Author: Nicholas Caito

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.

Yang B., Vasbinder M., Hird A.W., Su Q., Wang H., Yu Y., Toader D., Lyne P.D., Read J.A., Breed J., Ioannidis S., Deng C., Grondine M., DeGrace N., Whitston D., Brassil P., and Janetka J.W.
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
J Med Chem. doi: 10.1021/acs.jmedchem.7b01490. (2018) (Abstract)

2017 BMB Holiday Party

On December 16th, 2017, the BMB Department celebrated its annual Holiday Party at the Saint Louis Zoo. Everyone enjoyed the Zoo Wild Lights display, great food and a game of Rudolf the red-nose reindeer.

Click on the following to view more photos or a slideshow of the photos taken at the event.

Jim Janetka’s Paper with David Sibley Highlighted

Congratulations to Drs. Jim Janetka and Amarendar Maddirala, whose publication was selected as the journal cover of the most recent issue of J. Med. Chem, and was the topic of a recent viewpoint entitled “Novel Molecules To Treat Chronic Central Nervous System Toxoplasmosis” by Sandhya Kortagere. (more…)

Effects of Mechanical Forces on Cardiac Excitability in Heart Disease

December 20th, 2017 – Michael Greenberg, PhD, Assistant Professor of Biochemistry and Molecular Biophysics received a 2018 CIMED P&F award from the Center for the Investigation of Membrane Excitability Diseases for his work entitled “Effects of Mechanical Forces on Cardiac Excitability in Heart Disease”.

Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models

Maxwell I. Zimmerman, Kathryn M. Hart, Carrie A. Sibbald, Thomas E. Frederick, John R. Jimah, Catherine R. Knoverek, Niraj H. Tolia, and Gregory R. Bowman
Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models
ACS Cent. Sci., 2017, 3 (12), pp 1311–1321, DOI: 10.1021/acscentsci.7b00465 (2017) (Abstract)

Michael Kinch – Cutting NIH budget could cripple drug development

Michael Kinch A proposal to slash funding for the National Institutes of Health (NIH) could severely impair the development of new, life-saving drugs, according to a new analysis by researchers at Washington University School of Medicine in St. Louis.

NIH funding supports the early research needed to develop new, innovative drugs. President Donald Trump’s proposed budget calls for cutting the NIH budget by 21 percent, or about $7.2 billion.
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