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry.

Dr. Rackers presented his research entitled “HIPPO: A physics-based model for biomolecular interactions”. Dr. Rackers was a graduate student in the Computational and Molecular Biophysics Program. Mr. Rackers was nominated by his thesis mentor Dr. Jay Ponder. In Dr. Ponder’s lab, Josh’s work focused on using the tools of applied quantum mechanics to predict the behavior and interactions of biological molecules. This work is motivated by a deeply held belief that physics holds the answers to many of biology’s most important problems. (more…)

Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics.

Tyagi R., Elfawal M.A., Wildman S.A., Helander J., Bulman C.A., Sakanari J., Rosa B.A., Brindley P.J., Janetka J.W., Aroian R.V., & Mitreva M. (2019). “Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics.” Sci Rep. 2019 Jun 24;9(1):9085. doi: 10.1038/s41598-019-45548-7. (Abstract)

The role of pericellular serine proteases in tumor progression and resistance to anticancer therapy

June 14th, 2019 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, received a two-year Siteman Investment Program (SIP) award from the Siteman Cancer Center and Foundation for Barnes Jewish-Hospital for his research entitled “The role of pericellular serine proteases in tumor progression and resistance to anticancer therapy”.

Maxwell Zimmerman Awarded Pharmacology Prize

Maxwell ZimmermanCongratulations to Maxwell Zimmerman for being awarded the Dr. Philip Needleman Pharmacology Prize.

The award is presented annually from the Department of Developmental Biology to a graduating student demonstrating outstanding achievements it the field of Pharmacology. Maxwell is a PhD student in the Computational and Molecular Biophysics Program – he is completing his thesis research in the lab of Dr. Gregory Bowman. (more…)

Protein Environment and DNA Orientation Affect Protein-Induced Cy3 Fluorescence Enhancement.

Nguyen B., Ciuba M.A., Kozlov A.G., Levitus M., & Lohman T.M. (2019). “Protein Environment and DNA Orientation Affect Protein-Induced Cy3 Fluorescence Enhancement.” Biophys J. 2019 Jun 7. pii: S0006-3495(19)30448-5. doi: 10.1016/j.bpj.2019.05.026. [Epub ahead of print] (Abstract)

CarD and RbpA modify the kinetics of initial transcription and slow promoter escape of the Mycobacterium tuberculosis RNA polymerase.

Jensen D., Ruiz Manzano A., Rammohan J., Stallings C.L., & Galburt E.A. (2019). “CarD and RbpA modify the kinetics of initial transcription and slow promoter escape of the Mycobacterium tuberculosis RNA polymerase.” Nucleic Acids Res. 2019 May 25. pii: gkz449. doi: 10.1093/nar/gkz449. [Epub ahead of print] (Abstract)