Author: Nicholas Caito

Targeting Hepatocyte Growth Factor with Protease Inhibitors in Lung Cancer

April 9th, 2018 – Jim Janetka, PhD, Associate Professor of Biochemistry and Molecular Biophysics, and Co-Founder of ProteXase Therapeutics, Inc., along with Lidija Klampfer, PhD, Co-Founder and Chief Scientific Officer of ProteXase Therapeutics, Inc., received a one-year SBIR grant award from the National Cancer Institute for their research entitled “Targeting Hepatocyte Growth Factor with Protease Inhibitors in Lung Cancer”.

Spotlight on Research – Marshall Lab

The Marshall Lab performs a synergistic application of organic synthesis (solution- and solid-phase chemistry), enzymatic assays (electrophoretic mobility shift assays (EMSA) and surface plasmon resonance (SPR)), and computational chemistry techniques (homology modeling, molecular docking, molecular dynamics simulations, QSAR and 3D QSAR models) to rationally develop novel isoform-selective Lysine Deacetylases Inhibitors (KDACIs) as new therapeutics for the treatment of cancer, HIV-1, schistosomiasis and malaria.

Spotlight on Research – Greenberg Lab

The Greenberg Lab focuses on how cytoskeletal motors function in both health and disease. Currently, the lab is studying mutations that cause familial cardiomyopathies, the leading cause of sudden cardiac death in people under 30 years old. The lab uses an array of biochemical, biophysical, and cell biological techniques to decipher how these mutations affect heart contraction from the level of single molecules to the level of engineered tissues. Insights into the disease pathogenesis will guide efforts to develop novel therapies.

Congratulations to Paige Cloonan (pictured, on the left), an undergraduate researcher in Michael Greenberg’s lab, for winning the Undergraduate Poster Award Competition at the 2018 Biophysical Society Meeting.

Paige is currently in her fourth year, majoring in Biomedical Engineering. The winning poster was entitled “Mechanical and Structural Analysis of Cardiomyopathies at the Single Cell Level”.

Spotlight on Research – Bowman Lab

The Bowman Lab seeks to understand the distribution of different structures a protein adopts and how this ensemble determines a proteins function. Examples of ongoing research projects include 1) understanding how mutations in the enzyme beta-lactamase change its specificity without changing the protein’s crystal structure, 2) designing allosteric drugs, and 3) developing algorithms for quickly building models of the different structures a protein adopts.